Search Results - "Pousa, Antonio Lopez"

Selective depletion of metastatic stem cells as therapy for human colorectal cancer by Céspedes, María Virtudes, Unzueta, Ugutz, Aviñó, Anna, Gallardo, Alberto, Álamo, Patricia, Sala, Rita, Sánchez‐Chardi, Alejandro, Casanova, Isolda, Mangues, María Antònia, Lopez‐Pousa, Antonio, Eritja, Ramón, Villaverde, Antonio, Vázquez, Esther, Mangues, Ramón

“…Selective elimination of metastatic stem cells (MetSCs) promises to block metastatic dissemination. Colorectal cancer (CRC) cells overexpressing CXCR4 display…”
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Relevance of Reference Centers in Sarcoma Care and Quality Item Evaluation: Results from the Prospective Registry of the Spanish Group for Research in Sarcoma (GEIS) by Martin‐Broto, Javier, Hindi, Nadia, Cruz, Josefina, Martinez‐Trufero, Javier, Valverde, Claudia, De Sande, Luis M., Sala, Angeles, Bellido, Lorena, De Juan, Ana, Rubió‐Casadevall, Jordi, Diaz‐Beveridge, Roberto, Cubedo, Ricardo, Tendero, Oscar, Salinas, Diego, Gracia, Isidro, Ramos, Rafael, Baguè, Silvia, Gutierrez, Antonio, Duran‐Moreno, José, Lopez‐Pousa, Antonio

“…Background Reference centers (RCs) are a key point for improving the survival of patients with soft‐tissue sarcomas (STS). The aim of this study was to…”
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The combined use of EFS, GPX2, and SPRR1A expression could distinguish favorable from poor clinical outcome among epithelial‐like head and neck carcinoma subtypes by Pavón, Miguel Angel, Arroyo‐Solera, Irene, León, Xavier, Téllez‐Gabriel, Marta, Virós, David, Gallardo, Alberto, Céspedes, Maria Virtudes, Casanova, Isolda, Lopez‐Pousa, Antonio, Barnadas, Agustí, Quer, Miquel, Mangues, Ramón

“…Background We aimed at identifying molecular markers predictive of clinical outcome in patients with head and neck cancer based on the expression profile of…”
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Higher metastatic efficiency of KRas G12V than KRas G13D in a colorectal cancer model by Alamo, Patricia, Gallardo, Alberto, Di Nicolantonio, Federica, Pavón, Miguel Angel, Casanova, Isolda, Trias, Manuel, Mangues, María Antonia, Lopez‐Pousa, Antonio, Villaverde, Antonio, Vázquez, Esther, Bardelli, Alberto, Céspedes, María Virtudes, Mangues, Ramón

“…ABSTRACT Although all KRas (protein that in humans is encoded by the KRas gene) point mutants are considered to have a similar prognostic capacity, their…”
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Phase III Study Comparing Cisplatin Plus Fluorouracil to Paclitaxel, Cisplatin, and Fluorouracil Induction Chemotherapy Followed by Chemoradiotherapy in Locally Advanced Head and Neck Cancer by HITT, Ricardo, LOPEZ-POUSA, Antonio, PASTOR, Pedro, VALENTI, Vicente, BELON, Joaquin, SANCHEZ, Miguel A, CHAIB, Carlos, PALLARES, Cinta, ANTON, Antonio, CERVANTES, Andrés, PAZ-ARES, Luis, CORTES-FUNES, Hernan, MARTINEZ-TRUFERO, Javier, ESCRIG, Vicente, CARIES, Joan, RIZO, Alfredo, ISLA, Dolores, VEGA, M. Eugenia, MARTI, Juan L, LOBO, Francisco

“…To compare the antitumor activity and toxicity of the two induction chemotherapy treatments of paclitaxel, cisplatin, and fluorouracil (FU; PCF) versus…”
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CINSARC in high‐risk soft tissue sarcoma patients treated with neoadjuvant chemotherapy: Results from the ISG‐STS 1001 study by Frezza, Anna Maria, Stacchiotti, Silvia, Chibon, Frederic, Coindre, Jean‐Michelle, Italiano, Antoine, Romagnosa, Cleofe, Bagué, Silvia, Dei Tos, Angelo Paolo, Braglia, Luca, Palmerini, Emanuela, Quagliuolo, Vittorio, Broto, Javier Martin, Lopez Pousa, Antonio, Grignani, Giovanni, Brunello, Antonella, Blay, Jean‐Yves, Beveridge, Robert Diaz, Lugowska, Iwona, Lesluyes, Tom, Maestro, Roberta, Merlo, Franco Domenico, Casali, Paolo Giovanni, Gronchi, Alessandro

