Search Results - "Powell, Isaac J"

Evidence supports a faster growth rate and/or earlier transformation to clinically significant prostate cancer in black than in white American men, and influences racial progression and mortality disparity by Powell, Isaac J, Bock, Cathryn H, Ruterbusch, Julie J, Sakr, Wael

“…The incidence of prostate cancer is approximately 60% higher and the mortality rate is 2 to 3 times greater in black than in white American men. We propose…”
Get more information

Exome Sequencing of African-American Prostate Cancer Reveals Loss-of-Function ERF Mutations by Huang, Franklin W, Mosquera, Juan Miguel, Garofalo, Andrea, Oh, Coyin, Baco, Maria, Amin-Mansour, Ali, Rabasha, Bokang, Bahl, Samira, Mullane, Stephanie A, Robinson, Brian D, Aldubayan, Saud, Khani, Francesca, Karir, Beerinder, Kim, Eejung, Chimene-Weiss, Jeremy, Hofree, Matan, Romanel, Alessandro, Osborne, Joseph R, Kim, Jong Wook, Azabdaftari, Gissou, Woloszynska-Read, Anna, Sfanos, Karen, De Marzo, Angelo M, Demichelis, Francesca, Gabriel, Stacey, Van Allen, Eliezer M, Mesirov, Jill, Tamayo, Pablo, Rubin, Mark A, Powell, Isaac J, Garraway, Levi A

“…African-American men have the highest incidence of and mortality from prostate cancer. Whether a biological basis exists for this disparity remains unclear…”
Get more information

Pro-inflammatory cytokines and chemokines initiate multiple prostate cancer biologic pathways of cellular proliferation, heterogeneity and metastasis in a racially diverse population and underlie the genetic/biologic mechanism of racial disparity: Update by Powell, Isaac J., Chinni, Sreenivasa R., Reddy, Sunil S., Zaslavsky, Alexander, Gavande, Navnath

“…•Pro-inflammatory cytokine genes found to be more interactive and more expressed among AAM.•These cytokines are functional drivers of aggressive prostate…”
Get full text

Epidemiology and pathophysiology of prostate cancer in African-American men by Powell, Isaac J

“…Along with increasing age and a positive family history subSaharan African ancestry has long been recognized as an important risk factor for prostate cancer…”
Get more information

Minireview: The Molecular and Genomic Basis for Prostate Cancer Health Disparities by Powell, Isaac J, Bollig-Fischer, Aliccia

“…Despite more aggressive screening across all demographics and gradual declines in mortality related to prostate cancer (PCa) in the United States, race…”
Get full text

REVEL: An Ensemble Method for Predicting the Pathogenicity of Rare Missense Variants by Ioannidis, Nilah M., Rothstein, Joseph H., Pejaver, Vikas, Middha, Sumit, McDonnell, Shannon K., Baheti, Saurabh, Musolf, Anthony, Li, Qing, Holzinger, Emily, Karyadi, Danielle, Cannon-Albright, Lisa A., Teerlink, Craig C., Stanford, Janet L., Isaacs, William B., Xu, Jianfeng, Cooney, Kathleen A., Lange, Ethan M., Schleutker, Johanna, Carpten, John D., Powell, Isaac J., Cussenot, Olivier, Cancel-Tassin, Geraldine, Giles, Graham G., MacInnis, Robert J., Maier, Christiane, Hsieh, Chih-Lin, Wiklund, Fredrik, Catalona, William J., Foulkes, William D., Mandal, Diptasri, Eeles, Rosalind A., Kote-Jarai, Zsofia, Bustamante, Carlos D., Schaid, Daniel J., Hastie, Trevor, Ostrander, Elaine A., Bailey-Wilson, Joan E., Radivojac, Predrag, Thibodeau, Stephen N., Whittemore, Alice S., Sieh, Weiva

“…The vast majority of coding variants are rare, and assessment of the contribution of rare variants to complex traits is hampered by low statistical power and…”
Get full text

Genes Associated with Prostate Cancer Are Differentially Expressed in African American and European American Men by POWELL, Isaac J, DYSON, Greg, BOLLIG-FISCHER, Aliccia, LAND, Susan, RUTERBUSCH, Julie, BOCK, Cathryn H, LENK, Steve, HERAWI, Mehsati, EVERSON, Richard, GIROUX, Craig N, SCHWARTZ, Ann G

“…Despite more aggressive screening across all demographics and gradual declines in mortality related to prostate cancer (PCa) in the United States, disparities…”
Get full text

Deconstructing, Addressing, and Eliminating Racial and Ethnic Inequities in Prostate Cancer Care by Nyame, Yaw A, Cooperberg, Matthew R, Cumberbatch, Marcus G, Eggener, Scott E, Etzioni, Ruth, Gomez, Scarlett L, Haiman, Christopher, Huang, Franklin, Lee, Cheryl T, Litwin, Mark S, Lyratzopoulos, Georgios, Mohler, James L, Murphy, Adam B, Pettaway, Curtis, Powell, Isaac J, Sasieni, Peter, Schaeffer, Edward M, Shariat, Shahrokh F, Gore, John L

“…Men of African ancestry have demonstrated markedly higher rates of prostate cancer mortality than men of other races and ethnicities around the world. In fact,…”
Get full text

