Search Results - "Postoak, J. Luke"

IL-10–producing B cells are enriched in murine pericardial adipose tissues and ameliorate the outcome of acute myocardial infarction by Wu, Lan, Dalal, Rajeev, Cao, Connie D., Postoak, J. Luke, Yang, Guan, Zhang, Qinkun, Wang, Zhizhang, Lal, Hind, Van Kaer, Luc

“…Acute myocardial infarction (MI) provokes an inflammatory response in the heart that removes damaged tissues to facilitate tissue repair/regeneration. However,…”
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Pik3c3 deficiency in myeloid cells imparts partial resistance to experimental autoimmune encephalomyelitis associated with reduced IL-1β production by Yang, Guan, Song, Wenqiang, Xu, Jielin, Postoak, J. Luke, Cheng, Feixiong, Martinez, Jennifer, Zhang, Jianhua, Wu, Lan, Van Kaer, Luc

“…The PIK3C3/VPS34 subunit of the class III phosphatidylinositol 3-kinase (PtdIns3K) complex plays a role in both canonical and noncanonical autophagy, key…”
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Innate and Innate-like Effector Lymphocytes in Health and Disease by Van Kaer, Luc, Postoak, J Luke, Song, Wenqiang, Wu, Lan

“…Lymphocytes can be functionally partitioned into subsets belonging to the innate or adaptive arms of the immune system. Subsets of innate and innate-like…”
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Role of autophagy in MHC class I-restricted antigen presentation by Van Kaer, Luc, Parekh, Vrajesh V., Postoak, J. Luke, Wu, Lan

“…•Autophagic activity enhances MHC class I cell surface internalization and degradation.•Autophagic activity inhibits the classical MHC class I antigen…”
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PIK3C3/VPS34 keeps body fats healthy by Song, Wenqiang, Postoak, J. Luke, Wu, Lan, Van Kaer, Luc

“…Adipose tissue, or body fat, plays a critical role in the maintenance of health and the development of metabolic diseases. The pathological expansion of…”
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PIK3C3/VPS34 helps school T cells in the thymus by Postoak, J. Luke, Song, Wenqiang, Wu, Lan, Van Kaer, Luc

“…The development of a broad repertoire of T cells in the immune system requires interaction of T cell receptors expressed by immature T cells with peptide/major…”
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Dendritic cell PIK3C3/VPS34 controls the pathogenicity of CNS autoimmunity independently of LC3-associated phagocytosis by Yang, Guan, Postoak, J Luke, Song, Wenqiang, Martinez, Jennifer, Zhang, Jianhua, Wu, Lan, Van Kaer, Luc

“…PIK3C3/VPS34 is a key player in macroautophagy/autophagy and MAP1LC3/LC3-associated phagocytosis (LAP), which play critical roles in dendritic cell (DC)…”
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Thymic epithelial cells require lipid kinase Vps34 for CD4 but not CD8 T cell selection by Postoak, J Luke, Song, Wenqiang, Yang, Guan, Guo, Xingyi, Xiao, Shiyun, Saffold, Cherie E, Zhang, Jianhua, Joyce, Sebastian, Manley, Nancy R, Wu, Lan, Van Kaer, Luc

“…The generation of a functional, self-tolerant T cell receptor (TCR) repertoire depends on interactions between developing thymocytes and antigen-presenting…”
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Optimization of the Irf8 +32-kb enhancer disrupts dendritic cell lineage segregation by Ou, Feiya, Liu, Tian-Tian, Desai, Pritesh, Ferris, Stephen T., Kim, Sunkyung, Shen, Haolin, Ohara, Ray A., Jo, Suin, Chen, Jing, Postoak, J. Luke, Du, Siling, Diamond, Michael S., Murphy, Theresa L., Murphy, Kenneth M.

