Search Results - "Povstyan, Oleksandr"

Modeling of full-length Piezo1 suggests importance of the proximal N-terminus for dome structure by Chong, Jiehan, De Vecchis, Dario, Hyman, Adam J., Povstyan, Oleksandr V., Ludlow, Melanie J., Shi, Jian, Beech, David J., Kalli, Antreas C.

“…Piezo1 forms a mechanically activated calcium-permeable nonselective cation channel that is functionally important in many cell types. Structural data exist…”
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Improved PIEZO1 agonism through 4‐benzoic acid modification of Yoda1 by Parsonage, Gregory, Cuthbertson, Kevin, Endesh, Naima, Murciano, Nicoletta, Hyman, Adam J., Revill, Charlotte H., Povstyan, Oleksandr V., Chuntharpursat‐Bon, Eulashini, Debant, Marjolaine, Ludlow, Melanie J., Futers, Timothy Simon, Lichtenstein, Laeticia, Kinsella, Jacob A., Bartoli, Fiona, Rotordam, Maria Giustina, Becker, Nadine, Brüggemann, Andrea, Foster, Richard, Beech, David J.

“…Background and Purpose The protein PIEZO1 forms mechanically activated, calcium‐permeable, non‐selective cation channels in numerous cell types from several…”
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G-protein βγ subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity by Stott, Jennifer B., Povstyan, Oleksandr V., Carr, Georgina, Barrese, Vincenzo, Greenwood, Iain A.

“…Significance The Kv7.4 potassium channel is a critical regulator of vascular contractility both at rest and as a functional endpoint for a number of endogenous…”
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Novel small-molecule modulation of PIEZO1 investigated by conventional and automated patch-clamp by Kinsella, Jacob A., Parsonage, Gregory, Povstyan, Oleksandr V., Murciano, Nicoletta, Trowbridge, Rachel, Revill, Charlotte, Nelson, Adam, Giustina Rotordam, Maria, Becker, Nadine, Bruggemann, Andrea, Foster, Richard, Beech, David J.

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RBCs prevent rapid PIEZO1 inactivation and expose slow deactivation as a mechanism of dehydrated hereditary stomatocytosis by Evans, Elizabeth L., Povstyan, Oleksandr V., De Vecchis, Dario, Macrae, Fraser, Lichtenstein, Laeticia, Futers, T. Simon, Parsonage, Gregory, Humphreys, Neil E., Adamson, Antony, Kalli, Antreas C., Ludlow, Melanie J., Beech, David J.

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TMEM16A is implicated in the regulation of coronary flow and is altered in hypertension by Askew Page, Henry R., Dalsgaard, Thomas, Baldwin, Samuel N., Jepps, Thomas A., Povstyan, Oleksandr, Olesen, Søren P., Greenwood, Iain A.

“…Background and Purpose Coronary artery disease leads to ischaemic heart disease and ultimately myocardial infarction. Thus, it is important to determine the…”
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MicroRNA-153 targeting of KCNQ4 contributes to vascular dysfunction in hypertension by Carr, Georgina, Barrese, Vincenzo, Stott, Jennifer B, Povstyan, Oleksandr V, Jepps, Thomas A, Figueiredo, Hericka B, Zheng, Dongling, Jamshidi, Yalda, Greenwood, Iain A

“…Kv7.4, a voltage-dependent potassium channel expressed throughout the vasculature, controls arterial contraction and is compromised in hypertension by an…”
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Thomas (Tom) B. Bolton – a major force in smooth muscle research by Zholos, Alexander V., Greenwood, Iain A., Lang, Rick J., Benham, Christopher D., Aaronson, Philip I., Garland, Christopher J., Weston, Arthur H., Prestwich, Sally A., Gordienko, Dmitri V., Povstyan, Oleksandr V., Zhang, Hailin, Clapp, Lucie H., Pucovsky, Vladimir, Tare, Marianne, Fenech, Claire J., Unno, Toshihiro, Muraki, Katsuhiko, Shi, Jian, Hughes, Alun D., Halstead, Thomas K., Beech, David J.