“…Background The Complexity INdex in SARComas (CINSARC) is a transcriptional signature derived from the expression of 67 genes involved in mitosis control and…”
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Salvage surgery after local recurrence in patients with head and neck carcinoma treated with chemoradiotherapy or bioradiotherapy by León, Xavier, Agüero, Adriana, López, Montserrat, García, Jacinto, Farré, Nuria, López-Pousa, Antonio, Quer, Miquel

“…Abstract Objective To analyze the oncologic outcomes and surgical complications after salvage surgery for recurrence following chemoradiotherapy or…”
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Neoadjuvant Chemotherapy in High-Risk Soft Tissue Sarcomas: Final Results of a Randomized Trial From Italian (ISG), Spanish (GEIS), French (FSG), and Polish (PSG) Sarcoma Groups by Gronchi, Alessandro, Palmerini, Emanuela, Quagliuolo, Vittorio, Martin Broto, Javier, Lopez Pousa, Antonio, Grignani, Giovanni, Brunello, Antonella, Blay, Jean-Yves, Tendero, Oscar, Diaz Beveridge, Robert, Ferraresi, Virginia, Lugowska, Iwona, Merlo, Domenico Franco, Fontana, Valeria, Marchesi, Emanuela, Braglia, Luca, Donati, Davide Maria, Palassini, Elena, Bianchi, Giuseppe, Marrari, Andrea, Morosi, Carlo, Stacchiotti, Silvia, Bagué, Silvia, Coindre, Jean Michel, Dei Tos, Angelo Paolo, Picci, Piero, Bruzzi, Paolo, Casali, Paolo Giovanni

“…To determine whether the administration of histology-tailored neoadjuvant chemotherapy (HT) was superior to the administration of standard anthracycline plus…”
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Histotype-tailored neoadjuvant chemotherapy versus standard chemotherapy in patients with high-risk soft-tissue sarcomas (ISG-STS 1001): an international, open-label, randomised, controlled, phase 3, multicentre trial by Gronchi, Alessandro, Dr, Ferrari, Stefano, MD, Quagliuolo, Vittorio, MD, Broto, Javier Martin, MD, Pousa, Antonio Lopez, MD, Grignani, Giovanni, MD, Basso, Umberto, MD, Blay, Jean-Yves, Prof, Tendero, Oscar, MD, Beveridge, Robert Diaz, MD, Ferraresi, Virginia, MD, Lugowska, Iwona, MD, Merlo, Domenico Franco, MD, Fontana, Valeria, MSc, Marchesi, Emanuela, MSc, Donati, Davide Maria, MD, Palassini, Elena, MD, Palmerini, Emanuela, MD, De Sanctis, Rita, MD, Morosi, Carlo, MD, Stacchiotti, Silvia, MD, Bagué, Silvia, MD, Coindre, Jean Michelle, Prof, Dei Tos, Angelo Paolo, Prof, Picci, Piero, MD, Bruzzi, Paolo, MD, Casali, Paolo Giovanni, MD

“…Summary Background Previous trials from our group suggested an overall survival benefit with five cycles of adjuvant full-dose epirubicin plus ifosfamide in…”
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Cediranib in patients with alveolar soft-part sarcoma (CASPS): a double-blind, placebo-controlled, randomised, phase 2 trial by Judson, Ian, Morden, James P, Kilburn, Lucy, Leahy, Michael, Benson, Charlotte, Bhadri, Vivek, Campbell-Hewson, Quentin, Cubedo, Ricardo, Dangoor, Adam, Fox, Lisa, Hennig, Ivo, Jarman, Katy, Joubert, Warren, Kernaghan, Sarah, López Pousa, Antonio, McNeil, Catriona, Seddon, Beatrice, Snowdon, Claire, Tattersall, Martin, Toms, Christy, Martinez Trufero, Javier, Bliss, Judith M

