Search Results - "Pothuri, Bhavana"

Appropriate Selection of PARP Inhibitors in Ovarian Cancer by Smith, Maria, Pothuri, Bhavana

“…Opinion statement Poly-ADP-ribose polymerase inhibitors (PARPi) are a class of anti-cancer drugs that target DNA repair pathways and have shown promising…”
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Editorial Response to Hepato-Biliary Disease Resection for Patients with Advanced Epithelial Ovarian Cancer: Prognostic Role and Optimal Cytoreduction by Lee, Sarah S., Pothuri, Bhavana

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Safety and antitumor activity of dostarlimab in patients with advanced or recurrent DNA mismatch repair deficient/microsatellite instability-high (dMMR/MSI-H) or proficient/stable (MMRp/MSS) endometrial cancer: interim results from GARNET—a phase I, single-arm study by Oaknin, Ana, Gilbert, Lucy, Tinker, Anna V, Brown, Jubilee, Mathews, Cara, Press, Joshua, Sabatier, Renaud, O’Malley, David M, Samouelian, Vanessa, Boni, Valentina, Duska, Linda, Ghamande, Sharad, Ghatage, Prafull, Kristeleit, Rebecca, Leath III, Charles, Guo, Wei, Im, Ellie, Zildjian, Sybil, Han, Xinwei, Duan, Tao, Veneris, Jennifer, Pothuri, Bhavana

“…BackgroundDostarlimab is a humanized monoclonal antibody that binds with high affinity to PD-1, resulting in inhibition of binding to PD-L1 and PD-L2. We…”
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Endometrial cancer: A society of gynecologic oncology evidence-based review and recommendations by Hamilton, Chad A., Pothuri, Bhavana, Arend, Rebecca C., Backes, Floor J., Gehrig, Paola A., Soliman, Pamela T., Thompson, J. Spencer, Urban, Renata R., Burke, William M.

“…In 2014, the Society of Gynecologic Oncology's Clinical Practice Committee published a clinical update reviewing the treatment of women with endometrial…”
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Endometrial cancer: A society of gynecologic oncology evidence-based review and recommendations, part II by Hamilton, Chad A., Pothuri, Bhavana, Arend, Rebecca C., Backes, Floor J., Gehrig, Paola A., Soliman, Pamela T., Thompson, J. Spencer, Urban, Renata R., Burke, William M.

“…In 2014, the Society of Gynecologic Oncology's Clinical Practice Committee published a clinical update reviewing the treatment of women with endometrial…”
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Race- associated molecular differences in uterine serous carcinoma by Lara, Olivia D, Karpel, Hannah, Friedman, Steven, Hacker, Kari E, Pothuri, Bhavana

“…Endometrial cancer (EMCA) is the most common gynecologic malignancy, and new diagnoses are increasing in the United States. Black patients are more likely to…”
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Phase I and pharmacokinetic study of veliparib, a PARP inhibitor, and pegylated liposomal doxorubicin (PLD) in recurrent gynecologic cancer and triple negative breast cancer with long-term follow-up by Pothuri, Bhavana, Brodsky, Allison L., Sparano, Joseph A., Blank, Stephanie V., Kim, Mimi, Hershman, Dawn L., Tiersten, Amy, Kiesel, Brian F., Beumer, Jan H., Liebes, Leonard, Muggia, Franco

“…Objective Poly(ADP-ribosyl) polymerases (PARPs) are nuclear enzymes with roles in DNA damage recognition and repair. PARP1 inhibition enhances the effects of…”
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Improving clinical trial enrollment in minority racial and ethnic patients with gynecologic malignancy by Lara, Olivia D., Allen, Kathryn, Yakubov, Amin, Pothuri, Bhavana

“…•Low minority enrollment into clinical trials remains a critical issue in the setting of rising incidence and mortality rates among minority patients with…”
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Identification of copy number gain and overexpressed genes on chromosome arm 20q by an integrative genomic approach in cervical cancer: Potential role in progression by Scotto, Luigi, Narayan, Gopeshwar, Nandula, Subhadra V., Arias-Pulido, Hugo, Subramaniyam, Shivakumar, Schneider, Achim, Kaufmann, Andreas M., Wright, Jason D., Pothuri, Bhavana, Mansukhani, Mahesh, Murty, Vundavalli V.

“…Recurrent karyotypic abnormalities are a characteristic feature of cervical cancer (CC) cells, which may result in deregulated expression of important genes…”
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The Role of Palliative Surgery in Gynecologic Cancer Cases by Hope, Joanie Mayer, Pothuri, Bhavana

“…CME Learning Objectives Describe the range of palliative procedures utilized in gynecologic cancers. Evaluate the indications for palliative bowel surgery in…”
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Transient rise in CA 125 in a woman with ovarian carcinoma and COVID-19 infection by Smith, Maria, Lara, Olivia D., Pothuri, Bhavana

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Medical marijuana utilization in gynecologic cancer patients by Fehniger, Julia, Brodsky, Allison L., Kim, Arum, Pothuri, Bhavana

