Search Results - "Portero, Vincent"

Electrophysiological Abnormalities in VLCAD Deficient hiPSC-Cardiomyocytes Can Be Improved by Lowering Accumulation of Fatty Acid Oxidation Intermediates by Knottnerus, Suzan J G, Mengarelli, Isabella, Wüst, Rob C I, Baartscheer, Antonius, Bleeker, Jeannette C, Coronel, Ruben, Ferdinandusse, Sacha, Guan, Kaomei, IJlst, Lodewijk, Li, Wener, Luo, Xiaojing, Portero, Vincent M, Ulbricht, Ying, Visser, Gepke, Wanders, Ronald J A, Wijburg, Frits A, Verkerk, Arie O, Houtkooper, Riekelt H, Bezzina, Connie R

“…Patients with very long-chain acyl-CoA dehydrogenase deficiency (VLCADD) can present with life-threatening cardiac arrhythmias. The pathophysiological…”
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Identification of Large Families in Early Repolarization Syndrome by Gourraud, Jean-Baptiste, MD, Le Scouarnec, Solena, PhD, Sacher, Frederic, MD, Chatel, Stéphanie, PhD, Derval, Nicolas, MD, Portero, Vincent, MS, Chavernac, Pascal, MD, Sandoval, Juan E., PhD, Mabo, Philippe, MD, PhD, Redon, Richard, PhD, Schott, Jean-Jacques, PhD, Le Marec, Hervé, MD, PhD, Haïssaguerre, Michel, MD, PhD, Probst, Vincent, MD, PhD

“…Objectives The aim of this study was to identify families affected by early repolarization syndrome (ERS) and to determine the mode of transmission of the…”
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KV4.3 Expression Modulates NaV1.5 Sodium Current by Portero, Vincent, Wilders, Ronald, Casini, Simona, Charpentier, Flavien, Verkerk, Arie O., Remme, Carol Ann

“…In cardiomyocytes, the voltage-gated transient outward potassium current (Ito) is responsible for the phase-1 repolarization of the action potential (AP)…”
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Functional Consequences of the SCN5A -p.Y1977N Mutation within the PY Ubiquitylation Motif: Discrepancy between HEK293 Cells and Transgenic Mice by Casini, Simona, Albesa, Maxime, Wang, Zizun, Portero, Vincent, Ross-Kaschitza, Daniela, Rougier, Jean-Sébastien, Marchal, Gerard A, Chung, Wendy K, Bezzina, Connie R, Abriel, Hugues, Remme, Carol Ann

“…Dysfunction of the cardiac sodium channel Nav1.5 (encoded by the gene) is associated with arrhythmias and sudden cardiac death. mutations associated with long…”
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Absence of Functional Nav1.8 Channels in Non-diseased Atrial and Ventricular Cardiomyocytes by Casini, Simona, Marchal, Gerard A., Kawasaki, Makiri, Nariswari, Fransisca A., Portero, Vincent, van den Berg, Nicoline W.E., Guan, Kaomei, Driessen, Antoine H.G., Veldkamp, Marieke W., Mengarelli, Isabella, de Groot, Joris R., Verkerk, Arie O., Remme, Carol Ann

“…Purpose Several studies have indicated a potential role for SCN10A /Na V 1.8 in modulating cardiac electrophysiology and arrhythmia susceptibility. However, by…”
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An Untethered Heart Rhythm Monitoring System with Automated AI‐Based Arrhythmia Detection for Closed‐Loop Experimental Application by Deng, Shanliang, den Ouden, Bram L, De Coster, Tim, Bart, Cindy I, Bax, Wilhelmina H, Poelma, René H, de Vries, Antoine AF, Zhang, Guo Qi, Portero, Vincent, Pijnappels, Daniël A

“…The heart produces bioelectrical signals, which can be measured as an electrocardiogram (ECG) for the detection of rhythm disturbances. Rapid and precise…”
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Electrophysiological Abnormalities in VLCAD Deficient hiPSC-Cardiomyocytes Do not Improve with Carnitine Supplementation by Verkerk, Arie O, Knottnerus, Suzan J G, Portero, Vincent, Bleeker, Jeannette C, Ferdinandusse, Sacha, Guan, Kaomei, IJlst, Lodewijk, Visser, Gepke, Wanders, Ronald J A, Wijburg, Frits A, Bezzina, Connie R, Mengarelli, Isabella, Houtkooper, Riekelt H

