Search Results - "Poutou, Joanna"

Virally programmed extracellular vesicles sensitize cancer cells to oncolytic virus and small molecule therapy by Wedge, Marie-Eve, Jennings, Victoria A., Crupi, Mathieu J. F., Poutou, Joanna, Jamieson, Taylor, Pelin, Adrian, Pugliese, Giuseppe, de Souza, Christiano Tanese, Petryk, Julia, Laight, Brian J., Boileau, Meaghan, Taha, Zaid, Alluqmani, Nouf, McKay, Hayley E., Pikor, Larissa, Khan, Sarwat Tahsin, Azad, Taha, Rezaei, Reza, Austin, Bradley, He, Xiaohong, Mansfield, David, Rose, Elaine, Brown, Emily E. F., Crawford, Natalie, Alkayyal, Almohanad, Surendran, Abera, Singaravelu, Ragunath, Roy, Dominic G., Migneco, Gemma, McSweeney, Benjamin, Cottee, Mary Lynn, Jacobus, Egon J., Keller, Brian A., Yamaguchi, Takafumi N., Boutros, Paul C., Geoffrion, Michele, Rayner, Katey J., Chatterjee, Avijit, Auer, Rebecca C., Diallo, Jean-Simon, Gibbings, Derrick, tenOever, Benjamin R., Melcher, Alan, Bell, John C., Ilkow, Carolina S.

“…Recent advances in cancer therapeutics clearly demonstrate the need for innovative multiplex therapies that attack the tumour on multiple fronts. Oncolytic or…”
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Complementary dual-virus strategy drives synthetic target and cognate T-cell engager expression for endogenous-antigen agnostic immunotherapy by Taha, Zaid, Crupi, Mathieu Joseph François, Alluqmani, Nouf, MacKenzie, Duncan, Vallati, Sydney, Whelan, Jack Timothy, Fareez, Faiha, Alwithenani, Akram, Petryk, Julia, Chen, Andrew, Spinelli, Marcus Mathew, Ng, Kristy, Sobh, Judy, de Souza, Christiano Tanese, Bharadwa, Priya Rose, Lee, Timothy Kit Hin, Thomas, Dylan Anthony, Huang, Ben Zhen, Kassas, Omar, Poutou, Joanna, Gilchrist, Victoria Heather, Boulton, Stephen, Thomson, Max, Marius, Ricardo, Hooshyar, Mohsen, McComb, Scott, Arulanandam, Rozanne, Ilkow, Carolina Solange, Bell, John Cameron, Diallo, Jean-Simon

“…Targeted antineoplastic immunotherapies have achieved remarkable clinical outcomes. However, resistance to these therapies due to target absence or antigen…”
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Characterization of Critical Determinants of ACE2-SARS CoV-2 RBD Interaction by Brown, Emily E F, Rezaei, Reza, Jamieson, Taylor R, Dave, Jaahnavi, Martin, Nikolas T, Singaravelu, Ragunath, Crupi, Mathieu J F, Boulton, Stephen, Tucker, Sarah, Duong, Jessie, Poutou, Joanna, Pelin, Adrian, Yasavoli-Sharahi, Hamed, Taha, Zaid, Arulanandam, Rozanne, Surendran, Abera, Ghahremani, Mina, Austin, Bradley, Matar, Chantal, Diallo, Jean-Simon, Bell, John C, Ilkow, Carolina S, Azad, Taha

“…Despite sequence similarity to SARS-CoV-1, SARS-CoV-2 has demonstrated greater widespread virulence and unique challenges to researchers aiming to study its…”
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Fatty acid transport protein inhibition sensitizes breast and ovarian cancers to oncolytic virus therapy via lipid modulation of the tumor microenvironment by Surendran, Abera, Jamalkhah, Monire, Poutou, Joanna, Birtch, Rayanna, Lawson, Christine, Dave, Jaahnavi, Crupi, Mathieu J F, Mayer, Justin, Taylor, Victoria, Petryk, Julia, de Souza, Christiano Tanese, Moodie, Neil, Billingsley, Jacob Lecompte, Austin, Bradley, Cormack, Nicole, Blamey, Natalie, Rezaei, Reza, McCloskey, Curtis W, Fekete, Emily E F, Birdi, Harsimrat K, Neault, Serge, Jamieson, Taylor R, Wylie, Brenna, Tucker, Sarah, Azad, Taha, Vanderhyden, Barbara, Tai, Lee-Hwa, Bell, John C, Ilkow, Carolina S

“…Adipocytes in the tumour microenvironment are highly dynamic cells that have an established role in tumour progression, but their impact on anti-cancer therapy…”
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Engineering Rapalog-Inducible Genetic Switches Based on Split-T7 Polymerase to Regulate Oncolytic Virus-Driven Production of Tumour-Localized IL-12 for Anti-Cancer Immunotherapy by Martin, Nikolas T, Crupi, Mathieu J F, Taha, Zaid, Poutou, Joanna, Whelan, Jack T, Vallati, Sydney, Petryk, Julia, Marius, Ricardo, Austin, Bradley, Azad, Taha, Boulanger, Mason, Burgess, Tamara, Sanders, Ilson, Victoor, Camille, Dickinson, Bryan C, Diallo, Jean-Simon, Ilkow, Carolina S, Bell, John C

