Search Results - "Poston, Kathleen L"

Episodic recognition memory and the hippocampus in Parkinson's disease: A review by Das, Tanusree, Hwang, Jaclyn J., Poston, Kathleen L.

“…Parkinson's disease is a progressive neurodegenerative disorder of aging. The hallmark pathophysiology includes the development of neuronal Lewy bodies in the…”
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Functional brain networks and abnormal connectivity in the movement disorders by Poston, Kathleen L., Eidelberg, David

“…Clinical manifestations of movement disorders, such as Parkinson's disease (PD) and dystonia, arise from neurophysiological changes within the…”
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Establishing a framework for neuropathological correlates and glymphatic system functioning in Parkinson’s disease by Sundaram, Saranya, Hughes, Rachel L., Peterson, Eric, Müller-Oehring, Eva M., Brontë-Stewart, Helen M., Poston, Kathleen L., Faerman, Afik, Bhowmick, Chloe, Schulte, Tilman

“…•During sleep, glymphatic system (GS) activation clears toxins from the brain.•Striatal dopamine modulates clock gene expression and sleep-wake…”
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Abnormalities in Metabolic Network Activity Precede the Onset of Motor Symptoms in Parkinson's Disease by Tang, Chris C, Poston, Kathleen L, Dhawan, Vijay, Eidelberg, David

“…Imaging studies show that Parkinson's disease (PD) alters the activity of motor- and cognition-related metabolic brain networks. However, it is not known…”
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Influence of common reference regions on regional tau patterns in cross-sectional and longitudinal [18F]-AV-1451 PET data by Young, Christina B., Landau, Susan M., Harrison, Theresa M., Poston, Kathleen L., Mormino, Elizabeth C.

“…Tau PET has allowed for critical insights into in vivo patterns of tau accumulation and change in individuals early in the Alzheimer's disease (AD) continuum…”
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Domain-specific accuracy of the Montreal Cognitive Assessment subsections in Parkinson's disease by Hendershott, Taylor R, Zhu, Delphine, Llanes, Seoni, Poston, Kathleen L

“…Abstract Objective The Montreal Cognitive Assessment (MoCA) is among the most widely adopted screening tools for cognitive impairment because it includes tests…”
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AAV2- GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial by LeWitt, Peter A, Prof, Rezai, Ali R, Prof, Leehey, Maureen A, Prof, Ojemann, Steven G, MD, Flaherty, Alice W, MD, Eskandar, Emad N, MD, Kostyk, Sandra K, MD, Thomas, Karen, DO, Sarkar, Atom, MD, Siddiqui, Mustafa S, MD, Tatter, Stephen B, Prof, Schwalb, Jason M, MD, Poston, Kathleen L, MD, Henderson, Jaimie M, MD, Kurlan, Roger M, Prof, Richard, Irene H, MD, Van Meter, Lori, MS, Sapan, Christine V, PhD, During, Matthew J, Prof, Kaplitt, Michael G, MD, Feigin, Andrew, Dr

“…Summary Background Gene transfer of glutamic acid decarboxylase ( GAD ) and other methods that modulate production of GABA in the subthalamic nucleus improve…”
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Differential diagnosis of parkinsonism: a metabolic imaging study using pattern analysis by Tang, Chris C, MD, Poston, Kathleen L, MD, Eckert, Thomas, MD, Feigin, Andrew, MD, Frucht, Steven, MD, Gudesblatt, Mark, MD, Dhawan, Vijay, PhD, Lesser, Martin, PhD, Vonsattel, Jean-Paul, MD, Fahn, Stanley, MD, Eidelberg, David, MD

“…Summary Background Idiopathic Parkinson's disease can present with symptoms similar to those of multiple system atrophy or progressive supranuclear palsy. We…”
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An increased rate of longitudinal cognitive decline is observed in Parkinson's disease patients with low CSF Aß42 and an APOE ε4 allele by Shahid, Marian, Kim, Jeehyun, Leaver, Katherine, Hendershott, Taylor, Zhu, Delphine, Cholerton, Brenna, Henderson, Victor W., Tian, Lu, Poston, Kathleen L.

“…Low concentrations of cerebrospinal fluid (CSF) amyloid-beta (Aβ-42) are associated with increased risk of cognitive decline in Parkinson's disease (PD). We…”
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APOE effects on regional tau in preclinical Alzheimer's disease by Young, Christina B, Johns, Emily, Kennedy, Gabriel, Belloy, Michael E, Insel, Philip S, Greicius, Michael D, Sperling, Reisa A, Johnson, Keith A, Poston, Kathleen L, Mormino, Elizabeth C

“…APOE variants are strongly associated with abnormal amyloid aggregation and additional direct effects of APOE on tau aggregation are reported in animal and…”
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High cerebrospinal amyloid-β 42 is associated with normal cognition in individuals with brain amyloidosis by Sturchio, Andrea, Dwivedi, Alok K., Young, Christina B., Malm, Tarja, Marsili, Luca, Sharma, Jennifer S., Mahajan, Abhimanyu, Hill, Emily J., Andaloussi, Samir EL, Poston, Kathleen L., Manfredsson, Fredric P., Schneider, Lon S., Ezzat, Kariem, Espay, Alberto J.