“…Alveolar soft-part sarcoma (ASPS) is a rare soft-tissue sarcoma that is unresponsive to chemotherapy. Cediranib, a tyrosine-kinase inhibitor, has shown…”
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Neoadjuvant Chemotherapy in High-Grade Myxoid Liposarcoma: Results of the Expanded Cohort of a Randomized Trial From Italian (ISG), Spanish (GEIS), French (FSG), and Polish Sarcoma Groups (PSG) by Gronchi, Alessandro, Palmerini, Emanuela, Quagliuolo, Vittorio, Martin Broto, Javier, Lopez Pousa, Antonio, Grignani, Giovanni, Brunello, Antonella, Blay, Jean-Yves, Tendero, Oscar, Diaz Beveridge, Robert, Ferraresi, Virginia, Lugowska, Iwona, Pizzamiglio, Sara, Verderio, Paolo, Fontana, Valeria, Donati, Davide Maria, Palassini, Elena, Sanfilippo, Roberta, Bianchi, Giuseppe, Bertuzzi, Alexia, Morosi, Carlo, Pasquali, Sandro, Stacchiotti, Silvia, Bagué, Silvia, Coindre, Jean Michel, Miceli, Rosalba, Dei Tos, Angelo Paolo, Casali, Paolo Giovanni

“…A randomized trial was conducted to compare neoadjuvant standard (S) anthracycline + ifosfamide (AI) regimen with histology-tailored (HT) regimen in selected…”
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Expanding the molecular landscape of undifferentiated sarcomas of bone with a novel EWSR1‐SSX3 gene fusion by Fumagalli, Caterina, Orellana, Ruth, Ferré, Malena, Gonzalez, Allan, Catasús, Lluis, Vázquez, Tania, Sebio, Ana, López‐Pousa, Antonio, Llauger, Jaume, Peiró, Ana, Antonescu, Cristina R.

“…Undifferentiated sarcomas characterized by a primitive monomorphic round to spindle cell phenotype and often non‐specific immunoprofile remain difficult to…”
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Nivolumab and sunitinib combination in advanced soft tissue sarcomas: a multicenter, single-arm, phase Ib/II trial by Martin-Broto, Javier, Hindi, Nadia, Grignani, Giovanni, Martinez-Trufero, Javier, Redondo, Andres, Valverde, Claudia, Stacchiotti, Silvia, Lopez-Pousa, Antonio, D'Ambrosio, Lorenzo, Gutierrez, Antonio, Perez-Vega, Herminia, Encinas-Tobajas, Victor, de Alava, Enrique, Collini, Paola, Peña-Chilet, Maria, Dopazo, Joaquin, Carrasco-Garcia, Irene, Lopez-Alvarez, Maria, Moura, David S, Lopez-Martin, Jose A

“…BackgroundSarcomas exhibit low expression of factors related to immune response, which could explain the modest activity of PD-1 inhibitors. A potential…”
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Walking one hour per day and the derived neutrophil-to-lymphocyte ratio are associated with outcome in palliative second-line immunotherapy for patients with recurrent and/or metastatic squamous cell carcinoma of head and neck by Caballero-Borrego, Miguel, Piedra, Aida, Gallego, Óscar, López-Pousa, Antonio, Castillo, Paola, Navarrete, Pilar, Prat, Alba, Grau, Juan J.

“…•Immune system status influences the effectiveness of immunotherapy.•Exercising improves the immune system.•The neutrophil-lymphocyte derived ratio is a…”
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Pazopanib for treatment of advanced extraskeletal myxoid chondrosarcoma: a multicentre, single-arm, phase 2 trial by Stacchiotti, Silvia, MD, Ferrari, Stefano, MD, Redondo, Andres, MD, Hindi-Muniz, Nadia, MD, Palmerini, Emanuela, MD, Vaz Salgado, Maria Angeles, MD, Frezza, Anna Maria, MD, Casali, Paolo Giovanni, Prof, Gutierrez, Antonio, MD, Lopez-Pousa, Antonio, MD, Grignani, Giovanni, MD, Italiano, Antoine, Prof, LeCesne, Axel, MD, Dumont, Sarah, MD, Blay, Jean Yves, Prof, Penel, Nicolas, MD, Bernabeu, Daniel, MD, de Alava, Enrique, Prof, Karanian, Marie, MD, Morosi, Carlo, MD, Brich, Silvia, PhD, Dagrada, Gian Paolo, PhD, Vallacchi, Viviana, PhD, Castelli, Chiara, PhD, Brenca, Monica, PhD, Racanelli, Dominga, PhD, Maestro, Roberta, PhD, Collini, Paola, MD, Cruz, Josefina, MD, Martin-Broto, Javier, MD

