Search Results - "Porter, M B"

Design, execution, and analysis of CRISPR–Cas9-based deletions and genetic interaction networks in the fungal pathogen Candida albicans by Halder, Viola, Porter, Caroline B. M., Chavez, Alejandro, Shapiro, Rebecca S.

“…The study of fungal pathogens is of immediate importance, yet progress is hindered by the technical challenges of genetic manipulation. For Candida species,…”
Get full text

Author Correction: Design, execution, and analysis of CRISPR–Cas9-based deletions and genetic interaction networks in the fungal pathogen Candida albicans by Halder, Viola, Porter, Caroline B. M., Chavez, Alejandro, Shapiro, Rebecca S.

“…The version of this paper originally published contained reference errors. The sentence “To dissect complex genetic interactions in C. albicans , a…”
Get full text

Mouse fetal growth restriction through parental and fetal immune gene variation and intercellular communications cascade by Kaur, Gurman, Porter, Caroline B. M., Ashenberg, Orr, Lee, Jack, Riesenfeld, Samantha J., Hofree, Matan, Aggelakopoulou, Maria, Subramanian, Ayshwarya, Kuttikkatte, Subita Balaram, Attfield, Kathrine E., Desel, Christiane A. E., Davies, Jessica L., Evans, Hayley G., Avraham-Davidi, Inbal, Nguyen, Lan T., Dionne, Danielle A., Neumann, Anna E., Jensen, Lise Torp, Barber, Thomas R., Soilleux, Elizabeth, Carrington, Mary, McVean, Gil, Rozenblatt-Rosen, Orit, Regev, Aviv, Fugger, Lars

“…Fetal growth restriction (FGR) affects 5–10% of pregnancies, and can have serious consequences for both mother and child. Prevention and treatment are limited…”
Get full text

Antibiotic efficacy is linked to bacterial cellular respiration by Lobritz, Michael A, Peter Belenky, Caroline B. M. Porter, Arnaud Gutierrez, Jason H. Yang, Eric G. Schwarz, Daniel J. Dwyer, Ahmad S. Khalil, James J. Collins

“…Bacteriostatic and bactericidal antibiotic treatments result in two fundamentally different phenotypic outcomes—the inhibition of bacterial growth or,…”
Get full text

Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide α-CGRP Modulates Group 2 Innate Lymphoid Cell Responses by Xu, Heping, Ding, Jiarui, Porter, Caroline B.M., Wallrapp, Antonia, Tabaka, Marcin, Ma, Sai, Fu, Shujie, Guo, Xuanxuan, Riesenfeld, Samantha J., Su, Chienwen, Dionne, Danielle, Nguyen, Lan T., Lefkovith, Ariel, Ashenberg, Orr, Burkett, Patrick R., Shi, Hai Ning, Rozenblatt-Rosen, Orit, Graham, Daniel B., Kuchroo, Vijay K., Regev, Aviv, Xavier, Ramnik J.

“…Signaling abnormalities in immune responses in the small intestine can trigger chronic type 2 inflammation involving interaction of multiple immune cell types…”
Get full text

Skin-resident innate lymphoid cells converge on a pathogenic effector state by Bielecki, Piotr, Riesenfeld, Samantha J., Hütter, Jan-Christian, Torlai Triglia, Elena, Kowalczyk, Monika S., Ricardo-Gonzalez, Roberto R., Lian, Mi, Amezcua Vesely, Maria C., Kroehling, Lina, Xu, Hao, Slyper, Michal, Muus, Christoph, Ludwig, Leif S., Christian, Elena, Tao, Liming, Kedaigle, Amanda J., Steach, Holly R., York, Autumn G., Skadow, Mathias H., Yaghoubi, Parastou, Dionne, Danielle, Jarret, Abigail, McGee, Heather M., Porter, Caroline B. M., Licona-Limón, Paula, Bailis, Will, Jackson, Ruaidhrí, Gagliani, Nicola, Gasteiger, Georg, Locksley, Richard M., Regev, Aviv, Flavell, Richard A.

“…Tissue-resident innate lymphoid cells (ILCs) help sustain barrier function and respond to local signals. ILCs are traditionally classified as ILC1, ILC2 or…”
Get full text

A multi-modal single-cell and spatial expression map of metastatic breast cancer biopsies across clinicopathological features by Klughammer, Johanna, Abravanel, Daniel L., Segerstolpe, Åsa, Blosser, Timothy R., Goltsev, Yury, Cui, Yi, Goodwin, Daniel R., Sinha, Anubhav, Ashenberg, Orr, Slyper, Michal, Vigneau, Sébastien, Jané‐Valbuena, Judit, Alon, Shahar, Caraccio, Chiara, Chen, Judy, Cohen, Ofir, Cullen, Nicole, DelloStritto, Laura K., Dionne, Danielle, Files, Janet, Frangieh, Allison, Helvie, Karla, Hughes, Melissa E., Inga, Stephanie, Kanodia, Abhay, Lako, Ana, MacKichan, Colin, Mages, Simon, Moriel, Noa, Murray, Evan, Napolitano, Sara, Nguyen, Kyleen, Nitzan, Mor, Ortiz, Rebecca, Patel, Miraj, Pfaff, Kathleen L., Porter, Caroline B. M., Rotem, Asaf, Strauss, Sarah, Strasser, Robert, Thorner, Aaron R., Turner, Madison, Wakiro, Isaac, Waldman, Julia, Wu, Jingyi, Gómez Tejeda Zañudo, Jorge, Zhang, Diane, Lin, Nancy U., Tolaney, Sara M., Winer, Eric P., Boyden, Edward S., Chen, Fei, Nolan, Garry P., Rodig, Scott J., Zhuang, Xiaowei, Rozenblatt-Rosen, Orit, Johnson, Bruce E., Regev, Aviv, Wagle, Nikhil

