Search Results - "Possenti, R."

TLQP-21, a VGF-derived peptide, increases energy expenditure and prevents the early phase of diet-induced obesity by Bartolomucci, A, La Corte, G, Possenti, R, Locatelli, V, Rigamonti, A.E, Torsello, A, Bresciani, E, Bulgarelli, I, Rizzi, R, Pavone, F

“…The vgf gene has been identified as an energy homeostasis regulator. Vgf encodes a 617-aa precursor protein that is processed to yield an incompletely…”
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Nerve growth factor derivative NGF61/100 promotes outgrowth of primary sensory neurons with reduced signs of nociceptive sensitization by Severini, C., Petrocchi Passeri, P., Ciotti, M.T., Florenzano, F., Petrella, C., Malerba, F., Bruni, B., D'Onofrio, M., Arisi, I., Brandi, R., Possenti, R., Calissano, P., Cattaneo, A.

“…Nerve Growth Factor (NGF) is being considered as a therapeutic candidate for Alzheimer's disease. However, the development of an NGF-based therapy is limited…”
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TLQP-21, a VGF-derived peptide, stimulates exocrine pancreatic secretion in the rat by Petrella, C., Broccardo, M., Possenti, R., Severini, C., Improta, G.

“…► TLQP-21 increases exocrine secretion from pancreatic rat lobules. ► The stimulatory effect on enzyme outflow is indirect and involves PGs release. ► TLQP-21…”
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Substance P activates ADAM9 mRNA expression and induces α-secretase-mediated amyloid precursor protein cleavage by Marolda, R., Ciotti, M.T., Matrone, C., Possenti, R., Calissano, P., Cavallaro, S., Severini, C.

“…Altered levels of Substance P (SP), a neuropeptide endowed with neuroprotective and anti-apoptotic properties, were found in brain areas and spinal fluid of…”
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SP protects cerebellar granule cells against β-amyloid-induced apoptosis by down-regulation and reduced activity of Kv4 potassium channels by Pieri, M., Amadoro, G., Carunchio, I., Ciotti, M.T., Quaresima, S., Florenzano, F., Calissano, P., Possenti, R., Zona, C., Severini, C.

“…The tachykinin endecapeptide substance P (SP) has been demonstrated to exert a functional role in neurodegenerative disorders, including Alzheimer's disease…”
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Biophysical characterization of a binding site for TLQP-21, a naturally occurring peptide which induces resistance to obesity by Cassina, V., Torsello, A., Tempestini, A., Salerno, D., Brogioli, D., Tamiazzo, L., Bresciani, E., Martinez, J., Fehrentz, J.A., Verdié, P., Omeljaniuk, R.J., Possenti, R., Rizzi, L., Locatelli, V., Mantegazza, F.

“…Recently, we demonstrated that TLQP-21 triggers lipolysis and induces resistance to obesity by reducing fat accumulation [1]. TLQP-21 is a 21 amino acid…”
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In vitro and in vivo pharmacological role of TLQP‐21, a VGF‐derived peptide, in the regulation of rat gastric motor functions by Severini, C, La Corte, G, Improta, G, Broccardo, M, Agostini, S, Petrella, C, Sibilia, V, Pagani, F, Guidobono, F, Bulgarelli, I, Ferri, GL, Brancia, C, Rinaldi, AM, Levi, A, Possenti, R

“…Background and purpose:  Vgf gene expression has been detected in various endocrine and neuronal cells in the gastrointestinal tract. In this study we…”
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Implication of the VGF-derived peptide TLQP-21 in mouse acute and chronic stress responses by Razzoli, M., Bo, E., Pascucci, T., Pavone, F., D‘Amato, F.R., Cero, C., Sanghez, V., Dadomo, H., Palanza, P., Parmigiani, S., Ceresini, G., Puglisi-Allegra, S., Porta, M., Panzica, G.C., Moles, A., Possenti, R., Bartolomucci, A.

“…► We investigate the role of VGF in stress-induced changes in mice. ► VGF-immunoreactive fibers were found in different hypothalamic nuclei. ► The VGF-derived…”
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Isolation and characterization of VGF peptides in rat brain. Role of PC1/3 and PC2 in the maturation of VGF precursor by Trani, E., Giorgi, A., Canu, N., Amadoro, G., Rinaldi, A. M., Halban, P. A., Ferri, L., Possenti, R., Schininà†, M. E., Levi, A.