“…Brain amyloidosis does not invariably predict dementia. We hypothesized that high soluble 42-amino acid β amyloid (Aβ42) peptide levels are associated with…”
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Longitudinal Analysis of Multiple Neurotransmitter Metabolites in Cerebrospinal Fluid in Early Parkinson's Disease by Kremer, Thomas, Taylor, Kirsten I., Siebourg‐Polster, Juliane, Gerken, Thomas, Staempfli, Andreas, Czech, Christian, Dukart, Juergen, Galasko, Douglas, Foroud, Tatiana, Chahine, Lana M., Coffey, Christopher S., Simuni, Tanya, Weintraub, Daniel, Seibyl, John, Poston, Kathleen L., Toga, Arthur W., Tanner, Caroline M., Marek, Kenneth, Hutten, Samantha J., Dziadek, Sebastian, Trenkwalder, Claudia, Pagano, Gennaro, Mollenhauer, Brit

“…ABSTRACT Background Cerebrospinal fluid (CSF) levels of monoamine metabolites may represent biomarkers of Parkinson's disease (PD). Objective The aim of this…”
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Reliability of remote National Alzheimer's Coordinating Center Uniform Data Set data by Smith, Viktorija, Younes, Kyan, Poston, Kathleen L., Mormino, Elizabeth C., Young, Christina B.

“…INTRODUCTION The National Alzheimer's Coordinating Center (NACC) Uniform Data Set (UDS) neuropsychological battery is being used to track cognition in…”
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Hippocampal CA1 subfield predicts episodic memory impairment in Parkinson's disease by La, Christian, Linortner, Patricia, Bernstein, Jeffrey D, Ua Cruadhlaoich, Matthew A I, Fenesy, Michelle, Deutsch, Gayle K, Rutt, Brian K, Tian, Lu, Wagner, Anthony D, Zeineh, Michael, Kerchner, Geoffrey A, Poston, Kathleen L

“…Parkinson's disease (PD) episodic memory impairments are common; however, it is not known whether these impairments are due to hippocampal pathology…”
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Impaired 24-h activity patterns are associated with an increased risk of Alzheimer's disease, Parkinson's disease, and cognitive decline by Winer, Joseph R, Lok, Renske, Weed, Lara, He, Zihuai, Poston, Kathleen L, Mormino, Elizabeth C, Zeitzer, Jamie M

“…Sleep-wake regulating circuits are affected during prodromal stages in the pathological progression of both Alzheimer's disease (AD) and Parkinson's disease…”
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Dopamine-related dissociation of cortical and subcortical brain activations in cognitively unimpaired Parkinson’s disease patients OFF and ON medications by Kim, Jeehyun, Zhang, Kai, Cai, Weidong, YorkWilliams, Sophie, Ua Cruadhlaoich, Matthew A.I., Llanes, Seoni, Menon, Vinod, Poston, Kathleen L.

“…Despite dopaminergic depletion that is severe enough to cause the motor symptoms of Parkinson’s disease (PD), many patients remain cognitively unimpaired…”
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Single-cell peripheral immunoprofiling of lewy body and Parkinson's disease in a multi-site cohort by Phongpreecha, Thanaphong, Mathi, Kavita, Cholerton, Brenna, Fox, Eddie J, Sigal, Natalia, Espinosa, Camilo, Reincke, Momsen, Chung, Philip, Hwang, Ling-Jen, Gajera, Chandresh R, Berson, Eloise, Perna, Amalia, Xie, Feng, Shu, Chi-Hung, Hazra, Debapriya, Channappa, Divya, Dunn, Jeffrey E, Kipp, Lucas B, Poston, Kathleen L, Montine, Kathleen S, Maecker, Holden T, Aghaeepour, Nima, Montine, Thomas J

“…Multiple lines of evidence support peripheral organs in the initiation or progression of Lewy body disease (LBD), a spectrum of neurodegenerative diagnoses…”
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Quantitative estimate of cognitive resilience and its medical and genetic associations by Phongpreecha, Thanaphong, Godrich, Dana, Berson, Eloise, Espinosa, Camilo, Kim, Yeasul, Cholerton, Brenna, Chang, Alan L, Mataraso, Samson, Bukhari, Syed A, Perna, Amalia, Yakabi, Koya, Montine, Kathleen S, Poston, Kathleen L, Mormino, Elizabeth, White, Lon, Beecham, Gary, Aghaeepour, Nima, Montine, Thomas J

“…We have proposed that cognitive resilience (CR) counteracts brain damage from Alzheimer's disease (AD) or AD-related dementias such that older individuals who…”
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Dementia with Lewy Bodies Drug Therapies in Clinical Trials: Systematic Review up to 2022 by Abdelnour, Carla, Gonzalez, Maria Camila, Gibson, Lucy L., Poston, Kathleen L., Ballard, Clive G., Cummings, Jeffrey L., Aarsland, Dag

“…Introduction Reviews of randomized clinical trials (RCTs) in dementia with Lewy bodies (DLB) are essential for informing ongoing research efforts of…”
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Computerized cognitive practice effects in relation to amyloid and tau in preclinical Alzheimer's disease: Results from a multi‐site cohort by Young, Christina B., Mormino, Elizabeth C., Poston, Kathleen L., Johnson, Keith A., Rentz, Dorene M., Sperling, Reisa A., Papp, Kathryn V.

“…Scalable cognitive paradigms that provide metrics such as the Computerized Cognitive Composite (C3) may be sensitive enough to relate to Alzheimer's disease…”
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