Search Results - "Powell, D. R."

Extensive retreat and re-advance of the West Antarctic Ice Sheet during the Holocene by Kingslake, J., Scherer, R. P., Albrecht, T., Coenen, J., Powell, R. D., Reese, R., Stansell, N. D., Tulaczyk, S., Wearing, M. G., Whitehouse, P. L.

“…To predict the future contributions of the Antarctic ice sheets to sea-level rise, numerical models use reconstructions of past ice-sheet retreat after the…”
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Antarctic ice-sheet sensitivity to obliquity forcing enhanced through ocean connections by Levy, R. H., Meyers, S. R., Naish, T. R., Golledge, N. R., McKay, R. M., Crampton, J. S., DeConto, R. M., De Santis, L., Florindo, F., Gasson, E. G. W., Harwood, D. M., Luyendyk, B. P., Powell, R. D., Clowes, C., Kulhanek, D. K.

“…Deep sea geological records indicate that Antarctic ice-sheet growth and decay is strongly influenced by the Earth’s astronomical variations (known as…”
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LX4211, a Dual SGLT1/SGLT2 Inhibitor, Improved Glycemic Control in Patients With Type 2 Diabetes in a Randomized, Placebo-Controlled Trial by Zambrowicz, B, Freiman, J, Brown, P M, Frazier, K S, Turnage, A, Bronner, J, Ruff, D, Shadoan, M, Banks, P, Mseeh, F, Rawlins, D B, Goodwin, N C, Mabon, R, Harrison, B A, Wilson, A, Sands, A, Powell, D R

“…Thirty‐six patients with type 2 diabetes mellitus (T2DM) were randomized 1:1:1 to receive a once‐daily oral dose of placebo or 150 or 300 mg of the dual…”
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Galactic Cosmic Radiation Induces Persistent Epigenome Alterations Relevant to Human Lung Cancer by Kennedy, E. M., Powell, D. R., Li, Z., Bell, J. S. K., Barwick, B. G., Feng, H., McCrary, M. R., Dwivedi, B., Kowalski, J., Dynan, W. S., Conneely, K. N., Vertino, P. M.

“…Human deep space and planetary travel is limited by uncertainties regarding the health risks associated with exposure to galactic cosmic radiation (GCR), and…”
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Insulin-like growth factor binding protein-1: recent findings and new directions by Lee, P D, Giudice, L C, Conover, C A, Powell, D R

“…In 1988, insulin-like growth factor-binding protein-1 (IGFBP-1) became the first characterized member of a group of structurally related soluble proteins which…”
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Bacterial abundance and composition in marine sediments beneath the Ross Ice Shelf, Antarctica by Carr, S. A., Vogel, S. W., Dunbar, R. B., Brandes, J., Spear, J. R., Levy, R., Naish, T. R., Powell, R. D., Wakeham, S. G., Mandernack, K. W.

“…Marine sediments of the Ross Sea, Antarctica, harbor microbial communities that play a significant role in the decomposition, mineralization, and recycling of…”
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Hydrogen Transfer to Carbonyls and Imines from a Hydroxycyclopentadienyl Ruthenium Hydride:  Evidence for Concerted Hydride and Proton Transfer by Casey, Charles P, Singer, Steven W, Powell, Douglas R, Hayashi, Randy K, Kavana, Michael

“…Reaction of {[2,5-Ph2-3,4-Tol2(η5-C4CO)]2H}Ru2(CO)4(μ-H) (6) with H2 formed [2,5-Ph2-3,4-Tol2(η5-C4COH)Ru(CO)2H] (8), the active species in catalytic carbonyl…”
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Direct control of the Forkhead transcription factor AFX by protein kinase B by Burgering, Boudewijn M. Th, Kops, Geert J. P. L, Ruiter, Nancy D. de, De Vries-Smits, Alida M. M, Powell, David R, Bos, Johannes L

“…The phosphatidylinositol-3-OH-kinase (PI(3)K) effector protein kinase B (refs 1, 2) regulates certain insulin-responsive genes,, but the transcription factors…”
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Asymmetric Memory at Labile, Stereogenic Boron:  Enolate Alkylation of Oxazaborolidinones by Vedejs, E, Fields, S. C, Hayashi, R, Hitchcock, S. R, Powell, D. R, Schrimpf, M. R

“…Oxazaborolidinones 3, 25, 32, 42, 49, and 53 can be obtained as single diastereomers by crystallization-induced asymmetric transformation (AT). Asymmetric…”
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Obesity drugs and their targets: correlation of mouse knockout phenotypes with drug effects in vivo by Powell, D. R.

