Search Results - "Portugal, Jose"

Mithramycin and its analogs: Molecular features and antitumor action by Portugal, José

“…The antitumor antibiotic mithramycin A (MTA) binds to G/C-rich DNA sequences in the presence of dications. MTA inhibits transcription regulated by the Sp1…”
Get full text

Challenging transcription by DNA-binding antitumor drugs by Portugal, José

“…[Display omitted] Cancer has been associated with altered gene expression. Therefore, transcription and its regulation by transcription factors are considered…”
Get full text

Sp1 transcription factor: A long-standing target in cancer chemotherapy by Vizcaíno, Carolina, Mansilla, Sylvia, Portugal, José

“…Sp1 (specificity protein 1) is a well-known member of a family of transcription factors that also includes Sp2, Sp3 and Sp4, which are implicated in an ample…”
Get full text

Insights into DNA‐drug interactions in the era of omics by Portugal, José

“…Despite the rise of sophisticated new targeting strategies in cancer chemotherapy, many classic DNA‐binding drugs remain on the front line of the therapy…”
Get full text

Noncovalent Binding to DNA: Still a Target in Developing Anticancer Agents by Portugal, José, Barceló, Francisca

“…DNA-binding compounds are of extraordinary importance in medicine, accounting for a substantial portion of antitumor drugs in clinical usage. However, their…”
Get more information

Mechanisms of drug-induced mitotic catastrophe in cancer cells by Portugal, José, Mansilla, Sylvia, Bataller, Marc

“…Mitotic catastrophe is a mechanism of cell death characterized by the occurrence of aberrant mitosis with the formation of large cells that contain multiple…”
Get more information

Toxicity of airborne nanoparticles: Facts and challenges by Portugal, José, Bedia, Carmen, Amato, Fulvio, Juárez-Facio, Ana T., Stamatiou, Rodopi, Lazou, Antigone, Campiglio, Chiara E., Elihn, Karine, Piña, Benjamin

“…•Air pollution is the most significant environmental risk factor for living organisms.•Airborne Nanoparticles (NP < 100 nm) harm the respiratory,…”
Get full text

Perspectives on the Use of Toxicogenomics to Assess Environmental Risk by Portugal, José, Mansilla, Sylvia, Piña, Benjamin

“…Environmental toxicogenomics aims to collect, analyze and interpret data on changes in gene expression and protein activity resulting from exposure to toxic…”
Get full text

Linking the use of reclaimed water to indicators of crop stress by metabolomic and transcriptomic analyses. A tool to compare water irrigation quality by Mansilla, Sylvia, Escolà, Mònica, Piña, Benjamin, Portugal, José, Iakovides, Iakovos C, Beretsou, Vasiliki G, Christou, Anastasis, Fatta-Kassinos, Despo, Bayona, Josep M, Matamoros, Víctor

“…The occurrence of contaminants of emerging concern (CECs) or heavy metals in reclaimed water used for agricultural irrigation may affect crop morphology and…”
Get full text

Transport-related airborne nanoparticles: Sources, different aerosol modes, and their toxicity by Vouitsis, Ilias, Portugal, José, Kontses, Anastasios, Karlsson, Hanna L., Faria, Melissa, Elihn, Karine, Juárez-Facio, Ana Teresa, Amato, Fulvio, Piña, Benjamin, Samaras, Zisis

“…Nanoparticle emissions from transport are of considerable importance because of their dominance in terms of particle number concentration in most urban…”
Get full text

Chemotherapeutic targeting of cell death pathways by Mansilla, Sylvia, Llovera, Laia, Portugal, Jose

“…Cell death plays an important role in cancer growth and progression, as well as in the efficiency of chemotherapy. Although apoptosis is commonly regarded as…”
Get more information

Toxicity and health effects of ultrafine particles: Towards an understanding of the relative impacts of different transport modes by Vallabani, N.V. Srikanth, Gruzieva, Olena, Elihn, Karine, Juárez-Facio, Ana Teresa, Steimer, Sarah S., Kuhn, Jana, Silvergren, Sanna, Portugal, José, Piña, Benjamin, Olofsson, Ulf, Johansson, Christer, Karlsson, Hanna L.

“…Exposure to particulate matter (PM) has been associated with a wide range of adverse health effects, but it is still unclear how particles from various…”
Get full text

Sedation practices and clinical outcomes in mechanically ventilated patients in a prospective multicenter cohort by Aragón, Romina E, Proaño, Alvaro, Mongilardi, Nicole, de Ferrari, Aldo, Herrera, Phabiola, Roldan, Rollin, Paz, Enrique, Jaymez, Amador A, Chirinos, Eduardo, Portugal, Jose, Quispe, Rocio, Brower, Roy G, Checkley, William

“…We sought to study the association between sedation status, medications (benzodiazepines, opioids, and antipsychotics), and clinical outcomes in a…”
Get full text

MALDI-TOF analysis of blood serum proteome can predict the presence of monoclonal gammopathy of undetermined significance by Barceló, Francisca, Gomila, Rosa, de Paul, Ivan, Gili, Xavier, Segura, Jaume, Pérez-Montaña, Albert, Jimenez-Marco, Teresa, Sampol, Antonia, Portugal, José

“…Monoclonal gammopathy of undetermined significance (MGUS) is a plasma cell dyscrasia that can progress to malignant multiple myeloma (MM). Specific molecular…”
Get full text

Compounds of emerging concern as new plant stressors linked to water reuse and biosolid application in agriculture by Mansilla, Sylvia, Portugal, José, Bayona, Josep M., Matamoros, Victor, Leiva, Ana María, Vidal, Gladys, Piña, Benjamin

“…Global crop production is limited by water, nitrogen, and phosphorous availability. Reclaimed water and organic fertilizers, such as crop residues, animal…”
Get full text

Genome-wide modulation of gene transcription in ovarian carcinoma cells by a new mithramycin analogue by Vizcaíno, Carolina, Núñez, Luz-Elena, Morís, Francisco, Portugal, José

“…Ovarian cancer has a poor prognosis due to intrinsic or acquired resistance to some cytotoxic drugs, raising the interest in new DNA-binding agents such as…”
Get full text

The pathogenic potential of Campylobacter concisus strains associated with chronic intestinal diseases by Kaakoush, Nadeem O, Deshpande, Nandan P, Wilkins, Marc R, Tan, Chew Gee, Burgos-Portugal, Jose A, Raftery, Mark J, Day, Andrew S, Lemberg, Daniel A, Mitchell, Hazel

“…Campylobacter concisus has garnered increasing attention due to its association with intestinal disease, thus, the pathogenic potential of strains isolated…”
Get full text

Sp1 transcription factor as a target for anthracyclines: Effects on gene transcription by Mansilla, Sylvia, Portugal, José

“…The analysis of how anthracyclines interfere with DNA–protein complexes, and the evaluation of their effects on gene transcription, can promote the development…”
Get full text

Apoptotic-like death occurs through a caspase-independent route in colon carcinoma cells undergoing mitotic catastrophe by Llovera, Laia, Mansilla, Sylvia, Portugal, José

“…Abstract We have examined the relationship between chemotherapy-induced mitotic catastrophe and cell death by apoptosis in both wild-type and p53(−/−) HCT116…”
Get full text

A nuclear budding mechanism in transiently arrested cells generates drug-sensitive and drug-resistant cells by Mansilla, Sylvia, Bataller, Marc, Portugal, José

“…HCT116 (p53 +/+) human colon carcinoma cells treated with nanomolar concentrations of doxorubicin underwent transient senescence, synthesized DNA, showed…”
Get full text