Search Results - "Porter, Jeffery A."

Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma by Jiang, Xiaomo, Hao, Huai-Xiang, Growney, Joseph D., Woolfenden, Steve, Bottiglio, Cindy, Ng, Nicholas, Lu, Bo, Hsieh, Mindy H., Bagdasarian, Linda, Meyer, Ronald, Smith, Timothy R., Avello, Monika, Charlat, Olga, Xie, Yang, Porter, Jeffery A., Pan, Shifeng, Liu, Jun, McLaughlin, Margaret E., Cong, Feng

“…A growing number of agents targeting ligand-induced Wnt/β-catenin signaling are being developed for cancer therapy. However, clinical development of these…”
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Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers by Hoffman, Gregory R., Rahal, Rami, Buxton, Frank, Xiang, Kay, McAllister, Gregory, Frias, Elizabeth, Bagdasarian, Linda, Huber, Janina, Lindeman, Alicia, Chen, Dongshu, Romero, Rodrigo, Ramadan, Nadire, Phadke, Tanushree, Haas, Kristy, Jaskelioff, Mariela, Wilson, Boris G., Meyer, Matthew J., Saenz-Vash, Veronica, Zhai, Huili, Myer, Vic E., Porter, Jeffrey A., Keen, Nicholas, McLaughlin, Margaret E., Mickanin, Craig, Roberts, Charles W. M., Stegmeier, Frank, Jagani, Zainab

“…Defects in epigenetic regulation play a fundamental role in the development of cancer, and epigenetic regulators have recently emerged as promising therapeutic…”
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Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62 by DeJesus, Rowena, Moretti, Francesca, McAllister, Gregory, Wang, Zuncai, Bergman, Phil, Liu, Shanming, Frias, Elizabeth, Alford, John, Reece-Hoyes, John S, Lindeman, Alicia, Kelliher, Jennifer, Russ, Carsten, Knehr, Judith, Carbone, Walter, Beibel, Martin, Roma, Guglielmo, Ng, Aylwin, Tallarico, John A, Porter, Jeffery A, Xavier, Ramnik J, Mickanin, Craig, Murphy, Leon O, Hoffman, Gregory R, Nyfeler, Beat

“…SQSTM1 is an adaptor protein that integrates multiple cellular signaling pathways and whose expression is tightly regulated at the transcriptional and…”
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Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies by Ettenberg, Seth A., Charlat, Olga, Daley, Michael P., Liu, Shanming, Vincent, Karen J., Stuart, Darrin D., Schuller, Alwin G., Yuan, Jing, Ospina, Beatriz, Green, John, Yu, Qunyan, Walsh, Renee, Li, Sharon, Schmitz, Rita, Heine, Holger, Bilic, Sanela, Ostrom, Lance, Mosher, Rebecca, Hartlepp, K. Felix, Zhu, Zhenping, Fawell, Stephen, Yao, Yung-Mae, Stover, David, Finan, Peter M., Porter, Jeffery A., Sellers, William R., Klagge, Ingo M., Cong, Feng, Nusse, Roeland

“…Disregulated Wnt/β-catenin signaling has been linked to various human diseases, including cancers. Inhibitors of oncogenic Wnt signaling are likely to have a…”
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Sonic hedgehog myocardial gene therapy: tissue repair through transient reconstitution of embryonic signaling by Losordo, Douglas W, Kusano, Kengo F, Pola, Roberto, Murayama, Toshinori, Curry, Cynthia, Kawamoto, Atsuhiko, Iwakura, Atsushi, Shintani, Satoshi, Ii, Masaaki, Asai, Jun, Tkebuchava, Tengiz, Thorne, Tina, Takenaka, Hideya, Aikawa, Ryuichi, Goukassian, David, von Samson, Patrick, Hamada, Hiromichi, Yoon, Young-sup, Silver, Marcy, Eaton, Elizabeth, Ma, Hong, Heyd, Lindsay, Kearney, Marianne, Munger, William, Porter, Jeffery A, Kishore, Raj

“…Sonic hedgehog (Shh) is a crucial regulator of organ development during embryogenesis. We investigated whether intramyocardial gene transfer of naked DNA…”
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Identification of a Small Molecule Inhibitor of the Hedgehog Signaling Pathway: Effects on Basal Cell Carcinoma-like Lesions by Williams, Juliet A., Guicherit, Oivin M., Zaharian, Beatrice I., Xu, Yin, Chai, Ling, Wichterle, Hynek, Kon, Charlene, Gatchalian, Christine, Porter, Jeffery A., Rubin, Lee L., Wang, Frank Y.