“…Patients with a deficiency in very long-chain acyl-CoA dehydrogenase (VLCAD), an enzyme that is involved in the mitochondrial beta-oxidation of long-chain…”
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Block copolymer/DNA vaccination induces a strong allergen-specific local response in a mouse model of house dust mite asthma by Rolland-Debord, Camille, Lair, David, Roussey-Bihouée, Tiphaine, Hassoun, Dorian, Evrard, Justine, Cheminant, Marie-Aude, Chesné, Julie, Braza, Faouzi, Mahay, Guillaume, Portero, Vincent, Sagan, Christine, Pitard, Bruno, Magnan, Antoine

“…Allergic asthma is caused by abnormal immunoreactivity against allergens such as house dust mites among which Dermatophagoides farinae (Der f) is a common…”
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Dysfunction of the Voltage‐Gated K+ Channel β2 Subunit in a Familial Case of Brugada Syndrome by Portero, Vincent, Le Scouarnec, Solena, Es‐Salah‐Lamoureux, Zeineb, Burel, Sophie, Gourraud, Jean‐Baptiste, Bonnaud, Stéphanie, Lindenbaum, Pierre, Simonet, Floriane, Violleau, Jade, Baron, Estelle, Moreau, Eléonore, Scott, Carol, Chatel, Stéphanie, Loussouarn, Gildas, O'Hara, Thomas, Mabo, Philippe, Dina, Christian, Le Marec, Hervé, Schott, Jean‐Jacques, Probst, Vincent, Baró, Isabelle, Marionneau, Céline, Charpentier, Flavien, Redon, Richard

“…Background The Brugada syndrome is an inherited cardiac arrhythmia associated with high risk of sudden death. Although 20% of patients with Brugada syndrome…”
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Microtubule plus-end tracking proteins: novel modulators of cardiac sodium channels and arrhythmogenesis by Marchal, Gerard A, Galjart, Niels, Portero, Vincent, Remme, Carol Ann

“…Abstract The cardiac sodium channel NaV1.5 is an essential modulator of cardiac excitability, with decreased NaV1.5 levels at the plasma membrane and…”
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Genetic Risk in Early Repolarization Syndrome by Schott, Jean-Jacques, Gourraud, Jean-Baptiste, Portero, Vincent, Le Scouarnec, Solena, Chavernac, Pascal, Mabo, Philippe, Sacher, Frederic, Haïssaguerre, Michel, Le Marec, Herve

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Optoelectronic control of cardiac rhythm: Toward shock‐free ambulatory cardioversion of atrial fibrillation by Portero, Vincent, Deng, Shanliang, Boink, Gerard J. J., Zhang, Guo Qi, Vries, Antoine, Pijnappels, Daniël A.

“…Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia, progressive in nature, and known to have a negative impact on mortality, morbidity, and…”
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Chronically elevated branched chain amino acid levels are pro-arrhythmic by Portero, Vincent, Nicol, Thomas, Podliesna, Svitlana, Marchal, Gerard A, Baartscheer, Antonius, Casini, Simona, Tadros, Rafik, Treur, Jorien L, Tanck, Michael W T, Cox, I Jane, Probert, Fay, Hough, Tertius A, Falcone, Sara, Beekman, Leander, Müller-Nurasyid, Martina, Kastenmüller, Gabi, Gieger, Christian, Peters, Annette, Kääb, Stefan, Sinner, Moritz F, Blease, Andrew, Verkerk, Arie O, Bezzina, Connie R, Potter, Paul K, Remme, Carol Ann

“…Abstract Aims Cardiac arrhythmias comprise a major health and economic burden and are associated with significant morbidity and mortality, including cardiac…”
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Testing the burden of rare variation in arrhythmia-susceptibility genes provides new insights into molecular diagnosis for Brugada syndrome by Le Scouarnec, Solena, Karakachoff, Matilde, Gourraud, Jean-Baptiste, Lindenbaum, Pierre, Bonnaud, Stéphanie, Portero, Vincent, Duboscq-Bidot, Laëtitia, Daumy, Xavier, Simonet, Floriane, Teusan, Raluca, Baron, Estelle, Violleau, Jade, Persyn, Elodie, Bellanger, Lise, Barc, Julien, Chatel, Stéphanie, Martins, Raphaël, Mabo, Philippe, Sacher, Frédéric, Haïssaguerre, Michel, Kyndt, Florence, Schmitt, Sébastien, Bézieau, Stéphane, Le Marec, Hervé, Dina, Christian, Schott, Jean-Jacques, Probst, Vincent, Redon, Richard

