Search Results - "Poupon, M. F."

Modeling of response to endocrine therapy in a panel of human luminal breast cancer xenografts by Cottu, P., Marangoni, E., Assayag, F., de Cremoux, P., Vincent-Salomon, A., Guyader, Ch, de Plater, L., Elbaz, C., Karboul, N., Fontaine, J. J., Chateau-Joubert, S., Boudou-Rouquette, P., Alran, S., Dangles-Marie, V., Gentien, D., Poupon, M.-F., Decaudin, D.

“…Resistance to endocrine therapy is a major complication of luminal breast cancer and studies of the biological features of hormonal resistance are limited by…”
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CD44 targeting reduces tumour growth and prevents post-chemotherapy relapse of human breast cancers xenografts by Marangoni, E, Lecomte, N, Durand, L, de Pinieux, G, Decaudin, D, Chomienne, C, Smadja-Joffe, F, Poupon, M-F

“…CD44 is a marker of tumour-initiating cells and is upregulated in invasive breast carcinoma; however, its role in the cancer progression is unknown. Here, we…”
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Newly characterised ex vivo colospheres as a three-dimensional colon cancer cell model of tumour aggressiveness by Weiswald, L-B, Richon, S, Validire, P, Briffod, M, Lai-Kuen, R, Cordelières, F P, Bertrand, F, Dargere, D, Massonnet, G, Marangoni, E, Gayet, B, Pocard, M, Bieche, I, Poupon, M-F, Bellet, D, Dangles-Marie, V

“…Background: New models continue to be required to improve our understanding of colorectal cancer progression. To this aim, we characterised in this study a…”
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Influence of epidermal growth factor receptor (EGFR), p53 and intrinsic MAP kinase pathway status of tumour cells on the antiproliferative effect of ZD1839 ('Iressa') by Magné, N, Fischel, J L, Dubreuil, A, Formento, P, Poupon, M-F, Laurent-Puig, P, Milano, G

“…of ZD1839 ("Iressa") is an orally active, selective epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), which blocks signal transduction…”
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Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels by GIOVANNETTI, E, BACKUS, H. H. J, WOUTERS, D, FERREIRA, C. G, VAN HOUTEN, V. M. M, BRAKENHOFF, R. H, POUPON, M.-F, AZZARELLO, A, PINEDO, H. M, PETERS, G. J

“…Colorectal cancer (CRC) resistance to fluoropyrimidines and other inhibitors of thymidylate synthase (TS) is a serious clinical problem often associated with…”
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Mutations in OGG1, a gene involved in the repair of oxidative DNA damage, are found in human lung and kidney tumours by CHEVILLARD, S, RADICELLA, J. P, LEVALOIS, C, LEBEAU, J, POUPON, M.-F, OUDARD, S, DUTRILLAUX, B, BOITEUX, S

“…The human OGG1 gene encodes a DNA glycosylase activity catalysing the excision of the mutagenic lesion 7,8-dihydro-8-oxoguanine from oxidatively damaged DNA…”
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Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore by RAVAGNAN, L, MARZO, I, ZHIHUA XIE, REED, J. C, KROEMER, G, COSTANTINI, P, SUSIN, S. A, ZAMZAMI, N, PETIT, P. X, HIRSCH, F, GOULBERN, M, POUPON, M.-F, MICCOLI, L

“…The molecular mode of action of lonidamine, a therapeutic agent employed in cancer chemotherapy, has been elusive. Here we provide evidence that lonidamine…”
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Potentiation of antitumour activity of docetaxel by combination with trastuzumab in a human prostate cancer xenograft model and underlying mechanisms by LEGRIER, M.-E, OUDARD, S, JUDDE, J.-G, GUYADER, C, DE PINIEUX, G, BOYE, K, DE CREMOUX, P, DUTRILLAUX, B, POUPON, M.-F

“…Antitumour activity of docetaxel (Taxotere) in hormone-dependent (HD) and hormone-independent (HID) prostate cancer PAC120 xenograft model was previously…”
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Sensitivity to CPT-11 of xenografted human colorectal cancers as a function of microsatellite instability and p53 status by BRAS-GONCALVES, R. A, ROSTY, C, LAURENT-PUIG, P, SOULIE, P, DUTRILLAUX, B, POUPON, M.-F

“…Biological parameters influencing the response of human colorectal cancers (CRCs) to CPT-11, a topoisomerase 1 (top1) inhibitor, were investigated using a…”
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Methionine Depletion Enhances the Antitumoral Efficacy of Cytotoxic Agents in Drug-resistant Human Tumor Xenografts by F. Poirson-Bichat, R. A. Bras Gonçalves, L. Miccoli, B. Dutrillaux, M. F. Poupon

