Search Results - "Postmus, Iris"

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation by Saleheen, Danish, Lehne, Benjamin, Leach, Irene Mateo, Wahl, Simone, Tan, Sian-Tsung, Afzal, Uzma, Bonder, Marc Jan, Hartiala, Jaana, Kleber, Marcus E, Sapari, Nur Sabrina, Saxena, Richa, Stolk, Lisette, Teh, Ai Ling, Wu, Jer-Yuarn, Aits, Imke, Das, Shikta, Kim, Yun Kyoung, Luan, Jian'an, Pereira, Mark A, Tragante, Vinicius, White, Jon, Yamamoto, Ken, Ahmed, Alauddin, Akiyama, Koichi, Asif, Rasheed, Barroso, Inês, Braun, Timothy R, Chen, Chien-Hsiun, Courtney, Regina, Delgado, Graciela, Gao, Yu-Tang, Wander, Gurpreet S, He, Jing, Hsu, Chris, Huang, Wei, Ichihara, Sahoko, Igase, Michiya, Isono, Masato, Justesen, Johanne M, Kibriya, Muhammad G, Koh, Woon-Puay, Kohara, Katsuhiko, Kumari, Meena, Lee, Nanette R, Liao, Jiemin, Liewald, David C M, Matsushita, Yumi, Mihailov, Evelin, Mills, Rebecca, Müller-Nurasyid, Martina, Nabika, Toru, Nakashima, Eitaro, Ohkubo, Takayoshi, Ohnaka, Keizo, Pham, Son T, Ruggiero, Daniela, Shimokawa, Kazuro, Spiering, Wilko, Ueshima, Hirotsugu, Uitterlinden, André G, Umemura, Satoshi, Vaarasmaki, Marja, van Dam, Rob M, van Veldhuisen, Dirk J, Viikari, Jorma S, Wong, Tien-Yin, Yamaguchi, Shuhei, Yuan, Jian-Min, Zhou, Xueya, Ciullo, Marina, Clarke, Robert, Franke, Andre, Friedlander, Yechiel, Guo, Zhirong, Jarvelin, Marjo-Riitta, Kajio, Hiroshi, Kivimaki, Mika, Lee, Jong-Young, Lehtimäki, Terho, Pedersen, Oluf, Takayanagi, Ryoichi, Ahsan, Habibul, Deary, Ian J, Franco, Oscar H, Holbrook, Joanna D, Kim, Bong-Jo, Lin, Xu, Liu, Jianjun, Sanghera, Dharambir K, Shu, Xiao-Ou, van Meurs, Joyce B J, Wijmenga, Cisca, Vineis, Paolo, Kyrtopoulos, Soterios A, Kleinjans, Jos C S, McCarthy, Mark I, Teo, Yik-Ying, He, Jiang, Elliott, Paul, Chambers, John C

“…John Chambers, Jaspal Kooner, Pim van der Harst, Shyong Tai, Paul Elliott, Jiang He, Norihiro Kato and colleagues performed a genome-wide association study of…”
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Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age by Deelen, Joris, Beekman, Marian, Uh, Hae-Won, Broer, Linda, Ayers, Kristin L, Tan, Qihua, Kamatani, Yoichiro, Bennet, Anna M, Tamm, Riin, Trompet, Stella, Guðbjartsson, Daníel F, Flachsbart, Friederike, Rose, Giuseppina, Viktorin, Alexander, Fischer, Krista, Nygaard, Marianne, Cordell, Heather J, Crocco, Paolina, van den Akker, Erik B, Böhringer, Stefan, Helmer, Quinta, Nelson, Christopher P, Saunders, Gary I, Alver, Maris, Andersen-Ranberg, Karen, Breen, Marie E, van der Breggen, Ruud, Caliebe, Amke, Capri, Miriam, Cevenini, Elisa, Collerton, Joanna C, Dato, Serena, Davies, Karen, Ford, Ian, Gampe, Jutta, Garagnani, Paolo, de Geus, Eco J C, Harrow, Jennifer, van Heemst, Diana, Heijmans, Bastiaan T, Heinsen, Femke-Anouska, Hottenga, Jouke-Jan, Hofman, Albert, Jeune, Bernard, Jonsson, Palmi V, Lathrop, Mark, Lechner, Doris, Martin-Ruiz, Carmen, Mcnerlan, Susan E, Mihailov, Evelin, Montesanto, Alberto, Mooijaart, Simon P, Murphy, Anne, Nohr, Ellen A, Paternoster, Lavinia, Postmus, Iris, Rivadeneira, Fernando, Ross, Owen A, Salvioli, Stefano, Sattar, Naveed, Schreiber, Stefan, Stefánsson, Hreinn, Stott, David J, Tiemeier, Henning, Uitterlinden, André G, Westendorp, Rudi G J, Willemsen, Gonneke, Samani, Nilesh J, Galan, Pilar, Sørensen, Thorkild I A, Boomsma, Dorret I, Jukema, J Wouter, Rea, Irene Maeve, Passarino, Giuseppe, de Craen, Anton J M, Christensen, Kaare, Nebel, Almut, Stefánsson, Kári, Metspalu, Andres, Magnusson, Patrik, Blanché, Hélène, Christiansen, Lene, Kirkwood, Thomas B L, van Duijn, Cornelia M, Franceschi, Claudio, Houwing-Duistermaat, Jeanine J, Slagboom, P Eline

