Search Results - "Posseme, C."
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Smoking changes adaptive immunity with persistent effects
Published in Nature (London) (2024)“…Individuals differ widely in their immune responses, with age, sex and genetic factors having major roles in this inherent variability 1 – 6 . However, the…”
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Early IFNβ secretion determines variable downstream IL-12p70 responses upon TLR4 activation
Published in Cell reports (Cambridge) (28-06-2022)“…The interleukin-12 (IL-12) family comprises the only heterodimeric cytokines mediating diverse functional effects. We previously reported a striking bimodal…”
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Rhesus negative males have an enhanced IFNγ-mediated immune response to influenza A virus
Published in Genes and immunity (01-04-2022)“…The Rhesus D antigen (RhD) has been associated with susceptibility to several viral infections. Reports suggest that RhD-negative individuals are better…”
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Novel DSP Spectrin 6 Region Variant Causes Neonatal Erythroderma, Failure to Thrive, Severe Herpes Simplex Infections and Brain Lesions
Published in Acta dermato-venereologica (01-07-2019)“…Desmoplakin (DSP) and Desmoglein 1 (DSG1) variants result in skin barrier defects leading to erythroderma, palmoplantar keratoderma and variable [AQ4] other…”
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Enhanced TLR3 responsiveness in hepatitis C virus resistant women from the Irish anti-D cohort
Published in Cell reports. Medicine (15-11-2022)“…Natural resistance to infection is an overlooked outcome after hepatitis C virus (HCV) exposure. Between 1977 and 1979, 1,200 Rhesus D-negative Irish women…”
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Le syndrome VEXAS se caractérise par une activation des voies de l’inflammasome dans le sang et les tissus et par une dérégulation du compartiment monocytaire
Published in La revue de medecine interne (01-12-2022)“…Des mutations acquises du gène UBA1, survenant dans les cellules myéloïdes et entraînant l’expression d’une isoforme catalytiquement altérée de l’enzyme E1,…”
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Succès des inhibiteurs de JAK dans une nouvelle présentation de maladie auto-inflammatoire associée à JAK1
Published in La revue de medecine interne (01-06-2023)“…Les cytokines sont des régulateurs clés de la réponse immunitaire innée et adaptative. À ce titre, un nombre important de variants pathogènes de cytokines, de…”
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