“…Efficacy of chemotherapy is limited in numerous tumors by specific cellular mechanisms that inactivate cytotoxic antitumoral drugs, such as ATP-dependent drug…”
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Tumour suppressive properties of fibroblast growth factor receptor 2-IIIb in human bladder cancer by RICOL, D, CAPPELLEN, D, THIERY, J. P, RADVANYI, F, EL MARJOU, A, GIL-DIEZ-DE-MEDINA, S, GIRAULT, J.-M, YOSHIDA, T, FERRY, G, TUCKER, G, POUPON, M.-F, CHOPIN, D

“…FGFRs (fibroblast growth factor receptors) are encoded by four genes (FGFR1-4). Alternative splicing results in various receptor isoforms. The FGFR2-IIIb…”
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Superior in vivo experimental antitumour activity of vinflunine, relative to vinorelbine, in a panel of human tumour xenografts by Hill, B.T, Fiebig, H.-H, Waud, W.R, Poupon, M.-F, Colpaert, F, Kruczynski, A

“…The antitumour activity of vinflunine, 20′,20′-dichloro-3′,4′-dihydrovinorelbine, a fluorinated Vinca alkaloid obtained by reaction in superacid media, was…”
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Fine mapping of human HOX gene clusters by Apiou, F, Flagiello, D, Cillo, C, Malfoy, B, Poupon, M F, Dutrillaux, B

“…The chromosome localization of human HOX gene clusters has been reinvestigated by fluorescence in situ hybridization (FISH). Three loci were precisely…”
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Mucinous differentiation features associated with hormonal escape in a human prostate cancer xenograft by LEGRIER, M.-E, DE PINIEUX, G, BOYE, K, ARVELO, F, JUDDE, J-G, FONTAINE, J-J, BARA, J, POUPON, M-F

“…Many theories mention hypersensitive, promiscuous, outlaw or bypass signalling pathways to explain the acquisition of hormone independence in prostate cancer…”
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High glycolysis in gliomas despite low hexokinase transcription and activity correlated to chromosome 10 loss by OUDARD, S, ARVELO, F, MICCOLI, L, APIOU, F, DUTRILLAUX, A. M, POISSON, M, DUTRILLAUX, B, POUPON, M. F

“…Loss of chromosome 10 was observed in 10 out of 12 xenografted glioblastomas studied. Chromosome 10 carries the gene coding the hexokinase type 1 isoenzyme…”
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Gliomas are driven by glycolysis: putative roles of hexokinase, oxidative phosphorylation and mitochondrial ultrastructure by Oudard, S, Boitier, E, Miccoli, L, Rousset, S, Dutrillaux, B, Poupon, M F

“…To elucidate the reasons for glycolytic deviation commonly found in brain tumors, hexokinase (HK) activity, mitochondria-HK binding, oxidative phosphorylation…”
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Correlation between genetic alterations and growth of human malignant glioma xenografted in nude mice by LEURAUD, P, TAILLANDIER, L, POUPON, M.-F, SANSON, M, AGUIRRE-CRUZ, L, MEDIONI, J, CRINIERE, E, MARIE, Y, DUTRILLAUX, A. M, KUJAS, M, DUPREZ, A, DELATTRE, J.-Y

“…In order to develop preclinical models of malignant astrocytomas and oligodendrogliomas, a series of 54 resected gliomas (37 from oligodendroglial lineage and…”
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The peripheral benzodiazepine receptors : a review by BEURDELEY-THOMAS, A, MICCOLI, L, OUDARD, S, DUTRILLAUX, B, POUPON, M. F

“…Peripheral benzodiazepine receptors (PBRs) have been identified in various peripheral tissues as well as in glial cells in the brain. This review describes the…”
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Uptake of doxorubicin from loaded nanoparticles in multidrug-resistant leukemic murine cells by COLIN DE VERDIERE, A, DUBERNET, C, NEMATI, F, POUPON, M. F, PUISIEUX, COUVREUR, P

“…Previous studies have clearly demonstrated that polyisobutylcyanoacrylate (PIBCA) doxorubicin-loaded nanoparticles (NS-Dox PIBCA) can overcome the resistance…”
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Light-induced photoactivation of hypericin affects the energy metabolism of human glioma cells by inhibiting hexokinase bound to mitochondria by MICCOLI, L, BEURDELEY-THOMAS, A, DE PINIEUX, G, SUREAU, F, OUDARD, S, DUTRILLAUX, B, POUPON, M.-F

“…Glucose-dependent energy required for glioma metabolism depends on hexokinase, which is mainly bound to mitochondria. A decrease in intracellular pH leads to a…”
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