“…The approval of different cytokines as anti-neoplastic agents has been challenged by dose-limiting toxicities. Although reducing dose levels affords improved…”
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A T cell-targeted multi-antigen vaccine generates robust cellular and humoral immunity against SARS-CoV-2 infection by Boulton, Stephen, Poutou, Joanna, Gill, Rida, Alluqmani, Nouf, He, Xiaohong, Singaravelu, Ragunath, Crupi, Mathieu J.F., Petryk, Julia, Austin, Bradley, Angka, Leonard, Taha, Zaid, Teo, Iris, Singh, Siddarth, Jamil, Rameen, Marius, Ricardo, Martin, Nikolas, Jamieson, Taylor, Azad, Taha, Diallo, Jean-Simon, Ilkow, Carolina S., Bell, John C.

“…SARS-CoV-2, the etiological agent behind the coronavirus disease 2019 (COVID-19) pandemic, has continued to mutate and create new variants with increased…”
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A Versatile Vector for In Vivo Monitoring of Type I Interferon Induction and Signaling by Nistal-Villan, Estanislao, Poutou, Joanna, Rodríguez-Garcia, Estefania, Buñuales, Maria, Carte-Abad, Beatriz, Prieto, Jesus, Gonzalez-Aseguinolaza, Gloria, Hernandez-Alcoceba, Ruben, Larrea, Esther

“…Development of reporter systems for in vivo examination of IFN-β induction or signaling of type I interferon (IFN-I) pathways is of great interest in order to…”
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Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization by Azad, Taha, Singaravelu, Ragunath, Crupi, Mathieu J.F., Jamieson, Taylor, Dave, Jaahnavi, Brown, Emily E.F., Rezaei, Reza, Taha, Zaid, Boulton, Stephen, Martin, Nikolas T., Surendran, Abera, Poutou, Joanna, Ghahremani, Mina, Nouri, Kazem, Whelan, Jack T., Duong, Jessie, Tucker, Sarah, Diallo, Jean-Simon, Bell, John C., Ilkow, Carolina S.

“…The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic presents an urgent need for an effective vaccine. Molecular characterization…”
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A High-Throughput NanoBiT-Based Serological Assay Detects SARS-CoV-2 Seroconversion by Azad, Taha, Rezaei, Reza, Singaravelu, Ragunath, Jamieson, Taylor R, Crupi, Mathieu J F, Surendran, Abera, Poutou, Joanna, Taklifi, Parisa, Cowan, Juthaporn, Cameron, Donald William, Ilkow, Carolina S

“…High-throughput detection strategies for antibodies against SARS-CoV-2 in patients recovering from COVID-19, or in vaccinated individuals, are urgently…”
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Recombinant in vitro assembled hepatitis C virus core particles induce strong specific immunity enhanced by formulation with an oil-based adjuvant by Acosta-Rivero, Nelson, Poutou, Joanna, Alvarez-Lajonchere, Liz, Guerra, Ivis, Aguilera, Yaraima, Musacchio, Alexis, Rodríguez, Armando, Aguilar, Julio C, Falcon, Viviana, Alvarez-Obregon, Julio C, Soria, Yordanka, Torres, Dinorah, Linares, Marbelis, Pérez, Angel, Morales-Grillo, Juan, Dueñas-Carrera, Santiago

“…In the present work, immunogenicity of recombinant in vitro assembled hepatitis C virus core particles, HCcAg.120-VLPs, either alone or in combination with…”
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Redirecting oncolytic viruses: Engineering opportunists to take control of the tumour microenvironment by Jamieson, Taylor R., Poutou, Joanna, Ilkow, Carolina S.

“…[Display omitted] •Oncolytic viruses are replicating bio-therapeutics that selectively infect and kill cancer cells.•Oncolytic immunotherapy can dismantle the…”
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Adaptation of vectors and drug-inducible systems for controlled expression of transgenes in the tumor microenvironment by Poutou, Joanna, Bunuales, Maria, Gonzalez-Aparicio, Manuela, German, Beatriz, Zugasti, Ines, Hernandez-Alcoceba, Ruben

“…Biological therapies based on recombinant proteins such as antibodies or cytokines are continuously improving the repertoire of treatments against cancer…”
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Nanoluciferase complementation-based bioreporter reveals the importance of N-linked glycosylation of SARS-CoV-2 S for viral entry by Azad, Taha, Singaravelu, Ragunath, Taha, Zaid, Jamieson, Taylor R., Boulton, Stephen, Crupi, Mathieu J.F., Martin, Nikolas T., Fekete, Emily E.F., Poutou, Joanna, Ghahremani, Mina, Pelin, Adrian, Nouri, Kazem, Rezaei, Reza, Marshall, Christopher Boyd, Enomoto, Masahiro, Arulanandam, Rozanne, Alluqmani, Nouf, Samson, Reuben, Gingras, Anne-Claude, Cameron, D. William, Greer, Peter A., Ilkow, Carolina S., Diallo, Jean-Simon, Bell, John C.