“…The genetic contribution to the variation in human lifespan is ∼ 25%. Despite the large number of identified disease-susceptibility loci, it is not known which…”
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External validity of randomized controlled trials in older adults, a systematic review by van Deudekom, Floor J, Postmus, Iris, van der Ham, Danielle J, Pothof, Alexander B, Broekhuizen, Karen, Blauw, Gerard J, Mooijaart, Simon P

“…To critically assess the external validity of randomized controlled trials (RCTs) it is important to know what older adults have been enrolled in the trials…”
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Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a) by Deshmukh, Harshal A., Colhoun, Helen M., Johnson, Toby, McKeigue, Paul M., Betteridge, D. John, Durrington, Paul N., Fuller, John H., Livingstone, Shona, Charlton-Menys, Valentine, Neil, Andrew, Poulter, Neil, Sever, Peter, Shields, Denis C., Stanton, Alice V., Chatterjee, Aurobindo, Hyde, Craig, Calle, Roberto A., DeMicco, David A., Trompet, Stella, Postmus, Iris, Ford, Ian, Jukema, J. Wouter, Caulfield, Mark, Hitman, Graham A.

“…We carried out a genome-wide association study (GWAS) of LDL-c response to statin using data from participants in the Collaborative Atorvastatin Diabetes Study…”
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Statin-induced LDL cholesterol response and type 2 diabetes: a bidirectional two-sample Mendelian randomization study by Smit, Roelof A. J., Trompet, Stella, Leong, Aaron, Goodarzi, Mark O., Postmus, Iris, Warren, Helen, Theusch, Elizabeth, Barnes, Michael R., Arsenault, Benoit J., Li, Xiaohui, Feng, QiPing, Chasman, Daniel I., Cupples, L. Adrienne, Hitman, Graham A., Krauss, Ronald M., Psaty, Bruce M., Rotter, Jerome I., Cessie, Saskia le, Stein, C. Michael, Jukema, J. Wouter

“…It remains unclear whether the increased risk of new-onset type 2 diabetes (T2D) seen in statin users is due to low LDL-C concentrations, or due to the…”
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Factors associated with health status and exacerbations in COPD maintenance therapy with dry powder inhalers by W. H. Kocks, Janwillem, Wouters, Hans, Bosnic-Anticevich, Sinthia, van Cooten, Joyce, Correia de Sousa, Jaime, Cvetkovski, Biljana, Dekhuijzen, Richard, Dijk, Lars, Dvortsin, Evgeni, Garcia Pardo, Marina, Gardev, Asparuh, Gawlik, Radosław, van Geer - Postmus, Iris, van der Ham, Iris, Harbers, Marten, de la Hoz, Alberto, Janse, Ymke, Kerkhof, Marjan, Lavorini, Federico, Maricoto, Tiago, Meijer, Jiska, Metz, Boyd, Price, David, Roman-Rodriguez, Miguel, Schuttel, Kirsten, Stoker, Nilouq, Tsiligianni, Ioanna, Usmani, Omar, Leving, Marika T.

