Search Results - "Poulton, Kay"

HLA‐C expression level in both unstimulated and stimulated human umbilical vein endothelial cells is defined by allotype by Carey, B. Sean, Poulton, Kay V., Poles, Anthony

“…Human leukocyte antigens (HLA) are present on the surface of all nucleated cells, with the level of expression dependent on the particular HLA locus, the cell…”
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HLA expression levels of unstimulated and cytokine stimulated human umbilical vein endothelial cells by Carey, B. Sean, Poulton, Kay V., Poles, Anthony

“…Transplant rejection occurs following recipient recognition of mismatched HLA on donor tissue, but active rejection is dependent not only upon the severity of…”
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Predicting flow cytometry crossmatch results from single‐antigen bead testing by Flynn, Patrick A., Fernando, Sebastian, Worthington, Judith E., Poulton, Kay V.

“…The aim of this study was to devise an algorithm that would predict flow cytometry crossmatch (FCXM) results using single‐antigen bead (SAB) mean fluorescent…”
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Immunology of cord blood T-cells favors augmented disease response during clinical pediatric stem cell transplantation for acute leukemia by Borrill, Roisin, Poulton, Kay, Wynn, Robert

“…Allogeneic hematopoietic stem cell transplantation (HSCT) has been an important and efficacious treatment for acute leukemia in children for over 60 years. It…”
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Associations between human leukocyte antigens and renal function by Lowe, Marcus, Payton, Antony, Verma, Arpana, Worthington, Judith, Gemmell, Isla, Hamilton, Patrick, Ollier, William, Augustine, Titus, Poulton, Kay

“…Human leukocyte antigens (HLA) have been associated with renal function, but previous studies report contradictory findings with little consensus on the exact…”
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Factors affecting HLA expression: A review by Carey, B. Sean, Poulton, Kay Victoria, Poles, Anthony

“…The detection and semiquantitative measurement of circulating human leucocyte antigen (HLA)‐specific antibodies is essential for the management of patients…”
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High quality clinical grade human embryonic stem cell lines derived from fresh discarded embryos by Ye, Jinpei, Bates, Nicola, Soteriou, Despina, Grady, Lisa, Edmond, Clare, Ross, Alex, Kerby, Alan, Lewis, Philip A, Adeniyi, Tope, Wright, Ronnie, Poulton, Kay V, Lowe, Marcus, Kimber, Susan J, Brison, Daniel R

“…Human embryonic stem cells (hESCs) hold tremendous promise for cell replacement therapies for a range of degenerative diseases. In order to provide…”
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HLA typing and its influence on organ transplantation by Sheldon, Stephen, Poulton, Kay

“…Human leukocyte antigen (HLA) molecules are expressed on almost all nucleated cells, and they are the major molecules that initiate graft rejection. There are…”
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Definitions of histocompatibility typing terms by Nunes, Eduardo, Heslop, Helen, Fernandez-Vina, Marcelo, Taves, Cynthia, Wagenknecht, Dawn R., Eisenbrey, A. Bradley, Fischer, Gottfried, Poulton, Kay, Wacker, Kara, Hurley, Carolyn Katovich, Noreen, Harriet, Sacchi, Nicoletta

“…Histocompatibility testing for stem cell and solid organ transplantation has become increasingly complex as newly discovered HLA alleles are described. HLA…”
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Strategies for Success With Umbilical Cord Haematopoietic Stem Cell Transplantation in Children With Malignant and Non-Malignant Disease Indications by Wynn, Rob, Nataraj, Ramya, Nadaf, Rubiya, Poulton, Kay, Logan, Alison

“…Umbilical Cord blood is an intuitively attractive stem cell source, but its use has declined since it is associated with an increased procedure-related…”
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Evaluating the Clinical Relevance of Antibodies against Non-Human Leukocyte Antigen in Kidney Transplantation by Bhutani, Shiv, Harris, Shelley, Carr, Michelle, Russell-Lowe, Marcus, Worthington, Judith, Wu, Henry H L, Chinnadurai, Rajkumar, Poulton, Kay

