Search Results - "Post, J P van der"
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1
Biomarkers for the effects of benzodiazepines in healthy volunteers
Published in British journal of clinical pharmacology (01-01-2003)“…Studies of novel centrally acting drugs in healthy volunteers are traditionally concerned with kinetics and tolerability, but useful information may also be…”
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2
The central nervous system effects, pharmacokinetics and safety of the NAALADase‐inhibitor GPI 5693
Published in British journal of clinical pharmacology (01-08-2005)“…Aim The aim was to assess the central nervous system (CNS) effects, pharmacokinetics and safety of GPI 5693, an inhibitor of a novel CNS‐drug target, NAALADase…”
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3
Pharmacokinetic/pharmacodynamic Assessment of Tolerance to Central Nervous System Effects of a 3 mg Sustained Release Tablet of Rilmenidine in Hypertensive Patients
Published in Journal of psychopharmacology (Oxford) (01-06-2004)“…Previous single-dose studies have shown clear blood pressure-lowering effects of a potential sustained release (SR) profile of rilmenidine, with…”
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4
Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa
Published in Journal of psychopharmacology (Oxford) (01-06-2008)“…5-hydroxytryptophan (5-HTP) is a direct 5-hydroxytryptamine (5-HT) precursor used to assess central serotonergic function. Its use has been limited by a narrow…”
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5
Pharmacodynamic and pharmacokinetic effects of TPA023, a GABA(A) alpha(2,3) subtype-selective agonist, compared to lorazepam and placebo in healthy volunteers
Published in Journal of psychopharmacology (Oxford) (01-06-2007)“…TPA023, a GABA(A) alpha2,3 alphasubtype-selective partial agonist, is expected to have comparable anxiolytic efficacy as benzodiazepines with reduced sedating…”
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6
Pharmacodynamic and pharmacokinetic effects of TPA023, a GABAA α2,3 subtype-selective agonist, compared to lorazepam and placebo in healthy volunteers
Published in Journal of psychopharmacology (Oxford) (01-07-2007)“…TPA023, a GABAA α2,3 αsubtype-selective partial agonist, is expected to have comparable anxiolytic efficacy as benzodiazepines with reduced sedating effects…”
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7
Pharmacodynamic and pharmacokinetic effects of MK-0343, a GABAA α2,3 subtype selective agonist, compared to lorazepam and placebo in healthy male volunteers
Published in Journal of psychopharmacology (Oxford) (01-01-2008)“…The use of non-selective γ-aminobutyric acid (GABA) enhancers, such as benzodiazepines in the treatment of anxiety disorders is still widespread but hampered…”
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8
Pharmacodynamic and pharmacokinetic effects of TPA023, a GABAA alpha2,3 subtype-selective agonist, compared to lorazepam and placebo in healthy volunteers
Published in Journal of psychopharmacology (Oxford) (01-06-2007)“…TPA023, a GABAA alpha2,3 subtype-selective partial agonist, is expected to have comparable anxiolytic efficacy as benzodiazepines with reduced sedating…”
Get full text
Journal Article -
9
Pharmacodynamic and pharmacokinetic effects of MK-0343, a GABA(A) alpha2,3 subtype selective agonist, compared to lorazepam and placebo in healthy male volunteers
Published in Journal of psychopharmacology (Oxford) (01-01-2008)“…The use of non-selective gamma-aminobutyric acid (GABA) enhancers, such as benzodiazepines in the treatment of anxiety disorders is still widespread but…”
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Journal Article -
10
Pharmacodynamic and pharmacokinetic effects of MK-0343, a GABA^sub A^ [alpha]^sub 2,3^ subtype selective agonist, compared to lorazepam and placebo in healthy male volunteers
Published in Journal of psychopharmacology (Oxford) (01-01-2008)“…The use of non-selective y-aminobutyric acid (GABA) enhancers, such as benzodiazepines in the treatment of anxiety disorders is still widespread but hampered…”
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Journal Article -
11
Biomarkers for the effects of benzodiazepines in healthy volunteers
Published in British journal of clinical pharmacology (01-11-2002)Get full text
Journal Article -
12
Pharmacodynamic and pharmacokinetic effects of MK-0343, a GABA sub(A) a sub(2,3) subtype selective agonist, compared to lorazepam and placebo in healthy male volunteers
Published in Journal of psychopharmacology (Oxford) (01-01-2008)“…The use of non-selective g-aminobutyric acid (GABA) enhancers, such as benzodiazepines in the treatment of anxiety disorders is still widespread but hampered…”
Get full text
Journal Article -
13
Pharmacodynamic and pharmacokinetic effects of MK-0343, a GABAA [alpha]2,3 subtype selective agonist, compared to lorazepam and placebo in healthy male volunteers
Published in Journal of psychopharmacology (Oxford) (01-01-2008)“…The use of non-selective γ-aminobutyric acid (GABA) enhancers, such as benzodiazepines in the treatment of anxiety disorders is still widespread but hampered…”
Get full text
Journal Article -
14
Pharmacodynamic and pharmacokinetic effects of TPA023, a GABAA [alpha]2,3 subtype-selective agonist, compared to lorazepam and placebo in healthy volunteers
Published in Journal of psychopharmacology (Oxford) (01-06-2007)“…TPA023, a GABAA α2,3 αsubtype-selective partial agonist, is expected to have comparable anxiolytic efficacy as benzodiazepines with reduced sedating effects…”
Get full text
Journal Article -
15
Pharmacodynamic and pharmacokinetic effects of TPA023, a GABA sub(A) a sub(2,3) subtype-selective agonist, compared to lorazepam and placebo in healthy volunteers
Published in Journal of psychopharmacology (Oxford) (01-06-2007)“…TPA023, a GABA sub(A) a2,3 asubtype-selective partial agonist, is expected to have comparable anxiolytic efficacy as benzodiazepines with reduced sedating…”
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Journal Article -
16
Concentration-effect relationships of two rilmenidine single-dose infusion rates in hypertensive patients
Published in Clinical pharmacology and therapeutics (01-10-2002)“…Objectives This study was designed to assess the concentration‐effect relationships for the antihypertensive effects of rilmenidine in patients to aid in the…”
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