Search Results - "Potter, Pamela E"

Pre- and post-synaptic cortical cholinergic deficits are proportional to amyloid plaque presence and density at preclinical stages of Alzheimer’s disease by Potter, Pamela E., Rauschkolb, Paula K., Pandya, Yoga, Sue, Lucia I., Sabbagh, Marwan N., Walker, Douglas G., Beach, Thomas G.

“…Amyloid imaging has identified cognitively normal older people with plaques as a group possibly at increased risk for developing Alzheimer’s disease-related…”
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Investigational medications for treatment of patients with Alzheimer disease by Potter, Pamela E

“…Development of effective treatments for patients with Alzheimer disease has been challenging. Currently approved treatments include acetylcholinesterase…”
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Curcumin: a natural substance with potential efficacy in Alzheimer's disease by Potter, Pamela E

“…Curcumin is a component of turmeric, a spice used in many types of cooking. Epidemiological evidence suggesting that populations that eat food with a…”
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Neuroprotection by a novel NMDAR functional glycine site partial agonist, GLYX-13 by Stanton, Patric K, Potter, Pamela E, Aguilar, Jennifer, Decandia, Maria, Moskal, Joseph R

“…GLYX-13 (threonine–proline–proline–threonine–amide) is an amidated di-pyrrolidine that acts as a functional partial agonist at the glycine site on…”
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Reduction of cerebrospinal fluid amyloid β after systemic administration of M1 muscarinic agonists by Beach, Thomas G, Walker, Douglas G, Potter, Pamela E, Sue, Lucia I, Fisher, Abraham

“…Overproduction of the peptide amyloid β (Aβ) is a critical event in Alzheimer’s disease (AD). Systemic administration of 3 M1-selective muscarinic agonists,…”
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Branched-chain amino acid-induced hippocampal norepinephrine release is antagonized by picrotoxin: evidence for a central mode of action by Torigoe, Kazunori, Potter, Pamela E, Katz, David P

“…Previous studies indicated that administration of a 1:1:1 mixture of the branched-chain amino acids leucine, isoleucine, and valine (BCAA) decreased the…”
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Thiorphan-induced neprilysin inhibition raises amyloid β levels in rabbit cortex and cerebrospinal fluid by Newell, Amanda J., Sue, Lucia I., Scott, Sarah, Rauschkolb, Paula K., Walker, Douglas G., Potter, Pamela E., Beach, Thomas G.

“…Studies on the pathogenesis of Alzheimer's disease (AD) suggest overproduction of amyloid β (Aβ) may not be the only pathogenic route to AD. Decreased…”
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Cholinergic deafferentation of the rabbit cortex: a new animal model of Aβ deposition by Beach, Thomas G, Potter, Pamela E, Kuo, Yu-Min, Emmerling, Mark R, Durham, Robert A, Webster, Scott D, Walker, Douglas G, Sue, Lucia I, Scott, Sarah, Layne, Kathryn J, Roher, Alex E

“…Brain deposition of the amyloid β-peptide (Aβ) is a critical step in the pathogenesis of Alzheimer's disease (AD) and human cerebral amyloid angiopathy (CAA)…”
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Norclozapine Reduces Beta Amyloid 1‐42 Levels and Increases ChAT Levels in 3xTg‐AD Female Mice by Burkart, Ashley, Potter, Pamela E, Jones, Douglas C

“…Abstract only Alzheimer's disease (AD) is a neurodegenerative disease characterized by synaptic dysfunction and cholinergic cell death. Major pathological…”
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Purification of Human Fetal Hippocampal Neurons by Flow Cytometry for Transplantation by Chiu, Fung-Chow, Potter, Pamela E., Rozental, Renato

“…We have established primary cultures, highly enriched in neurons, from the hippocampus of human fetal brains at 20–23 gestational weeks. More than 80% of cells…”
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Dopamine in the rat ventral pallidum/substantia innominata: biochemical and electrophysiological studies by Napier, T C, Potter, P E

“…Recent anatomical literature suggests that dopaminergic projections ascending from the midbrain terminate within the ventral pallidum/substantia innominata…”
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Early cholinergic deficit in Alzheimer’s disease: Can cholinergic replacement therapy decrease deposition of B-amyloid? by Potter, Pamela E.

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Inhibition of high affinity choline transport attenuates both cholinergic and non-cholinergic effects of ethylcholine aziridinium (AF64A) by Potter, P E, Tedford, C E, Kindel, G, Hanin, I

“…Ethylcholine aziridinium (AF64A) has been proposed as a specific cholinergic neurotoxin. In earlier studies, using AF64A, we reported that slow infusion of 1-2…”
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Localized changes in blood-brain barrier permeability following the administration of antineoplastic drugs by MacDonell, L A, Potter, P E, Leslie, R A

“…The effects of four antineoplastic drugs on the permeability of the blood-brain barrier to Evans blue-albumin and to horseradish peroxidase were studied in…”
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O4-03-06 Cortical cholinergic deficit is associated with plaque development at preclinical stages of Alzheimer's disease by Potter, Pamela E., Pandya, Yoga, Poston, Marissa, Rauschkolb, Paula, Sue, Lucia, Walker, Douglas, Connor, Donald, Sabbagh, Marwan, Beach, Thomas

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Cortical Cholinergic Denervation Elicits Vascular Aβ Deposition by ROHER, ALEX E., KUO, YU-MIN, POTTER, PAMELA E., EMMERLING, MARK R., DURHAM, ROBERT A., WALKER, DOUGLAS G., SUE, LUCIA I., HONER, WILLIAM G., BEACH, THOMAS G.

“…: Selective destruction of the cholinergic nucleus basalis magnocellularis (nbm) in the rabbit by the p75 neurotrophin receptor (NTR) immunoglobulin G (IgG)…”
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Anti-amyloidogenic activity of cholinergic agents by Beach, Thomas G., Walker, Douglas G., Roher, Alex E., Potter, Pamela E.

“…Overproduction of the peptide amyloid β (Aβ) is thought to be a critical pathogenic event in Alzheimer's disease (AD), leading to the formation of senile…”
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Selective deafferentation of the rabbit cortex: A new animal model of Alzheimer's disease by Roher, Alex E., Potter, Pamela E., Kuo, Yu-Min, Emmerling, Mark R., Durham, Robert A., Webster, Scott D., Walker, Douglas G., Beach, Thomas G.

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Modulation of hippocampal norepinephrine release by cholinergic agonists is altered by AF64A lesion by Potter, Pamela E., Thorne, Beverly, Gaughan, Christopher

“…The effect of lesioning hippocampal cholinergic neurons with the neurotoxin AF64A on the ability of cholinergic agonists to modulate stimulation-induced…”
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Lesion with the neurotoxin AF64A alters hippocampal cholinergic receptor function by thorne, Beverley, Potter, Pamela E.

“…The effect of selective lesion of cholinergic inputs to the hippocampus on the function of hippocampal cholinergic receptors was examined. Hippocampal…”
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