“…The link between basal cell carcinoma (BCC) and aberrant activation of the Hedgehog (Hh) signaling pathway has been well established in humans and in mouse…”
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Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development by Porter, Jeffrey A., Young, Keith E., Beachy, Philip A.

“…To determine the function of the pS2 trefoil protein, which is normally expressed in the gastric mucosa, the mouse pS2 (mpS2) gene was inactivated. The antral…”
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ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner by Hao, Huai-Xiang, Xie, Yang, Zhang, Yue, Charlat, Olga, Oster, Emma, Avello, Monika, Lei, Hong, Mickanin, Craig, Liu, Dong, Ruffner, Heinz, Mao, Xiaohong, Ma, Qicheng, Zamponi, Raffaella, Bouwmeester, Tewis, Finan, Peter M., Kirschner, Marc W., Porter, Jeffery A., Serluca, Fabrizio C., Cong, Feng

“…R-spondin proteins strongly potentiate Wnt signalling and function as stem-cell growth factors. Despite the biological and therapeutic significance, the…”
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Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists by Frank-Kamenetsky, Maria, Zhang, Xiaoyan M, Bottega, Steve, Guicherit, Oivin, Wichterle, Hynek, Dudek, Henryk, Bumcrot, David, Wang, Frank Y, Jones, Simon, Shulok, Janine, Rubin, Lee L, Porter, Jeffery A

“…The Hedgehog (Hh) signaling pathway is vital to animal development as it mediates the differentiation of multiple cell types during embryogenesis. In adults,…”
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SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice by Palacino, James, Swalley, Susanne E, Song, Cheng, Cheung, Atwood K, Shu, Lei, Zhang, Xiaolu, Van Hoosear, Mailin, Shin, Youngah, Chin, Donovan N, Keller, Caroline Gubser, Beibel, Martin, Renaud, Nicole A, Smith, Thomas M, Salcius, Michael, Shi, Xiaoying, Hild, Marc, Servais, Rebecca, Jain, Monish, Deng, Lin, Bullock, Caroline, McLellan, Michael, Schuierer, Sven, Murphy, Leo, Blommers, Marcel J J, Blaustein, Cecile, Berenshteyn, Frada, Lacoste, Arnaud, Thomas, Jason R, Roma, Guglielmo, Michaud, Gregory A, Tseng, Brian S, Porter, Jeffery A, Myer, Vic E, Tallarico, John A, Hamann, Lawrence G, Curtis, Daniel, Fishman, Mark C, Dietrich, William F, Dales, Natalie A, Sivasankaran, Rajeev

“…A high-throughput screen identified a small molecule that promoted inclusion of SMN2 exon 7, increased SMN2 protein levels and extended survival in a SMA mouse…”
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RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling by Zhang, Yue, Liu, Shanming, Mickanin, Craig, Feng, Yan, Charlat, Olga, Michaud, Gregory A., Schirle, Markus, Shi, Xiaoying, Hild, Marc, Bauer, Andreas, Myer, Vic E., Finan, Peter M., Porter, Jeffery A., Huang, Shih-Min A., Cong, Feng

“…Axin negatively regulates Wnt signalling by promoting degradation of β-catenin. Poly(ADP)-ribosylation of axin induces its degradation to relieve this…”
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Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling by Bauer, Andreas, Myer, Vic, Fawell, Stephen, Ghidelli, Sonja, Shi, Xiaoying, Rau, Christina, Schirle, Markus, Serluca, Fabrizio, Zhang, Yue, Bouwmeester, Tewis, Charlat, Olga, Mickanin, Craig, Curtis, Daniel, Stegmeier, Frank, Hild, Marc, Cong, Feng, Mishina, Yuji M, Wilson, Christopher J, Liu, Shanming, Wiessner, Stephanie, Tomlinson, Ronald, Fazal, Aleem, Shao, Wenlin, Shultz, Michael, Wiellette, Elizabeth, Michaud, Gregory A, Cheng, Hong, Schlegl, Judith, Finan, Peter M, Porter, Jeffery A, Lu, Chris, Cheung, Atwood, Lengauer, Christoph, Tallarico, John A, Kirschner, Marc W, Huang, Shih-Min A

