Search Results - "Pottier, Agnes"

Delivering the power of nanomedicine to patients today by Germain, Matthieu, Caputo, Fanny, Metcalfe, Su, Tosi, Giovanni, Spring, Kathleen, Åslund, Andreas K.O., Pottier, Agnes, Schiffelers, Raymond, Ceccaldi, Alexandre, Schmid, Ruth

“…The situation of the COVID-19 pandemic reminds us that we permanently need high-value flexible solutions to urgent clinical needs including simplified…”
Get full text

New use of metals as nanosized radioenhancers by Pottier, Agnès, Borghi, Elsa, Levy, Laurent

“…Since the discovery of cisplatin about 40 years ago, the design of innovative metal-based anticancer drugs is a growing area of research. Transition metal…”
Get full text

Nanoscale radiotherapy with hafnium oxide nanoparticles by Maggiorella, Laurence, Barouch, Gilles, Devaux, Corinne, Pottier, Agnès, Deutsch, Eric, Bourhis, Jean, Borghi, Elsa, Levy, Laurent

“…There is considerable interest in approaches that could improve the therapeutic window of radiotherapy. In this study, hafnium oxide nanoparticles were…”
Get more information

Metals as radio-enhancers in oncology: The industry perspective by Pottier, Agnés, Borghi, Elsa, Levy, Laurent

“…Radio-enhancers, metal-based nanosized agents, could play a key role in oncology. They may unlock the potential of radiotherapy by enhancing the radiation dose…”
Get full text

A new opportunity for nanomedicines: Micellar cytochrome P450 inhibitors to improve drug efficacy in a cancer therapy model by Paolini, Marion, Poul, Laurence, Darmon, Audrey, Germain, Matthieu, Pottier, Agnès, Levy, Laurent, Vibert, Eric

“…Abstract Nanomedicines are mainly used as drug delivery systems; here we evaluate a new application - to inhibit a drug's metabolism thereby enhancing its…”
Get full text

Priming the body to receive the therapeutic agent to redefine treatment benefit/risk profile by Germain, Matthieu, Meyre, Marie-Edith, Poul, Laurence, Paolini, Marion, Berjaud, Céline, Mpambani, Francis, Bergere, Maxime, Levy, Laurent, Pottier, Agnès

“…Many therapeutic agents offer a low useful dose (dose responsible for efficacy)/useless dose (dose eliminated or responsible for toxicity) ratio, mainly due to…”
Get full text

The future of nanosized radiation enhancers by Pottier, Agnes, Borghi, Elsa, Levy, Laurent

“…Radiotherapy has a universal and predictable mode of action, that is, a physical mode of action consisting of the deposit of a dose of energy in tissues…”
Get full text

Nano-sized cytochrome P450 3A4 inhibitors to block hepatic metabolism of docetaxel by Paolini, Marion, Poul, Laurence, Berjaud, Céline, Germain, Matthieu, Darmon, Audrey, Bergère, Maxime, Pottier, Agnès, Levy, Laurent, Vibert, Eric

“…Most drugs are metabolized by hepatic cytochrome P450 3A4 (CYP3A4), resulting in their reduced bioavailability. In this study, we present the design and…”
Get full text

MRI contrast variation of thermosensitive magnetoliposomes triggered by focused ultrasound: a tool for image-guided local drug delivery by Lorenzato, Cyril, Cernicanu, Alexandru, Meyre, Marie-Edith, Germain, Matthieu, Pottier, Agnès, Levy, Laurent, de Senneville, Baudouin Denis, Bos, Clemens, Moonen, Chrit, Smirnov, Pierre

“…Improved drug delivery control during chemotherapy has the potential to increase the therapeutic index. MRI contrast agent such as iron oxide nanoparticles can…”
Get more information

Hafnium oxide nanoparticles: toward an in vitro predictive biological effect? by Marill, Julie, Anesary, Naeemunnisa Mohamed, Zhang, Ping, Vivet, Sonia, Borghi, Elsa, Levy, Laurent, Pottier, Agnes

“…Hafnium oxide, NBTXR3 nanoparticles were designed for high dose energy deposition within cancer cells when exposed to ionizing radiation. The purpose of this…”
Get full text

Pp IX Silica Nanoparticles Demonstrate Differential Interactions with In Vitro Tumor Cell Lines and In Vivo Mouse Models of Human Cancers by Simon, Virginie, Devaux, Corinne, Darmon, Audrey, Donnet, Thibault, Thiénot, Edouard, Germain, Matthieu, Honnorat, Jérôme, Duval, Alex, Pottier, Agnès, Borghi, Elsa, Levy, Laurent, Marill, Julie

