Search Results - "Posner, G."

Multimerin-1 and cancer: a review by Posner, Mareike G

“…Multimerin-1 (MMRN1) is a platelet protein with a role in haemostasis and coagulation. It is also present in endothelial cells (ECs) and the extracellular…”
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Using both qualitative and quantitative data in parameter identification for systems biology models by Mitra, Eshan D., Dias, Raquel, Posner, Richard G., Hlavacek, William S.

“…In systems biology, qualitative data are often generated, but rarely used to parameterize models. We demonstrate an approach in which qualitative and…”
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Case Study: Using H5P to design and deliver interactive laboratory practicals by Unsworth, Amanda J, Posner, Mareike G

“…We describe the use of HTML5P (H5P) content collaboration framework to deliver an interactive, online alternative to an assessed laboratory practical on the…”
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Daily Forecasting of Regional Epidemics of Coronavirus Disease with Bayesian Uncertainty Quantification, United States by Lin, Yen Ting, Neumann, Jacob, Miller, Ely F, Posner, Richard G, Mallela, Abhishek, Safta, Cosmin, Ray, Jaideep, Thakur, Gautam, Chinthavali, Supriya, Hlavacek, William S

“…To increase situational awareness and support evidence-based policymaking, we formulated a mathematical model for coronavirus disease transmission within a…”
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Targeting the tumor microenvironment in cancer: why hyaluronidase deserves a second look by Whatcott, Clifford J, Han, Haiyong, Posner, Richard G, Hostetter, Galen, Von Hoff, Daniel D

“…Increased extracellular matrix (ECM) deposition is a characteristic observed in many solid tumors. Increased levels of one ECM component-namely, hyaluronan…”
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Bayesian Inference of State-Level COVID-19 Basic Reproduction Numbers across the United States by Mallela, Abhishek, Neumann, Jacob, Miller, Ely F, Chen, Ye, Posner, Richard G, Lin, Yen Ting, Hlavacek, William S

“…Although many persons in the United States have acquired immunity to COVID-19, either through vaccination or infection with SARS-CoV-2, COVID-19 will pose an…”
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Clinical study of genomic drivers in pancreatic ductal adenocarcinoma by Barrett, Michael T, Deiotte, Ray, Lenkiewicz, Elizabeth, Malasi, Smriti, Holley, Tara, Evers, Lisa, Posner, Richard G, Jones, Timothy, Han, Haiyong, Sausen, Mark, Velculescu, Victor E, Drebin, Jeffrey, O'Dwyer, Peter, Jameson, Gayle, Ramanathan, Ramesh K, Von Hoff, Daniel D

“…Background: Pancreatic ductal adenocarcinoma (PDA) is a lethal cancer with complex genomes and dense fibrotic stroma. This study was designed to identify…”
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The Benefits of Using Case Study Focussed, Problem Based Learning Approaches to Unit Design for Biomedical Science Students by Posner, Mareike G, Dempsey, Nina C, Unsworth, Amanda J

“…As part of the Biomedical Sciences undergraduate degree course students are required to apply biological principles to the interpretation of clinical case…”
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Can community health workers improve adherence to highly active antiretroviral therapy in the USA? A review of the literature by Kenya, S, Chida, N, Symes, S, Shor‐Posner, G

“…Objectives Highly active antiretroviral therapy (HAART) has transformed HIV infection into a manageable chronic illness, yet AIDS mortality among ethnic…”
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PyBioNetFit and the Biological Property Specification Language by Mitra, Eshan D., Suderman, Ryan, Colvin, Joshua, Ionkov, Alexander, Hu, Andrew, Sauro, Herbert M., Posner, Richard G., Hlavacek, William S.