“…The stability of the Wnt pathway transcription factor β-catenin is tightly regulated by the multi-subunit destruction complex. Deregulated Wnt pathway activity…”
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Sonic Hedgehog Protein Signals Not as a Hydrolytic Enzyme but as an Apparent Ligand for Patched by Fuse, N, Maiti, T, Wang, B, Porter, J A, Hall, T M, Leahy, D J, Beachy, P A

“…The amino-terminal signaling domain of the Sonic hedgehog secreted protein (Shh-N), which derives from the Shh precursor through an autoprocessing reaction…”
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Hedgehog Patterning Activity: Role of a Lipophilic Modification Mediated by the Carboxy-Terminal Autoprocessing Domain by Porter, Jeffery A, Ekker, Stephen C, Park, Woo-Jin, von Kessler, Doris P, Young, Keith E, Chen, Chien-Huan, Ma, Yong, Woods, Amina S, Cotter, Robert J, Koonin, Eugene V, Beachy, Philip A

“…Autocatalytic processing mediated by the carboxy-terminal domain of the hedgehog (hh) protein precursor (Hh) generates an amino-terminal product that accounts…”
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Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy by Bonazzi, Simone, d'Hennezel, Eva, Beckwith, Rohan E J, Xu, Lei, Fazal, Aleem, Magracheva, Anna, Ramesh, Radha, Cernijenko, Artiom, Antonakos, Brandon, Bhang, Hyo-Eun C, Caro, Roxana García, Cobb, Jennifer S, Ornelas, Elizabeth, Ma, Xiaolei, Wartchow, Charles A, Clifton, Matthew C, Forseth, Ry R, Fortnam, Bethany Hughes, Lu, Hongbo, Csibi, Alfredo, Tullai, Jennifer, Carbonneau, Seth, Thomsen, Noel M, Larrow, Jay, Chie-Leon, Barbara, Hainzl, Dominik, Gu, Yi, Lu, Darlene, Meyer, Matthew J, Alexander, Dylan, Kinyamu-Akunda, Jacqueline, Sabatos-Peyton, Catherine A, Dales, Natalie A, Zécri, Frédéric J, Jain, Rishi K, Shulok, Janine, Wang, Y Karen, Briner, Karin, Porter, Jeffery A, Tallarico, John A, Engelman, Jeffrey A, Dranoff, Glenn, Bradner, James E, Visser, Michael, Solomon, Jonathan M

“…Malignant tumors can evade destruction by the immune system by attracting immune-suppressive regulatory T cells (Treg) cells. The IKZF2 (Helios) transcription…”
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Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway by Fan, Chen-Ming, Porter, Jeffery A, Chiang, Chin, Chang, David T, Beachy, Philip A, Tessier-Lavigne, Marc

“…A long-range signal encoded by the Sonic hedgehog ( Shh) gene has been implicated as the ventral patterning influence from the notochord that induces…”
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Directed Differentiation of Embryonic Stem Cells into Motor Neurons by Wichterle, Hynek, Lieberam, Ivo, Porter, Jeffery A., Jessell, Thomas M.

“…Inductive signals and transcription factors involved in motor neuron generation have been identified, raising the question of whether these developmental…”
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Pharmaceuticals A new grammar for drug discovery by Porter, Jeffery A, Fishman, Mark C

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Sonic Hedgehog Is Required for Progenitor Cell Maintenance in Telencephalic Stem Cell Niches by Machold, Robert, Hayashi, Shigemi, Rutlin, Michael, Muzumdar, Mandar D., Nery, Susana, Corbin, Joshua G., Gritli-Linde, Amel, Dellovade, Tammy, Porter, Jeffery A., Rubin, Lee L., Dudek, Henryk, McMahon, Andrew P., Fishell, Gord

“…To directly test the requirement for hedgehog signaling in the telencephalon from early neurogenesis, we examined conditional null alleles of both the Sonic…”
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Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling by Cooper, Michael K., Porter, Jeffery A., Young, Keith E., Beachy, Philip A.

“…Veratrum alkaloids and distal inhibitors of cholesterol biosynthesis have been studied for more than 30 years as potent teratogens capable of inducing cyclopia…”
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