“…SummaryBackgroundExtraskeletal myxoid chondrosarcoma is a rare sarcoma with low sensitivity to cytotoxic chemotherapy. Retrospective evidence suggests that…”
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Short, Full-Dose Adjuvant Chemotherapy in High-Risk Adult Soft Tissue Sarcomas: A Randomized Clinical Trial From the Italian Sarcoma Group and the Spanish Sarcoma Group by GRONCHI, Alessandro, FRUSTACI, Sergio, DEI TOS, Angelo Paolo, DE PAOLI, Antonino, LONGHI, Alessandra, POVEDA, Andres, QUAGLIUOLO, Vittorio, COMANDONE, Alessandro, CASALI, Paolo Giovanni, PICCI, Piero, MERCURI, Mario, MARTIN, Javier, LOPEZ-POUSA, Antonio, VERDERIO, Paolo, MARIANI, Lidia, VALAGUSSA, Pinuccia, MICELI, Rosalba, STACCHIOTTI, Silvia

“…A previous randomized clinical trial by the Italian Sarcoma Group (ISG) had shown a survival benefit of adjuvant chemotherapy (CT) in high-risk extremity soft…”
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A phase II trial of weekly nab-paclitaxel for progressive and symptomatic desmoid tumors by Martin-Broto, Javier, Redondo, Andres, Moura, David S., Valverde, Claudia, Morales, Jose Manuel, Lopez-Pousa, Antonio, Martinez-Trufero, Javier, Gutierrez, Antonio, Díaz-Beveridge, Roberto, Luna, Pablo, Martinez-Marin, Virginia, Marcilla, David, Arribas, Ivan, Ledesma, Patricio, Lopez-Martin, Jose Antonio, Di Lernia, Davide, Zamora, Jorge, Hindi, Nadia

“…Desmoid fibromatosis (DF) are mesenchymal neoplasms, with potential aggressive course and relevant clinical impact. New systemic therapy modalities are needed…”
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Randomized Phase II Study Comparing Gemcitabine Plus Dacarbazine Versus Dacarbazine Alone in Patients With Previously Treated Soft Tissue Sarcoma: A Spanish Group for Research on Sarcomas Study by GARCIA-DEL-MURO, Xavier, LOPEZ-POUSA, Antonio, MEANA, Andrés, PERICAY, Carlos, CUBEDO, Ricardo, RUBIO, Jordi, DE JUAN, Ana, LAINEZ, Nuria, ANTONIO CARRASCO, Juan, DE ANDRES, Raquel, BUESA, Jose M, MAUREL, Joan, MARTIN, Javier, MARTINEZ-TRUFERO, Javier, CASADO, Antonio, GOMEZ-ESAANA, Auxiliadora, FRA, Joaquin, CRUZ, Josefina, POVEDA, Andres

“…To assess the activity and toxicity of the combination of gemcitabine plus dacarbazine (DTIC) in patients with advanced soft tissue sarcoma (STS) in a…”
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Complete Longitudinal Analyses of the Randomized, Placebo-Controlled, Phase III Trial of Sunitinib in Patients with Gastrointestinal Stromal Tumor following Imatinib Failure by DEMETRI, George D, GARRETT, Christopher R, PAZ-ARES, Luis, BLAY, Jean-Yves, MCARTHUR, Grant A, QIANG XU, XIN HUANG, HARMON, Charles S, TASSELL, Vanessa, COHEN, Darrel P, CASALI, Paolo G, SCHÖFFSKI, Patrick, SHAH, Manisha H, VERWEIJ, Jaap, LEYVRAZ, Serge, HURWITZ, Herbert I, LOPEZ POUSA, Antonio, LE CESNE, Axel, GOLDSTEIN, David

“…To analyze final long-term survival and clinical outcomes from the randomized phase III study of sunitinib in gastrointestinal stromal tumor patients after…”
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GSDMD-dependent pyroptotic induction by a multivalent CXCR4-targeted nanotoxin blocks colorectal cancer metastases by Sala, Rita, Rioja-Blanco, Elisa, Serna, Naroa, Sánchez-García, Laura, Álamo, Patricia, Alba-Castellón, Lorena, Casanova, Isolda, López-Pousa, Antonio, Unzueta, Ugutz, Céspedes, María Virtudes, Vázquez, Esther, Villaverde, Antonio, Mangues, Ramon

“…Colorectal cancer (CRC) remains the third cause of cancer-related mortality in Western countries, metastases are the main cause of death. CRC treatment remains…”
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