Search Results - "Pos, Klaas M"

AcrB: a mean, keen, drug efflux machine by Kobylka, Jessica, Kuth, Miriam S., Müller, Reinke T., Geertsma, Eric R., Pos, Klaas M.

“…Gram‐negative bacteria are intrinsically resistant against cytotoxic substances by means of their outer membrane and a network of multidrug efflux systems,…”
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Allosteric drug transport mechanism of multidrug transporter AcrB by Tam, Heng-Keat, Foong, Wuen Ee, Oswald, Christine, Herrmann, Andrea, Zeng, Hui, Pos, Klaas M.

“…Gram-negative bacteria maintain an intrinsic resistance mechanism against entry of noxious compounds by utilizing highly efficient efflux pumps. The E. coli…”
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Structure, mechanism and cooperation of bacterial multidrug transporters by Du, Dijun, van Veen, Hendrik W, Murakami, Satoshi, Pos, Klaas M, Luisi, Ben F

“…•Structure-based mechanisms are available for five major classes of multi-drug transporters.•Three transporter classes form tripartite assemblies spanning the…”
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RND efflux pumps: structural information translated into function and inhibition mechanisms by Ruggerone, Paolo, Murakami, Satoshi, Pos, Klaas M, Vargiu, Attilio V

“…Efflux pumps of the Resistance Nodulation Division (RND) superfamily play a major role in the intrinsic and acquired resistance of Gram-negative pathogens to…”
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Transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB by Oswald, Christine, Tam, Heng-Keat, Pos, Klaas M.

“…The deployment of multidrug efflux pumps is a powerful defence mechanism for Gram-negative bacterial cells when exposed to antimicrobial agents. The major…”
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Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives by Sjuts, Hanno, Vargiu, Attilio V., Kwasny, Steven M., Nguyen, Son T., Kim, Hong-Suk, Ding, Xiaoyuan, Ornik, Alina R., Ruggerone, Paolo, Bowlin, Terry L., Nikaido, Hiroshi, Pos, Klaas M., Opperman, Timothy J.

“…The Escherichia coli AcrAB-TolC efflux pump is the archetype of the resistance nodulation cell division (RND) exporters from Gram-negative bacteria…”
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Tripartite assembly of RND multidrug efflux pumps by Daury, Laetitia, Orange, François, Taveau, Jean-Christophe, Verchère, Alice, Monlezun, Laura, Gounou, Céline, Marreddy, Ravi K. R., Picard, Martin, Broutin, Isabelle, Pos, Klaas M., Lambert, Olivier

“…Tripartite multidrug efflux systems of Gram-negative bacteria are composed of an inner membrane transporter, an outer membrane channel and a periplasmic…”
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Binding and Transport of Carboxylated Drugs by the Multidrug Transporter AcrB by Tam, Heng-Keat, Malviya, Viveka N., Foong, Wuen-Ee, Herrmann, Andrea, Malloci, Giuliano, Ruggerone, Paolo, Vargiu, Attilio V., Pos, Klaas M.

“…AcrAB(Z)-TolC is the main drug efflux transporter complex in Escherichia coli. The extrusion of various toxic compounds depends on several drug binding sites…”
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Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop by Eicher, Thomas, Cha, Hi-jea, Seeger, Markus A, Brandstätter, Lorenz, El-Delik, Jasmin, Bohnert, Jürgen A, Kern, Winfried V, Verrey, François, Grütter, Markus G, Diederichs, Kay, Pos, Klaas M

“…AcrAB-TolC is the major efflux protein complex in Escherichia coli extruding a vast variety of antimicrobial agents from the cell. The inner membrane component…”
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Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms by Ornik-Cha, Alina, Wilhelm, Julia, Kobylka, Jessica, Sjuts, Hanno, Vargiu, Attilio V., Malloci, Giuliano, Reitz, Julian, Seybert, Anja, Frangakis, Achilleas S., Pos, Klaas M.

“…Upon antibiotic stress Gram-negative pathogens deploy resistance-nodulation-cell division-type tripartite efflux pumps. These include a H + /drug antiporter…”
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Structural characterization of the EmrAB-TolC efflux complex from E. coli by Yousefian, Narek, Ornik-Cha, Alina, Poussard, Sylvie, Decossas, Marion, Berbon, Melanie, Daury, Laetitia, Taveau, Jean-Christophe, Dupuy, Jean-William, Đorđević-Marquardt, Selena, Lambert, Olivier, Pos, Klaas M.

