Search Results - "Portoles, Pilar"

Differential effects of the second SARS-CoV-2 mRNA vaccine dose on T cell immunity in naive and COVID-19 recovered individuals by Lozano-Ojalvo, Daniel, Camara, Carmen, Lopez-Granados, Eduardo, Nozal, Pilar, del Pino-Molina, Lucía, Bravo-Gallego, Luz Yadira, Paz-Artal, Estela, Pion, Marjorie, Correa-Rocha, Rafael, Ortiz, Alberto, Lopez-Hoyos, Marcos, Iribarren, Marta Erro, Portoles, Jose, Rojo-Portoles, Maria Pilar, Ojeda, Gloria, Cervera, Isabel, Gonzalez-Perez, Maria, Bodega-Mayor, Irene, Montes-Casado, Maria, Portoles, Pilar, Perez-Olmeda, Mayte, Oteo, Jesus, Sanchez-Tarjuelo, Rodrigo, Pothula, Venu, Schwarz, Megan, Brahmachary, Manisha, Tan, Anthony Tanoto, Le Bert, Nina, Berin, Cecilia, Bertoletti, Antonio, Guccione, Ernesto, Ochando, Jordi

“…The rapid development of mRNA-based vaccines against the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) led to the design of accelerated…”
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The PI-3-Kinase P110α Catalytic Subunit of T Lymphocytes Modulates Collagen-Induced Arthritis by Montes-Casado, María, Ojeda, Gloria, Criado, Gabriel, Rojo, José M, Portolés, Pilar

“…The phosphatidylinositol 3-kinase (PI3K) family of enzymes plays a determinant role in inflammation and autoimmune responses. However, the implication of the…”
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PI3-Kinase p110α Deficiency Modulates T Cell Homeostasis and Function and Attenuates Experimental Allergic Encephalitis in Mature Mice by Rojo, José M., Montes-Casado, María, Aragoneses-Fenoll, Laura, Ojeda, Gloria, Dianzani, Umberto, Portolés, Pilar

“…Class I phosphoinositide 3-kinases (PI3K) are involved in the development of normal and autoimmune responses, including Experimental Autoimmune…”
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Role of endocytosis and trans‐endocytosis in ICOS costimulator‐induced downmodulation of the ICOS Ligand by Aragoneses‐Fenoll, Laura, Montes‐Casado, María, Ojeda, Gloria, García‐Paredes, Lucía, Arimura, Yutaka, Yagi, Junji, Dianzani, Umberto, Portolés, Pilar, Rojo, José M.

“…The interaction between the T‐lymphocyte costimulatory molecule ICOS and its ligand (ICOS‐L) is needed for efficient immune responses, but expression levels…”
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CD28 is expressed by macrophages with anti‐inflammatory potential and limits their T‐cell activating capacity by Estrada‐Capetillo, Lizbeth, Aragoneses‐Fenoll, Laura, Domínguez‐Soto, Ángeles, Fuentelsaz‐Romero, Sara, Nieto, Concha, Simón‐Fuentes, Miriam, Alonso, Bárbara, Portolés, Pilar, Corbí, Angel L., Rojo, Jose M., Puig‐Kröger, Amaya

“…CD28 expression is generally considered to be T lymphocyte specific. We have previously shown CD28 mRNA expression in M‐CSF‐dependent anti‐inflammatory…”
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T-Cell-Specific Loss of the PI-3-Kinase p110α Catalytic Subunit Results in Enhanced Cytokine Production and Antitumor Response by Aragoneses-Fenoll, Laura, Ojeda, Gloria, Montes-Casado, María, Acosta-Ampudia, Yeny, Dianzani, Umberto, Portolés, Pilar, Rojo, José M

“…Class IA phosphatidylinositol 3-kinase (PI3K) catalytic subunits p110α and p110δ are targets in cancer therapy expressed at high levels in T lymphocytes. The…”
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Development of Potent Cellular and Humoral Immune Responses in Long-Term Hemodialysis Patients After 1273-mRNA SARS-CoV-2 Vaccination by Gonzalez-Perez, Maria, Montes-Casado, Maria, Conde, Patricia, Cervera, Isabel, Baranda, Jana, Berges-Buxeda, Marcos J, Perez-Olmeda, Mayte, Sanchez-Tarjuelo, Rodrigo, Utrero-Rico, Alberto, Lozano-Ojalvo, Daniel, Torre, Denis, Schwarz, Megan, Guccione, Ernesto, Camara, Carmen, Llópez-Carratalá, M Rosario, Gonzalez-Parra, Emilio, Portoles, Pilar, Ortiz, Alberto, Portoles, Jose, Ochando, Jordi

“…Long-term hemodialysis (HD) patients are considered vulnerable and at high-risk of developing severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2)…”
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Characteristics of TCR/CD3 complex CD3ε chains of regulatory CD4+ T (Treg) lymphocytes: role in Treg differentiation in vitro and impact on Treg in vivo by Jose M. Rojo, Gloria Ojeda, Yenny Y. Acosta, Maria Montes-Casado, Gabriel Criado, Pilar Portolés

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The TCR/CD3 complex: opening the gate to successful vaccination by Portolés, Pilar, Rojo, Jose M

