Search Results - "Pouli, A E"

Glucose generates sub-plasma membrane ATP microdomains in single islet beta-cells. Potential role for strategically located mitochondria by Kennedy, H J, Pouli, A E, Ainscow, E K, Jouaville, L S, Rizzuto, R, Rutter, G A

“…Increases in the concentration of free ATP within the islet beta-cell may couple elevations in blood glucose to insulin release by closing ATP-sensitive K+…”
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Secretory-granule dynamics visualized in vivo with a phogrin-green fluorescent protein chimaera by Pouli, A E, Emmanouilidou, E, Zhao, C, Wasmeier, C, Hutton, J C, Rutter, G A

“…To image the behaviour in real time of single secretory granules in neuroendocrine cells we have expressed cDNA encoding a fusion construct between the…”
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The cytotoxic effect of volatile organic compounds of the gas phase of cigarette smoke on lung epithelial cells by Pouli, Aristea E., Hatzinikolaou, Dimitris G., Piperi, Christina, Stavridou, Anastasia, Psallidopoulos, Miltiades C., Stavrides, John C.

“…Health effects of cigarette smoke (CS) in humans are well known from both clinical and epidemiological studies. However, the mechanism behind CS toxicity and…”
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Insulin targeting to the regulated secretory pathway after fusion with green fluorescent protein and firefly luciferase by Pouli, A E, Kennedy, H J, Schofield, J G, Rutter, G A

“…We have prepared recombinant cDNAs encoding chimaeras between human preproinsulin (sp.B.C.A., for B-, Connecting- and A-peptides) and a thermostable mutant of…”
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Imaging Ca2+ concentration changes at the secretory vesicle surface with a recombinant targeted cameleon by Emmanouilidou, Evaggelia, Teschemacher, Anja G., Pouli, Aristea E., Nicholls, Linda I., Seward, Elizabeth P., Rutter, Guy A.

“…Regulated exocytosis involves the Ca2+-triggered fusion of secretory vesicles with the plasma membrane, by activation of vesicle membrane Ca2+-binding proteins…”
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Study of the mechanisms of cigarette smoke gas phase cytotoxicity by Piperi, Christina, Pouli, Aristea E, Katerelos, Nikolaos A, Hatzinikolaou, Dimitris G, Stavridou, Anastasia, Psallidopoulos, Miltiades C

“…The cytotoxicity of cigarette smoke (CS) in humans is well-documented, but the mechanism behind CS toxicity and carcinogenicity remains unknown. We are…”
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Glucose enhances insulin promoter activity in MIN6 beta-cells independently of changes in intracellular Ca2+ concentration and insulin secretion by Kennedy, H J, Rafiq, I, Pouli, A E, Rutter, G A

“…Recent studies have suggested that glucose may activate insulin gene transcription through increases in intracellular Ca(2+) concentration, possibly acting via…”
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A phogrin-aequorin chimaera to image free Ca2+ in the vicinity of secretory granules by Pouli, A E, Karagenc, N, Wasmeier, C, Hutton, J C, Bright, N, Arden, S, Schofield, J G, Rutter, G A

“…Microdomains of high Ca2+ concentration ([Ca2+]) may be critical to the control of intracellular processes such as secretion and metabolism without…”
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Analysis of the Gas Phase of Cigarette Smoke by Gas Chromatography Coupled with UV-Diode Array Detection by Hatzinikolaou, Dimitris G, Lagesson, Verner, Stavridou, Anastasia J, Pouli, Aristea E, Lagesson-Andrasko, Ludmila, Stavrides, John C

“…A gas chromatography method, coupled with diode array photometric spectral detection in the ultraviolet region (167−330 nm), was developed for the analysis of…”
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Imaging Ca super(2+) concentration changes at the secretory vesicle surface with a recombinant targeted cameleon by Emmanouilidou, E, Teschemacher, A G, Pouli, A E, Nicholls, LI, Seward, E P, Rutter, G A

“…Regulated exocytosis involves the Ca super(2+)-triggered fusion of secretory vesicles with the plasma membrane, by activation of vesicle membrane Ca…”
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