Search Results - "Pothuizen, Helen H.J."

Ethological concepts enhance the translational value of animal models by Peters, Suzanne M., Pothuizen, Helen H.J., Spruijt, Berry M.

“…The translational value of animal models is an issue of ongoing discussion. We argue that ‘Refinement’ of animal experiments is needed and this can be achieved…”
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The prenatal methylazoxymethanol acetate treatment: a neurodevelopmental animal model for schizophrenia? by Jongen-Rêlo, Ana L, Leng, Andreas, Lüber, Marcel, Pothuizen, Helen H.J, Weber, Liz, Feldon, Joram

“…The prenatal methylazoxymethanol acetate (MAM) treatment has been proposed as a suitable model for the neurodevelopmental aspects of schizophrenia since the…”
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Effects of prenatal methylazoxymethanol acetate (MAM) treatment in rats on water maze performance by Leng, Andreas, Jongen-Rêlo, Ana L., Pothuizen, Helen H.J., Feldon, Joram

“…Prenatal methylazoxymethanol acetate (MAM) treatment has been shown to induce morphological abnormalities in cortical areas of the offspring. Based on the…”
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Selective nucleus accumbens core lesions enhance dizocilpine-induced but not apomorphine-induced disruption of prepulse inhibition in rats by Pothuizen, Helen H.J, Neumann, Ken R, Feldon, Joram, Yee, Benjamin K

“…Prepulse inhibition refers to the reduction in startle reaction to a startle-eliciting ‘pulse’ when it is shortly preceded by a weak ‘prepulse’ stimulus. The…”
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Comparison of central corticosteroid receptor expression in male Lewis and Fischer rats by Jongen-Rêlo, Ana L, Pothuizen, Helen H.J, Feldon, Joram, Pryce, Christopher R

“…The histocompatible inbred Lewis (LEW) and Fischer (F344) rat strains exhibit marked phenotypic differences in the hormonal activity of the…”
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Reproducibility and relevance of future behavioral sciences should benefit from a cross fertilization of past recommendations and today's technology: “Back to the future” by Spruijt, Berry M., Peters, Suzanne M., de Heer, Raymond C., Pothuizen, Helen H.J., van der Harst, Johanneke E.

“…•Standard behavioral tests have limited validity and lack reproducibility.•Advanced methods and technologies are available, but marginally applied.•The lack of…”
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Do rats with retrosplenial cortex lesions lack direction? by Pothuizen, Helen H. J., Aggleton, John P., Vann, Seralynne D.

“…The retrosplenial cortex is seen as a convergence point for different classes of spatial cue, yet aside from allocentric processing, little is known about…”
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Novel approach to automatically classify rat social behavior using a video tracking system by Peters, Suzanne M., Pinter, Ilona J., Pothuizen, Helen H.J., de Heer, Raymond C., van der Harst, Johanneke E., Spruijt, Berry M.

“…•Current animal models, if involving social behavior at all, are limited to very short and simple measurements.•Social behavior is mostly manually annotated,…”
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Double dissociation of the effects of selective nucleus accumbens core and shell lesions on impulsive-choice behaviour and salience learning in rats by Pothuizen, Helen H. J., Jongen-Rêlo, Ana L., Feldon, Joram, Yee, Benjamin K.

“…The nucleus accumbens can be subdivided into at least two anatomically distinct subregions: a dorsolateral ‘core’ and a ventromedial ‘shell’, and this…”
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Granular and dysgranular retrosplenial cortices provide qualitatively different contributions to spatial working memory: evidence from immediate-early gene imaging in rats by Pothuizen, Helen H. J., Davies, Moira, Albasser, Mathieu M., Aggleton, John P., Vann, Seralynne D.

“…The present study revealed striking task‐dependent differences in immediate‐early gene activity in the two main subregions (granular and dysgranular) of the…”
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Effects of selective granular retrosplenial cortex lesions on spatial working memory in rats by Pothuizen, Helen H.J., Davies, Moira, Aggleton, John P., Vann, Seralynne D.

“…The rat retrosplenial cortex comprises two major subregions (granular and dysgranular) that differ in morphology and connectivity. Although the effects of…”
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Dissociation of function between the dorsal and the ventral hippocampus in spatial learning abilities of the rat: a within-subject, within-task comparison of reference and working spatial memory by Pothuizen, Helen H. J., Zhang, Wei-Ning, Jongen-Rêlo, Ana L., Feldon, Joram, Yee, Benjamin K.

“…Lesions restricted to the dorsal, but not the ventral, hippocampus severely impair the formation of spatial memory. This dissociation was first demonstrated…”
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Lesions to the ventral, but not the dorsal, medial prefrontal cortex enhance latent inhibition by George, David N., Duffaud, Anaïs M., Pothuizen, Helen H. J., Haddon, Josephine E., Killcross, Simon

“…The acquisition of a conditioned response to a stimulus when it is paired with a reinforcer is retarded if the stimulus has previously been repeatedly…”
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Comparison of maternal separation and early handling in terms of their neurobehavioral effects in aged rats by Lehmann, Julia, Pryce, Christopher R., Jongen-Rêlo, Ana L., Stöhr, Thomas, Pothuizen, Helen H.J., Feldon, Joram

“…In the rat, relative to pup nonhandling (NH), early handling (EH) leads to old-adult offspring with a hyporesponsive HPA axis, superior spatial cognition, and…”
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The Effects of Temporary Inactivation of the Core and the Shell Subregions of the Nucleus Accumbens on Prepulse Inhibition of the Acoustic Startle Reflex and Activity in Rats by POTHUIZEN, Helen H. J, JONGEN-RLEO, Ana L, FELDON, Joram

“…The nucleus accumbens can be dissociated into at least two subregions: a 'core' and a 'shell'. Using temporary chemical inactivation of these subregions, we…”
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Facilitated extinction of appetitive instrumental conditioning following excitotoxic lesions of the core or the medial shell subregion of the nucleus accumbens in rats by POTHUIZEN, Helen H. J, FELDON, Joram, YEE, Benjamin K

“…The nucleus accumbens has been implicated in the control of goal-directed behaviour, including instrumental conditioning. Here, we evaluated the effect of…”
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Co-expression of calretinin and γ-aminobutyric acid in neurons of the entorhinal cortex of the common marmoset monkey by Pothuizen, Helen H.J., Feldon, Joram, Jongen-Rêlo, Ana L.

“…The γ‐aminobutyric acid (GABA)‐containing interneuron population in the entorhinal cortex has been shown to consist of several subpopulations. In addition to…”
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