Search Results - "Powell, JR"

High-affinity FRβ-specific CAR T cells eradicate AML and normal myeloid lineage without HSC toxicity by Lynn, R C, Feng, Y, Schutsky, K, Poussin, M, Kalota, A, Dimitrov, D S, Powell Jr, D J

“…Acute myeloid leukemia (AML) is an aggressive malignancy, and development of new treatments to prolong remissions is warranted. Chimeric antigen receptor (CAR)…”
Get full text

Targeting of folate receptor β on acute myeloid leukemia blasts with chimeric antigen receptor–expressing T cells by Lynn, Rachel C., Poussin, Mathilde, Kalota, Anna, Feng, Yang, Low, Philip S., Dimitrov, Dimiter S., Powell Jr, Daniel J.

“…T cells expressing a chimeric antigen receptor (CAR) can produce dramatic results in lymphocytic leukemia patients; however, therapeutic strategies for myeloid…”
Get full text

Adoptive immunotherapy for cancer: building on success by Gattinoni, Luca, Restifo, Nicholas P, Powell, Daniel J, Rosenberg, Steven A

“…Adoptive cell transfer after host preconditioning by lymphodepletion represents an important advance in cancer immunotherapy. Here, we describe how a…”
Get full text

Adoptive T cell therapy for ovarian cancer by Gitto, Sarah B., Ihewulezi, Chibuike J.N., Powell, Daniel J.

“…Although ovarian cancer patients typically respond to standard of care therapies, including chemotherapy and DNA repair inhibitors, the majority of tumors…”
Get full text

Expression of inducible factors reprograms CAR-T cells for enhanced function and safety by Smole, Anže, Benton, Alexander, Poussin, Mathilde A., Eiva, Monika A., Mezzanotte, Claudia, Camisa, Barbara, Greco, Beatrice, Sharma, Prannda, Minutolo, Nicholas G., Gray, Falon, Bear, Adham S., Baroja, Miren L., Cummins, Casey, Xu, Chong, Sanvito, Francesca, Goldgewicht, Andrea Lang, Blanchard, Tatiana, Rodriguez-Garcia, Alba, Klichinsky, Michael, Bonini, Chiara, June, Carl H., Posey, Avery D., Linette, Gerald P., Carreno, Beatriz M., Casucci, Monica, Powell, Daniel J.

“…Despite the success of CAR-T cell cancer immunotherapy, challenges in efficacy and safety remain. Investigators have begun to enhance CAR-T cells with the…”
Get full text

CD137+ tumor infiltrating lymphocytes predicts ovarian cancer survival by Tubridy, Elizabeth A., Eiva, Monika A., Liu, Fang, Omran, Dalia K., Gysler, Stefan, Brown, Erica G., Roy, Allison G., Zeng, Yuyan, Oh, Jinhee, Cao, Quy, Gitto, Sarah B., Powell, Daniel J.

“…Ovarian cancer (OC) is the leading cause of death from gynecologic malignancy in the United States, and biomarkers of patient outcomes are limited. Data using…”
Get full text

Dichotomous impact of affinity on the function of T cell engaging bispecific antibodies by Poussin, Mathilde, Sereno, Arlene, Wu, Xiufeng, Huang, Flora, Manro, Jason, Cao, Shanshan, Carpenito, Carmine, Glasebrook, Andrew, Powell Jr, Daniel J, Demarest, Stephen

“…BackgroundBispecific T cell engagers represent the majority of bispecific antibodies (BsAbs) entering the clinic to treat metastatic cancer. The ability to…”
Get full text

Immunotherapy for Ovarian Cancer: What's Next? by KANDALAFT, Lana E, POWELL, Daniel J, SINGH, Nathan, COUKOS, George

“…In the past decade, we have witnessed important gains in the treatment of ovarian cancer; however, additional advances are required to reduce mortality. With…”
Get full text

Targeted ablation of the PTH/PTHrP receptor in osteocytes impairs bone structure and homeostatic calcemic responses by Powell, William F, Barry, Kevin J, Tulum, Irena, Kobayashi, Tatsuya, Harris, Stephen E, Bringhurst, F Richard, Divieti Pajevic, Paola

“…Parathyroid hormone (PTH) is a major physiologic regulator of calcium, phosphorous, and skeletal homeostasis. Cells of the osteoblastic lineage are key targets…”
Get full text

Natural TCRs targeting KRASG12V display fine specificity and sensitivity to human solid tumors by Bear, Adham S, Nadler, Rebecca B, O'Hara, Mark H, Stanton, Kelsey L, Xu, Chong, Saporito, Robert J, Rech, Andrew J, Baroja, Miren L, Blanchard, Tatiana, Elliott, Maxwell H, Ford, Michael J, Jones, Richard C, Patel, Shivang, Brennan, Andrea L, O'Neil, Zachary, Powell, Jr, Daniel J, Vonderheide, Robert H, Linette, Gerald P, Carreno, Beatriz M

“…Neoantigens derived from KRASMUT have been described, but the fine antigen specificity of T cell responses directed against these epitopes are poorly…”
Get full text

Signaling via a CD28/CD40 chimeric costimulatory antigen receptor (CoStAR™), targeting folate receptor alpha, enhances T cell activity and augments tumor reactivity of tumor infiltrating lymphocytes by Kalaitsidou, Milena, Moon, Owen R, Sykorova, Martina, Bao, Leyuan, Qu, Yun, Sukumaran, Sujita, Valentine, Michael, Zhou, Xingliang, Pandey, Veethika, Foos, Kay, Medvedev, Sergey, Powell, Jr, Daniel J, Udyavar, Akshata, Gschweng, Eric, Rodriguez, Ruben, Dudley, Mark E, Hawkins, Robert E, Kueberuwa, Gray, Bridgeman, John S