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Synergistic interplay of Gβγ and phosphatidylinositol 4,5-bisphosphate dictates Kv7.4 channel activity by Povstyan, Oleksandr V., Barrese, Vincenzo, Stott, Jennifer B, Greenwood, Iain A

“…Kv7.4 channels are key determinants of arterial contractility and cochlear mechanosensation that, like all Kv7 channels, have an obligatory requirement for…”
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Synergistic interplay of G beta gamma and phosphatidylinositol 4,5-bisphosphate dictates Kv7.4 channel activity by Povstyan, Oleksandr V, Barrese, Vincenzo, Stott, Jennifer B, Greenwood, Iain A

“…Kv7.4 channels are key determinants of arterial contractility and cochlear mechanosensation that, like all Kv7 channels, have an obligatory requirement for…”
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PIEZO1 and PECAM1 interact at cell-cell junctions and partner in endothelial force sensing by Chuntharpursat-Bon, Eulashini, Povstyan, Oleksandr V., Ludlow, Melanie J., Carrier, David J., Debant, Marjolaine, Shi, Jian, Gaunt, Hannah J., Bauer, Claudia C., Curd, Alistair, Simon Futers, T., Baxter, Paul D., Peckham, Michelle, Muench, Stephen P., Adamson, Antony, Humphreys, Neil, Tumova, Sarka, Bon, Robin S., Cubbon, Richard, Lichtenstein, Laeticia, Beech, David J.

“…Two prominent concepts for the sensing of shear stress by endothelium are the PIEZO1 channel as a mediator of mechanically activated calcium ion entry and the…”
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ATP-Evoked Sustained Vasoconstrictions Mediated by Heteromeric P2X1/4 Receptors in Cerebral Arteries by Harhun, Maksym I, Povstyan, Oleksandr V, Albert, Anthony P, Nichols, Claire M

“…BACKGROUND AND PURPOSE—Current knowledge states that vasoconstrictor responses to ATP are mediated by rapidly desensitizing ligand-gated P2X1 receptors in…”
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Ca2+ entry following P2X receptor activation induces IP3 receptor‐mediated Ca2+ release in myocytes from small renal arteries by Povstyan, Oleksandr V, Harhun, Maksym I, Gordienko, Dmitri V

“…BACKGROUND AND PURPOSE P2X receptors mediate sympathetic control and autoregulation of the renal circulation triggering contraction of renal vascular smooth…”
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Purinoreceptor‐mediated current in myocytes from renal resistance arteries by Harhun, Maksym I, Povstyan, Oleksandr V, Gordienko, Dmitri V

“…Background and purpose:  Ionotropic purinoreceptors (P2X) in renal vascular smooth muscle cells (RVSMCs) are involved in mediating the sympathetic control and…”
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Characterization of transcriptional and posttranscriptional properties of native and cultured phenotypically modulated vascular smooth muscle cells by Huggins, Christopher L, Povstyan, Oleksandr V, Harhun, Maksym I

“…Various in vitro models are used for studying phenotypic modulation of vascular smooth muscle cells (VSMCs) and the established culture of vascular smooth…”
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Vascular smooth muscle cells from small human omental arteries express P2X1 and P2X4 receptor subunits by Nichols, Claire M., Povstyan, Oleksandr V., Albert, Anthony P., Gordienko, Dmitry V., Khan, Omar, Vasilikostas, Georgios, Khong, Teck K., Wan, Andrew, Reddy, Marcus, Harhun, Maksym I.

“…Stimulation of P2X receptors by ATP in vascular smooth muscle cells (VSMCs) is proposed to mediate vascular tone. However, understanding of P2X…”
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Function of Interstitial Cells of Cajal in the Rabbit Portal Vein by Harhun, Maksym I, Gordienko, Dmitri V, Povstyan, Oleksandr V, Moss, Ray F, Bolton, Thomas B

“…Interstitial cells of Cajal (ICCs) were identified in the intact fixed media of the rabbit portal vein (RPV) using c-kit staining. The following experiments…”
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Close relation of arterial ICC‐like cells to the contractile phenotype of vascular smooth muscle cell by Pucovský, Vladimír, Harhun, Maksym I., Povstyan, Oleksandr V., Gordienko, Dmitri V., Moss, Ray F., Bolton, Thomas B.

“…This work aimed to establish the lineage of cells similar to the interstitial cells of Cajal (ICC), the arterial ICC‐like (AIL) cells, which have recently been…”
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Kv 7.4 Channel Activity is Dependent upon PIP2 and Gβγ Subunits by Povstyan, Oleksandr, Stott, Jennifer, Barrese, Vincenzo, Greenwood, Iain

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Gβγ Subunits Modulation of Kv7.4 Channels Expressed in HEK293 Cells at the Single Channel Level by Povstyan, Oleksandr, Stott, Jennifer B., Greenwood, Iain A.

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