“…Gram-negative bacteria export a large variety of antimicrobial compounds by forming two-membrane spanning tripartite multidrug efflux systems composed of an…”
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Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps by Plé, Coline, Tam, Heng-Keat, Vieira Da Cruz, Anais, Compagne, Nina, Jiménez-Castellanos, Juan-Carlos, Müller, Reinke T., Pradel, Elizabeth, Foong, Wuen Ee, Malloci, Giuliano, Ballée, Alexia, Kirchner, Moritz A., Moshfegh, Parisa, Herledan, Adrien, Herrmann, Andrea, Deprez, Benoit, Willand, Nicolas, Vargiu, Attilio Vittorio, Pos, Klaas M., Flipo, Marion, Hartkoorn, Ruben C.

“…Efflux transporters of the RND family confer resistance to multiple antibiotics in Gram-negative bacteria. Here, we identify and chemically optimize…”
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Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB by Eicher, Thomas, Seeger, Markus A, Anselmi, Claudio, Zhou, Wenchang, Brandstätter, Lorenz, Verrey, François, Diederichs, Kay, Faraldo-Gómez, José D, Pos, Klaas M

“…Membrane transporters of the RND superfamily confer multidrug resistance to pathogenic bacteria, and are essential for cholesterol metabolism and embryonic…”
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A natural prodrug activation mechanism in nonribosomal peptide synthesis by Reimer, Daniela, Pos, Klaas M, Thines, Marco, Grün, Peter, Bode, Helge B

“…Cleavage of peptide precursors is well known for ribosomally produced sequences. Investigation of xenocoumacin biosynthesis now points to a similar function in…”
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Crystal structure and mechanistic basis of a functional homolog of the antigen transporter TAP by Nöll, Anne, Thomas, Christoph, Herbring, Valentina, Zollmann, Tina, Barth, Katja, Mehdipour, Ahmad Reza, Tomasiak, Thomas M., Brüchert, Stefan, Joseph, Benesh, Abele, Rupert, Oliéric, Vincent, Wang, Meitian, Diederichs, Kay, Hummer, Gerhard, Stroud, Robert M., Pos, Klaas M., Tampé, Robert

“…ABC transporters form one of the largest protein superfamilies in all domains of life, catalyzing the movement of diverse substrates across membranes. In this…”
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Structural Asymmetry of AcrB Trimer Suggests a Peristaltic Pump Mechanism by Seeger, Markus A, Schiefner, André, Eicher, Thomas, Verrey, François, Diederichs, Kay, Pos, Klaas M

“…The AcrA/AcrB/TolC complex spans the inner and outer membranes of Escherichia coli and serves as its major drug-resistance pump. Driven by the proton motive…”
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Dynamics of Intact MexAB-OprM Efflux Pump: Focusing on the MexA-OprM Interface by López, Cesar A., Travers, Timothy, Pos, Klaas M., Zgurskaya, Helen I., Gnanakaran, S.

“…Antibiotic efflux is one of the most critical mechanisms leading to bacterial multidrug resistance. Antibiotics are effluxed out of the bacterial cell by a…”
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Cytochrome c Oxidase Biogenesis and Metallochaperone Interactions: Steps in the Assembly Pathway of a Bacterial Complex by Schimo, Sonja, Wittig, Ilka, Pos, Klaas M, Ludwig, Bernd

“…Biogenesis of mitochondrial cytochrome c oxidase (COX) is a complex process involving the coordinate expression and assembly of numerous subunits (SU) of dual…”
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Update on the Discovery of Efflux Pump Inhibitors against Critical Priority Gram-Negative Bacteria by Compagne, Nina, Vieira Da Cruz, Anais, Müller, Reinke T, Hartkoorn, Ruben C, Flipo, Marion, Pos, Klaas M

“…Antimicrobial resistance (AMR) has become a major problem in public health leading to an estimated 4.95 million deaths in 2019. The selective pressure caused…”
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Switch Loop Flexibility Affects Substrate Transport of the AcrB Efflux Pump by Müller, Reinke T., Travers, Timothy, Cha, Hi-jea, Phillips, Joshua L., Gnanakaran, S., Pos, Klaas M.

“…The functionally important switch loop of the trimeric multidrug transporter AcrB separates the access and deep drug binding pockets in every protomer. This…”
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