Re: African American Race is Not Associated with Risk of Reclassification during Active Surveillance: Results from Canary Prostate Cancer Active Surveillance StudyJ. M. Schenk, L. F. Newcomb, Y. Zheng, A. V. Faino, K. Zhu, Y. A. Nyame, J. D. Brooks, P. R. Carroll, M. R. Cooperberg, A. Dash, C. P. Filson, M. E. Gleave, M. Liss, F. M. Martin, T. M. Morgan, P. S. Nelson, I. M. Thompson, A. A. Wagner and D. W. Lin J Urol 2020; 203: 727-733 by Powell, Isaac J, Heilbrun, Lance K, Kittles, Rick A

Get full text

Reducing Prostate Cancer Racial Disparity: Evidence for Aggressive Early Prostate Cancer PSA Testing of African American Men by POWELL, Isaac J, VIGNEAU, Fawn D, BOCK, Cathryn H, RUTERBUSCH, Julie, HEILBRUN, Lance K

“…There is continuing controversy about prostate cancer testing and the recent American Urological Association guidelines. We hypothesize that the reduction and…”
Get full text

Interplay of Race, Socioeconomic Status, and Treatment on Survival of Patients With Prostate Cancer by Schwartz, Kendra, Powell, Isaac J, Underwood, Willie, George, Julie, Yee, Cecilia, Banerjee, Mousumi

“…Objectives To compare overall and prostate cancer-specific survival, using the Detroit Surveillance, Epidemiology, and End Results registry data, among 8679…”
Get full text

Re: Pathological and Biochemical Outcomes among African-American and Caucasian Men with Low Risk Prostate Cancer in the SEARCH Database: Implications for Active Surveillance Candidacy: M. S. Leapman, S. J. Freedland, W. J. Aronson, C. J. Kane, M. K. Terris, K. Walker, C. L. Amling, P. R. Carroll and M. R. Cooperberg J Urol 2016;196:1408–1414 by Heilbrun, Lance K., Powell, Isaac J.

Get full text

A study of circulating microRNAs identifies a new potential biomarker panel to distinguish aggressive prostate cancer by Farran, Batoul, Dyson, Gregory, Craig, Douglas, Dombkowski, Alan, Beebe-Dimmer, Jennifer L, Powell, Isaac J, Podgorski, Izabela, Heilbrun, Lance, Bolton, Susan, Bock, Cathryn H

“…Abstract Prostate cancer is one of the most common cancers in men worldwide. Currently available diagnostic and prognostic tools for this disease, such as…”
Get full text

A Randomized Trial Comparing Web-Based Decision Aids on Prostate Cancer Knowledge for African-American Men by Ellison, Gary L., PhD, MPH, Weinrich, Sally P., PhD, FAAN, Lou, Mimi, MS, Xu, Hongyan, PhD, Powell, Isaac J., MD, Baquet, Claudia R., MD, MPH

“…Objectives: Few decision aids are tailored for African-American men. We sought to determine if web-based decision aids increased knowledge of prostate cancer…”
Get full text

Epidemiology, pathology, and genetics of prostate cancer among African Americans compared with other ethnicities by Williams, Heinric, Powell, Isaac J

“…Prostate cancer is the most common cancer affecting men in the Western world. In the United States, it is the second leading cause of cancer related deaths…”
Get more information

Legends in Urology by Powell, Isaac J

Get more information

Risk of Becoming Lost to Follow-up During Active Surveillance for Prostate Cancer by Ginsburg, Kevin B., Auffenberg, Gregory B., Qi, Ji, Powell, Isaac J., Linsell, Susan M., Montie, James E., Miller, David C., Cher, Michael L.

“…Active surveillance (AS) has emerged as the preferred management strategy for many men with prostate cancer (PC); however, insufficient longitudinal monitoring…”
Get full text

Improved overall survival trends of men with newly diagnosed M1 prostate cancer: a SWOG phase III trial experience (S8494, S8894 and S9346) by Tangen, Catherine M, Hussain, Maha H A, Higano, Celestia S, Eisenberger, Mario A, Small, Eric J, Wilding, George, Donnelly, Bryan J, Schelhammer, Paul F, Crawford, E David, Vogelzang, Nicholas J, Powell, Isaac J, Thompson, Jr, Ian M

“…Frequent prostate specific antigen testing for screening and monitoring prostate cancer has led to significant stage migration. We evaluated whether overall…”
Get more information

Neoadjuvant therapy before radical prostatectomy for clinical T3/T4 carcinoma of the prostate: 5-year followup, Phase II Southwest Oncology Group Study 9109 by Powell, Isaac J, Tangen, Catherine M, Miller, Gary J, Lowe, Bruce A, Haas, Gabriel, Carroll, Peter R, Osswald, Michael B, DeVERE WHITE, Ralph, Thompson, Jr, Ian M, Crawford, E David

“…Several investigators have examined the role of hormonal therapy before definitive local therapy for locally advanced prostate cancer to improve outcome. We…”
Get more information

Radical prostatectomy nomograms in black American men: accuracy and applicability by Bianco, Jr, Fernando J, Kattan, Michael W, Scardino, Peter T, Powell, Isaac J, Pontes, J Edson, Wood, Jr, David P

“…Nomograms have been developed to allow the prediction of disease recurrence based on clinical and pathological parameters in patients with clinically localized…”
Get more information