“…The ongoing COVID-19 pandemic has highlighted the immediate need for the development of antiviral therapeutics targeting different stages of the SARS-CoV-2…”
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Single-dose replicating poxvirus vector-based RBD vaccine drives robust humoral and T cell immune response against SARS-CoV-2 infection by Boulton, Stephen, Poutou, Joanna, Martin, Nikolas T., Azad, Taha, Singaravelu, Ragunath, Crupi, Mathieu J.F., Jamieson, Taylor, He, Xiaohong, Marius, Ricardo, Petryk, Julia, Tanese de Souza, Christiano, Austin, Bradley, Taha, Zaid, Whelan, Jack, Khan, Sarwat T., Pelin, Adrian, Rezaei, Reza, Surendran, Abera, Tucker, Sarah, Fekete, Emily E.F., Dave, Jaahnavi, Diallo, Jean-Simon, Auer, Rebecca, Angel, Jonathan B., Cameron, D. William, Cailhier, Jean-Francois, Lapointe, Réjean, Potts, Kyle, Mahoney, Douglas J., Bell, John C., Ilkow, Carolina S.

“…The coronavirus disease 2019 (COVID-19) pandemic requires the continued development of safe, long-lasting, and efficacious vaccines for preventive responses to…”
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Inhibition of adenovirus infection by mifepristone by Marrugal-Lorenzo, José A., Serna-Gallego, Ana, González-González, Loreto, Buñuales, Maria, Poutou, Joanna, Pachón, Jerónimo, Gonzalez-Aparicio, Manuela, Hernandez-Alcoceba, Ruben, Sánchez-Céspedes, Javier

“…The repurposing of drugs approved by the regulatory agencies for other indications is emerging as a valuable alternative for the development of new…”
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Gene therapy approaches against cancer using in vivo and ex vivo gene transfer of interleukin-12 by Hernandez-Alcoceba, Ruben, Poutou, Joanna, Ballesteros-Briones, María Cristina, Smerdou, Cristian

“…IL-12 is an immunostimulatory cytokine with strong antitumor properties. Systemic administration of IL-12 in cancer patients led to severe toxic effects,…”
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Capsid-deficient alphaviruses generate propagative infectious microvesicles at the plasma membrane by Ruiz-Guillen, Marta, Gabev, Evgeni, Quetglas, Jose I., Casales, Erkuden, Ballesteros-Briones, María Cristina, Poutou, Joanna, Aranda, Alejandro, Martisova, Eva, Bezunartea, Jaione, Ondiviela, Marina, Prieto, Jesus, Hernandez-Alcoceba, Ruben, Abrescia, Nicola G. A., Smerdou, Cristian

“…Alphavirus budding is driven by interactions between nucleocapsids assembled in the cytoplasm and envelope proteins present at the plasma membrane. So far, the…”
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Enhanced therapeutic effect using sequential administration of antigenically distinct oncolytic viruses expressing oncostatin M in a Syrian hamster orthotopic pancreatic cancer model by Nistal-Villan, Estanislao, Bunuales, Maria, Poutou, Joanna, Gonzalez-Aparicio, Manuela, Bravo-Perez, Carlos, Quetglas, Jose I, Carte, Beatriz, Gonzalez-Aseguinolaza, Gloria, Prieto, Jesus, Larrea, Esther, Hernandez-Alcoceba, Ruben

“…The limited efficacy of current treatments against pancreatic cancer has prompted the search of new alternatives such as virotherapy. Activation of the immune…”
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Transient depletion of specific immune cell populations to improve adenovirus-mediated transgene expression in the liver by Alzuguren, Pilar, Hervas-Stubbs, Sandra, Gonzalez-Aseguinolaza, Gloria, Poutou, Joanna, Fortes, Puri, Mancheno, Uxua, Bunuales, Maria, Olagüe, Cristina, Razquin, Nerea, Van Rooijen, Nico, Enguita, Monica, Hernandez-Alcoceba, Ruben

“…Background & Aims Adenoviral (Ad) vectors are currently one of the most efficient tools for in vivo gene transfer to the liver. However, anti‐Ad immune…”
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110. Safety and Antitumor Effect of Oncolytic and Helper-Dependent Adenoviruses Expressing Interleukin-12 Variants in a Hamster Pancreatic Cancer Model by Poutou, Joanna, Bunuales, Maria, Gonzalez, Manuela, Garcia-Aragoncillo, Eva, Quetglas, Jose I., Casado, Raquel, Bravo-Perez, Carlos, Alzuguren, Pilar, Hernandez-Alcoceba, Ruben

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