Search Results - "Poulakis, K."
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Multi-cohort and longitudinal Bayesian clustering study of stage and subtype in Alzheimer’s disease
Published in Nature communications (05-08-2022)“…Understanding Alzheimer’s disease (AD) heterogeneity is important for understanding the underlying pathophysiological mechanisms of AD. However, AD atrophy…”
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Frontoparietal atrophy trajectories in cognitively unimpaired elderly individuals using longitudinal Bayesian clustering
Published in Computers in biology and medicine (01-11-2024)“…Frontal and/or parietal atrophy has been reported during aging. To disentangle the heterogeneity previously observed, this study aimed to uncover different…”
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Brain myoinositol as a potential marker of amyloid-related pathology: A longitudinal study
Published in Neurology (29-01-2019)“…OBJECTIVETo investigate the association between longitudinal changes in proton magnetic resonance spectroscopy (MRS) metabolites and amyloid pathology in…”
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Unraveling Parkinson's disease heterogeneity using subtypes based on multimodal data
Published in Parkinsonism & related disorders (01-09-2022)“…Parkinson's disease (PD) is a clinically and neuroanatomically heterogeneous neurodegenerative disease characterized by different subtypes. To this date, no…”
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Cerebrospinal Fluid Biomarkers, Brain Structural and Cognitive Performances Between Normotensive and Hypertensive Controlled, Uncontrolled and Untreated 70-Year-Old Adults
Published in Frontiers in aging neuroscience (12-01-2022)“…Hypertension is an important risk factor for Alzheimer's disease (AD). The pathophysiological mechanisms underlying the relationship between AD and…”
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Clustering and disease subtyping in Neuroscience, toward better methodological adaptations
Published in Frontiers in computational neuroscience (2023)“…[...]in research the differences between the two are often overlooked. [...]we want to highlight the applications and challenges of clustering, where…”
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[18F]THK5317 imaging as a tool for predicting prospective cognitive decline in Alzheimer’s disease
Published in Molecular psychiatry (01-10-2021)“…Cross-sectional studies have indicated potential for positron emission tomography (PET) in imaging tau pathology in Alzheimer’s disease (AD); however, its…”
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Investigating underlying brain structures and influence of mild and subjective cognitive impairment on dual-task performance in people with Parkinson’s disease
Published in Scientific reports (25-04-2024)“…Cognitive impairment can affect dual-task abilities in Parkinson’s disease (PD), but it remains unclear whether this is also driven by gray matter alterations…”
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Author Correction: Multi-cohort and longitudinal Bayesian clustering study of stage and subtype in Alzheimer’s disease
Published in Nature communications (10-07-2024)Get full text
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Demographic and Clinical Characteristics of Individuals with Mild Cognitive Impairment Related to Grade of Alcohol Consumption
Published in Dementia and geriatric cognitive disorders (01-01-2022)“…While alcohol overconsumption is regarded as a risk factor for Alzheimer's disease, the specific relationship between alcohol consumption and cognitive…”
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Clinical characteristics of Mild Cognitive Impairment cohort with grade of alcohol consumption
Published in EUROPEAN JOURNAL OF NEUROLOGY (2022)Get full text
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Fully bayesian longitudinal unsupervised learning for the assessment and visualization of AD heterogeneity and progression
Published in Aging (Albany, NY.) (2020)“…Tau pathology and brain atrophy are the closest correlate of cognitive decline in Alzheimer's disease (AD). Understanding heterogeneity and longitudinal…”
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Exploring Responsiveness to Highly Challenging Balance and Gait Training in Parkinson's Disease
Published in Movement disorders clinical practice (Hoboken, N.J.) (01-11-2024)“…Background Exercise potentially improves gait, balance, and habitual physical activity in Parkinson's disease (PD). However, given the heterogeneous nature of…”
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Heterogeneous patterns of brain atrophy in Alzheimer's disease
Published in Neurobiology of aging (01-05-2018)“…There is increasing evidence showing that brain atrophy varies between patients with Alzheimer's disease (AD), suggesting that different anatomical patterns…”
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Comparison of subtyping methods for neuroimaging studies in Alzheimer’s disease: a call for harmonization
Published in Brain communications (01-01-2020)“…Abstract Biological subtypes in Alzheimer’s disease, originally identified on neuropathological data, have been translated to in vivo biomarkers such as…”
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MRI subtypes in Parkinson’s disease across diverse populations and clustering approaches
Published in NPJ Parkinson's Disease (16-08-2024)“…Parkinson’s disease (PD) is clinically heterogeneous, which suggests the existence of subtypes; however, there has been no consensus regarding their…”
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Longitudinal deterioration of white-matter integrity: heterogeneity in the ageing population
Published in Brain communications (01-01-2021)“…Abstract Deterioration in white-matter health plays a role in cognitive ageing. Our goal was to discern heterogeneity of white-matter tract vulnerability in…”
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MRI data-driven clustering reveals different subtypes of Dementia with Lewy bodies
Published in NPJ Parkinson's Disease (20-01-2023)“…Dementia with Lewy bodies (DLB) is a neurodegenerative disorder with a wide heterogeneity of symptoms, which suggests the existence of different subtypes. We…”
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