Search Results - "Posma, Jens J."

Roles of Coagulation Proteases and PARs (Protease-Activated Receptors) in Mouse Models of Inflammatory Diseases by Posma, Jens J, Grover, Steven P, Hisada, Yohei, Owens, A Phillip, Antoniak, Silvio, Spronk, Henri M, Mackman, Nigel

“…Activation of the blood coagulation cascade leads to fibrin deposition and platelet activation that are required for hemostasis. However, aberrant activation…”
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Targeting Coagulation Factor Xa Promotes Regression of Advanced Atherosclerosis in Apolipoprotein-E Deficient Mice by Posthuma, Jelle J., Posma, Jens J. N., van Oerle, Rene, Leenders, Peter, van Gorp, Rick H., Jaminon, Armand M. G., Mackman, Nigel, Heitmeier, Stefan, Schurgers, Leon J., ten Cate, Hugo, Spronk, Henri M. H.

“…Atherosclerosis is a progressive inflammatory vascular disorder, complicated by plaque rupture and subsequently atherothrombosis. In vitro studies indicate…”
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Differential roles of factors IX and XI in murine placenta and hemostasis under conditions of low tissue factor by Grover, Steven P., Schmedes, Clare M., Auriemma, Alyson C., Butler, Emily, Parrish, Molly L., Miszta, Adam, Cleuren, Audrey C., Visser, Mayken, Heitmeier, Stefan, Posma, Jens J., Spronk, Henri M., Antoniak, Silvio, Wolberg, Alisa S., Pawlinski, Rafal, Gailani, David, Mackman, Nigel

“…The intrinsic tenase complex (FIXa-FVIIIa) of the intrinsic coagulation pathway and, to a lesser extent, thrombin-mediated activation of FXI, are necessary to…”
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Effect of combining aspirin and rivaroxaban on atherosclerosis in mice by Grover, Steven P., Coughlin, Taylor, Fleifil, Salma M., Posma, Jens J.N., Spronk, Henri H.M., Heitmeier, Stefan, Owens, A. Phillip, Mackman, Nigel

“…The platelet inhibitor aspirin reduces inflammation and atherosclerosis in both apolipoprotein E deficient (apoE−/−) mice and low-density lipoprotein receptor…”
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Pleiotropic, Cellular Effects of Rivaroxaban on Autophagy Explain Atheroprotective Effects by Posma, Jens J N, Sluimer, Judith C

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Protease-activated receptors are potential regulators in the development of arterial endofibrosis in high-performance athletes by Posthuma, Jelle J., Posma, Jens J.N., Schep, Goof, Bender, Mart M.H., van Oerle, Rene, van der Wal, Allard C., ten Cate, Hugo, Spronk, Henri M.H.

“…High-performance athletes can develop symptomatic arterial flow restriction during exercise caused by endofibrosis. The pathogenesis is poorly understood;…”
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Thrombin-mediated activation of PAR1 enhances doxorubicin-induced cardiac injury in mice by Grover, Steven P., Bharathi, Vanthana, Posma, Jens J., Griffin, John H., Palumbo, Joseph S., Mackman, Nigel, Antoniak, Silvio

“…•Cardiomyocyte and cardiac fibroblast PAR1 contribute to doxorubicin-induced cardiac injury.•PAR1 cleavage at R41 confers pathologic Galphaq signaling during…”
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Effects of storage and leukocyte reduction on the concentration and procoagulant activity of extracellular vesicles in canine packed red cells by Avenick, Daniel, Kidd, Linda, Istvan, Stephanie, Dong, Fanglong, Richter, Keith, Edwards, Nicole, Hisada, Yohei, Posma, Jens J.N., Massih, Cherein Abdel, Mackman, Nigel

“…Objectives To characterize the size and procoagulant activity of extracellular vesicles (EV) that accumulate in canine packed red blood cells (pRBCs) over time…”
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Roles of Coagulation Proteases and Protease-activated Receptors in Mouse Models of Inflammatory Diseases by Posma, Jens J, Grover, Steven P, Hisada, Yohei, Owens, A. Phillip, Antoniak, Silvio, Spronk, Henri M, Mackman, Nigel

“…Activation of the blood coagulation cascade leads to fibrin deposition and platelet activation that are required for hemostasis. However, aberrant activation…”
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Abstract 328: Coagulation Proteases are Potential Regulators in the Development of Exercise-Related Endofibrosis by Posthuma, Jelle J, Posma, Jens J, Schep, Goof, Bender, Mart, van Oerle, Rene, ten Cate, Hugo, Spronk, Henri M

“…Abstract only Background: High performance athletes can develop symptomatic arterial flow restriction during exercise, caused by endofibrosis. The disease is…”
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Abstract 599: Exposure to Biodiesel Exhaust Triggers Atherosclerotic Plaque Destabilisation through Increased Apoptosis of Vascular Smooth Muscle Cells in the Arterial Vessel Wall by Posma, Jens J, Kilinç, Evrin, Borissoff, Julian I, Haegens, Astrid, Jedynska, Aleksandra D, Ten Cate, Hugo, Kooter, Ingeborg M, Spronk, Henri M

“…Abstract only Introduction: Long-term exposure to air pollutants increases cardiovascular morbidity and mortality. Particulate matter (PM) derived from diesel…”
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