Search Results - "Posavad, C M"

Tipping the scales of herpes simplex virus reactivation: The important responses are local by Posavad, Christine M, Koelle, David M, Corey, Lawrence

“…Herpes simplex viruses type 1 (HSV-1) and 2 (HSV-2) establish life-long latent and persistent infections in neural tissue after initial contact of infectious…”
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Enrichment of herpes simplex virus type 2 (HSV-2) reactive mucosal T cells in the human female genital tract by Posavad, C M, Zhao, L, Dong, L, Jin, L, Stevens, C E, Magaret, A S, Johnston, C, Wald, A, Zhu, J, Corey, L, Koelle, D M

“…Local mucosal cellular immunity is critical in providing protection from HSV-2. To characterize and quantify HSV-2-reactive mucosal T cells, lymphocytes were…”
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Persistence of mucosal T-cell responses to herpes simplex virus type 2 in the female genital tract by Posavad, C M, Zhao, L, Mueller, D E, Stevens, C E, Huang, M L, Wald, A, Corey, L

“…Relatively little is known about the human T-cell response to herpes simplex virus type 2 (HSV-2) in the female genital tract, a major site of heterosexual…”
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High frequency of CD8+ cytotoxic T-lymphocyte precursors specific for herpes simplex viruses in persons with genital herpes by Posavad, C M, Koelle, D M, Corey, L

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Chronic Vulvar Ulceration in an Immunocompetent Woman Due to Acyclovir-Resistant, Thymidine Kinase-Deficient Herpes Simplex Virus by Swetter, Susan M., Hill, Edgar L., Kern, Earl R., Koelle, David M., Posavad, Christine M., Lawrence, Wendell, Safrin, Sharon

“…A 34-year-old healthy woman presented with a 15-month history of persistent, nonhealing vulvar ulcerations due to herpes simplex virus (HSV) type 2. Extensive…”
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Frequent reactivation of herpes simplex virus among HIV-1-infected patients treated with highly active antiretroviral therapy by Posavad, Christine M., Wald, Anna, Kuntz, Steven, Huang, Meei Li, Selke, Stacy, Krantz, Elizabeth, Corey, Lawrence

“…The effect of highly active antiretroviral therapy (HAART) on control of herpes simplex virus (HSV) in human immunodeficiency virus (HIV) type 1-infected…”
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Herpes simplex virus-infected human fibroblasts are resistant to and inhibit cytotoxic T-lymphocyte activity by POSAVAD, C. M, ROSENTHAL, K. L

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Clearance of HSV-2 from recurrent genital lesions correlates with infiltration of HSV-specific cytotoxic T lymphocytes by Koelle, D M, Posavad, C M, Barnum, G R, Johnson, M L, Frank, J M, Corey, L

“…The mechanisms involved in host clearance of symptomatic mucocutaneous herpes simplex virus (HSV) infection are unclear. We studied the functional properties…”
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Infection and inhibition of human cytotoxic T lymphocytes by herpes simplex virus by POSAVAD, C. M, NEWTON, J. J, ROSENTHAL, K. L

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T Cell Immunity to Herpes Simplex Viruses in Seronegative Subjects: Silent Infection or Acquired Immunity? by Posavad, Christine M, Wald, Anna, Hosken, Nancy, Huang, Meei Li, Koelle, David M, Ashley, Rhoda L, Corey, Lawrence

“…During the course of investigating T cell responses to HSV among volunteers entering trials of investigational genital herpes vaccines, 6 of the 24…”
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Inhibition of human CTL-mediated lysis by fibroblasts infected with herpes simplex virus by Posavad, CM, Newton, JJ, Rosenthal, KL

“…Previously, we demonstrated that human anti-HSV CTL and allo-antigen-specific CTL were inhibited in lysing their normally sensitive target cells when they were…”
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Severe Genital Herpes Infections in HIV-Infected Individuals with Impaired Herpes Simplex Virus-Specific CD8+Cytotoxic T Lymphocyte Responses by Posavad, Christine M., Koelle, David M., Shaughnessy, Mary F., Corey, Lawrence

“…The specific mechanisms underlying the varied susceptibility of HIV-infected (HIV+) individuals to opportunistic infections (OI) are still incompletely…”
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CTL Are Inactivated by Herpes Simplex Virus-Infected Cells Expressing a Viral Protein Kinase by Sloan, Derek D, Zahariadis, George, Posavad, Christine M, Pate, Nichlos T, Kussick, Steven J, Jerome, Keith R

“…Numerous cell-to-cell signals tightly regulate CTL function. Human fibroblasts infected with HSV type 1 or 2 can generate such a signal and inactivate human…”
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Long Term Persistence of Herpes Simplex Virus-Specific CD8+ CTL in Persons with Frequently Recurring Genital Herpes by Posavad, Christine M, Huang, Meei Li, Barcy, Serge, Koelle, David M, Corey, Lawrence

“…Herpes simplex virus (HSV) establishes a lifelong infection in humans. Reactivation of latent virus occurs intermittently so that the immune system is…”
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Search for Polymorphisms in the Genes for Herpesvirus Entry Mediator, Nectin-1, and Nectin-2 in Immune Seronegative Individuals by Struyf, Frank, Posavad, Christine M., Keyaerts, Els, Van Ranst, Marc, Corey, Lawrence, Spear, Patricia G.

“…Recently, individuals have been identified who possess T cell responses to herpes simplex virus (HSV) antigens despite the absence of detectable anti-HSV…”
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Long Term Persistence of Herpes Simplex Virus-Specific CD8 super(+) CTL in Persons with Frequently Recurring Genital Herpes by Posavad, C M, Li Huang, M, Barcy, S, Koelle, D M, Corey, L

“…Herpes simplex virus (HSV) establishes a lifelong infection in humans. Reactivation of latent virus occurs intermittently so that the immune system is…”
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High frequency of CD8 super(+) cytotoxic T-lymphocyte precursors specific for herpes simplex viruses in persons with genital herpes by Posavad, C M, Koelle, D M, Corey, L

“…Herpes simplex virus (HSV)-specific CD8 super(+) cytotoxic T lymphocytes (CTL) have rarely been detected in humans, presumably because of virus-induced…”
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Severe genital herpes infections in HIV-infected individuals with impaired herpes simplex virus-specific CD8 super(+) cytotoxic T lymphocyte responses by Posavad, C M, Koelle, D M, Shaughnessy, M F, Corey, L

“…The specific mechanisms underlying the varied susceptibility of HIV-infected (HIV+) individuals to opportunistic infections (OI) are still incompletely…”
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