Search Results - "Porter, Lisa"

Dissecting the roles of the Tuberin protein in the subcellular localization of the G2/M Cyclin, Cyclin B1 by Pillon, Adam, Dare-Shih, Jessica, Fong, Jackie, Fidalgo da Silva, Elizabeth, Porter, Lisa A

“…Tuberin is a major component of the protein regulatory complex known as the Tuberous Sclerosis Complex and plays a crucial role in cell cycle progression and…”
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Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomised trial by Bergenstal, Richard M, Dr, Wysham, Carol, MD, MacConell, Leigh, PhD, Malloy, Jaret, PhD, Walsh, Brandon, PhD, Yan, Ping, PhD, Wilhelm, Ken, MD, Malone, Jim, MD, Porter, Lisa E, MD

“…Summary Background Most patients with type 2 diabetes begin pharmacotherapy with metformin, but eventually need additional treatment. We assessed the safety…”
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Mg and Al-induced phase transformation and stabilization of Ga2O3-based γ-phase spinels by Tang, Jingyu, Jiang, Kunyao, House, Stephen D., Xu, Chengchao, Xiao, Kelly, Porter, Lisa M., Davis, Robert F.

“…Ga2O3 films were deposited on (100) MgAl2O4 spinel substrates at 550, 650, 750, and 850  ° C using metal-organic chemical vapor deposition and investigated…”
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Stabilization of c-Myc by the atypical cell cycle regulator, Spy1, decreases efficacy of breast cancer treatments by Ferraiuolo, Rosa-Maria, Fifield, Bre-Anne, Hamm, Caroline, Porter, Lisa A.

“…Purpose c-Myc is frequently upregulated in breast cancers, however, targeting c-Myc has proven to be a challenge. Targeting of downstream mediators of c-Myc,…”
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Neuroendocrine differentiation of prostate cancer leads to PSMA suppression by Bakht, Martin K, Derecichei, Iulian, Li, Yinan, Ferraiuolo, Rosa-Maria, Dunning, Mark, Oh, So Won, Hussein, Abdulkadir, Youn, Hyewon, Stringer, Keith F, Jeong, Chang Wook, Cheon, Gi Jeong, Kwak, Cheol, Kang, Keon Wook, Lamb, Alastair D, Wang, Yuzhuo, Dong, Xuesen, Porter, Lisa A

“…Prostate-specific membrane antigen (PSMA) is overexpressed in most prostate adenocarcinoma (AdPC) cells and acts as a target for molecular imaging. However,…”
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Frequently used antiemetic agent dexamethasone enhances the metastatic behaviour of select breast cancer cells by Crozier, Martin, Tubman, Janice, Fifield, Bre-Anne, Ferraiuolo, Rosa-Maria, Ritchie, Jenna, Zuccato, Katie, Mailloux, Emily, Sinha, Indrajit, Hamm, Caroline, Porter, Lisa A

“…Glucocorticoids, such as dexamethasone (Dex), are used to prevent common side effects induced by chemotherapy and are heavily prescribed for solid cancers such…”
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Fitted filtration efficiency and breathability of 2-ply cotton masks: Identification of cotton consumer categories acceptable for home-made cloth mask construction by Drouillard, Ken G, Tomkins, Amanda, Lackie, Sharon, Laengert, Scott, Baker, Allison, Clase, Catherine M, De Lannoy, Charles F, Cavallo-Medved, Dora, Porter, Lisa A, Rudman, Rebecca S

“…The objective of this study was to characterize commercially-available cotton fabrics to determine their suitability as materials for construction of cloth…”
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Atypical cell cycle regulation promotes mammary stem cell expansion during mammary development and tumourigenesis by Fifield, Bre-Anne, Vusich, John, Haberfellner, Erika, Andrechek, Eran R, Porter, Lisa A

“…The cell cycle of mammary stem cells must be tightly regulated to ensure normal homeostasis of the mammary gland to prevent abnormal proliferation and…”
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DURATION-1: Exenatide Once Weekly Produces Sustained Glycemic Control and Weight Loss Over 52 Weeks by BUSE, John B, DRUCKER, Daniel J, TAYLOR, Kristin L, KIM, Terri, WALSH, Brandon, HAO HU, WILHELM, Ken, TRAUTMANN, Michael, SHEN, Larry Z, PORTER, Lisa E

“…In the Diabetes Therapy Utilization: Researching Changes in A1C, Weight and Other Factors Through Intervention with Exenatide Once Weekly (DURATION-1) study,…”
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Thermal stability and phase transformation of α-, κ(ε)-, and γ-Ga2O3 films under different ambient conditions by Tang, Jingyu, Jiang, Kunyao, Tseng, Po-Sen, Kurchin, Rachel C., Porter, Lisa M., Davis, Robert F.