“…The success of vaccination is directly or indirectly based on the specificity of antigen recognition by T lymphocytes, their efficient activation and…”
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CD4+ICOS+ T lymphocytes inhibit T cell activation ‘in vitro’ and attenuate autoimmune encephalitis ‘in vivo’ by Rojo, Jose M., Pini, Eliana, Ojeda, Gloria, Bello, Raquel, Dong, Chen, Flavell, Richard A., Dianzani, Umberto, Portolés, Pilar

“…The inducible co-stimulator (ICOS, CD278) is essential to the efficient development of normal and pathological immune reactions. Since ICOS-deficient mice have…”
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Biased binding of class IA phosphatidyl inositol 3-kinase subunits to inducible costimulator (CD278) by Acosta, Yenny Y., Zafra, Maria Paz, Ojeda, Gloria, Bernardone, Ilaria Seren, Dianzani, Umberto, Portolés, Pilar, Rojo, Jose M.

“…To better understand T lymphocyte costimulation by inducible costimulator (ICOS; H4; CD278), we analyzed proteins binding to ICOS peptides phosphorylated at…”
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Complement regulatory protein Crry/p65 costimulation expands natural Treg cells with enhanced suppressive properties in proteoglycan‐induced arthritis by Ojeda, Gloria, Pini, Eliana, Eguiluz, César, Montes‐Casado, María, Broere, Femke, van Eden, Willem, Rojo, Jose M., Portolés, Pilar

“…Objective To investigate the costimulatory role of Crry/p65 (Crry), a membrane complement regulatory protein, on the expansion and function of natural Treg…”
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Loss of N-terminal charged residues of mouse CD3 epsilon chains generates isoforms modulating antigen T cell receptor-mediated signals and T cell receptor-CD3 interactions by Bello, Raquel, Feito, Maria Jose, Ojeda, Gloria, Portolés, Pilar, Rojo, Jose M

“…The antigen T cell receptor (TCR)-CD3 complexes present on the cell surface of CD4(+) T lymphocytes and T cell lines express CD3 epsilon chain isoforms with…”
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N-terminal negatively charged residues in CD3ε chains as a phylogenetically conserved trait potentially yielding isoforms with different isoelectric points: Analysis of human CD3ε chains by Bello, Raquel, Feito, Maria Jose, Ojeda, Gloria, Portolés, Pilar, Rojo, Jose M

“…Abstract CD3ε chains are essential to the structure, expression and signaling of T cell receptors. Here, we extend to human CD3ε our previous data in mouse…”
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An Immunological Approach to the Biocompatibility of Mesoporous SiO2-CaO Nanospheres by Montes-Casado, María, Sanvicente, Adrian, Casarrubios, Laura, Feito, María José, Rojo, José M., Vallet-Regí, María, Arcos, Daniel, Portolés, Pilar, Portolés, María Teresa

“…Mesoporous bioactive glass nanospheres (NanoMBGs) have high potential for clinical applications. However, the impact of these nanoparticles on the immune…”
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ICOS deficiency hampers the homeostasis, development and function of NK cells by Montes-Casado, María, Ojeda, Gloria, Aragoneses-Fenoll, Laura, López, Daniel, de Andrés, Belén, Gaspar, María Luisa, Dianzani, Umberto, Rojo, José M, Portolés, Pilar

“…Signaling through the inducible costimulator ICOS is required for the homeostasis and function of various immune cell populations, with an outstanding role in…”
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Crry/p65, a Membrane Complement Regulatory Protein, Has Costimulatory Properties on Mouse T Cells by Fernandez-Centeno, Elena, de Ojeda, Gloria, Rojo, Jose M, Portoles, Pilar

“…It is known that certain type I membrane molecules (complement receptors type 1 and 2) belonging to the regulators of complement activation (RCA) family are…”
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Maintenance of Potent Cellular and Humoral Immune Responses in Long-Term Hemodialysis Patients after 1273-mRNA SARS-CoV-2 Vaccination by Gonzalez-Perez, Maria, Baranda, Jana, Berges-Buxeda, Marcos J, Conde, Patricia, Pérez-Olmeda, Mayte, Lozano-Ojalvo, Daniel, Cámara, Carmen, Del Rosario Llópez-Carratalá, Maria, Gonzalez-Parra, Emilio, Portolés, Pilar, Ortiz, Alberto, Portoles, Jose, Ochando, Jordi

“…Continuous evaluation of the coronavirus disease 2019 (COVID-19) vaccine effectiveness in hemodialysis (HD) patients is critical in this immunocompromised…”
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Dissociation of actin polymerization and lipid raft accumulation by ligation of the Inducible Costimulator (ICOS, CD278) by Acosta, Yenny Y, Ojeda, Gloria, Zafra, Maria Paz, Bernardone, Ilaria Seren, Sánchez, Alejandra, Dianzani, Umberto, Portolés, Pilar, Rojo, Jose M

“…Abstract T lymphocyte antigen activation is facilitated by clustering of membrane glycosphingolipid-enriched microdomains (GEMs, lipid “rafts”) at the T…”
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T-cell receptor by Rojo, Jose M, Bello, Raquel, Portolés, Pilar

“…The T-cell antigen receptor complex (TCR/CD3) is a cell surface structure that defines the T lymphocyte lineage, where it fulfills two basic functions, namely…”
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