Serogroups, and drug resistance of nontyphoidal Salmonella in symptomatic patients with community-acquired diarrhea and chicken meat samples in Tehran

is considered as a main cause of community-acquired diarrhea in humans, however, sources of the multi-drug resistant (MDR) strains and their link with the disease are not well known. This study aimed to investigate the frequency, serogroup diversity, and antimicrobial susceptibility patterns of stra...

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Published in:	Iranian journal of veterinary research Vol. 21; no. 4; pp. 269 - 278
Main Authors:	Besharati, S, Sadeghi, A, Ahmadi, F, Tajeddin, E, Mohammad Salehi, R, Fani, F, Pouladfar, Gh, Nikmanesh, B, Majidpour, A, Soleymanzadeh Moghadam, S, Mirab Samiee, S, Rahnamaye Farzami, M, Rahbar, M, Eslami, P, Rakhshani, N, Eshrati, B, Gouya, M M, Fallah, F, Karimi, A, Owlia, P, Alebouyeh, M
Format:	Journal Article
Language:	English
Published:	Iran School of Veterinary Medicine, University of Shiraz 01-01-2020
Subjects:	Original Diarrhea Salmonella Drug resistance Beta-Lactamases Meat
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Summary:	is considered as a main cause of community-acquired diarrhea in humans, however, sources of the multi-drug resistant (MDR) strains and their link with the disease are not well known. This study aimed to investigate the frequency, serogroup diversity, and antimicrobial susceptibility patterns of strains in poultry meat and stool samples of patients with community acquired diarrhea in Tehran. We compared the frequency of non-typhoidal serogroups, the similarities of their resistance patterns to 10 antimicrobial compounds, the prevalence of extended spectrum β-lactamase (ESBL) and ampicillinase C (AmpC) genetic determinants, and class 1 and 2 integrons in 100 chicken meat and 400 stool samples of symptomatic patients in Tehran during June 2018 to March 2019. was isolated from 75% and 5.5% of the chicken meats and human stool samples, respectively. The chicken meat isolates mainly belonged to serogroup C (88%, 66/75), while the human stool isolates were mainly related to serogroup D (59.1%, 13/22). The MDR phenotype and the most common rates of resistance to antibiotics, including tetracycline, trimethoprim/sulfamethoxazole (TS) and azithromycin, were detected in 4.5% and 45.3%, 59% and 13.6%, 43% and 9.1%, 42% and 9.1% of the human stool and chicken meat samples, respectively. Carriage of , , and genes in the meat isolate with ESBL resistance phenotype and , , and among the 7 meat strains with AmpC resistance phenotype was not confirmed using polymerase chain reaction (PCR). High prevalence of class 1 and 2 integrons was characterized and showed a correlation with resistance to TS and chloramphenicol. These findings showed a lack of association between chicken meats and human isolates due to discrepancy between the characterized serogroups and resistance phenotypes.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1728-1997 2252-0589
DOI:	10.22099/IJVR.2020.36912.5387