Search Results - "Pospelova, T V"

Cyclin-dependent kinase inhibitor p21(Waf1): contemporary view on its role in senescence and oncogenesis by Romanov, V S, Pospelov, V A, Pospelova, T V

“…p21(Waf1) was identified as a protein suppressing cyclin E/A-CDK2 activity and was originally considered as a negative regulator of the cell cycle and a tumor…”
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p21(Waf1) is required for cellular senescence but not for cell cycle arrest induced by the HDAC inhibitor sodium butyrate by Romanov, V S, Abramova, M V, Svetlikova, S B, Bykova, T V, Zubova, S G, Aksenov, N D, Fornace, Jr, A J, Pospelova, T V, Pospelov, V A

“…Cell senescence is characterized by senescent morphology and permanent loss of proliferative potential. HDAC inhibitors (HDACI) induce senescence and/or…”
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Transformation of Innovation Processes and Socio-Cultural Specificity of South Korea in the framework of the Fourth Industrial Revolution by Pospelova, T. V., Yarygina, A. B.

“…Purpose : the main purpose of this article is to explore the specific characteristics of the innovation development of South Korea. To achieve this goal the…”
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Establishment of HindIIIG-1 Cell Line, Obtained after Irradiation of HindIIIG Cells Resistant to Apoptosis, Characterizes by Genomic Instability, Altered DNA Repair Mechanisms and Activation of Autophagy by Chitikova, Z. V., Yartseva, N. M., Bykova, T. V., Zubova, S. G., Kochetkova, E. Y., Pospelov, V. A., Pospelova, T. V.

“…Genomic instability and heterogeneity are the key features of cancer cells that allow their survival under environmental stress. A rapid accumulation of a…”
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Karyotypic Changes of Apoptosis-Resistant Rat Cells HindIIIG during Prolonged Cultivation after Exposure to Ionizing Irradiation by Yartseva, N. M., Shitikova, Zh. V., Bykova, T. V., Zubova, S. G., Kochetkova, E. Yu, Pospelov, V. A., Pospelova, T. V.

“…Genome instability manifested by multiple reorganization contributes to the acquisition of new properties by tumor cells, resistance to therapy in particular…”
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Chromosomal Instability and Evolution of Transformed Phenotype in Cell Lines Selected from Senescent Rat Embryonic Fibroblasts with Rapamycin by Yartseva, N. M., Bykova, T. V., Zubova, S. G., Pospelov, V. A., Pospelova, T. V.

“…The karyotype and phenotype evolution in cell lines (Rapa) obtained by rapamycin selection from rat embryonic fibroblasts (REF) has been studied. Rapamycin, an…”
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The MEK/ERK pathway is essential for maintenance of cytoprotective autophagy in E1A+cHA-RAS transformants after exposure to radiation by Kochetkova, E. Yu, Blinova, G. I., Zubova, S. G., Bykova, T. V., Pospelov, V. A., Pospelova, T. V.

“…Autophagy is a conserved process of protein and organelle degradation that serves to maintain cell viability. Autophagy is frequently induced in response to…”
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CHLOROQUINE DOES NOT CANCEL E1A+cHa-Ras TRANSFORMANTS’ DEATH INDUCED BY mTOR KINASE INHIBITOR pp242 by Bykova, T V, Zubova, S G, Kochetkova, E Yu, Pospelova, T V

“…We have studied the dependence of cell viability on cell autophagy in control and senescent E1A+cHa-Ras transformed rat embryo fibroblasts. pp242, a TORC1/C2…”
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Selective repression of c- fos gene transcription in rat embryo fibroblasts transformed by oncogenes E1A and cHa-ras by Abramova, M.V, Kukushkin, A.N, Svetlikova, S.B, Pospelova, T.V, Pospelov, V.A

“…Transformation of REF cells by oncogenes E1A and c Ha-ras leads to activation of AP-1 factor concomitantly with down-regulation of c- fos gene transcription…”
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Transformation with the E1A+cHa-ras Oncogenes Enhances the Trans-Repressor Function of the Elk-1 Transcription Factor by Usenko, T N, Pospelova, T V, Pospelov, V A