“…Although metastatic disease is the leading cause of cancer-related deaths, its tumor microenvironment remains poorly characterized due to technical and…”
Get full text

A single-cell landscape of high-grade serous ovarian cancer by Izar, Benjamin, Tirosh, Itay, Stover, Elizabeth H., Wakiro, Isaac, Cuoco, Michael S., Alter, Idan, Rodman, Christopher, Leeson, Rachel, Su, Mei-Ju, Shah, Parin, Iwanicki, Marcin, Walker, Sarah R., Kanodia, Abhay, Melms, Johannes C., Mei, Shaolin, Lin, Jia-Ren, Porter, Caroline B. M., Slyper, Michal, Waldman, Julia, Jerby-Arnon, Livnat, Ashenberg, Orr, Brinker, Titus J., Mills, Caitlin, Rogava, Meri, Vigneau, Sébastien, Sorger, Peter K., Garraway, Levi A., Konstantinopoulos, Panagiotis A., Liu, Joyce F., Matulonis, Ursula, Johnson, Bruce E., Rozenblatt-Rosen, Orit, Rotem, Asaf, Regev, Aviv

“…Malignant abdominal fluid (ascites) frequently develops in women with advanced high-grade serous ovarian cancer (HGSOC) and is associated with drug resistance…”
Get full text

Hinged circular fixator construct for correction of congenital metatarsal deformity in a foal by Porter, E G, Cuddy, L C, Graham, A S, Reese, D J, Porter, M B, Morton, A J, Lewis, D D

“…A five-week-old American Quarter Horse colt was presented for evaluation of a left hindlimb deformity and lameness. Radiographs of the left hindlimb revealed a…”
Get more information

Tissue-resident memory and circulating T cells are early responders to pre-surgical cancer immunotherapy by Luoma, Adrienne M., Suo, Shengbao, Wang, Yifan, Gunasti, Lauren, Porter, Caroline B.M., Nabilsi, Nancy, Tadros, Jenny, Ferretti, Andrew P., Liao, Sida, Gurer, Cagan, Chen, Yu-Hui, Criscitiello, Shana, Ricker, Cora A., Dionne, Danielle, Rozenblatt-Rosen, Orit, Uppaluri, Ravindra, Haddad, Robert I., Ashenberg, Orr, Regev, Aviv, Van Allen, Eliezer M., MacBeath, Gavin, Schoenfeld, Jonathan D., Wucherpfennig, Kai W.

“…Neoadjuvant immune checkpoint blockade has shown promising clinical activity. Here, we characterized early kinetics in tumor-infiltrating and circulating…”
Get full text

Carbon Sources Tune Antibiotic Susceptibility in Pseudomonas aeruginosa via Tricarboxylic Acid Cycle Control by Meylan, Sylvain, Porter, Caroline B M, Yang, Jason H, Belenky, Peter, Gutierrez, Arnaud, Lobritz, Michael A, Park, Jihye, Kim, Sun H, Moskowitz, Samuel M, Collins, James J

“…Metabolically dormant bacteria present a critical challenge to effective antimicrobial therapy because these bacteria are genetically susceptible to antibiotic…”
Get more information

A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors by Slyper, Michal, Porter, Caroline B. M., Ashenberg, Orr, Waldman, Julia, Drokhlyansky, Eugene, Wakiro, Isaac, Smillie, Christopher, Smith-Rosario, Gabriela, Wu, Jingyi, Dionne, Danielle, Vigneau, Sébastien, Jané-Valbuena, Judit, Tickle, Timothy L., Napolitano, Sara, Su, Mei-Ju, Patel, Anand G., Karlstrom, Asa, Gritsch, Simon, Nomura, Masashi, Waghray, Avinash, Gohil, Satyen H., Tsankov, Alexander M., Jerby-Arnon, Livnat, Cohen, Ofir, Klughammer, Johanna, Rosen, Yanay, Gould, Joshua, Nguyen, Lan, Hofree, Matan, Tramontozzi, Peter J., Li, Bo, Wu, Catherine J., Izar, Benjamin, Haq, Rizwan, Hodi, F. Stephen, Yoon, Charles H., Hata, Aaron N., Baker, Suzanne J., Suvà, Mario L., Bueno, Raphael, Stover, Elizabeth H., Clay, Michael R., Dyer, Michael A., Collins, Natalie B., Matulonis, Ursula A., Wagle, Nikhil, Johnson, Bruce E., Rotem, Asaf, Rozenblatt-Rosen, Orit, Regev, Aviv