“…Protoporphyrin IX (Pp IX) silica nanoparticles, developed for effective use in photodynamic therapy (PDT), were explored in in vitro and in vivo models with…”
Get full text

Abstract LB-072: Redefine nanomedicine products bioavailability to improve anti-tumor efficacy by Germain, Matthieu, Poul, Laurence, Meyre, Marie-Edith, Paolini, Marion, Mpambani, Francis, Bergere, Maxime, Pottier, Agnes, Levy, Laurent

“…Abstract Introduction: The benefit of a nanomedicine is due to its bioavailability, its intrinsic efficacy balanced with its toxicity profile. The nanomedicine…”
Get full text

One pot synthesis of new hybrid versatile nanocarrier exhibiting efficient stability in biological environment for use in photodynamic therapy by Thienot, Edouard, Germain, Matthieu, Piejos, Kelthoum, Simon, Virginie, Darmon, Audrey, Marill, Julie, Borghi, Elsa, Levy, Laurent, Hochepied, Jean-François, Pottier, Agnès

“…A new versatile hybrid nanocarrier has been designed using a “soft chemistry” synthesis, to efficiently encapsulate a photosensitizer – the protoporphyrin IX…”
Get full text

Abstract LB-B18: Radiation therapy with presence of nanoparticles at the tumor cell level: optimizing treatment efficacy through nanoparticle design by Pottier, Agnès, Borghi, Elsa, Villagomez-Bernabe, Balder, Currell, Fred

“…Abstract Today, more than half of all cancer patients receive radiotherapy as part of their treatment. However, radiotherapy efficacy is often limited by…”
Get full text

Abstract 5193: Hafnium oxide nanoparticles (NBTXR3), a novel radiation enhancer achieves marked antitumor efficacy across five tumor types by Zhang, Ping, Vivet, Sonia, Paris, Sébastien, Pottier, Agnès

“…Abstract NBTXR3 are hafnium oxide nanoparticles (NPs) used for a single intratumor administration as radioenhancer in combination with radiation therapy (RT)…”
Get full text

Abstract 5183: The radioenhancer NBTXR3 brings anticancer efficacy to the cisplatin-based chemoradiation in vitro and in vivo by Pottier, Agnès, Vivet, Sonia, Paris, Sébastien, Lu, Bo

“…Abstract NBTXR3 is a radioenhancer composed of functionalized hafnium oxide nanoparticles, designed to enhance the radiation dose deposit within the cancer…”
Get full text

Hafnium oxide nanoparticles: toward an in vitropredictive biological effect? by Marill, Julie, Anesary, Naeemunnisa Mohamed, Zhang, Ping, Vivet, Sonia, Borghi, Elsa, Levy, Laurent, Pottier, Agnes

“…Background Hafnium oxide, NBTXR3 nanoparticles were designed for high dose energy deposition within cancer cells when exposed to ionizing radiation. The…”
Get full text

Abstract LB-A30: Hafnium oxide nanoparticles with radiotherapy induce immunogenic cell death by Marill, Julie, Mohamed, Naeemunnisa, Darmon, Audrey, Levy, Laurent, Borghi, Elsa, Pottier, Agnès, Paris, Sébastien

“…Abstract Background - Between 70 to 90% of patient have "cold" tumors, i.e. devoid or poorly infiltrated by immune cells, rendering inoperative their treatment…”
Get full text

Surface-Initiated Ring-Opening Polymerization:  A Versatile Method for Nanoparticle Ordering by Carrot, Géraldine, Rutot-Houzé, Delphine, Pottier, Agnès, Degée, Philippe, Hilborn, Jöns, Dubois, Philippe

“…The coordination−insertion ring-opening polymerization of ε-caprolactone was initiated from amine or hydroxyl groups spread over the surface of silica (ca. 30…”
Get full text

Abstract 2665: NBTXR3 hafnium oxide nanoparticle activated by ionizing radiation demonstrates marked radio-enhancement and antitumor effect via high energy deposit in human soft tissue sarcoma by Laurence, Maggiorella, Darmon, Audrey, Vivet, Sonia, Polrot, Mélanie, Zhang, Ping, Deutsch, Eric, Bourhis, Jean, Pottier, Agnès, Borghi, Elsa, Levy, Laurent

“…Abstract Local and systemic control of Soft Tissue Sarcoma (STS) remains a clinical challenge. Radiation therapy is part of the standard of care of STS. The…”
Get full text