“…Transfer of autologous tumor infiltrating lymphocytes (TIL) to patients with refractory melanoma has shown clinical efficacy in a number of trials. However,…”
Get full text

PARP Theranostic Auger Emitters Are Cytotoxic in BRCA Mutant Ovarian Cancer and Viable Tumors from Ovarian Cancer Patients Enable Ex-Vivo Screening of Tumor Response by Riad, Aladdin, Gitto, Sarah B, Lee, Hwan, Winters, Harrison D, Martorano, Paul M, Hsieh, Chia-Ju, Xu, Kuiying, Omran, Dalia K, Powell, Jr, Daniel J, Mach, Robert H, Makvandi, Mehran

“…Theranostics are emerging as a pillar of cancer therapy that enable the use of single molecule constructs for diagnostic and therapeutic application. As poly…”
Get full text

Autologous lysate-pulsed dendritic cell vaccination followed by adoptive transfer of vaccine-primed ex vivo co-stimulated T cells in recurrent ovarian cancer by Kandalaft, Lana E., Powell, Jr, Daniel J., Chiang, Cheryl L., Tanyi, Janos, Kim, Sarah, Bosch, Marnix, Montone, Kathy, Mick, Rosemarie, Levine, Bruce L., Torigian, Drew A., June, Carl H., Coukos, George

“…Novel strategies for the therapy of recurrent ovarian cancer are warranted. We report a study of a combinatorial approach encompassing dendritic cell…”
Get full text

Perspectives in Immunotherapy: meeting report from Immunotherapy Bridge (Naples, November 30th-December 1st, 2022) by Ascierto, Paolo A, Avallone, Antonio, Bifulco, Carlo, Bracarda, Sergio, Brody, Joshua D, Emens, Leisha A, Ferris, Robert L, Formenti, Silvia C, Hamid, Omid, Johnson, Douglas B, Kirchhoff, Tomas, Klebanoff, Christopher A, Lesinski, Gregory B, Monette, Anne, Neyns, Bart, Odunsi, Kunle, Paulos, Chrystal M, Powell, Jr, Daniel J, Rezvani, Katayoun, Segal, Brahm H, Singh, Nathan, Sullivan, Ryan J, Fox, Bernard A, Puzanov, Igor

“…The discovery and development of novel treatments that harness the patient's immune system and prevent immune escape has dramatically improved outcomes for…”
Get full text

A T cell receptor specific for an HLA-A03:01-restricted epitope in the endogenous retrovirus ERV-K-Env exhibits limited recognition of its cognate epitope by Grundy, Erin E, Shaw, Lauren C, Wang, Loretta, Lee, Abigail V, Argueta, James Castro, Powell, Jr, Daniel J, Ostrowski, Mario, Jones, R Brad, Cruz, C Russell Y, Gordish-Dressman, Heather, Chappell, Nicole P, Bollard, Catherine M, Chiappinelli, Katherine B

“…Transposable elements (TEs) are often expressed at higher levels in tumor cells than normal cells, implicating these genomic regions as an untapped pool of…”
Get full text

Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity by Palmer, Douglas C, Chan, Chi-Chao, Gattinoni, Luca, Wrzesinski, Claudia, Paulos, Chrystal M, Hinrichs, Christian S, Powell, Daniel J. Jr, Klebanoff, Christopher A, Finkelstein, Steven E, Fariss, Robert N, Yu, Zhiya, Nussenblatt, Robert B, Rosenberg, Steven A, Restifo, Nicholas P

“…Nonmutated tissue differentiation antigens expressed by tumors are attractive targets for cancer immunotherapy, but the consequences of a highly effective…”
Get full text

Therapeutic dendritic cell-based cancer vaccines: the state of the art by Strioga, Marius M, Felzmann, Thomas, Powell, Jr, Daniel J, Ostapenko, Valerijus, Dobrovolskiene, Neringa T, Matuskova, Miroslava, Michalek, Jaroslav, Schijns, Virgil E J

“…Dendritic cells (DCs) are the most potent professional antigen-presenting cells, capable of initiating proper adaptive immune responses. Although…”
Get full text

Optimizing parameters for clinical-scale production of high IL-12 secreting dendritic cells pulsed with oxidized whole tumor cell lysate by Chiang, Cheryl L-L, Maier, Dawn A, Kandalaft, Lana E, Brennan, Andrea L, Lanitis, Evripidis, Ye, Qunrui, Levine, Bruce L, Czerniecki, Brian J, Powell, Jr, Daniel J, Coukos, George

“…Dendritic cells (DCs) are the most potent antigen-presenting cell population for activating tumor-specific T cells. Due to the wide range of methods for…”
Get full text

Impacts of AMSU-A, MHS and IASI data assimilation on temperature and humidity forecasts with GSI–WRF over the western United States by Bao, Y, Xu, J, Powell Jr., A. M, Shao, M, Min, J, Pan, Y

“…Using NOAA's Gridpoint Statistical Interpolation (GSI) data assimilation system and NCAR's Advanced Research WRF (Weather Research and Forecasting) (ARW-WRF)…”
Get full text

Discovery of a Tidal Stream Extending from NGC 5053 by Lauchner, Adam, Powell, Jr., W. Lee, Wilhelm, Ronald

“…Here we report the discovery of a 6 tidal stream related to NGC 5053 using the Sloan Digital Sky Survey data. A matched-filter analysis has been employed to…”
Get full text