Search Results - "Potter, G A"

Pharmacokinetics in mice and growth-inhibitory properties of the putative cancer chemopreventive agent resveratrol and the synthetic analogue trans 3,4,5,4'-tetramethoxystilbene by SALE, S, VERSCHOYLE, R. D, BOOCOCK, D, JONES, D. J. L, WILSHER, N, RUPARELIA, K. C, POTTER, G. A, FARMER, P. B, STEWARD, W. P, GESCHER, A. J

“…Resveratrol (trans-3,5,4'-trihydroxystilbene) is a naturally occurring polyphenol with cancer chemopreventive properties in preclinical models of…”
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The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1 by Potter, G A, Patterson, L H, Wanogho, E, Perry, P J, Butler, P C, Ijaz, T, Ruparelia, K C, Lamb, J H, Farmer, P B, Stanley, L A, Burke, M D

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A mechanistic hypothesis for DNA adduct formation by tamoxifen following hepatic oxidative metabolism by Potter, G A, McCague, R, Jarman, M

“…A mechanism for the generation of electrophilic alkylating agents from tamoxifen by hepatic alpha-oxidation of its ethyl group is presented which accounts for…”
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Reduced genotoxicity of [D5-ethyl]-tamoxifen implicates alpha-hydroxylation of the ethyl group as a major pathway of tamoxifen activation to a liver carcinogen by Phillips, D H, Potter, G A, Horton, M N, Hewer, A, Crofton-Sleigh, C, Jarman, M, Venitt, S

“…A proposed mechanism for the metabolic activation of tamoxifen to electrophilic species that form DNA adducts leading to liver cancer involves…”
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Non-haematological solid tumours as surrogate granulocytes: a possible mechanism for metastatic spread by Butler, P.C., Potter, G.A.

“…The concept that non-haematological solid tumours utilize normal leukocyte mechanisms, specifically those of granulocytes, to facilitate metastatic spread is…”
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Novel steroidal inhibitors of human cytochrome P45017α (17α-hydroxylase-C17,20-lyase) : potential agents for the treatment of prostatic cancer by POTTER, G. A, BARRIE, S. E, JARMAN, M, ROWLANDS, M. G

“…Steroidal compounds having a 17-(3-pyridyl) substituent together with a 16,17-double bond have been synthesized, using a palladium-catalyzed cross-coupling…”
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Idoxifene: report of a phase I study in patients with metastatic breast cancer by COOMBES, R. C, HAYNES, B. P, DOWSETT, M, QUIGLEY, M, ENGLISH, J, JUDSON, I. R, GRIGGS, L. J, POTTER, G. A, MCCAGUE, R, JARMAN, M

“…Idoxifene, a novel antiestrogen with reduced estrogenic activity when compared to tamoxifen, has been given to 20 women with metastatic breast cancer, 19 of…”
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The nanoflare model and stellar quiescent radio emission by Falla, D. F., Potter, A. G.

“…The concept of the nanoflare, used in interpreting the solar X-ray corona, is extended to RS CVn stars which, unlike the Sun, exhibit non-thermal quiescent…”
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The deuterium isotope effect for the alpha-hydroxylation of tamoxifen by rat liver microsomes accounts for the reduced genotoxicity of [D5-ethyl]tamoxifen by Jarman, M, Poon, G K, Rowlands, M G, Grimshaw, R M, Horton, M N, Potter, G A, McCague, R

“…This study describes the application of on line HPLC-electrospray ionization MS in the structural determination of the metabolites formed following incubation…”
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Biochemistry and pharmacokinetics of potent non-steroidal cytochrome P450(17alpha) inhibitors by Barrie, S E, Haynes, B P, Potter, G A, Chan, F C, Goddard, P M, Dowsett, M, Jarman, M

“…Two potent non-steroidal inhibitors (CB7645 and CB7661) of human cytochrome P450(17alpha) were tested for in vivo activity in WHT mice. There were no signs of…”
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Rationally Designed Analogs of Tamoxifen with Improved Calmodulin Antagonism by Hardcastle, Ian R, Rowlands, Martin G, Houghton, John, Parr, Iris B, Potter, Gerard A, Jarman, Michael, Edwards, Karen J, Laughton, Charles A, Trent, John O, Neidle, Stephen