“…The neurotrophin responsive gene vgf is widely expressed in central and peripheral neurones, and in certain neuroendocrine cell populations. Its encoded VGF…”
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Pathophysiological role of TLQP-21: gastrointestinal and metabolic functions by Bartolomucci, A, Moles, A, Levi, A, Possenti, R

“…The present review summarizes recent findings on the metabolic and gastroenteric role of the VGF gene and a peptide derived by post-translational cleavage of…”
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Nutritional evaluation of safflower silage and biomass, seed and oil production by R. A. Possenti, A. M. Arantes, P. Brás, J. B. Andrade, E. Ferrari Júnior

“…The  objective  of  this study  was  to evaluate the nutritional value of safflower biomass  (Carthamus tinctorium L.) ensiled in three treatments. An apparent…”
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Chronic intracerebroventricular TLQP-21 delivery does not modulate the GH/IGF-1-axis and muscle strength in mice by Bartolomucci, A, Rigamonti, A.E, Bulgarelli, I, Torsello, A, Locatelli, V, Pavone, F, Levi, A, Possenti, R, Muller, E.E, Moles, A

“…Abstract Objective Biallelic ablation of VGF determines a dwarf phenotype. VGF precursor protein encodes for different biologically active peptides none of…”
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Tissue-specific processing of the neuroendocrine protein VGF by Trani, E, Ciotti, T, Rinaldi, A M, Canu, N, Ferri, G L, Levi, A, Possenti, R

“…VGF is a neuroendocrine-specific gene product that is up-regulated by nerve growth factor in the PC12 cell line. In rat neuroendocrine tissues two polypeptides…”
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A protein induced by NGF in PC12 cells is stored in secretory vesicles and released through the regulated pathway by Possenti, R., Eldridge, J.D., Paterson, B.M., Grasso, A., Levi, A.

“…We have previously described the isolation of a cDNA clone corresponding to an mRNA rapidly induced to high levels in PC12 cells by treatment with NGF. We…”
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A developmentally regulated nerve growth factor-induced gene, VGF, is expressed in geniculocortical afferents during synaptogenesis by Lombardo, A., Rabacchi, S.A., Cremisi, F., Pizzorusso, T., Cenni, M.C., Possenti, R., Barsacchi, G., Maffei, L.

“…The expression of the nerve growth factor=inducible gene VGF has been examined by in situ hybridization, Western blot and immunohistochemical studies in the…”
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Interplay of the E box, the cyclic AMP response element, and HTF4/HEB in transcriptional regulation of the neurospecific, neurotrophin-inducible vgf gene by Di Rocco, Giuliana, Pennuto, Maria, Illi, Barbara, Canu, Nadia, Filocamo, Gessica, Trani, Eugenia, Rinaldi, Anna Maria, Possenti, Roberta, Mandolesi, Georgia, Sirinian, M. Isabella, Jucker, Richard, Levi, Andrea, Nasi, Sergio

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Regulatory Elements in the Promoter Region of vgf, a Nerve Growth Factor- Inducible Gene by Possenti, Roberta, Di Rocco, Giuliana, Nasi, Sergio, Levi, Andrea

“…vgf, a gene coding for a protein secreted through the regulated pathway, is rapidly up-modulated by nerve growth factor in PC12 cells and is expressed in vivo…”
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Initiation of simian virus 40 DNA replication in vitro: aphidicolin causes accumulation of early-replicating intermediates and allows determination of the initial direction of DNA synthesis by DECKER, R. S, YAMAGUCHI, M, POSSENTI, R, DEPAMPHILIS, M. L

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In vitro initiation of DNA replication in simian virus 40 chromosomes by Decker, R S, Yamaguchi, M, Possenti, R, Bradley, M K, DePamphilis, M L

“…A soluble system has been developed that can initiate DNA replication de novo in simian virus 40 (SV40) chromatin isolated from virus-infected monkey cells as…”
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Characterization of the mechanisms involved in the gastric antisecretory effect of TLQP-21, a vgf-derived peptide, in rats by Sibilia, Valeria, Pagani, Francesca, Bulgarelli, Ilaria, Tulipano, Giovanni, Possenti, Roberta, Guidobono, Francesca

“…TLQP-21, a vgf -derived peptide modulates gastric emptying and prevents ethanol-induced gastric lesions in rats. However, it remains to be studied whether or…”
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