Search Results - "Portman, Douglas S"

C. elegans Males Integrate Food Signals and Biological Sex to Modulate State-Dependent Chemosensation and Behavioral Prioritization by Wexler, Leigh R., Miller, Renee M., Portman, Douglas S.

“…Dynamic integration of internal and external cues is essential for flexible, adaptive behavior. In C. elegans, biological sex and feeding state regulate…”
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Sex, Age, and Hunger Regulate Behavioral Prioritization through Dynamic Modulation of Chemoreceptor Expression by Ryan, Deborah A., Miller, Renee M., Lee, KyungHwa, Neal, Scott J., Fagan, Kelli A., Sengupta, Piali, Portman, Douglas S.

“…Adaptive behavioral prioritization requires flexible outputs from fixed neural circuits. In C. elegans, the prioritization of feeding versus mate searching…”
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Sex-specificity of the C. elegans metabolome by Burkhardt, Russell N., Artyukhin, Alexander B., Aprison, Erin Z., Curtis, Brian J., Fox, Bennett W., Ludewig, Andreas H., Palomino, Diana Fajardo, Luo, Jintao, Chaturbedi, Amaresh, Panda, Oishika, Wrobel, Chester J. J., Baumann, Victor, Portman, Douglas S., Lee, Siu Sylvia, Ruvinsky, Ilya, Schroeder, Frank C.

“…Recent studies of animal metabolism have revealed large numbers of novel metabolites that are involved in all aspects of organismal biology, but it is unclear…”
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Timing mechanism of sexually dimorphic nervous system differentiation by Pereira, Laura, Aeschimann, Florian, Wang, Chen, Lawson, Hannah, Serrano-Saiz, Esther, Portman, Douglas S, Großhans, Helge, Hobert, Oliver

“…The molecular mechanisms that control the timing of sexual differentiation in the brain are poorly understood. We found that the timing of sexually dimorphic…”
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The Makorin lep-2 and the lncRNA lep-5 regulate lin-28 to schedule sexual maturation of the C. elegans nervous system by Lawson, Hannah, Vuong, Edward, Miller, Renee M, Kiontke, Karin, Fitch, David Ha, Portman, Douglas S

“…Sexual maturation must occur on a controlled developmental schedule. In mammals, Makorin3 ( ) and the miRNA regulators are key regulators of this process, but…”
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Neuter No More: Fly Stem Cells Know Their Sex by Portman, Douglas S., Biteau, Benoît

“…While sex differences in hormonal regulation of development and tissue maintenance are well established, the importance of genetic sex determination in adult…”
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Behavioral evolution: No sex please, we're hermaphrodites by Portman, Douglas S

“…Many 'hard-wired', innate animal behaviors are related to reproduction. So what happens when reproductive systems evolve? New research in nematodes has…”
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dmd-3, a doublesex-related gene regulated by tra-1, governs sex-specific morphogenesis in C. elegans by Mason, D Adam, Rabinowitz, Jeremy S, Portman, Douglas S

“…Although sexual dimorphism is ubiquitous in animals, the means by which sex determination mechanisms trigger specific modifications to shared structures is not…”
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Neural Sex Modifies the Function of a C. elegans Sensory Circuit by Lee, KyungHwa, Portman, Douglas S.

“…Though sex differences in animal behavior are ubiquitous, their neural and genetic underpinnings remain poorly understood. In particular, the role of…”
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Sex-specific, pdfr-1-dependent modulation of pheromone avoidance by food abundance enables flexibility in C. elegans foraging behavior by Luo, Jintao, Portman, Douglas S.

“…To make adaptive feeding and foraging decisions, animals must integrate diverse sensory streams with multiple dimensions of internal state. In C. elegans,…”
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Sexual modulation of sex‐shared neurons and circuits in Caenorhabditis elegans by Portman, Douglas S.

“…Studies using the nematode C. elegans have provided unique insights into the development and function of sex differences in the nervous system. Enabled by the…”
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Neural networks mapped in both sexes of the worm by Portman, Douglas S.

“…Understanding how the brain’s functions emerge from the workings of neural circuits is a central pursuit of neuroscience. New wiring diagrams of the nervous…”
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Genetic Control of Sex Differences in C. elegans Neurobiology and Behavior by Portman, Douglas S.

“…As a well‐characterized, genetically tractable animal, the nematode Caenorhabditis elegans is an ideal model to explore the connections between genes and the…”
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Multiple doublesex-related genes specify critical cell fates in a C. elegans male neural circuit by Siehr, Meagan S, Koo, Pamela K, Sherlekar, Amrita L, Bian, Xuelin, Bunkers, Meredith R, Miller, Renee M, Portman, Douglas S, Lints, Robyn

“…In most animal species, males and females exhibit differences in behavior and morphology that relate to their respective roles in reproduction. DM…”
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C. elegans males optimize mate-preference decisions via sex-specific responses to multimodal sensory cues by Luo, Jintao, Bainbridge, Chance, Miller, Renee M, Barrios, Arantza, Portman, Douglas S

“…For sexually reproducing animals, selecting optimal mates is important for maximizing reproductive fitness. In the nematode C. elegans, populations reproduce…”
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Developmental biology: A hole in the matrix by Portman, Douglas S., Díaz-Balzac, Carlos A.

“…Neurons must access the environment to gather information, but this exposure must be carefully managed. New work finds that glial cells, the non-neuronal…”
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Sex differences in behavioral decision-making and the modulation of shared neural circuits by Mowrey, William R, Portman, Douglas S

“…Animals prioritize behaviors according to their physiological needs and reproductive goals, selecting a single behavioral strategy from a repertoire of…”
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Sexual Dimorphism and Sex Differences in Caenorhabditis elegans Neuronal Development and Behavior by Barr, Maureen M, García, L Rene, Portman, Douglas S

“…As fundamental features of nearly all animal species, sexual dimorphisms and sex differences have particular relevance for the development and function of the…”
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Social and sexual behaviors in C. elegans: the first fifty years by Portman, Douglas S.

“…For the first 25 years after the landmark 1974 paper that launched the field, most C. elegans biologists were content to think of their subjects as solitary…”
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Two C. elegans DM domain proteins, DMD-3 and MAB-3, function in late stages of male somatic gonad development by Smith, Michele, Lesperance, Megan, Herrmann, Alyssa, Vernooy, Stephanie, Cherian, Asher, Kivlehan, Emily, Whipple, Lauren, Portman, Douglas S., Mason, D. Adam

“…To bring about sexual dimorphism in form, information from the sex determination pathway must trigger sex-specific modifications in developmental programs…”
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