Protective effects of acerola juice on genotoxicity induced by iron in vivo

Metal ions such as iron can induce DNA damage by inducing reactive oxygen species (ROS) and oxidative stress. Vitamin C is one of the most widely consumed antioxidants worldwide, present in many fruits and vegetables, especially inMalpighia glabra L., popularly known as acerola, native to Brazil. Ac...

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Bibliographic Details
Published in:	Genetics and molecular biology Vol. 39; no. 1; pp. 122 - 128
Main Authors:	Horta, Roberta Nunes, Kahl, Vivian Francilia Silva, Sarmento, Merielen da Silva, Nunes, Marisa Fernanda Silva, Porto, Carem Rejane Maglione, Andrade, Vanessa Moraes de, Ferraz, Alexandre de Barros Falcão, Silva, Juliana Da
Format:	Journal Article
Language:	English
Published:	Brazil Sociedade Brasileira de Genética 01-03-2016
Subjects:	acerola juice BIOCHEMISTRY & MOLECULAR BIOLOGY comet assay GENETICS & HEREDITY genotoxicity iron micronucleus Mutagenesis genotoxicity iron micronucleus acerola juice comet assay
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Summary:	Metal ions such as iron can induce DNA damage by inducing reactive oxygen species (ROS) and oxidative stress. Vitamin C is one of the most widely consumed antioxidants worldwide, present in many fruits and vegetables, especially inMalpighia glabra L., popularly known as acerola, native to Brazil. Acerola is considered a functional fruit due to its high antioxidant properties and phenolic contents, and therefore is consumed to prevent diseases or as adjuvant in treatment strategies. Here, the influence of ripe and unripe acerola juices on iron genotoxicity was analyzed in vivo using the comet assay and micronucleus test. The comet assay results showed that acerola juice exerted no genotoxic or antigenotoxic activity. Neither ripe nor unripe acerola juices were mutagenic to animals treated with juices, in micronucleus test. However, when compared to iron group, the pre-treatment with acerola juices exerted antimutagenic activity, decreasing significantly micronucleus mean values in bone marrow. Stage of ripeness did not influence the interaction of acerola compounds with DNA, and both ripe and unripe acerola juices exerted protective effect over DNA damage generated by iron.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Shared authorship; both authors participated equally in all steps of the work.
ISSN:	1415-4757 1678-4685 1415-4757 1678-4685
DOI:	10.1590/1678-4685-gmb-2015-0157