Search Results - "Potten, C"

The stem cells of small intestinal crypts: where are they? by Potten, C. S., Gandara, R., Mahida, Y. R., Loeffler, M., Wright, N. A.

“…Recently, there has been resurgence of interest in the question of small intestinal stem cells, their precise location and numbers in the crypts. In this…”
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The relationship between ionizing radiation-induced apoptosis and stem cells in the small and large intestine by POTTEN, C. S, GRANT, H. K

“…Apoptosis is observed in the crypts of the small intestine of healthy animals and man (spontaneous apoptosis). The levels can be dramatically elevated 3-6 h…”
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Highly Persistent Label-Retaining Cells in the Hair Follicles of Mice and Their Fate Following Induction of Anagen by Morris, Rebecca J., Potten, Christopher S.

“…We have identified some unusually persistent label-retaining cells in the hair follicles of mice, and have investigated their role in hair growth…”
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Dissociation between steroid receptor expression and cell proliferation in the human breast by CLARKE, R. B, HOWELL, A, POTTEN, C. S, ANDERSON, E

“…We have shown previously that estradiol stimulates cell proliferation and progesterone receptor (PgR) synthesis in luminal epithelial cells of the normal human…”
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What Is Apoptosis, And Why Is It Important? by Renehan, Andrew G., Booth, Catherine, Potten, Christopher S.

“…This brief review has shown that many human diseases may result when cells die that shouldn't or others live that should die. Modulation of apoptotic processes…”
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Cell migration and organization in the intestinal crypt using a lattice-free model by Meineke, F. A., Potten, C. S., Loeffler, M.

“… We present a novel class of spatial models of cell movement and arrangement applied to the two‐dimensional cellular organization of the intestinal crypt. The…”
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What is an apoptotic index measuring? A commentary by POTTEN, C. S

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Stem cells: the intestinal stem cell as a paradigm by Bach, Simon P., Renehan, Andrew G., Potten, Christopher S.

“…Stem cell research provides a foundation for therapeutic advancement in oncology, clinical genetics and a diverse array of degenerative disorders. For example,…”
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Characterization of putative stem cells in isolated human colonic crypt epithelial cells and their interactions with myofibroblasts by Samuel, S, Walsh, R, Webb, J, Robins, A, Potten, C, Mahida, Y R

“…Colonic epithelial stem cells are believed to be located at the crypt base where they have previously been shown to express musashi-1. The colonic stem cell…”
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Regulation and Significance of Apoptosis in the Stem Cells of the Gastrointestinal Epithelium by Potten, C. S., Wilson, J. W., Booth, C.

“…In rapidly proliferating tissues the stringent control of cell proliferation and cell death by apoptosis is central to the maintenance of tissue homeostasis…”
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Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt by Potten, C S, Loeffler, M

“…We consider some of the problems involved in current discussions on stem cells in adult mammalian tissues. The present concepts involve a number of pitfalls,…”
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Two-week dietary soy supplementation has an estrogenic effect on normal premenopausal breast by HARGREAVES, D. F, POTTEN, C. S, HARDING, C, SHAW, L. E, MORTON, M. S, ROBERTS, S. A, HOWELL, A, BUNDRED, N. J

“…An association has been reported between consumption of a high soy diet and a low incidence of breast cancer within populations of Southeast Asia…”
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Bcl-w is an important determinant of damage-induced apoptosis in epithelia of small and large intestine by PRITCHARD, D. M, PRINT, C, O'REILLY, L, ADAMS, J. M, POTTEN, C. S, HICKMAN, J. A

“…The potential role of the bcl-2 relative bcl-w as a physiological regulator of apoptosis in intestinal epithelia has been investigated. Immunoblots for bcl-w…”
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Elevated serum insulin-like growth factor (IGF)-II and IGF binding protein-2 in patients with colorectal cancer by RENEHAN, A. G, JONES, J, POTTEN, C. S, SHALET, S. M, O'DWYER, S. T

“…This study explored the relationships of serum insulin-like growth factors, IGF-I and IGF-II, and their binding proteins (IGFBP)-2 and IGFBP-3, with key…”
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The Similarity of Action Spectra for Thymine Dimers in Human Epidermis and Erythema Suggests that DNA is the Chromophore for Erythema by Young, Antony R., Harrison, Graham I., Chadwick, Caroline A., Nikaido, Osamu, Ramsden, Jonathan, Potten, Christopher S.

“…The location of DNA photodamage within the epidermis is crucial as basal layer cells are the most likely to have carcinogenic potential. We have determined the…”
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Teduglutide ([Gly2]GLP-2) protects small intestinal stem cells from radiation damage by Booth, C., Booth, D., Williamson, S., Demchyshyn, L. L., Potten, C. S.

“…  Glucagon‐like peptide‐2 and its dipeptidyl peptidase (DP‐IV) resistant analogue teduglutide are trophic for the gastrointestinal epithelium. Exposure…”
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A putative human breast stem cell population is enriched for steroid receptor-positive cells by Clarke, Robert B., Spence, Katherine, Anderson, Elizabeth, Howell, Anthony, Okano, Hideyuki, Potten, Christopher S.

“…Breast epithelial stem cells are thought to be the primary targets in the etiology of breast cancer. Since breast cancers mostly express estrogen and…”
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Stem cells in gastrointestinal epithelium: numbers, characteristics and death by Potten, Christopher S.

“…gene in this region, and this probably contributes to the causes for the low cancer risk in the small bowel and the high risk in the large bowel. Current…”
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Gut instincts: thoughts on intestinal epithelial stem cells by Booth, C, Potten, C S

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Protection against mucosal injury by growth factors and cytokines by Booth, D, Potten, C S

“…This article provides an overview of published studies in which growth factors and cytokines were used to modify the sensitivity of intestinal stem cells to a…”
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