“…Single-cell genomics is essential to chart tumor ecosystems. Although single-cell RNA-Seq (scRNA-Seq) profiles RNA from cells dissociated from fresh tumors,…”
Get full text

Emergence of a High-Plasticity Cell State during Lung Cancer Evolution by Marjanovic, Nemanja Despot, Hofree, Matan, Chan, Jason E., Canner, David, Wu, Katherine, Trakala, Marianna, Hartmann, Griffin G., Smith, Olivia C., Kim, Jonathan Y., Evans, Kelly Victoria, Hudson, Anna, Ashenberg, Orr, Porter, Caroline B.M., Bejnood, Alborz, Subramanian, Ayshwarya, Pitter, Kenneth, Yan, Yan, Delorey, Toni, Phillips, Devan R., Shah, Nisargbhai, Chaudhary, Ojasvi, Tsankov, Alexander, Hollmann, Travis, Rekhtman, Natasha, Massion, Pierre P., Poirier, John T., Mazutis, Linas, Li, Ruifang, Lee, Joo-Hyeon, Amon, Angelika, Rudin, Charles M., Jacks, Tyler, Regev, Aviv, Tammela, Tuomas

“…Tumor evolution from a single cell into a malignant, heterogeneous tissue remains poorly understood. Here, we profile single-cell transcriptomes of genetically…”
Get full text

Bactericidal Antibiotics Induce Toxic Metabolic Perturbations that Lead to Cellular Damage by Belenky, Peter, Ye, Jonathan D., Porter, Caroline B.M., Cohen, Nadia R., Lobritz, Michael A., Ferrante, Thomas, Jain, Saloni, Korry, Benjamin J., Schwarz, Eric G., Walker, Graham C., Collins, James J.

“…Understanding how antibiotics impact bacterial metabolism may provide insight into their mechanisms of action and could lead to enhanced therapeutic…”
Get full text

A Distinct Transcriptional Program in Human CAR T Cells Bearing the 4-1BB Signaling Domain Revealed by scRNA-Seq by Boroughs, Angela C., Larson, Rebecca C., Marjanovic, Nemanja D., Gosik, Kirk, Castano, Ana P., Porter, Caroline B.M., Lorrey, Selena J., Ashenberg, Orr, Jerby, Livnat, Hofree, Matan, Smith-Rosario, Gabriela, Morris, Robert, Gould, Joshua, Riley, Lauren S., Berger, Trisha R., Riesenfeld, Samantha J., Rozenblatt-Rosen, Orit, Choi, Bryan D., Regev, Aviv, Maus, Marcela V.

“…T cells engineered to express chimeric antigen receptors (CARs) targeting CD19 have produced impressive outcomes for the treatment of B cell malignancies, but…”
Get full text

Increased energy demand from anabolic-catabolic processes drives β-lactam antibiotic lethality by Lobritz, Michael A, Andrews, Ian W, Braff, Dana, Porter, Caroline B M, Gutierrez, Arnaud, Furuta, Yoshikazu, Cortes, Louis B G, Ferrante, Thomas, Bening, Sarah C, Wong, Felix, Gruber, Charley, Bakerlee, Christopher W, Lambert, Guillaume, Walker, Graham C, Dwyer, Daniel J, Collins, James J

“…β-Lactam antibiotics disrupt the assembly of peptidoglycan (PG) within the bacterial cell wall by inhibiting the enzymatic activity of penicillin-binding…”
Get more information

Gaussian beam tracing for computing ocean acoustic fields by PORTER, M. B, BUCKER, H. P

“…The method of Gaussian beam tracing has recently received a great deal of attention in the seismological community. In comparison to standard ray tracing, the…”
Get full text

Single hydrophone source localization by Jesus, S.M., Porter, M.B., Stephan, Y., Demoulin, X., Rodriguez, O.C., Coelho, E.M.M.F.

“…The method presented in this paper assumes that the received signal is a linear combination of delayed and attenuated uncorrelated replicas of the source…”
Get full text

A CRISPR–Cas9-based gene drive platform for genetic interaction analysis in Candida albicans by Shapiro, Rebecca S., Chavez, Alejandro, Porter, Caroline B. M., Hamblin, Meagan, Kaas, Christian S., DiCarlo, James E., Zeng, Guisheng, Xu, Xiaoli, Revtovich, Alexey V., Kirienko, Natalia V., Wang, Yue, Church, George M., Collins, James J.

“…Candida albicans is the leading cause of fungal infections; yet, complex genetic interaction analysis remains cumbersome in this diploid pathogen. Here, we…”
Get full text

Comparative study between pony mares and ewes evaluating gonadotrophic response to administration of gonadotrophin-releasing hormone by Porter, M B, Cleaver, B D, Peltier, M, Robinson, G, Thatcher, W W, Sharp, D C

“…This study compared equine and ovine LH secretory responses to GnRH treatment. Dioestrous mares and ewes were challenged with continuous GnRH for 15 h. Mares…”
Get full text