Search Results - "Poss, Christopher S"

Two-directional chain synthesis and terminus differentiation by Poss, Christopher S, Schreiber, Stuart L

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A framework for setting enrollment goals to ensure participant diversity in sponsored clinical trials in the United States by Cullen, Mark R., Lemeshow, Adina R., Amaro, Sandra, Bandera, Elisa V., Cooper, Lisa A., Kawachi, Ichiro, Lunyera, Joseph, McKinley, Laura, Poss, Christopher S., Rottas, Melinda M., Schachterle, Stephen E., Thadeio, Peter F., Russo, Leo J.

“…Diversity in clinical trials (CTs) has the potential to improve health equity and close health disparities. Underrepresentation of historically underserved…”
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Piperazinyl CCR1 antagonists—optimization of human liver microsome stability by Brown, Matthew F., Bahnck, Kevin B., Blumberg, Laura C., Brissette, William H., Burrell, Sara A., Driscoll, James P., Fedeles, Flavia, Fisher, Michael B., Foti, Robert S., Gladue, Ronald P., Guzman-Martinez, Aikomari, Hayward, Matthew M., Lira, Paul D., Lillie, Brett M., Lu, Yi, Lundquist, Greg D., McElroy, Eric B., McGlynn, Molly A., Paradis, Timothy J., Poss, Christopher S., Roache, James H., Shavnya, Andrei, Shepard, Richard M., Trevena, Kristen A., Tylaska, Laurie A.

“…The synthesis, biological activity, and pharmacokinetic profile of CCR1 antagonists are described. The synthesis, biological activity, and pharmacokinetic…”
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Project-Focused Activity and Knowledge Tracker: A Unified Data Analysis, Collaboration, and Workflow Tool for Medicinal Chemistry Project Teams by Brodney, Marian D, Brosius, Arthur D, Gregory, Tracy, Heck, Steven D, Klug-McLeod, Jacquelyn L, Poss, Christopher S

“…Advances in the field of drug discovery have brought an explosion in the quantity of data available to medicinal chemists and other project team members. New…”
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CP-481,715, a Potent and Selective CCR1 Antagonist with Potential Therapeutic Implications for Inflammatory Diseases by Gladue, Ronald P., Tylaska, Laurie A., Brissette, William H., Lira, Paul D., Kath, John C., Poss, Christopher S., Brown, Matthew F., Paradis, Timothy J., Conklyn, Maryrose J., Ogborne, Kevin T., McGlynn, Molly A., Lillie, Brett M., DiRico, Amy P., Mairs, Erin N., McElroy, Eric B., Martin, William H., Stock, Ingrid A., Shepard, Richard M., Showell, Henry J., Neote, Kuldeep

“…The chemokines CCL3 and CCL5, as well as their shared receptor CCR1, are believed to play a role in the pathogenesis of several inflammatory diseases including…”
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Novel CCR1 antagonists with improved metabolic stability by BROWN, Matthew F, AVERY, Mike, LIRA, Paul D, LILLIE, Brett M, LUNDQUIST, Greg D, MAIRS, Erin N, MCELROY, Eric B, MCGLYNN, Molly A, PARADIS, Timothy J, POSS, Christopher S, ROSSULEK, Michelle I, SHEPARD, Richard M, BRISSETTE, William H, SIMS, Jeff, STRELEVITZ, Timothy J, TRUESDELL, Susan, TYLASKA, Laurie A, YOON, Kwansik, DEYE ZHENG, CHANG, J. H, COLIZZA, Kevin, CONKLYN, Maryrose, DIRICO, Amy P, GLADUE, Ronald P, KATH, John C, KRUEGER, Suzanne S

“…The synthesis, biological activity, and pharmacokinetic profile of novel CCR1 antagonists are described…”
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Potent small molecule CCR1 antagonists by KATH, John C, BRISSETTE, William H, MARTIN, William H, MCELROY, Eric B, MCGLYNN, Molly A, PARADIS, Timothy J, POSS, Christopher S, STOCK, Ingrid A, TYLASKA, Laurie A, DEYE ZHENG, BROWN, Matthew F, CONKLYN, Maryrose, DIRICO, Amy P, DORFF, Peter, GLADUE, Ronald P, LILLIE, Brett M, LIRA, Paul D, MAIRS, Erin N

“…The present manuscript details structure-activity relationship studies of lead structure 1, which led to the discovery of CCR1 antagonists >100-fold more…”
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Two-directional chain synthesis: an application to the synthesis of (+)-mycoticin A by Poss, Christopher S, Rychnovsky, Scott D, Schreiber, Stuart L

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Process Development of CP-481715, a Novel CCR1 Antagonist by Li, Bryan, Andresen, Brian, Brown, Matthew F, Buzon, Richard A, Chiu, Charles K.-F, Couturier, Michel, Dias, Eric, Urban, Frank J, Jasys, V. John, Kath, John C, Kissel, William, Le, Tung, Li, Z. Jane, Negri, Joanna, Poss, Christopher S, Tucker, John, Whritenour, David, Zandi, Kathleen

“…Process development for the synthesis of 2-quinoxalinecarboxamide, N-[(1S,2S,4R)-4-(aminocarbonyl)-1-[(3-fluorophenyl)methyl]-2,7-dihydroxy-7-methyloctyl] is…”
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