“…: Kidney transplantation is the preferred modality of kidney replacement therapy for eligible patients with end-stage kidney disease (ESKD), given that it has…”
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Donor KIR2DL1 Allelic Polymorphism Influences Posthematopoietic Progenitor Cell Transplantation Outcomes in the T Cell Depleted and Reduced Intensity Conditioning Setting by Wright, Paul A., van de Pasch, Loes A.L., Dignan, Fiona L., Kichula, Katherine M., Pollock, Nicholas R., Norman, Paul J., Marchan, Earl, Hill, Lesley, Vandelbosch, Sanne, Fullwood, Catherine, Sheldon, Stephen, Hampson, Lynne, Tholouli, Eleni, Poulton, Kay V.

“…•KIR2DL1*003 positive grafts are detrimental for both 5-year disease-free survival and relapse incidence.•KIR2DL1*003 heterozygous and KIR2DL1*003 homozygous…”
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Mannose-Binding Lectin Gene Polymorphisms as a Susceptibility Factor for Chronic Necrotizing Pulmonary Aspergillosis by Crosdale, Daniel J., Poulton, Kay V., Ollier, William E., Thomson, Wendy, Denning, David W.

“…It was investigated whether a deficiency of mannose-binding lectin (MBL), which binds Aspergillus species avidly in vitro, could account for chronic…”
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Polymorphisms of TLR4 but not CD14 are associated with a decreased risk of aggressive periodontitis by James, Jacqueline A., Poulton, Kay V., Haworth, Simone E., Payne, Debbie, McKay, Ian J., Clarke, Fiona M., Hughes, Francis J., Linden, Gerard J.

“…Objective: To study whether there is an association between the frequency of functional polymorphisms in the toll‐like receptor 4 (TLR4) and cluster…”
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Activated NK cells have a potential therapeutic role in sustaining donor engraftment following paediatric haematopoietic stem cell transplantation for non‐malignant disease by Khan, Ursalan A., Davidson, Judith A., Poulton, Kay V., Wynn, Robert F., Fildes, James E.

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A linkage and association analysis study in the multidrug resistance gene 1 (mdr1) in renal patients by Bazrafshani, Mohammad R, Poulton, Kay V, Mahmoodi, Merat

“…Several investigations demonstrated that the polymorphisms of multidrug resistance gene (MDR1) gene contribute to interindividual variability in…”
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SARS‐CoV‐2: An immunogenetics call to arms by Clark, Brendan, Poulton, Kay

“…Susceptibility to viral infection, development of immunity, response to treatment and patient clinical outcomes are all under the control of heritable factors…”
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Association of Symptomatic Acute Human Parvovirus B19 Infection with Human Leukocyte Antigen Class I and II Alleles by Kerr, Jonathan R., Mattey, Derek. L., Thomson, Wendy, Poulton, Kay V., Ollier, William E. R.

“…To determine the effect of the major histocompatibility complex on the development of symptoms during acute human parvovirus B19 infection, we compared human…”
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Human leukocyte antigen epitope mismatch loads and the development of de novo donor‐specific antibodies in cardiothoracic organ transplantation by Bedford, Amy, Jervis, Steven, Worthington, Judith, Lowe, Marcus, Poulton, Kay

“…De novo donor‐specific human leucocyte antigen (HLA) antibodies (dnDSA) are associated with increased risk of rejection and mortality in solid organ…”
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Homozygous HLA‐DQB106:02 combined with T‐cell receptor alpha polymorphism results in narcolepsy onset – A familial case report by Jervis, Steven, Payton, Antony, Verma, Arpana, Thomasson, Rachel, Poulton, Kay

“…Narcolepsy is a life‐long neurological disorder with well‐established genetic risk factors. Human leukocyte antigen‐DQB1*06:02 remains the strongest genetic…”
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