“…The Brugada syndrome (BrS) is a rare heritable cardiac arrhythmia disorder associated with ventricular fibrillation and sudden cardiac death. Mutations in the…”
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Targeting the Microtubule EB1-CLASP2 Complex Modulates Na V 1.5 at Intercalated Discs by Marchal, Gerard A, Jouni, Mariam, Chiang, David Y, Pérez-Hernández, Marta, Podliesna, Svitlana, Yu, Nuo, Casini, Simona, Potet, Franck, Veerman, Christiaan C, Klerk, Mischa, Lodder, Elisabeth M, Mengarelli, Isabella, Guan, Kaomei, Vanoye, Carlos G, Rothenberg, Eli, Charpentier, Flavien, Redon, Richard, George, Jr, Alfred L, Verkerk, Arie O, Bezzina, Connie R, MacRae, Calum A, Burridge, Paul W, Delmar, Mario, Galjart, Niels, Portero, Vincent, Remme, Carol Ann

“…[Figure: see text]…”
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RRAD mutation causes electrical and cytoskeletal defects in cardiomyocytes derived from a familial case of Brugada syndrome by Belbachir, Nadjet, Portero, Vincent, Al Sayed, Zeina R, Gourraud, Jean-Baptiste, Dilasser, Florian, Jesel, Laurence, Guo, Hongchao, Wu, Haodi, Gaborit, Nathalie, Guilluy, Christophe, Girardeau, Aurore, Bonnaud, Stephanie, Simonet, Floriane, Karakachoff, Matilde, Pattier, Sabine, Scott, Carol, Burel, Sophie, Marionneau, Céline, Chariau, Caroline, Gaignerie, Anne, David, Laurent, Genin, Emmanuelle, Deleuze, Jean-François, Dina, Christian, Sauzeau, Vincent, Loirand, Gervaise, Baró, Isabelle, Schott, Jean-Jacques, Probst, Vincent, Wu, Joseph C, Redon, Richard, Charpentier, Flavien, Le Scouarnec, Solena

“…Abstract Aims The Brugada syndrome (BrS) is an inherited cardiac disorder predisposing to ventricular arrhythmias. Despite considerable efforts, its genetic…”
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Optical ventricular cardioversion by local optogenetic targeting and LED implantation in a cardiomyopathic rat model by Nyns, Emile C A, Jin, Tianyi, Fontes, Magda S, van den Heuvel, Titus, Portero, Vincent, Ramsey, Catilin, Bart, Cindy I, Zeppenfeld, Katja, Schalij, Martin J, van Brakel, Thomas J, Ramkisoensing, Arti A, Zhang, Guoqi, Poelma, René H, Ördög, Balazs, de Vries, Antoine A F, Pijnappels, Daniël A

“…Abstract Aims Ventricular tachyarrhythmias (VTs) are common in the pathologically remodelled heart. These arrhythmias can be lethal, necessitating acute…”
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Anti-arrhythmic potential of the late sodium current inhibitor GS-458967 in murine Scn5a-1798insD+/- and human SCN5A-1795insD+/- iPSC-derived cardiomyocytes by Portero, Vincent, Casini, Simona, Hoekstra, Maaike, Verkerk, Arie O, Mengarelli, Isabella, Belardinelli, Luiz, Rajamani, Sridharan, Wilde, Arthur A M, Bezzina, Connie R, Veldkamp, Marieke W, Remme, Carol Ann

“…Selective inhibition of cardiac late sodium current (INaL) is an emerging target in the treatment of ventricular arrhythmias. We investigated the…”
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Light transmittance in human atrial tissue and transthoracic illumination in rats support translatability of optogenetic cardioversion of atrial fibrillation by Nyns, Emile C. A., Portero, Vincent, Deng, Shanliang, Jin, Tianyi, Harlaar, Niels, Bart, Cindy I., Brakel, Thomas J., Palmen, Meindert, Hjortnaes, Jesper, Ramkisoensing, Arti A., Zhang, Guo Qi, Poelma, René H., Ördög, Balázs, Vries, Antoine A. F., Pijnappels, Daniël A.

“…Background Optogenetics could offer a solution to the current lack of an ambulatory method for the rapid automated cardioversion of atrial fibrillation (AF),…”
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Targeting the Microtubule EB1-CLASP2 Complex Modulates NaV1.5 at Intercalated Discs by Marchal, Gerard A., Jouni, Mariam, Chiang, David Y., Pérez-Hernández, Marta, Podliesna, Svitlana, Yu, Nuo, Casini, Simona, Potet, Franck, Veerman, Christiaan C., Klerk, Mischa, Lodder, Elisabeth M., Mengarelli, Isabella, Guan, Kaomei, Vanoye, Carlos G., Rothenberg, Eli, Charpentier, Flavien, Redon, Richard, George, Alfred L., Verkerk, Arie O., Bezzina, Connie R., MacRae, Calum A., Burridge, Paul W., Delmar, Mario, Galjart, Niels, Portero, Vincent, Remme, Carol Ann

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