Search Results - "Porth, Owen"

Local delivery of cell surface-targeted immunocytokines programs systemic antitumor immunity by Santollani, Luciano, Maiorino, Laura, Zhang, Yiming J., Palmeri, Joseph R., Stinson, Jordan A., Duhamel, Lauren R., Qureshi, Kashif, Suggs, Jack R., Porth, Owen T., Pinney, William, Msari, Riyam Al, Walsh, Agnes A., Wittrup, K. Dane, Irvine, Darrell J.

“…Systemically administered cytokines are potent immunotherapeutics but can cause severe dose-limiting toxicities. To overcome this challenge, cytokines have…”
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145 Preclinical development of EDIT-201, a multiplexed CRISPR-Cas12a gene edited healthy donor derived NK cells demonstrating improved persistence and resistance to the tumor microenvironment by Wong, Karrie, Sexton, Steven, Donahue, Kelly, Lincy Prem Antony, Wasko, Kevin, Nasser, Jared, Leary, Glenn, Pfautz, Amanda, Porth, Owen, Pierce, William, Sousa, Patricia, Scott, Sean, Wilson, Aaron, Chang, Kai-Hsin, Zuris, John, Wilson, Christopher, Morgan, Richard, Borges, Christopher

“…BackgroundNatural killer (NK) cells distinguish tumor from healthy tissue via multiple mechanisms, including recognition of stress ligands and loss of MHC…”
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