“…The study aimed to determine the associations of Peak Inspiratory Flow (PIF), inhalation technique and adherence with health status and exacerbations in…”
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Design and rationale of a routine clinical care pathway and prospective cohort study in older patients needing intensive treatment by van Holstein, Yara, van Deudekom, Floor J, Trompet, Stella, Postmus, Iris, Uit den Boogaard, Anna, van der Elst, Marjan J T, de Glas, Nienke A, van Heemst, Diana, Labots, Geert, Altena, Mariëtte, Slingerland, Marije, Liefers, Gerrit Jan, van den Bos, Frederiek, van der Bol, Jessica M, Blauw, Gerard J, Portielje, Johanneke E A, Mooijaart, Simon P

“…Treatment decisions concerning older patients can be very challenging and individualised treatment plans are often required in this very heterogeneous group…”
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The Pharmacogenetics of Statin Therapy on Clinical Events: No Evidence that Genetic Variation Affects Statin Response on Myocardial Infarction by Trompet, Stella, Postmus, Iris, Warren, Helen R, Noordam, Raymond, Smit, Roelof A J, Theusch, Elizabeth, Li, Xiaohui, Arsenault, Benoit, Chasman, Daniel I, Hitman, Graham A, Munroe, Patricia B, Rotter, Jerome I, Psaty, Bruce M, Caulfield, Mark J, Krauss, Ron M, Cupples, Adrienne L, Jukema, Wouter J

“…The pharmacogenetic effect on cardiovascular disease reduction in response to statin treatment has only been assessed in small studies. In a pharmacogenetic…”
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Association between the rs7903146 Polymorphism in the TCF7L2 Gene and Parameters Derived with Continuous Glucose Monitoring in Individuals without Diabetes by van der Kroef, Sabrina, Noordam, Raymond, Deelen, Joris, Akintola, Abimbola A, Jansen, Steffy W M, Postmus, Iris, Wijsman, Carolien A, Beekman, Marian, Mooijaart, Simon P, Slagboom, P Eline, van Heemst, Diana

“…The rs7903146-T allele in the transcription factor 7-like 2 (TCF7L2) gene has been associated with impaired pancreatic insulin secretion, enhanced liver…”
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Systematic testing of literature reported genetic variation associated with coronary restenosis: results of the GENDER Study by Verschuren, Jeffrey J W, Trompet, Stella, Postmus, Iris, Sampietro, M Lourdes, Heijmans, Bastiaan T, Houwing-Duistermaat, Jeanine J, Slagboom, P Eline, Jukema, J Wouter

“…Coronary restenosis after percutaneous coronary intervention still remains a significant problem, despite all medical advances. Unraveling the mechanisms…”
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Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses by Trompet, Stella, de Craen, Anton J M, Postmus, Iris, Ford, Ian, Sattar, Naveed, Caslake, Muriel, Stott, David J, Buckley, Brendan M, Sacks, Frank, Devlin, James J, Slagboom, P Eline, Westendorp, Rudi G J, Jukema, J Wouter

“…The PHArmacogenetic study of Statins in the Elderly at risk (PHASE) is a genome wide association study in the PROspective Study of Pravastatin in the Elderly…”
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PCSK9 SNP rs11591147 is associated with low cholesterol levels but not with cognitive performance or noncardiovascular clinical events in an elderly population[S] by Postmus, Iris, Trompet, Stella, de Craen, Anton J.M., Buckley, Brendan M., Ford, Ian, Stott, David J., Sattar, Naveed, Slagboom, P. Eline, Westendorp, Rudi G.J., Jukema, J. Wouter

“…Proprotein convertase subtilisin-like/kexin type 9 (PCSK9) is a protein involved in LDL-cholesterol metabolism. The single-nucleotide polymorphism (SNP)…”
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A potential harmful effect of dexamethasone in non-severe COVID-19: results from the COPPER-pilot study by Kocks, Janwillem, Kerkhof, Marjan, Scherpenisse, Jan, van de Maat, Aimée, van Geer-Postmus, Iris, le Rütte, Thomas, Schaart, Jan, Gans, Reinold O B, Kerstjens, Huib A M

