Search Results - "Poulton, D."

Probability of Transmission of Malaria from Mosquito to Human Is Regulated by Mosquito Parasite Density in Naïve and Vaccinated Hosts by Churcher, Thomas S, Sinden, Robert E, Edwards, Nick J, Poulton, Ian D, Rampling, Thomas W, Brock, Patrick M, Griffin, Jamie T, Upton, Leanna M, Zakutansky, Sara E, Sala, Katarzyna A, Angrisano, Fiona, Hill, Adrian V S, Blagborough, Andrew M

“…Over a century since Ronald Ross discovered that malaria is caused by the bite of an infectious mosquito it is still unclear how the number of parasites…”
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Evaluation of a Human BCG Challenge Model to Assess Antimycobacterial Immunity Induced by BCG and a Candidate Tuberculosis Vaccine, MVA85A, Alone and in Combination by Harris, Stephanie A., Meyer, Joel, Satti, Iman, Marsay, Leanne, Poulton, Ian D., Tanner, Rachel, Minassian, Angela M., Fletcher, Helen A., McShane, Helen

“…Background. A new vaccine is urgently needed to combat tuberculosis. However, without a correlate of protection, selection of the vaccines to take forward into…”
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Safety and Immunogenicity of ChAd63/MVA Pfs25-IMX313 in a Phase I First-in-Human Trial by de Graaf, Hans, Payne, Ruth O, Taylor, Iona, Miura, Kazutoyo, Long, Carol A, Elias, Sean C, Zaric, Marija, Minassian, Angela M, Silk, Sarah E, Li, Lee, Poulton, Ian D, Baker, Megan, Draper, Simon J, Gbesemete, Diane, Brendish, Nathan J, Martins, Filipa, Marini, Arianna, Mekhaiel, David, Edwards, Nick J, Roberts, Rachel, Vekemans, Johan, Moyle, Sarah, Faust, Saul N, Berrie, Eleanor, Lawrie, Alison M, Hill, Fergal, Hill, Adrian V S, Biswas, Sumi

“…Transmission blocking vaccines targeting the sexual-stages of the malaria parasite could play a major role to achieve elimination and eradication of malaria…”
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Combining Viral Vectored and Protein-in-adjuvant Vaccines Against the Blood-stage Malaria Antigen AMA1: Report on a Phase 1a Clinical Trial by Hodgson, Susanne H, Choudhary, Prateek, Elias, Sean C, Milne, Kathryn H, Rampling, Thomas W, Biswas, Sumi, Poulton, Ian D, Miura, Kazutoyo, Douglas, Alexander D, Alanine, Daniel GW, Illingworth, Joseph J, de Cassan, Simone C, Zhu, Daming, Nicosia, Alfredo, Long, Carole A, Moyle, Sarah, Berrie, Eleanor, Lawrie, Alison M, Wu, Yimin, Ellis, Ruth D, Hill, Adrian V S, Draper, Simon J

“…The development of effective vaccines against difficult disease targets will require the identification of new subunit vaccination strategies that can induce…”
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CD1d-Restricted NKT Cells: An Interstrain Comparison by Hammond, Kirsten J. L, Pellicci, Daniel G, Poulton, Lynn D, Naidenko, Olga V, Scalzo, Anthony A, Baxter, Alan G, Godfrey, Dale I

“…CD1d-restricted Valpha14-Jalpha281 invariant alphabetaTCR(+) (NKT) cells are well defined in the C57BL/6 mouse strain, but they remain poorly characterized in…”
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Effect of vaccine dose on the safety and immunogenicity of a candidate TB vaccine, MVA85A, in BCG vaccinated UK adults by Pathan, Ansar A, Minassian, Angela M, Sander, Clare R, Rowland, Rosalind, Porter, David W, Poulton, Ian D, Hill, Adrian V.S, Fletcher, Helen A, McShane, Helen

“…Highlights ► We compared 3 doses of a the candidate TB vaccine MVA85A. ► All doses of the vaccine were safe and induced a Th1 type immune response. ► The…”
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Clinical Assessment of a Recombinant Simian Adenovirus ChAd63: A Potent New Vaccine Vector by O'Hara, Geraldine A., Duncan, Christopher J. A., Ewer, Katie J., Collins, Katharine A., Elias, Sean C., Halstead, Fenella D., Goodman, Anna L., Edwards, Nick J., Reyes-Sandoval, Arturo, Bird, Prudence, Rowland, Rosalind, Sheehy, Susanne H., Poulton, Ian D., Hutchings, Claire, Todryk, Stephen, Andrews, Laura, Folgori, Antonella, Berrie, Eleanor, Moyle, Sarah, Nicosia, Alfredo, Colloca, Stefano, Cortese, Riccardo, Siani, Loredana, Lawrie, Alison M., Gilbert, Sarah C., Hill, Adrian V. S.

“…Background. Vaccine development in human Plasmodium falciparum malaria has been hampered by the exceptionally high levels of CD8⁺ T cells required for…”
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Wideband, Bandpass, and Versatile Hybrid Filter Bank A/D Conversion for Software Radio by Lelandais-Perrault, C., Petrescu, T., Poulton, D., Duhamel, P., Oksman, J.

