Search Results - "Pospisilova, S"

MicroRNA isolation and stability in stored RNA samples by Mraz, M., Malinova, K., Mayer, J., Pospisilova, S.

“…MicroRNAs (miRNAs) are small RNA molecules, which act as post-transcriptional regulators of a gene expression, with important functions within the cell…”
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Detailed analysis of therapy-driven clonal evolution of TP53 mutations in chronic lymphocytic leukemia by Malcikova, J, Stano-Kozubik, K, Tichy, B, Kantorova, B, Pavlova, S, Tom, N, Radova, L, Smardova, J, Pardy, F, Doubek, M, Brychtova, Y, Mraz, M, Plevova, K, Diviskova, E, Oltova, A, Mayer, J, Pospisilova, S, Trbusek, M

“…In chronic lymphocytic leukemia (CLL), the worst prognosis is associated with TP53 defects with the affected patients being potentially directed to alternative…”
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ERIC recommendations for TP53 mutation analysis in chronic lymphocytic leukemia—update on methodological approaches and results interpretation by Malcikova, J., Tausch, E., Rossi, D., Sutton, L. A., Soussi, T., Zenz, T., Kater, A. P., Niemann, C. U., Gonzalez, D., Davi, F., Gonzalez Diaz, M., Moreno, C., Gaidano, G., Stamatopoulos, K., Rosenquist, R., Stilgenbauer, S., Ghia, P., Pospisilova, S.

“…In chronic lymphocytic leukemia (CLL), TP53 gene defects, due to deletion of the 17p13 locus and/or mutation(s) within the TP53 gene, are associated with…”
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High-quality full-length immunoglobulin profiling with unique molecular barcoding by Turchaninova, M A, Davydov, A, Britanova, O V, Shugay, M, Bikos, V, Egorov, E S, Kirgizova, V I, Merzlyak, E M, Staroverov, D B, Bolotin, D A, Mamedov, I Z, Izraelson, M, Logacheva, M D, Kladova, O, Plevova, K, Pospisilova, S, Chudakov, D M

“…This protocol enables high-throughput sequencing analysis of the full-length immunoglobulin repertoires in human and mouse using unique molecular identifiers…”
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Recurrent mutations refine prognosis in chronic lymphocytic leukemia by Baliakas, P, Hadzidimitriou, A, Sutton, L-A, Rossi, D, Minga, E, Villamor, N, Larrayoz, M, Kminkova, J, Agathangelidis, A, Davis, Z, Tausch, E, Stalika, E, Kantorova, B, Mansouri, L, Scarfò, L, Cortese, D, Navrkalova, V, Rose-Zerilli, M J J, Smedby, K E, Juliusson, G, Anagnostopoulos, A, Makris, A M, Navarro, A, Delgado, J, Oscier, D, Belessi, C, Stilgenbauer, S, Ghia, P, Pospisilova, S, Gaidano, G, Campo, E, Strefford, J C, Stamatopoulos, K, Rosenquist, R

“…Through the European Research Initiative on chronic lymphocytic leukemia (CLL) (ERIC), we screened 3490 patients with CLL for mutations within the NOTCH1 ( n…”
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Low-burden TP53 mutations in chronic phase of myeloproliferative neoplasms: association with age, hydroxyurea administration, disease type and JAK2 mutational status by Kubesova, B, Pavlova, S, Malcikova, J, Kabathova, J, Radova, L, Tom, N, Tichy, B, Plevova, K, Kantorova, B, Fiedorova, K, Slavikova, M, Bystry, V, Kissova, J, Gisslinger, B, Gisslinger, H, Penka, M, Mayer, J, Kralovics, R, Pospisilova, S, Doubek, M

“…The multistep process of TP53 mutation expansion during myeloproliferative neoplasm (MPN) transformation into acute myeloid leukemia (AML) has been documented…”
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ERIC recommendations on TP53 mutation analysis in chronic lymphocytic leukemia by Pospisilova, S, Gonzalez, D, Malcikova, J, Trbusek, M, Rossi, D, Kater, A P, Cymbalista, F, Eichhorst, B, Hallek, M, Döhner, H, Hillmen, P, van Oers, M, Gribben, J, Ghia, P, Montserrat, E, Stilgenbauer, S, Zenz, T

