Search Results - "Powdrill, Megan H"

Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance by Powdrill, Megan H, Tchesnokov, Egor P, Kozak, Robert A, Russell, Rodney S, Martin, Ross, Svarovskaia, Evguenia S, Mo, Hongmei, Kouyos, Roger D, Götte, Matthias

“…The development of resistance to direct-acting antivirals (DAAs) targeting the hepatitis C virus (HCV) can compromise therapy. However, mechanisms that…”
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A Bifunctional Nucleoside Probe for the Inhibition of the Human Immunodeficiency Virus-Type 1 Reverse Transcriptase by Shaw, Tyler A, Ablenas, Christopher J, Desrochers, Geneviève F, Powdrill, Megan H, Bilodeau, Didier A, Vincent-Rocan, Jean-François, Niu, Meijuan, Monette, Anne, Mouland, Andrew J, Beauchemin, André M, Pezacki, John Paul

“…Nucleoside analogs have proven effective for the inhibition of viral polymerases and are the foundation of many antiviral therapies. In this work, the…”
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Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase NS5B by Powdrill, Megan H, Bernatchez, Jean A, Götte, Matthias

“…More than 20 years after the identification of the hepatitis C virus (HCV) as a novel human pathogen, the only approved treatment remains a combination of…”
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MicroRNA-124 Regulates Fatty Acid and Triglyceride Homeostasis by Shaw, Tyler A, Singaravelu, Ragunath, Powdrill, Megan H, Nhan, Jordan, Ahmed, Nadine, Özcelik, Dennis, Pezacki, John Paul

“…MicroRNAs (miRNAs) are part of a complex regulatory network that modulates cellular lipid metabolism. Here, we identify miR-124 as a regulator of triglyceride…”
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Mechanism of Hepatitis C Virus RNA Polymerase Inhibition with Dihydroxypyrimidines by POWDRILL, Megan H, DEVAL, Jerome, NARJES, Frank, DE FRANCESCO, Raffaele, GÖTTE, Matthias

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Pyrophosphorolytic Excision of Nonobligate Chain Terminators by Hepatitis C Virus NS5B Polymerase by DEVAL, Jérome, POWDRILL, Megan H, D'ABRAMO, Claudia M, CELLAI, Luciano, GÖTTE, Matthias

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Antiviral Activity and Mode of Action of TMC647078, a Novel Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase by MARTIN BERKE, Jan, VIJGEN, Leen, VAN DEN EYNDE, Christel, LECLERCQ, Laurent, JONCKERS, Tim H. M, RABOISSON, Pierre, NILSSON, Magnus, SAMUELSSON, Bertil, ROSENQUIST, Asa, FANNING, Gregory C, LIN, Tse-I, LACHAU-DURAND, Sophie, POWDRILL, Megan H, RAWE, Svea, SJUVARSSON, Elena, ERIKSSON, Staffan, GÖTTE, Matthias, FRANSEN, Els, DEHERTOGH, Pascale

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Site-Specific Cross-Linking of a p19 Viral Suppressor of RNA Silencing Protein and Its RNA Targets Using an Expanded Genetic Code by Ahmed, Noreen, Foss, Dana V, Powdrill, Megan H, Pezacki, John Paul

“…The p19 viral suppressor of RNA silencing protein has useful applications in biotechnology due to its high affinity for binding to small RNAs such as small…”
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MicroRNA-7 mediates cross-talk between metabolic signaling pathways in the liver by Singaravelu, Ragunath, Quan, Curtis, Powdrill, Megan H., Shaw, Tyler A., Srinivasan, Prashanth, Lyn, Rodney K., Alonzi, Rhea C., Jones, Daniel M., Filip, Roxana, Russell, Rodney S., Pezacki, John P.