“…https://bit.ly/3P4nOjQ…”
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Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation by Teumer, Alexander, Chaker, Layal, Groeneweg, Stefan, Li, Yong, Barbieri, Caterina, Traglia, Michela, Ahluwalia, Tarunveer S., Appel, Emil Vincent R., Arking, Dan E., Arnold, Alice, Astrup, Arne, Beekman, Marian, Beilby, John P., Bekaert, Sofie, Boerwinkle, Eric, Brown, Suzanne J., De Buyzere, Marc, Campbell, Purdey J., Ceresini, Graziano, Cerqueira, Charlotte, Cucca, Francesco, Eckardt, Kai-Uwe, Ekici, Arif B., Eriksson, Johan G., Ferrrucci, Luigi, Fiers, Tom, Fiorillo, Edoardo, Ford, Ian, Fox, Caroline S., Fuchsberger, Christian, Gieger, Christian, Gögele, Martin, De Grandi, Alessandro, Greiser, Karin Halina, Hansen, Torben, van Heemst, Diana, Hicks, Andrew A., den Hollander, Wouter, Hui, Jennie, Ikram, M. Arfan, Ittermann, Till, Jensen, Richard A., Jing, Jiaojiao, Jukema, J. Wouter, Kajantie, Eero, Kamatani, Yoichiro, Kasbohm, Elisa, Kiemeney, Lambertus A., Kubo, Michiaki, Lapauw, Bruno, Liewald, David C. M., Lim, Ee Mun, Marina, Michela, Mascalzoni, Deborah, Matsuda, Koichi, Medenwald, Daniel, Meisinger, Christa, Meulenbelt, Ingrid, De Meyer, Tim, Meyer zu Schwabedissen, Henriette E., Mikolajczyk, Rafael, Moed, Matthijs, Netea-Maier, Romana T., Nolte, Ilja M., Okada, Yukinori, Pala, Mauro, Pattaro, Cristian, Pedersen, Oluf, Petersmann, Astrid, Porcu, Eleonora, Postmus, Iris, Pramstaller, Peter P., Ramos, Yolande F. M., Rawal, Rajesh, Redmond, Paul, Richards, J. Brent, Rivadeneira, Fernando, Sala, Cinzia F., Selvin, Elizabeth, Soranzo, Nicole, Sørensen, Thorkild I. A., Spector, Timothy D., Starr, John M., Stott, David J., Taes, Youri, Taliun, Daniel, Tanaka, Toshiko, Thuesen, Betina, Visser, W. Edward, Walsh, John P., Wilson, Scott G., Wolffenbuttel, Bruce H. R., Yang, Qiong, Zheng, Hou-Feng, Cappola, Anne, Peeters, Robin P., Naitza, Silvia, Völzke, Henry, Visser, Theo J., Medici, Marco

“…Thyroid dysfunction is an important public health problem, which affects 10% of the general population and increases the risk of cardiovascular morbidity and…”
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1966 Participation rate and yield of screening for albuminuria in the primary care setting for early identification of chronic kidney disease (SALINE) by van Mil, Dominique, Kieneker, Lyanne, van Geer-Postmus, Iris, Prins, Gerian, Harms, Evelien, Stoker, Nilouq, Leving, Marika, Oudenhuijzen, Martine, Kocks, Janwillem, Gansevoort, Ronald, Heerspink, Hiddo Lambers

“…Abstract Background and Aims Although guidelines recommend opportunistic screening for chronic kidney disease (CKD) in individuals with established risk…”
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Association Between Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical Hypothyroidism by Mooijaart, Simon P, Du Puy, Robert S, Stott, David J, Kearney, Patricia M, Rodondi, Nicolas, Westendorp, Rudi G. J, den Elzen, Wendy P. J, Postmus, Iris, Poortvliet, Rosalinde K. E, van Heemst, Diana, van Munster, Barbara C, Peeters, Robin P, Ford, Ian, Kean, Sharon, Messow, Claudia-Martina, Blum, Manuel R, Collet, Tinh-Hai, Watt, Torquil, Dekkers, Olaf M, Jukema, J. Wouter, Smit, Johannes W. A, Langhorne, Peter, Gussekloo, Jacobijn