“…This paper deals with analog-to-digital (A/D) conversion for future software/cognitive radio systems. For these applications, A/D converters should convert…”
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Risk from cattle trampling to nests of an endangered passerine evaluated using artificial nest experiments and simulations by Rolek, Brian W., Schrott, Gregory, Poulton, D. Zak, Bowman, Reed

“…Grasslands are often grazed by cattle and many grassland birds nest on the ground, potentially exposing nests to trampling. We tested for trampling risk…”
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Evaluation of the Efficacy of ChAd63-MVA Vectored Vaccines Expressing Circumsporozoite Protein and ME-TRAP Against Controlled Human Malaria Infection in Malaria-Naive Individuals by Hodgson, Susanne H., Ewer, Katie J., Bliss, Carly M., Edwards, Nick J., Rampling, Thomas, Anagnostou, Nicholas A., de Barra, Eoghan, Havelock, Tom, Bowyer, Georgina, Poulton, Ian D., de Cassan, Simone, Longley, Rhea, Illingworth, Joseph J., Douglas, Alexander D., Mange, Pooja B., Collins, Katharine A., Roberts, Rachel, Gerry, Stephen, Berrie, Eleanor, Moyle, Sarah, Colloca, Stefano, Cortese, Riccardo, Sinden, Robert E., Gilbert, Sarah C., Bejon, Philip, Lawrie, Alison M., Nicosia, Alfredo, Faust, Saul N., Hill, Adrian V. S.

“…Background. Circumsporozoite protein (CS) is the antigenic target for RTS, S, the most advanced malaria vaccine to date. Heterologous prime-boost with the…”
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ChAd63-MVA–vectored Blood-stage Malaria Vaccines Targeting MSP1 and AMA1: Assessment of Efficacy Against Mosquito Bite Challenge in Humans by Sheehy, Susanne H, Duncan, Christopher JA, Elias, Sean C, Choudhary, Prateek, Biswas, Sumi, Halstead, Fenella D, Collins, Katharine A, Edwards, Nick J, Douglas, Alexander D, Anagnostou, Nicholas A, Ewer, Katie J, Havelock, Tom, Mahungu, Tabitha, Bliss, Carly M, Miura, Kazutoyo, Poulton, Ian D, Lillie, Patrick J, Antrobus, Richard D, Berrie, Eleanor, Moyle, Sarah, Gantlett, Katherine, Colloca, Stefano, Cortese, Riccardo, Long, Carole A, Sinden, Robert E, Gilbert, Sarah C, Lawrie, Alison M, Doherty, Tom, Faust, Saul N, Nicosia, Alfredo, Hill, Adrian VS, Draper, Simon J

“…The induction of cellular immunity, in conjunction with antibodies, may be essential for vaccines to protect against blood-stage infection with the human…”
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Phase Ia clinical evaluation of the safety and immunogenicity of the Plasmodium falciparum blood-stage antigen AMA1 in ChAd63 and MVA vaccine vectors by Sheehy, Susanne H, Duncan, Christopher J A, Elias, Sean C, Biswas, Sumi, Collins, Katharine A, O'Hara, Geraldine A, Halstead, Fenella D, Ewer, Katie J, Mahungu, Tabitha, Spencer, Alexandra J, Miura, Kazutoyo, Poulton, Ian D, Dicks, Matthew D J, Edwards, Nick J, Berrie, Eleanor, Moyle, Sarah, Colloca, Stefano, Cortese, Riccardo, Gantlett, Katherine, Long, Carole A, Lawrie, Alison M, Gilbert, Sarah C, Doherty, Tom, Nicosia, Alfredo, Hill, Adrian V S, Draper, Simon J

“…Traditionally, vaccine development against the blood-stage of Plasmodium falciparum infection has focused on recombinant protein-adjuvant formulations in order…”
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Phase Ia Clinical Evaluation of the Plasmodium falciparum Blood-stage Antigen MSP1 in ChAd63 and MVA Vaccine Vectors by Sheehy, Susanne H, Duncan, Christopher JA, Elias, Sean C, Collins, Katharine A, Ewer, Katie J, Spencer, Alexandra J, Williams, Andrew R, Halstead, Fenella D, Moretz, Samuel E, Miura, Kazutoyo, Epp, Christian, Dicks, Matthew DJ, Poulton, Ian D, Lawrie, Alison M, Berrie, Eleanor, Moyle, Sarah, Long, Carole A, Colloca, Stefano, Cortese, Riccardo, Gilbert, Sarah C, Nicosia, Alfredo, Hill, Adrian VS, Draper, Simon J

“…Efficacy trials of antibody-inducing protein-in-adjuvant vaccines targeting the blood-stage Plasmodium falciparum malaria parasite have so far shown…”
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Cytometric and functional analyses of NK and NKT cell deficiencies in NOD mice by Poulton, Lynn D., Smyth, Mark J., Hawke, Christine G., Silveira, Pablo, Shepherd, Darren, Naidenko, Olga V., Godfrey, Dale I., Baxter, Alan G.