“…Rat embryo fibroblasts (REF) transformed with the complementing E1A and cHa-ras oncogenes show a downregulation of the c-fos early response gene, which is…”
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Roles of the TCF Phosphorylation State and the Chromatin Structure in the Negative Transcription Regulation of the c-fos Protooncogene in E1A+ras Transformed Cells by Abramova, M V, Kukushkin, A N, Pospelova, T V, Svetlikova, S B, Pospelov, V A

“…As compared with normal rat embryo fibroblasts (REF), c-fos transcription is suppressed in REF transformed with the E1A and cHa-ras complementing oncogenes…”
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Patterns of protein synthesis in various cells after extreme heat shock by Margulis, B A, Zhivotovski, B D, Pospelova, T V, Smagina, L V

“…The analysis of proteins synthesized in rat thymocytes and mouse teratocarcinoma PCC-4 Aza 1 and myeloma Sp2/0 cells after 1 h of treatment at 42 or 44 degrees…”
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Downregulation of c-fos gene transcription in cells transformed by E1A and cHa-ras oncogenes: a role of sustained activation of MAP/ERK kinase cascade and of inactive chromatin structure at c-fos promoter by KUKUSHKIN, Alexander N, ABRAMOVA, Maria V, SVETLIKOVA, Svetlana B, DARIEVA, Zalfia A, POSPELOVA, Tatiana V, POSPELOV, Valery A

“…REF cells transformed by oncogenes E1A and cHa-ras reveal high and constitutive DNA-binding activity of AP-1 factor lacking in c-Fos protein. Consistently, the…”
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FUTURE INNOVATION TRENDS IN LATIN AMERICA by T. V. Pospelova

“…This article off ers an analysis of innovation activities in three Latin American countries. Such components as the role of science, business communities, and…”
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E1A oncogene effect on the ability of p21(Waf1) to regulate G1/S arrest in E1A-expressing transformants following irradiation by Romanov, V S, Brichkina, A I, Pospelov, V A, Pospelova, T V

“…P21(Waf1) cyclin-dependent kinase inhibitor blocks cell cycle transition from G1 phase into DNA replication after DNA damage. The main targets of p21(Waf1) are…”
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Induction of premature senescence program by an inhibitor of histone deacetylase sodium butyrate in normal and transformed rat fibroblasts by Zubova, Iu G, Bykova, T V, Zubova, S G, Abramova, M V, Aksenov, N D, Pospelov, V A, Pospelova, T V

“…We investigated a possibility to induce the premature cell senescence in rat embryo fibroblasts and E1A + cHa-ras transformants. We found that after the…”
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The control of DNA replication in hybrids between neutrophils and fibroblasts by Prudovsky, I A, Kosimov, R B, Sukharev, S I, Pospelova, T V, Prasolov, V S, Zelenin, A V

“…DNA synthesis regulation in heterokaryons between mouse neutrophils and cultured cells of various proliferative potentials has been studied. The following…”
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Dependence of the Viability of Ras-Expressing Cells on Damage to Mitochondria Caused by Antitumor Agents by Kochetkova, E. Yu, Blinova, G. I., Boytsov, A. S., Pospelov, V. A., Pospelova, T. V.

“…Tumors with ocogenic Ras protein expression are hard to cure, since they are able to restore viability after treatment with antitumor agents by activating…”
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AP-1 and Krox-24 transcription factors activate the neurofilament light gene promoter in P19 embryonal carcinoma cells by POSPELOV, V. A, POSPELOVA, T. V, JULIEN, J.-P

“…Changes in the neuronal content of neurofilament proteins occur in some neuropathological conditions, but little is known about the molecular mechanisms that…”
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New insulin-competent adenylate cyclase signaling system as putative mechanism of antiapoptotic effect of insulin and insulin-like growth factor I by Plesneva, S A, Pospelova, T V, Kuznetsova, L A, Bykova, T V, Shpakov, A O, Pertseva, M N

“…(ProQuest: Abstract omitted; see image)[PUBLICATION ABSTRACT]…”
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