“…IMPORTANCE: It is unclear whether levothyroxine treatment provides clinically important benefits in adults aged 80 years and older with subclinical…”
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Assessment of causality between serum gamma-glutamyltransferase and type 2 diabetes mellitus using publicly available data: a Mendelian randomization study by Noordam, Raymond, Smit, Roelof Aj, Postmus, Iris, Trompet, Stella, van Heemst, Diana

“…In observational studies, high levels of gamma-glutamyltransferase (GGT) have been associated with a higher risk of type 2 diabetes mellitus (T2D). We aimed to…”
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Interethnic analyses of blood pressure loci in populations of East Asian and European descent by Takeuchi, Fumihiko, Akiyama, Masato, Matoba, Nana, Katsuya, Tomohiro, Nakatochi, Masahiro, Tabara, Yasuharu, Narita, Akira, Saw, Woei-Yuh, Moon, Sanghoon, Spracklen, Cassandra N., Chai, Jin-Fang, Kim, Young-Jin, Zhang, Liang, Wang, Chaolong, Li, Huaixing, Li, Honglan, Wu, Jer-Yuarn, Dorajoo, Rajkumar, Nierenberg, Jovia L., Wang, Ya Xing, He, Jing, Bennett, Derrick A., Takahashi, Atsushi, Momozawa, Yukihide, Hirata, Makoto, Matsuda, Koichi, Rakugi, Hiromi, Nakashima, Eitaro, Isono, Masato, Shirota, Matsuyuki, Hozawa, Atsushi, Ichihara, Sahoko, Matsubara, Tatsuaki, Yamamoto, Ken, Kohara, Katsuhiko, Igase, Michiya, Han, Sohee, Gordon-Larsen, Penny, Huang, Wei, Lee, Nanette R., Adair, Linda S., Hwang, Mi Yeong, Lee, Juyoung, Chee, Miao Li, Sabanayagam, Charumathi, Zhao, Wanting, Liu, Jianjun, Reilly, Dermot F., Sun, Liang, Huo, Shaofeng, Edwards, Todd L., Long, Jirong, Chang, Li-Ching, Chen, Chien-Hsiun, Yuan, Jian-Min, Koh, Woon-Puay, Friedlander, Yechiel, Kelly, Tanika N., Bin Wei, Wen, Xu, Liang, Cai, Hui, Xiang, Yong-Bing, Lin, Kuang, Clarke, Robert, Walters, Robin G., Millwood, Iona Y., Li, Liming, Chambers, John C., Kooner, Jaspal S., Elliott, Paul, van der Harst, Pim, Chen, Zhengming, Sasaki, Makoto, Shu, Xiao-Ou, Jonas, Jost B., He, Jiang, Heng, Chew-Kiat, Chen, Yuan-Tsong, Zheng, Wei, Lin, Xu, Teo, Yik-Ying, Tai, E-Shyong, Cheng, Ching-Yu, Wong, Tien Yin, Sim, Xueling, Mohlke, Karen L., Yamamoto, Masayuki, Kim, Bong-Jo, Miki, Tetsuro, Nabika, Toru, Yokota, Mitsuhiro, Kamatani, Yoichiro, Kubo, Michiaki, Kato, Norihiro