“…Recent evidence suggests that – in addition to 17p deletion – TP53 mutation is an independent prognostic factor in chronic lymphocytic leukemia (CLL). Data…”
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The impact of SF3B1 mutations in CLL on the DNA-damage response by te Raa, G D, Derks, I A M, Navrkalova, V, Skowronska, A, Moerland, P D, van Laar, J, Oldreive, C, Monsuur, H, Trbusek, M, Malcikova, J, Lodén, M, Geisler, C H, Hüllein, J, Jethwa, A, Zenz, T, Pospisilova, S, Stankovic, T, van Oers, M H J, Kater, A P, Eldering, E

“…Mutations or deletions in TP53 or ATM are well-known determinants of poor prognosis in chronic lymphocytic leukemia (CLL), but only account for approximately…”
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Restrictions in the T-cell repertoire of chronic lymphocytic leukemia: high-throughput immunoprofiling supports selection by shared antigenic elements by Vardi, A, Vlachonikola, E, Karypidou, M, Stalika, E, Bikos, V, Gemenetzi, K, Maramis, C, Siorenta, A, Anagnostopoulos, A, Pospisilova, S, Maglaveras, N, Chouvarda, I, Stamatopoulos, K, Hadzidimitriou, A

“…Immunoglobulin (IG) gene repertoire restrictions strongly support antigen selection in the pathogenesis of chronic lymphocytic leukemia (CLL). Given the…”
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Targeted next-generation sequencing in chronic lymphocytic leukemia: a high-throughput yet tailored approach will facilitate implementation in a clinical setting by Sutton, Lesley-Ann, Ljungström, Viktor, Mansouri, Larry, Young, Emma, Cortese, Diego, Navrkalova, Veronika, Malcikova, Jitka, Muggen, Alice F, Trbusek, Martin, Panagiotidis, Panagiotis, Davi, Frederic, Belessi, Chrysoula, Langerak, Anton W, Ghia, Paolo, Pospisilova, Sarka, Stamatopoulos, Kostas, Rosenquist, Richard

“…Next-generation sequencing has revealed novel recurrent mutations in chronic lymphocytic leukemia, particularly in patients with aggressive disease. Here, we…”
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miR-34a, miR-29c and miR-17-5p are downregulated in CLL patients with TP53 abnormalities by Mraz, M, Malinova, K, Kotaskova, J, Pavlova, S, Tichy, B, Malcikova, J, Stano Kozubik, K, Smardova, J, Brychtova, Y, Doubek, M, Trbusek, M, Mayer, J, Pospisilova, S

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Multiple productive IGH rearrangements denote oligoclonality even in immunophenotypically monoclonal CLL by Brazdilova, K, Plevova, K, Skuhrova Francova, H, Kockova, H, Borsky, M, Bikos, V, Malcikova, J, Oltova, A, Kotaskova, J, Tichy, B, Brychtova, Y, Mayer, J, Doubek, M, Pospisilova, S

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Distinct patterns of novel gene mutations in poor-prognostic stereotyped subsets of chronic lymphocytic leukemia: the case of SF3B1 and subset #2 by Strefford, J C, Sutton, L-A, Baliakas, P, Agathangelidis, A, Malčíková, J, Plevova, K, Scarfó, L, Davis, Z, Stalika, E, Cortese, D, Cahill, N, Pedersen, L B, di Celle, P F, Tzenou, T, Geisler, C, Panagiotidis, P, Langerak, A W, Chiorazzi, N, Pospisilova, S, Oscier, D, Davi, F, Belessi, C, Mansouri, L, Ghia, P, Stamatopoulos, K, Rosenquist, R