“…Computerized molecular modeling studies on the interactions of the antiestrogen tamoxifen (1) and its analogues bound to the calcium-binding protein calmodulin…”
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Characterization of Atmospheric Ammonia Emissions from a Commercial Chicken House on the Delmarva Peninsula by Siefert, Ronald L, Scudlark, Joseph R, Potter, Amelia G, Simonsen, Kirsten A, Savidge, Karen B

“…A three-dimensional sampling grid using passive collectors was used to characterize the downwind gas-phase ammonia plumes originating from a commercial chicken…”
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Pharmacokinetics and biodistribution of radiolabelled idoxifene: Prospects for the use of PET in the evaluation of a novel antioestrogen for cancer therapy by Young, H., Carnochan, P., Trivedi, M., Potter, G.A., Eccles, S.A., Haynes, B.P., Jarman, M., Ott, R.J.

“…With a view to evaluating the role of PET imaging in the development of new anticancer drugs, we are investigating the novel antioestrogen…”
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Effects of the potential chemopreventive agent DMU-135 on adenoma development in the ApcMin+ mouse by Sale, S, Tunstall, R G, Ruparelia, K C, Butler, P C, Potter, G A, Steward, W P, Gescher, A J

“…DMU-135 (3,4-Methylenedioxy-3',4',5'-trimethoxy chalcone) is a novel anticancer prodrug designed to be activated into a potent tyrosine kinase inhibitor by the…”
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Esters of 3-pyridylacetic acid that combine potent inhibition of 17α-hydroxylase/C17,20-lyase (cytochrome P45017α) with resistance to esterase hydrolysis by ROWLANDS, M. G, BARRIE, S. E, CHAN, F, HOUGHTON, J, JARMAN, M, MCCAGUE, R, POTTER, G. A

“…Esters of 3- and 4-pyridylacetic acid have been prepared and tested for inhibitory activity toward the human testicular 17 alpha-hydroxylase/C17,20-lyase and…”
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Development of a high performance zinc-62/copper-62 radionuclide generator for positron emission tomography by Zweit, J, Goodall, R, Cox, M, Babich, J W, Potter, G A, Sharma, H L, Ott, R J

“…Clinical utilisation of positron emission tomography could be enhanced by the availability of short-lived radionuclides derived from generator systems. The…”
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3- and 4-pyridylalkyl adamantanecarboxylates: inhibitors of human cytochrome P450(17 alpha) (17 alpha-hydroxylase/C17,20-lyase). Potential nonsteroidal agents for the treatment of prostatic cancer by Chan, F C, Potter, G A, Barrie, S E, Haynes, B P, Rowlands, M G, Houghton, J, Jarman, M

“…Various 3- and 4-pyridylalkyl 1-adamantanecarboxylates have been synthesized and tested for inhibitory activity toward the 17 alpha-hydroxylase and…”
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Contactless Nerve Stimulating Transducer by Hallgren, Richard C., Potter, A. G.

“…Stimulation of nervous tissue by means of an induced electric field produced by a contactless device is described. The unit is unique because it lends itself…”
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Comparison of the effects of the chemopreventive agent resveratrol and its synthetic analog trans 3,4,5,4'-tetramethoxystilbene (DMU-212) on adenoma development in the Apc(Min+) mouse and cyclooxygenase-2 in human-derived colon cancer cells by Sale, Stewart, Tunstall, Richard G, Ruparelia, Ketan C, Potter, Gerry A, Steward, William P, Gescher, Andreas J

“…Naturally occurring molecules with putative cancer chemopreventive properties such as the phytoalexin resveratrol (3,5,4'-trihydroxystilbene) are lead…”
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Effects of the potential chemopreventive agent DMU-135 on adenoma development in the Apc super(Min+) mouse by Sale, S, Tunstall, R G, Ruparelia, K C, Butler, P C, Potter, G A, Steward, W P, Gescher, A J

“…DMU-135 (3,4-Methylenedioxy-3',4',5'-trimethoxy chalcone) is a novel anticancer prodrug designed to be activated into a potent tyrosine kinase inhibitor by the…”
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