β‐Trifluoromethyl α,β‐unsaturated Ketones: Efficient Building Blocks for Diverse Trifluoromethylated Molecules

The trifluoromethyl (CF3) group is an advantageous structural motif in various biologically active molecules as well as materials, which is depicted by steadily increasing demand from the industries involved in drug discovery, agrochemicals and material development. β‐trifluoromethyl α,β‐unsaturated...

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Bibliographic Details
Published in:	Advanced synthesis & catalysis Vol. 362; no. 22; pp. 4794 - 4819
Main Authors:	Chaudhary, Bharatkumar, Kulkarni, Neeraj, Saiyed, Nehanaz, Chaurasia, Meenakshi, Desai, Surbhi, Potkule, Sagar, Sharma, Satyasheel
Format:	Journal Article
Language:	English
Published:	Heidelberg Wiley Subscription Services, Inc 18-11-2020
Subjects:	Agrochemicals Carbonyl compounds Carbonyls Chemical synthesis Conjugate addition Construction materials Enones Fluorinated building blocks Ketones Organic chemistry Trifluoromethyl group Trifluoromethylated heterocycles
Online Access:	Get full text
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Summary:	The trifluoromethyl (CF3) group is an advantageous structural motif in various biologically active molecules as well as materials, which is depicted by steadily increasing demand from the industries involved in drug discovery, agrochemicals and material development. β‐trifluoromethyl α,β‐unsaturated carbonyl compounds constitute a very efficient building blocks as starting material in the synthesis of fluorinated molecules. Their usage for the synthesis of various heterocycles and organic molecules bearing stereogenic carbon containing CF3 motif has received significant attention during the recent times. This review provides the existing methods for the synthesis of β‐substituted trifluoromethyl‐α,β‐unsaturated ketones and the efforts made by researchers for the synthetic development through various reactions by employing them as synthetic building blocks for trifluoromethylated organic scaffolds.
Bibliography:	These authors have contributed equally
ISSN:	1615-4150 1615-4169
DOI:	10.1002/adsc.202001018