“…Autoactivation of lineage-determining transcription factors mediates bistable expression, generating distinct cell phenotypes essential for complex body plans…”
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Lipid kinase PIK3C3 maintains healthy brown and white adipose tissues to prevent metabolic diseases by Song, Wenqiang, Postoak, J Luke, Yang, Guan, Guo, Xingyi, Pua, Heather H, Bader, Jackie, Rathmell, Jeffrey C, Kobayashi, Hanako, Haase, Volker H, Leaptrot, Katrina L, Schrimpe-Rutledge, Alexandra C, Sherrod, Stacy D, McLean, John A, Zhang, Jianhua, Wu, Lan, Van Kaer, Luc

“…Adequate mass and function of adipose tissues (ATs) play essential roles in preventing metabolic perturbations. The pathological reduction of ATs in…”
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Autophagy-related protein PIK3C3/VPS34 controls T cell metabolism and function: PIK3C3/VPS34 in T cell metabolism and function by Yang, Guan, Song, Wenqiang, Postoak, J. Luke, Chen, Jin, Martinez, Jennifer, Zhang, Jianhua, Wu, Lan, Van Kaer, Luc

“…The PIK3C3/VPS34 subunit of the class III phosphatidylinositol 3-kinase (PtdIns3K) complex is a key early player in macroautophagy/autophagy. In this study, we…”
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Dendritic cell PIK3C3/VPS34 controls the pathogenicity of CNS autoimmunity independently of LC3-associated phagocytosis by Yang, Guan, Postoak, J. Luke, Song, Wenqiang, Martinez, Jennifer, Zhang, Jianhua, Wu, Lan, Van Kaer, Luc

“…Abstract The PIK3C3/VPS34 subunit of the class III phosphatidylinositol 3-kinase (PtdIns3K) complex is a key player in macroautophagy/autophagy and…”
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Adipocyte-specific PIK3C3/VPS34 controls adipogenesis, metabolically-triggered inflammation, insulin resistance, and adaptive thermogenesis in mice by Song, Wenqiang, Yang, Guan, Postoak, J. Luke, Zhang, Jianhua, Wu, Lan, Van Kaer, Luc

“…Abstract Interactions between cells of the immune and metabolic systems play critical roles in controlling immune responsiveness and metabolic health. When…”
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Autophagy-related protein VPS34 controls the homeostasis and function of macrophages by Yang, Guan, Song, Wenqiang, Postoak, J. Luke, Martinez, Jennifer, Zhang, Jianhua, Wu, Lan, Van Kaer, Luc

“…Abstract Vacuolar protein sorting 34 (VPS34; also known as PIK3C3) plays a role in both canonical and noncanonical autophagy, key processes that control immune…”
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Cellular self‐cannibalism helps immune cells fight the flu by Postoak, Joshua Luke, Yang, Guan, Wu, Lan, Van Kaer, Luc

“…CD4 T cells are critical for generating protective immune responses to infection with influenza virus. Although most CD4 T cells react with peptides from…”
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Autophagy-related protein PIK3C3/VPS34 controls T cell metabolism and function by Yang, Guan, Song, Wenqiang, Postoak, J Luke, Chen, Jin, Martinez, Jennifer, Zhang, Jianhua, Wu, Lan, Van Kaer, Luc

“…The PIK3C3/VPS34 subunit of the class III phosphatidylinositol 3-kinase (PtdIns3K) complex is a key early player in macroautophagy/autophagy. In this study, we…”
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Dendritic cell PIK3C3/VPS34 controls the pathogenicity of CNS autoimmunity independently of LC3-associated phagocytosis by Yang, Guan, Postoak, J. Luke, Song, Wenqiang, Martinez, Jennifer, Zhang, Jianhua, Wu, Lan, Van Kaer, Luc

“…PIK3C3/VPS34 is a key player in macroautophagy/autophagy and MAP1LC3/LC3-associated phagocytosis (LAP), which play critical roles in dendritic cell (DC)…”
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Autophagy-related protein PIK3C3/VPS34 controls T cell metabolism and function: PIK3C3/VPS34 in T cell metabolism and function by Yang, Guan, Song, Wenqiang, Postoak, J. Luke, Chen, Jin, Martinez, Jennifer, Zhang, Jianhua, Wu, Lan, Van Kaer, Luc

“…The PIK3C3/VPS34 subunit of the class III phosphatidylinositol 3-kinase (PtdIns3K) complex is a key early player in macroautophagy/autophagy. In this study, we…”
Get full text