“…Defects in NK and NKT cell activities have been implicated in the etiology of type 1 (autoimmune) diabetes in NOD mice on the basis of experiments performed…”
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Optimising Controlled Human Malaria Infection Studies Using Cryopreserved P. falciparum Parasites Administered by Needle and Syringe by Sheehy, Susanne H, Spencer, Alexandra J, Douglas, Alexander D, Sim, B Kim Lee, Longley, Rhea J, Edwards, Nick J, Poulton, Ian D, Kimani, Domtila, Williams, Andrew R, Anagnostou, Nicholas A, Roberts, Rachel, Kerridge, Simon, Voysey, Merryn, James, Eric R, Billingsley, Peter F, Gunasekera, Anusha, Lawrie, Alison M, Hoffman, Stephen L, Hill, Adrian V S

“…Controlled human malaria infection (CHMI) studies have become a routine tool to evaluate efficacy of candidate anti-malarial drugs and vaccines. To date, CHMI…”
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Genetic Control of NKT Cell Numbers Maps to Major Diabetes and Lupus Loci by Esteban, Luis M, Tsoutsman, Tatiana, Jordan, Margaret A, Roach, Daniel, Poulton, Lynn D, Brooks, Andrew, Naidenko, Olga V, Sidobre, Stephane, Godfrey, Dale I, Baxter, Alan G

“…Natural killer T cells are an immunoregulatory population of lymphocytes that plays a critical role in controlling the adaptive immune system and contributes…”
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Repeat controlled human malaria infection of healthy UK adults with blood-stage Plasmodium falciparum: Safety and parasite growth dynamics by Salkeld, Jo, Themistocleous, Yrene, Barrett, Jordan R., Mitton, Celia H., Rawlinson, Thomas A., Payne, Ruth O., Hou, Mimi M., Khozoee, Baktash, Edwards, Nick J., Nielsen, Carolyn M., Sandoval, Diana Muñoz, Bach, Florian A., Nahrendorf, Wiebke, Ramon, Raquel Lopez, Baker, Megan, Ramos-Lopez, Fernando, Folegatti, Pedro M., Quinkert, Doris, Ellis, Katherine J., Poulton, Ian D., Lawrie, Alison M., Cho, Jee-Sun, Nugent, Fay L., Spence, Philip J., Silk, Sarah E., Draper, Simon J., Minassian, Angela M.

“…In endemic settings it is known that natural malaria immunity is gradually acquired following repeated exposures. Here we sought to assess whether similar…”
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alpha/beta-T cell receptor (TCR)+CD4-CD8- (NKT) thymocytes prevent insulin-dependent diabetes mellitus in nonobese diabetic (NOD)/Lt mice by the influence of interleukin (IL)-4 and/or IL-10 by Hammond, K J, Poulton, L D, Palmisano, L J, Silveira, P A, Godfrey, D I, Baxter, A G

“…We have previously shown that nonobese diabetic (NOD) mice are selectively deficient in alpha/beta-T cell receptor (TCR)+CD4-CD8- NKT cells, a defect that may…”
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Impact on malaria parasite multiplication rates in infected volunteers of the protein-in-adjuvant vaccine AMA1-C1/Alhydrogel+CPG 7909 by Duncan, Christopher J A, Sheehy, Susanne H, Ewer, Katie J, Douglas, Alexander D, Collins, Katharine A, Halstead, Fenella D, Elias, Sean C, Lillie, Patrick J, Rausch, Kelly, Aebig, Joan, Miura, Kazutoyo, Edwards, Nick J, Poulton, Ian D, Hunt-Cooke, Angela, Porter, David W, Thompson, Fiona M, Rowland, Ros, Draper, Simon J, Gilbert, Sarah C, Fay, Michael P, Long, Carole A, Zhu, Daming, Wu, Yimin, Martin, Laura B, Anderson, Charles F, Lawrie, Alison M, Hill, Adrian V S, Ellis, Ruth D

“…Inhibition of parasite growth is a major objective of blood-stage malaria vaccines. The in vitro assay of parasite growth inhibitory activity (GIA) is widely…”
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Protective CD8+ T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation by Ewer, Katie J., O’Hara, Geraldine A., Duncan, Christopher J. A., Collins, Katharine A., Sheehy, Susanne H., Reyes-Sandoval, Arturo, Goodman, Anna L., Edwards, Nick J., Elias, Sean C., Halstead, Fenella D., Longley, Rhea J., Rowland, Rosalind, Poulton, Ian D., Draper, Simon J., Blagborough, Andrew M., Berrie, Eleanor, Moyle, Sarah, Williams, Nicola, Siani, Loredana, Folgori, Antonella, Colloca, Stefano, Sinden, Robert E., Lawrie, Alison M., Cortese, Riccardo, Gilbert, Sarah C., Nicosia, Alfredo, Hill, Adrian V. S.

“…Induction of antigen-specific CD8 + T cells offers the prospect of immunization against many infectious diseases, but no subunit vaccine has induced CD8 + T…”
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