“…Phase transitions in metastable α-, κ(ε)-, and γ-Ga2O3 films to thermodynamically stable β-Ga2O3 during annealing in air, N2, and vacuum have been…”
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Exenatide once weekly versus liraglutide once daily in patients with type 2 diabetes (DURATION-6): a randomised, open-label study by Buse, John B, Prof, Nauck, Michael, Prof, Forst, Thomas, Prof, Sheu, Wayne H-H, Prof, Shenouda, Sylvia K, PhD, Heilmann, Cory R, PhD, Hoogwerf, Byron J, MD, Gao, Aijun, PhD, Boardman, Marilyn K, PharmD, Fineman, Mark, PhD, Porter, Lisa, MD, Schernthaner, Guntram, Prof

“…Summary Background Glucagon-like peptide-1 receptor agonists exenatide and liraglutide have been shown to improve glycaemic control and reduce bodyweight in…”
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Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study by Drucker, Daniel J, Dr, Buse, John B, MD, Taylor, Kristin, PhD, Kendall, David M, MD, Trautmann, Michael, MD, Zhuang, Dongliang, PhD, Porter, Lisa, MD

“…Summary Background Exenatide is an incretin mimetic that shares glucoregulatory properties with glucagon-like peptide 1 (GLP-1), and improves glycaemic…”
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Regulation of biological processes by ubiquitin ligases: a focus on the Pagano Lab's contribution by Kaldis, Philipp, Porter, Lisa A

“…Protein homeostasis depends on many fundamental processes including mRNA synthesis, translation, post-translational modifications, and proteolysis. In the late…”
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Transcriptomics Signature from Next-Generation Sequencing Data Reveals New Transcriptomic Biomarkers Related to Prostate Cancer by Alkhateeb, Abedalrhman, Rezaeian, Iman, Singireddy, Siva, Cavallo-Medved, Dora, Porter, Lisa A, Rueda, Luis

“…Prostate cancer is one of the most common types of cancer among Canadian men. Next-generation sequencing using RNA-Seq provides large amounts of data that may…”
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Rationale and Design of the EXenatide Study of Cardiovascular Event Lowering (EXSCEL) Trial by Holman, Rury R., FRCP, FMedSci, Bethel, M. Angelyn, MD, George, Jyothis, MRCPE, MRCP (UK), PhD, Sourij, Harald, MD, Doran, Zoë, RN, Keenan, Joanne, BA, Khurmi, Nardev S., MD, Mentz, Robert J., MD, Oulhaj, Abderrahim, PhD, Buse, John B., MD, PhD, Chan, Juliana C., MD, Iqbal, Nayyar, MD, Kundu, Sudeep, PhD, Maggioni, Aldo P., MD, Marso, Steven P., MD, Öhman, Peter, MD, PhD, Pencina, Michael J., PhD, Poulter, Neil, FMedSci, Porter, Lisa E., MD, Ramachandran, Ambady, MD, Zinman, Bernard, MD, Hernandez, Adrian F., MD, MHS

“…Abstract Exenatide once-weekly is an extended release formulation of exenatide, a glucagon-like peptide (GLP)-1 receptor agonist, which can improve glycemic…”
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Barriers to translational research in Windsor Ontario: a survey of clinical care providers and health researchers by Senecal, Justin B, Metcalfe, Karen, Wilson, Kaila, Woldie, Indryas, Porter, Lisa A

“…Abstract Background Translational research is an ideology focussed on streamlining the transition of novel research into clinical practice to ultimately…”
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Differential Expression of Glucose Transporters and Hexokinases in Prostate Cancer with a Neuroendocrine Gene Signature: A Mechanistic Perspective for 18 F-FDG Imaging of PSMA-Suppressed Tumors by Bakht, Martin K, Lovnicki, Jessica M, Tubman, Janice, Stringer, Keith F, Chiaramonte, Jonathan, Reynolds, Michael R, Derecichei, Iulian, Ferraiuolo, Rosa-Maria, Fifield, Bre-Anne, Lubanska, Dorota, Oh, So Won, Cheon, Gi Jeong, Kwak, Cheol, Jeong, Chang Wook, Kang, Keon Wook, Trant, John F, Morrissey, Colm, Coleman, Ilsa M, Wang, Yuzhuo, Ahmadzadehfar, Hojjat, Dong, Xuesen, Porter, Lisa A

“…Although the incidence of de novo neuroendocrine prostate cancer (PC) is rare, recent data suggest that low expression of prostate-specific membrane antigen…”
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Structural basis of divergent cyclin‐dependent kinase activation by Spy1/RINGO proteins by McGrath, Denise A, Fifield, Bre‐Anne, Marceau, Aimee H, Tripathi, Sarvind, Porter, Lisa A, Rubin, Seth M

“…Cyclin‐dependent kinases (Cdks) are principal drivers of cell division and are an important therapeutic target to inhibit aberrant proliferation. Cdk enzymatic…”
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Evaluating and optimizing Acid-pH and Direct Lysis RNA extraction for SARS-CoV-2 RNA detection in whole saliva by LaBute, Brayden, Fong, Jackie, Ziaee, Farinaz, Gombar, Robert, Stover, Mathew, Beaudin, Terry, Badalova, Maria, Geng, Qiudi, Corchis-Scott, Ryland, Podadera, Ana, Lago, Kyle, Xu, ZhenHuan, Lim, Fievel, Chiu, Felix, Fu, Minghua, Nie, Xiaofeng, Wu, Yuanmin, Quan, Corrina, Hamm, Caroline, McKay, R. Michael, Ng, Kenneth, Porter, Lisa A., Tong, Yufeng

“…COVID-19 has been a global public health and economic challenge. Screening for the SARS-CoV-2 virus has been a key part of disease mitigation while the world…”
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Paclitaxel-induced transcriptional regulation of Fas signaling pathway is antagonized by dexamethasone by Crozier, Martin, Porter, Lisa A.

“…Chemotherapy agents like paclitaxel are often a first line of therapy for triple-negative breast cancer patients and a last line of therapy for other…”
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