Search Results - "Powell, Ailsa"

Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease by Douangamath, Alice, Fearon, Daren, Gehrtz, Paul, Krojer, Tobias, Lukacik, Petra, Owen, C. David, Resnick, Efrat, Strain-Damerell, Claire, Aimon, Anthony, Ábrányi-Balogh, Péter, Brandão-Neto, José, Carbery, Anna, Davison, Gemma, Dias, Alexandre, Downes, Thomas D., Dunnett, Louise, Fairhead, Michael, Firth, James D., Jones, S. Paul, Keeley, Aaron, Keserü, György M., Klein, Hanna F., Martin, Mathew P., Noble, Martin E. M., O’Brien, Peter, Powell, Ailsa, Reddi, Rambabu N., Skyner, Rachael, Snee, Matthew, Waring, Michael J., Wild, Conor, London, Nir, von Delft, Frank, Walsh, Martin A.

“…COVID-19, caused by SARS-CoV-2, lacks effective therapeutics. Additionally, no antiviral drugs or vaccines were developed against the closely related…”
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Crystal Structures of Penicillin-binding Protein 2 from Penicillin-susceptible and -resistant Strains of Neisseria gonorrhoeae Reveal an Unexpectedly Subtle Mechanism for Antibiotic Resistance by Powell, Ailsa J., Tomberg, Joshua, Deacon, Ashley M., Nicholas, Robert A., Davies, Christopher

“…Penicillin-binding protein 2 (PBP2) from N. gonorrhoeae is the major molecular target for β-lactam antibiotics used to treat gonococcal infections. PBP2 from…”
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Crystal Structures of Complexes of Bacterial dd-Peptidases with Peptidoglycan-Mimetic Ligands: The Substrate Specificity Puzzle by Sauvage, Eric, Powell, Ailsa J., Heilemann, Jason, Josephine, Helen R., Charlier, Paulette, Davies, Christopher, Pratt, R.F.

“…The X-ray crystal structures of covalent complexes of the Actinomadura R39 dd-peptidase and Escherichia coli penicillin-binding protein (PBP) 5 with β-lactams…”
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Crystal structures of the lytic transglycosylase MltA from N.gonorrhoeae and E.coli: insights into interdomain movements and substrate binding by Powell, Ailsa J, Liu, Zhi-Jie, Nicholas, Robert A, Davies, Christopher

“…MltA is a lytic transglycosylase of Gram-negative bacteria that cleaves the beta-1,4 glycosidic linkages between N-acetylmuramic acid (MurNAc) and…”
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Turning high-throughput structural biology into predictive inhibitor design by Saar, Kadi L, McCorkindale, William, Fearon, Daren, Boby, Melissa, Barr, Haim, Ben-Shmuel, Amir, London, Nir, von Delft, Frank, Chodera, John D, Lee, Alpha A

“…A common challenge in drug design pertains to finding chemical modifications to a ligand that increases its affinity to the target protein. An underutilized…”
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Crystallographic fragment screening of SARS-CoV-2 drug discovery targets by Fearon, Daren, Douangamath, Alice, Powell, Ailsa, Dias, Alex, Aimon, Anthony, Brandao-Neto, Jose, Dunnett, Louise, Skyner, Rachael, Gorrie-Stone, Tyler, Thompson, Warren, von Delft, Frank

“…Abstract only…”
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Crystal Structures of the Lytic Transglycosylase MltA from N. gonorrhoeae and E. coli : Insights into Interdomain Movements and Substrate Binding by Powell, Ailsa J., Liu, Zhi-Jie, Nicholas, Robert A., Davies, Christopher

“…MltA is a lytic transglycosylase of Gram-negative bacteria that cleaves the β-1,4 glycosidic linkages between N-acetylmuramic acid (MurNAc) and…”
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Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking by Schuller, Marion, Correy, Galen J., Gahbauer, Stefan, Fearon, Daren, Wu, Taiasean, Díaz, Roberto Efraín, Young, Iris D., Carvalho Martins, Luan, Smith, Dominique H., Schulze-Gahmen, Ursula, Owens, Tristan W., Deshpande, Ishan, Merz, Gregory E., Thwin, Aye C., Biel, Justin T., Peters, Jessica K., Moritz, Michelle, Herrera, Nadia, Kratochvil, Huong T., Aimon, Anthony, Bennett, James M., Brandao Neto, Jose, Cohen, Aina E., Dias, Alexandre, Douangamath, Alice, Dunnett, Louise, Fedorov, Oleg, Ferla, Matteo P., Fuchs, Martin R., Gorrie-Stone, Tyler J., Holton, James M., Johnson, Michael G., Krojer, Tobias, Meigs, George, Powell, Ailsa J., Rack, Johannes Gregor Matthias, Rangel, Victor L., Russi, Silvia, Skyner, Rachael E., Smith, Clyde A., Soares, Alexei S., Wierman, Jennifer L., Zhu, Kang, O’Brien, Peter, Jura, Natalia, Ashworth, Alan, Irwin, John J., Thompson, Michael C., Gestwicki, Jason E., von Delft, Frank, Shoichet, Brian K., Fraser, James S., Ahel, Ivan

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) macrodomain within the nonstructural protein 3 counteracts host-mediated antiviral adenosine…”
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Crystal Structures of Penicillin-binding Protein 2 from Penicillin-susceptible and -resistant Strains of Neisseria gonorrhoeae Reveal an Unexpectedly Subtle Mechanism for Antibiotic ResistanceS by Powell, Ailsa J., Tomberg, Joshua, Deacon, Ashley M., Nicholas, Robert A., Davies, Christopher

“…Penicillin-binding protein 2 (PBP2) from N. gonorrhoeae is the major molecular target for β-lactam antibiotics used to treat gonococcal infections. PBP2 from…”
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