“…•Medical marijuana was used by gynecologic cancer patients a median of 5.2 (range 0.6–25.4) months.•The most common indications for medical marijuana use were…”
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Quality-adjusted time without symptoms of disease or toxicity and quality-adjusted progression-free survival with niraparib maintenance in first-line ovarian cancer in the PRIMA trial by Barretina-Ginesta, Maria-Pilar, Monk, Bradley J., Han, Sileny, Pothuri, Bhavana, Auranen, Annika, Chase, Dana M., Lorusso, Domenica, Anderson, Charles, Abadie-Lacourtoisie, Sophie, Cloven, Noelle, Braicu, Elena I., Amit, Amnon, Redondo, Andrés, Shah, Ruchit, Kebede, Nehemiah, Hawkes, Carol, Gupta, Divya, Woodward, Tatia, O’Malley, David M., González-Martín, Antonio

“…Background: The PRIMA phase 3 trial showed niraparib significantly prolongs median progression-free survival (PFS) versus placebo in patients with advanced…”
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Integrative genomics analysis of chromosome 5p gain in cervical cancer reveals target over-expressed genes, including Drosha by Scotto, Luigi, Narayan, Gopeshwar, Nandula, Subhadra V, Subramaniyam, Shivakumar, Kaufmann, Andreas M, Wright, Jason D, Pothuri, Bhavana, Mansukhani, Mahesh, Schneider, Achim, Arias-Pulido, Hugo, Murty, Vundavalli V

“…Copy number gains and amplifications are characteristic feature of cervical cancer (CC) genomes for which the underlying mechanisms are unclear. These changes…”
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Promoter hypermethylation-mediated inactivation of multiple Slit-Robo pathway genes in cervical cancer progression by Narayan, Gopeshwar, Goparaju, Chandra, Arias-Pulido, Hugo, Kaufmann, Andreas M, Schneider, Achim, Dürst, Matthias, Mansukhani, Mahesh, Pothuri, Bhavana, Murty, Vundavalli V

“…Cervical Cancer (CC) exhibits highly complex genomic alterations. These include hemizygous deletions at 4p15.3, 10q24, 5q35, 3p12.3, and 11q24, the chromosomal…”
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Brachytherapy: A critical component of primary radiation therapy for cervical cancer by Holschneider, Christine H., Petereit, Daniel G., Chu, Christina, Hsu, I-Chow, Ioffe, Yevgeniya J., Klopp, Ann H., Pothuri, Bhavana, Chen, Lee-may, Yashar, Catheryn

“…Brachytherapy is well-established as an integral component in the standard of care for treatment of patients receiving primary radiotherapy for cervical…”
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Correction: Heterotypic CAF-tumor spheroids promote early peritoneal metastatis of ovarian cancer by Gao, Qinglei, Yang, Zongyuan, Xu, Sen, Li, Xiaoting, Yang, Xin, Jin, Ping, Liu, Yi, Zhou, Xiaoshui, Zhang, Taoran, Gong, Cheng, Wei, Xiao, Liu, Dan, Sun, Chaoyang, Chen, Gang, Hu, Junbo, Meng, Li, Zhou, Jianfeng, Sawada, Kenjiro, Fruscio, Robert, Grunt, Thomas W, Wischhusen, Jörg, Vargas-Hernández, Víctor Manuel, Pothuri, Bhavana, Coleman, Robert L

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Epigenetic inactivation of TRAIL decoy receptors at 8p12-21.3 commonly deleted region confers sensitivity to Apo2L/trail-Cisplatin combination therapy in cervical cancer by Narayan, Gopeshwar, Xie, Dongxu, Ishdorj, Ganchimeg, Scotto, Luigi, Mansukhani, Mahesh, Pothuri, Bhavana, Wright, Jason D., Kaufmann, Andreas M., Schneider, Achim, Arias-Pulido, Hugo, Murty, Vundavalli V.

“…Multiple chromosomal regions are affected by deletions in cervical cancer (CC) genomes, but their consequence and target gene involvement remains unknown. Our…”
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Genetic analysis of the early natural history of epithelial ovarian carcinoma by Pothuri, Bhavana, Leitao, Mario M, Levine, Douglas A, Viale, Agnès, Olshen, Adam B, Arroyo, Crispinita, Bogomolniy, Faina, Olvera, Narciso, Lin, Oscar, Soslow, Robert A, Robson, Mark E, Offit, Kenneth, Barakat, Richard R, Boyd, Jeff

“…The high mortality rate associated with epithelial ovarian carcinoma (EOC) reflects diagnosis commonly at an advanced stage, but improved early detection is…”
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Heterotypic CAF-tumor spheroids promote early peritoneal metastasis of ovarian cancer by Gao, Qinglei, Yang, Zongyuan, Xu, Sen, Li, Xiaoting, Yang, Xin, Jin, Ping, Liu, Yi, Zhou, Xiaoshui, Zhang, Taoran, Gong, Cheng, Wei, Xiao, Liu, Dan, Sun, Chaoyang, Chen, Gang, Hu, Junbo, Meng, Li, Zhou, Jianfeng, Sawada, Kenjiro, Fruscio, Robert, Grunt, Thomas W., Wischhusen, Jörg, Vargas-Hernández, Víctor Manuel, Pothuri, Bhavana, Coleman, Robert L.

“…High-grade serous ovarian cancer (HGSOC) is hallmarked by early onset of peritoneal dissemination, which distinguishes it from low-grade serous ovarian cancer…”
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