“…Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a…”
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Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins by Postmus, Iris, Trompet, Stella, Deshmukh, Harshal A., Barnes, Michael R., Li, Xiaohui, Warren, Helen R., Chasman, Daniel I., Zhou, Kaixin, Arsenault, Benoit J., Donnelly, Louise A., Wiggins, Kerri L., Avery, Christy L., Griffin, Paula, Feng, QiPing, Taylor, Kent D., Li, Guo, Evans, Daniel S., Smith, Albert V., de Keyser, Catherine E., Johnson, Andrew D., de Craen, Anton J. M., Buckley, Brendan M., Ford, Ian, Westendorp, Rudi G. J., Eline Slagboom, P., Sattar, Naveed, Munroe, Patricia B., Sever, Peter, Poulter, Neil, Stanton, Alice, Shields, Denis C., O’Brien, Eoin, Shaw-Hawkins, Sue, Ida Chen, Y.-D., Nickerson, Deborah A., Smith, Joshua D., Pierre Dubé, Marie, Matthijs Boekholdt, S., Kees Hovingh, G., Kastelein, John J. P., McKeigue, Paul M., Betteridge, John, Neil, Andrew, Durrington, Paul N., Doney, Alex, Carr, Fiona, Morris, Andrew, McCarthy, Mark I., Groop, Leif, Ahlqvist, Emma, Bis, Joshua C., Rice, Kenneth, Smith, Nicholas L., Lumley, Thomas, Whitsel, Eric A., Stürmer, Til, Boerwinkle, Eric, Ngwa, Julius S., O’Donnell, Christopher J., Wei, Wei-Qi, Wilke, Russell A., Liu, Ching-Ti, Sun, Fangui, Guo, Xiuqing, Heckbert, Susan R, Post, Wendy, Sotoodehnia, Nona, Arnold, Alice M., Stafford, Jeanette M., Ding, Jingzhong, Herrington, David M., Kritchevsky, Stephen B., Eiriksdottir, Gudny, Launer, Leonore J., Harris, Tamara B., Chu, Audrey Y., Giulianini, Franco, MacFadyen, Jean G., Barratt, Bryan J., Nyberg, Fredrik, Stricker, Bruno H., Uitterlinden, André G., Hofman, Albert, Rivadeneira, Fernando, Emilsson, Valur, Franco, Oscar H., Ridker, Paul M., Gudnason, Vilmundur, Liu, Yongmei, Denny, Joshua C., Ballantyne, Christie M., Adrienne Cupples, L., Psaty, Bruce M., Palmer, Colin N. A., Tardif, Jean-Claude, Colhoun, Helen M., Hitman, Graham, Krauss, Ronald M., Wouter Jukema, J, Caulfield, Mark J.

“…Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic…”
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Effect of Smoking on Blood Pressure and Resting Heart Rate: A Mendelian Randomization Meta-Analysis in the CARTA Consortium by Linneberg, Allan, Jacobsen, Rikke K, Skaaby, Tea, Taylor, Amy E, Fluharty, Meg E, Jeppesen, Jørgen L, Bjorngaard, Johan H, Åsvold, Bjørn O, Gabrielsen, Maiken E, Campbell, Archie, Marioni, Riccardo E, Kumari, Meena, Marques-Vidal, Pedro, Kaakinen, Marika, Cavadino, Alana, Postmus, Iris, Ahluwalia, Tarunveer S, Wannamethee, S Goya, Lahti, Jari, Räikkönen, Katri, Palotie, Aarno, Wong, Andrew, Dalgård, Christine, Ford, Ian, Ben-Shlomo, Yoav, Christiansen, Lene, Kyvik, Kirsten O, Kuh, Diana, Eriksson, Johan G, Whincup, Peter H, Mbarek, Hamdi, de Geus, Eco J.C, Vink, Jacqueline M, Boomsma, Dorret I, Smith, George Davey, Lawlor, Debbie A, Kisialiou, Aliaksei, McConnachie, Alex, Padmanabhan, Sandosh, Jukema, J Wouter, Power, Chris, Hyppönen, Elina, Preisig, Martin, Waeber, Gerard, Vollenweider, Peter, Korhonen, Tellervo, Laatikainen, Tiina, Salomaa, Veikko, Kaprio, Jaakko, Kivimaki, Mika, Smith, Blair H, Hayward, Caroline, Sørensen, Thorkild I.A, Thuesen, Betina H, Sattar, Naveed, Morris, Richard W, Romundstad, Pål R, Munafò, Marcus R, Jarvelin, Marjo-Riitta, Husemoen, Lise Lotte N

“…BACKGROUND—Smoking is an important cardiovascular disease risk factor, but the mechanisms linking smoking to blood pressure are poorly understood. METHODS AND…”
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