“…Summary Sequencing of the human genome has yielded thousands of potential drug targets. The difficulty now is in determining which targets have real…”
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Proteinuria and Perinatal Lethality in Mice Lacking NEPH1, a Novel Protein with Homology to NEPHRIN by Donoviel, Dorit B., Freed, Deon D., Vogel, Hannes, Potter, David G., Hawkins, Edith, Barrish, James P., Mathur, Brian N., Turner, C. Alexander, Geske, Robert, Montgomery, Charles A., Starbuck, Michael, Brandt, Mary, Gupta, Anupma, Ramirez-Solis, Ramiro, Zambrowicz, Brian P., Powell, David R.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A Comparison of Monocyclic and Bicyclic Phospholanes as Acyl-Transfer Catalysts by Vedejs, E, Daugulis, O, Harper, L. A, MacKay, J. A, Powell, D. R

“…The synthesis and evaluation of chiral phosphines 11, 15a, 19a, 24a, and 28a as nucleophilic catalysts for anhydride activation and kinetic resolution of…”
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Regulation and function of insulin-like growth factor-binding protein-1 by Lee, P D, Conover, C A, Powell, D R

“…Insulin-like growth factor-binding protein (IGFBP)-1 is one of six homologous proteins that specifically bind and modulate the mitogenic and metabolic actions…”
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Residue-based control of helix shape in β-peptide oligomers by Appella, Daniel H, Christianson, Laurie A, Klein, Daniel A, Powell, Douglas R, Huang, Xiaolin, Barchi, Joseph J, Gellman, Samuel H

“…Proteins and RNA are unique among known polymers in their ability to adopt compact and well-defined folding patterns. These two biopolymers can perform complex…”
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Prelingual Deafness: High Prevalence of a 30delG Mutation in the Connexin 26 Gene by Denoyelle, Françoise, Weil, Dominique, Maw, Marion A., Wilcox, Stephen A., Lench, Nicholas J., Allen-Powell, Denise R., Osborn, Amelia H., Dahl, Hans-Henrik M., Middleton, Anna, Houseman, Mark J., Dodé, Catherine, Marlin, Sandrine, Boulila-ElGaïed, Amel, Grati, Mohammed, Ayadi, Hammadi, BenArab, Saïda, Bitoun, Pierre, Lina-Granade, Geneviève, Godet, Jacqueline, Mustapha, Mirna, Loiselet, Jacques, El-Zir, Élie, Aubois, Anne, Joannard, Alain, Levilliers, Jacqueline, Garabédian, Éréa-Noël, Mueller, Robert F., McKinlay Gardner, R. J., Petit, Christine

“…Prelingual non-syndromic (isolated) deafness is the most frequent hereditary sensory defect. In >80% of the cases, the mode of transmission is autosomal…”
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Physical processes in Subglacial Lake Whillans, West Antarctica: Inferences from sediment cores by Hodson, T.O., Powell, R.D., Brachfeld, S.A., Tulaczyk, S., Scherer, R.P.

“…The hydrologic system beneath the Antarctic Ice Sheet is thought to influence both the dynamics and distribution of fast flowing ice streams, which discharge…”
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Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: transcription factor FKHR binds the insulin response sequence by AYALA, J. E, STREEPER, R. S, DESGROSELLIER, J. S, DURHAM, S. K, SUWANICHKUL, A, SVITEK, C. A, GOLDMAN, J. K, BARR, F. G, POWELL, D. R, O'BRIEN, R. M

“…Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: transcription factor FKHR binds the…”
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Crystallization-Induced Asymmetric Transformation vs Quasi-Racemate Formation in Tetravalent Boron Complexes by Vedejs, E, Chapman, R. W, Lin, S, Müller, M, Powell, D. R

“…Crystallization-induced asymmetric transformation (AT) has been achieved with the salicaldimine complexes 8/9, 11/12, and 14a/15a and with the…”
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Adenoviral modification of mouse brain derived endothelial cells, bEnd3, to induce apoptosis by vascular endothelial growth factor by MITSUUCHI, Y, POWELL, D. R, GALLO, J. M

“…A second generation genetically-engineered cell-based drug delivery system, referred to as apoptotic-induced drug delivery (AIDD), was developed using…”
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Mapping quantitative trait loci for serum insulin-like growth factor-1 levels in mice by Rosen, C.J, Churchill, G.A, Donahue, L.R, Shultz, K.L, Burgess, J.K, Powell, D.R, Beamer, W.G

“…Serum insulin-like growth factor-1 (IGF-1) and femoral bone mineral density (BMD) differ between two inbred strains of mice, C3H/HeJ (C3H) and C57BL/6J (B6),…”
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