“…In systems biology modeling, important steps include model parameterization, uncertainty quantification, and evaluation of agreement with experimental…”
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Dissecting RAF Inhibitor Resistance by Structure-based Modeling Reveals Ways to Overcome Oncogenic RAS Signaling by Rukhlenko, Oleksii S, Khorsand, Fahimeh, Krstic, Aleksandar, Rozanc, Jan, Alexopoulos, Leonidas G, Rauch, Nora, Erickson, Keesha E, Hlavacek, William S, Posner, Richard G, Gómez-Coca, Silvia, Rosta, Edina, Fitzgibbon, Cheree, Matallanas, David, Rauch, Jens, Kolch, Walter, Kholodenko, Boris N

“…Clinically used RAF inhibitors are ineffective in RAS mutant tumors because they enhance homo- and heterodimerization of RAF kinases, leading to paradoxical…”
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Modeling cell line-specific recruitment of signaling proteins to the insulin-like growth factor 1 receptor by Erickson, Keesha E, Rukhlenko, Oleksii S, Shahinuzzaman, Md, Slavkova, Kalina P, Lin, Yen Ting, Suderman, Ryan, Stites, Edward C, Anghel, Marian, Posner, Richard G, Barua, Dipak, Kholodenko, Boris N, Hlavacek, William S

“…Receptor tyrosine kinases (RTKs) typically contain multiple autophosphorylation sites in their cytoplasmic domains. Once activated, these autophosphorylation…”
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Tumor-stromal interactions in pancreatic cancer by Whatcott, Clifford, Han, Haiyong, Posner, Richard G, Von Hoff, Daniel D

“…The tumor associated stroma has been described in recent years as being complicit in tumor growth in pancreatic cancer. The stroma hosts a variety of…”
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Skin cancer prevention: A possible role of 1,25dihydroxyvitamin D3 and its analogs by Dixon, K.M., Deo, S.S., Wong, G., Slater, M., Norman, A.W., Bishop, J.E., Posner, G.H., Ishizuka, S., Halliday, G.M., Reeve, V.E., Mason, R.S.

“…We previously reported that the natural hormone 1,25dihydroxyvitamin D3 (1,25(OH) 2D 3) protects human skin cells from ultraviolet radiation (UVR)-induced…”
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Use of Mechanistic Models to Integrate and Analyze Multiple Proteomic Datasets by Stites, Edward C., Aziz, Meraj, Creamer, Matthew S., Von Hoff, Daniel D., Posner, Richard G., Hlavacek, William S.

“…Proteins in cell signaling networks tend to interact promiscuously through low-affinity interactions. Consequently, evaluating the physiological importance of…”
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Quantification of early nonpharmaceutical interventions aimed at slowing transmission of Coronavirus Disease 2019 in the Navajo Nation and surrounding states (Arizona, Colorado, New Mexico, and Utah) by Miller, Ely F, Neumann, Jacob, Chen, Ye, Mallela, Abhishek, Lin, Yen Ting, Hlavacek, William S, Posner, Richard G

“…During an early period of the Coronavirus Disease 2019 (COVID-19) pandemic, the Navajo Nation, much like New York City, experienced a relatively high rate of…”
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Vitamin D metabolites and analogs induce lipoxygenase mRNA expression and activity as well as reactive oxygen species (ROS) production in human bone cell line by Somjen, D., Katzburg, S., Grafi-Cohen, M., Knoll, E., Sharon, O., Posner, G.H.

“…Vitamin D metabolites and its less-calcemic analogs (vitamin D compounds) are beneficial for bone and modulate cell growth and energy metabolism. We now…”
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Computational model for autophagic vesicle dynamics in single cells by Martin, Katie R., Barua, Dipak, Kauffman, Audra L., Westrate, Laura M., Posner, Richard G., Hlavacek, William S., MacKeigan, Jeffrey P.

“…Macroautophagy (autophagy) is a cellular recycling program essential for homeostasis and survival during cytotoxic stress. This process, which has an emerging…”
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RuleMonkey: software for stochastic simulation of rule-based models by Colvin, Joshua, Monine, Michael I, Gutenkunst, Ryan N, Hlavacek, William S, Von Hoff, Daniel D, Posner, Richard G

“…The system-level dynamics of many molecular interactions, particularly protein-protein interactions, can be conveniently represented using reaction rules,…”
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Comparative genomic analysis reveals 2-oxoacid dehydrogenase complex lipoylation correlation with aerobiosis in archaea by Borziak, Kirill, Posner, Mareike G, Upadhyay, Abhishek, Danson, Michael J, Bagby, Stefan, Dorus, Steve

“…Metagenomic analyses have advanced our understanding of ecological microbial diversity, but to what extent can metagenomic data be used to predict the…”
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