Effect of ovariohysterectomy on canine postsurgical leukocyte function

The effect of surgery on phagocytic activity of blood leukocytes and mitogen-induced blastogenesis of lymphocytes was studied in fourteen dogs. Simple ovariohysterectomy with anaesthesia induced by ketamine and xylazine or by ketamine, xylazine and halothane caused a short nonsignificant depression...

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Bibliographic Details
Published in:	Acta veterinaria Hungarica (Budapest. 1983) Vol. 51; no. 2; pp. 219 - 227
Main Authors:	Mojzisová, Jana, Hromada, R, Valocký, I, Paulík, S, Hipíková, Vlasta, Bajová, Viera, Posiváková, Serena, Bugarský, A
Format:	Journal Article
Language:	English
Published:	Hungary Akadémiai Kiadó 01-01-2003
Subjects:	Adrenergic alpha-Antagonists - administration & dosage Adrenergic alpha-Antagonists - adverse effects Anesthetics, Dissociative - administration & dosage Anesthetics, Dissociative - adverse effects Anesthetics, Inhalation - administration & dosage Anesthetics, Inhalation - adverse effects Animals Dogs Female Halothane - administration & dosage Halothane - adverse effects Hysterectomy - adverse effects Hysterectomy - veterinary Ketamine - administration & dosage Ketamine - adverse effects Leukocyte Count Leukocytes - drug effects Leukocytes - immunology Ovariectomy - adverse effects Ovariectomy - veterinary Phagocytosis - drug effects Xylazine - administration & dosage Xylazine - adverse effects
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Summary:	The effect of surgery on phagocytic activity of blood leukocytes and mitogen-induced blastogenesis of lymphocytes was studied in fourteen dogs. Simple ovariohysterectomy with anaesthesia induced by ketamine and xylazine or by ketamine, xylazine and halothane caused a short nonsignificant depression of phagocytic activity that persisted for four hours after surgery. Ingestion capacity of leukocytes decreased significantly immediately after surgery. Mitogen-induced blastogenesis of lymphocytes was depressed significantly in the first 48 hours and despite partial recovery this parameter did not reach the value of the control groups until the end of observation (7 days). A more conspicuous decrease of blastogenic response of blood lymphocytes to mitogens was found after the use of ketamine and xylazine in a dose maintaining anaesthesia. Anaesthesia with ketamine and xylazine in the lower dose and maintained with halothane resulted in a later improvement of the blastogenic response of lymphocytes.
Bibliography:	http://dx.doi.org/10.1556%2FAVet.51.2003.2.10 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0236-6290 1588-2705
DOI:	10.1556/AVet.51.2003.2.10