“…MicroRNAs (miRNAs) have emerged as critical regulators of cellular metabolism. To characterise miRNAs crucial to the maintenance of hepatic lipid homeostasis,…”
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Dynamics of Hepatitis C Virus (HCV) RNA-dependent RNA Polymerase NS5B in Complex with RNA by Karam, Pierre, Powdrill, Megan H., Liu, Hsiao-Wei, Vasquez, Colins, Mah, Wayne, Bernatchez, Jean, Götte, Matthias, Cosa, Gonzalo

“…The hepatitis C virus (HCV) non-structural protein 5B (NS5B) is an RNA-dependent RNA polymerase that is essentially required for viral replication. Although…”
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The role of microRNAs in metabolic interactions between viruses and their hosts by Powdrill, Megan H, Desrochers, Geneviève F, Singaravelu, Ragunath, Pezacki, John Paul

“…[Display omitted] •Viruses use microRNAs to modulate metabolic pathways essential for infection.•Hijacking of lipid pathways is common due to the reliance of…”
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Reactivity of N -acyl hydrazone probes with the mammalian proteome by Shaw, Tyler A, Powdrill, Megan H, Sherratt, Allison R, Garland, Keira, Li, Bin-Jie, Beauchemin, André M, Pezacki, John Paul

“…Small molecule probes with distinct reactivities are useful tools for the identification and characterization of protein modifications and function. Herein, we…”
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Hydrophobic Triaryl-Substituted β-Lactams as Activity-Based Probes for Profiling Eukaryotic Enzymes and Host-Pathogen Interactions by Nasheri, Neda, McKay, Craig S., Fulton, Kelly, Twine, Susan, Powdrill, Megan H., Sherratt, Allison R., Pezacki, John Paul

“…ABPP with β‐lactams: We identified the eukaryotic targets of β‐lactam‐containing compounds by activity‐based protein profiling. Using this method, we…”
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Suppressing RNA silencing with small molecules and the viral suppressor of RNA silencing protein p19 by Danielson, Dana C., Filip, Roxana, Powdrill, Megan H., O'Hara, Shifawn, Pezacki, John P.

“…RNA silencing is a gene regulatory and host defense mechanism whereby small RNA molecules are engaged by Argonaute (AGO) proteins, which facilitate gene…”
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Hepatitis C Virus Helicase Binding Activity Monitored through Site-Specific Labeling Using an Expanded Genetic Code by Ablenas, Christopher J, Gidi, Yasser, Powdrill, Megan H, Ahmed, Noreen, Shaw, Tyler A, Mesko, Mihai, Götte, Matthias, Cosa, Gonzalo, Pezacki, John Paul

“…The mechanism of unwinding catalyzed by the hepatitis C virus nonstructural protein 3 helicase (NS3h) has been a subject of considerable interest, with NS3h…”
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6‑Hydroxydopamine Inhibits the Hepatitis C Virus through Alkylation of Host and Viral Proteins and the Induction of Oxidative Stress by Lafreniere, Matthew A, Powdrill, Megan H, Singaravelu, Ragunath, Pezacki, John Paul

“…Many viruses, including the hepatitis C virus (HCV), are dependent on the host RNA silencing pathway for replication. In this study, we screened small molecule…”
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Synthesis and antiviral activity of 2′-deoxy-2′-fluoro-2′- C-methyl-7-deazapurine nucleosides, their phosphoramidate prodrugs and 5′-triphosphates by Shi, Junxing, Zhou, Longhu, Zhang, Hongwang, McBrayer, Tamara R., Detorio, Mervi A., Johns, Melissa, Bassit, Leda, Powdrill, Megan H., Whitaker, Tony, Coats, Steven J., Götte, Matthias, Schinazi, Raymond F.

“…Thirty novel α- and β- d-2′-deoxy-2′-fluoro-2′- C-methyl-7-deazapurine nucleoside analogs were synthesized and evaluated for in vitro antiviral activity…”
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Chemical Methods for Probing Virus–Host Proteomic Interactions by Strmiskova, Miroslava, Desrochers, Geneviève F, Shaw, Tyler A, Powdrill, Megan H, Lafreniere, Matthew A, Pezacki, John Paul

“…Interactions between host and pathogen proteins constitute an important aspect of both infectivity and the host immune response. Different viruses have evolved…”
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Reactivity of -acyl hydrazone probes with the mammalian proteome by Shaw, Tyler A, Powdrill, Megan H, Sherratt, Allison R, Garland, Keira, Li, Bin-Jie, Beauchemin, André M, Pezacki, John Paul

“…Small molecule probes with distinct reactivities are useful tools for the identification and characterization of protein modifications and function. Herein, we…”
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Hydrophobic Triaryl-Substituted [beta]-Lactams as Activity-Based Probes for Profiling Eukaryotic Enzymes and Host-Pathogen Interactions by Nasheri, Neda, McKay, Craig S, Fulton, Kelly, Twine, Susan, Powdrill, Megan H, Sherratt, Allison R, Pezacki, John Paul

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