“…Recent studies have revealed recurrent mutations of the NOTCH1 , SF3B1 and BIRC3 genes in chronic lymphocytic leukemia (CLL), especially among aggressive,…”
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TP53 mutation profile in chronic lymphocytic leukemia: evidence for a disease specific profile from a comprehensive analysis of 268 mutations by Zenz, T, Vollmer, D, Trbusek, M, Smardova, J, Benner, A, Soussi, T, Helfrich, H, Heuberger, M, Hoth, P, Fuge, M, Denzel, T, Häbe, S, Malcikova, J, Kuglik, P, Truong, S, Patten, N, Wu, L, Oscier, D, Ibbotson, R, Gardiner, A, Tracy, I, Lin, K, Pettitt, A, Pospisilova, S, Mayer, J, Hallek, M, Döhner, H, Stilgenbauer, S

“…The TP53 mutation profile in chronic lymphocytic leukemia (CLL) and the correlation of TP53 mutations with allele status or associated molecular genetics are…”
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MicroRNAs in urine supernatant as potential non-invasive markers for bladder cancer detection by Pospisilova, S, Pazourkova, E, Horinek, A, Brisuda, A, Svobodova, I, Soukup, V, Hrbacek, J, Capoun, O, Hanus, T, Mares, J, Korabecna, M, Babjuk, M

“…Urinary bladder carcinoma contributes to 4% of newly diagnosed oncological diseases in the Czech Republic. Biomarkers for its early non-invasive detection are…”
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FOXO1‐RICTOR AXIS INDUCES AKT PHOSPHORYLATION DURING CLL CELL ADAPTATION TO BCR INHIBITORS: IMPLICATIONS FOR COMBINATORIAL THERAPY by Ondrisova, L., Seda, V., Hoferkova, E., Chiodin, G., Hlavac, K., Kostalova, L., Pavlasova, G. Mladonicka, Filip, D., Zeni, P. Faria, Oppelt, J., Panovska, A., Plevova, K., Pospisilova, S., Simkovic, M., Vrbacky, F., Lysak, D., Fernandes, S. M., Davids, M. S., Maiques‐Diaz, A., Charalampopoulou, S., Martin‐Subero, J. I., Brown, J. R., Doubek, M., Forconi, F., Mayer, J., Mraz, M.

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P620: DYNAMICS OF GENOMIC ABERRATIONS IN RELATION TO DISEASE ACTIVITY IN UNTREATED PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA by Navrkalova, V., Kotaskova, J., Plevova, K., Reigl, T., Valisova, M., Bohunova, M., Zenatova, M., Radova, L., Panovska, A., Pospisilova, S.

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An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-204 Receptors by Bikos, Vasilis, Karypidou, Maria, Stalika, Evangelia, Baliakas, Panagiotis, Xochelli, Aliki, Sutton, Lesley-Ann, Papadopoulos, George, Agathangelidis, Andreas, Papadopoulou, Evdoxia, Davis, Zadie, Algara, Patricia, Kanellis, George, Traverse-Glehen, Alexandra, Mollejo, Manuela, Anagnostopoulos, Achilles, Ponzoni, Maurilio, Gonzalez, David, Pospisilova, Sarka, Matutes, Estella, Piris, Miguel Angel, Papadaki, Theodora, Ghia, Paolo, Rosenquist, Richard, Oscier, David, Darzentas, Nikos, Tzovaras, Dimitrios, Belessi, Chrysoula, Hadzidimitriou, Anastasia, Stamatopoulos, Kostas

“…Prompted by the extensive biases in the immunoglobulin (IG) gene repertoire of splenic marginal-zone lymphoma (SMZL), supporting antigen selection in SMZL…”
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Innovation in the prognostication of chronic lymphocytic leukemia: how far beyond TP53 gene analysis can we go? by Pospisilova, Sarka, Sutton, Lesley-Ann, Malcikova, Jitka, Tausch, Eugen, Rossi, Davide, Montserrat, Emili, Moreno, Carol, Stamatopoulos, Kostas, Gaidano, Gianluca, Rosenquist, Richard, Ghia, Paolo

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OP08.06: Differentially expressed miRNAs in Trisomy 21 placenta and their potential involvement in Down's syndrome pathologies by Svobodová, I., Korabečná, M., Calda, P., Brestak, M., Pazourková, E., Pospíšilová, Š., Krkavcová, M., Novotná, M., Horinek, A.

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