Search Results - "Porter, E. K."

Stereo‐selective inhibition of transient receptor potential TRPC5 cation channels by neuroactive steroids by Majeed, Y, Amer, MS, Agarwal, AK, McKeown, L, Porter, KE, O'Regan, DJ, Naylor, J, Fishwick, CWG, Muraki, K, Beech, DJ

“…BACKGROUND AND PURPOSE Transient receptor potential canonical 5 (TRPC5) channels are widely expressed, including in the CNS, where they potentiate fear…”
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Binaries of massive black holes in rotating clusters: dynamics, gravitational waves, detection and the role of eccentricity by Amaro-Seoane, P., Eichhorn, C., Porter, E. K., Spurzem, R.

“…The dynamical evolution of binaries of intermediate-mass black holes (IMBHs; massive black holes with a mass ranging between 102 and 104 M⊙) in stellar…”
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Cellular mechanisms by which proinsulin C-peptide prevents insulin-induced neointima formation in human saphenous vein by Mughal, R. S., Scragg, J. L., Lister, P., Warburton, P., Riches, K., O’Regan, D. J., Ball, S. G., Turner, N. A., Porter, K. E.

“…Aims/hypothesis Endothelial cells (ECs) and smooth muscle cells (SMCs) play key roles in the development of intimal hyperplasia in saphenous vein (SV) bypass…”
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Upregulated TRPC1 Channel in Vascular Injury In Vivo and Its Role in Human Neointimal Hyperplasia by Kumar, B, Dreja, K, Shah, S S, Cheong, A, Xu, S -Z, Sukumar, P, Naylor, J, Forte, A, Cipollaro, M, McHugh, D, Kingston, P A, Heagerty, A M, Munsch, C M, Bergdahl, A, Hultgårdh-Nilsson, A, Gomez, M F, Porter, K E, Hellstrand, P, Beech, D J

“…Occlusive vascular disease is a widespread abnormality leading to lethal or debilitating outcomes such as myocardial infarction and stroke. It is part of…”
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The Effect of Six Different Statins on the Proliferation, Migration, and Invasion of Human Smooth Muscle Cells by Corpataux, J.-M., Naik, J., Porter, K.E., London, N.J.M.

“…Intimal hyperplasia (IH) can occur after any vascular injury and results from smooth muscle cells (SMC) proliferation, migration, and invasion into the…”
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Hypoxic remodelling of Ca2+ stores does not alter human cardiac myofibroblast invasion by Riches, K, Hettiarachchi, N T, Porter, K E, Peers, C

“…Cardiac fibroblasts are the most abundant cell type in the heart, and play a key role in the maintenance and repair of the myocardium following damage such as…”
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Statins for the prevention of vein graft stenosis: a role for inhibition of matrix metalloproteinase-9 by Porter, K E, Turner, N A

“…Saphenous vein (SV) grafts are commonly used to bypass coronary arteries that are diseased due to atherosclerosis. However, the development of intimal…”
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Diabetes and the Abdominal Aortic Aneurysm by Shantikumar, S, Ajjan, R, Porter, K.E, Scott, D.J.A

“…Abstract Objective The aim of this review is to delineate the association between abdominal aortic aneurysms (AAAs) and diabetes mellitus. Mechanisms for the…”
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Hypoxic Modulation of Ca²⁺ Signaling in Human Venous and Arterial Endothelial Cells by Aley, P. K, Bauer, C. C, Dallas, M. L, Boyle, J. P, Porter, K. E, Peers, C

“…Our understanding of vascular endothelial cell physiology is based on studies of endothelial cells cultured from various vascular beds of different species for…”
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Trauma related guilt cognitions partially mediate the relationship between PTSD symptom severity and functioning among returning combat veterans by Norman, S.B., Haller, M., Kim, Hyungjin Myra, Allard, C.B., Porter, K.E., Stein, M.B., Venners, M.R., Authier, C.C., Rauch, S.A.M.

“…Trauma related guilt, a distressing emotion associated with negative cognitions regarding one's actions or inaction during a traumatic event, is common among…”
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Enhanced Invasive Properties Exhibited by Smooth Muscle Cells are Associated with Elevated Production of MMP-2 in Patients with Aortic Aneurysms by Goodall, S., Porter, K.E., Bell, P.R., Thompson, M.M.

“…Background: abdominal aortic aneurysms (AAA) are associated with excessive vascular matrix remodelling. Recent findings suggest a systemic overproduction of…”
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A Comparison of Six Statins on the Development of Intimal Hyperplasia in a Human Vein Culture Model by Corpataux, J.-M., Naik, J., Porter, K.E., London, N.J.M.

“…Intimal hyperplasia (IH) threatens the patency of up to 35% of saphenous vein (SV) bypass grafts. In addition to reducing cholesterol levels, statins may…”
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Raised levels of plasma big endothelin 1 in patients with colorectal cancer by Simpson, R. A., Dickinson, T., Porter, K. E., London, N. J. M., Hemingway, D. M.

“…Background The aim was to assess the role of plasma Big Endothelin (ET) 1 levels as a marker of disease presence and stage in colorectal adenocarcinoma…”
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Marimastat inhibits neointimal thickening in a model of human vein graft stenosis by Porter, K. E., Loftus, I. M., Peterson, M., Bell, P. R. F., London, N. J. M., Thompson, M. M.

“…Background There is now accumulating evidence that matrix metalloproteinases (MMPs), the physiological mediators of matrix deposition and degradation, play an…”
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Endothelin-B receptors mediate intimal hyperplasia in an organ culture of human saphenous vein by Porter, Karen E., Olojugba, Deji H., Masood, Imran, Pemberton, Mark, Bell, Peter R.F., London, Nicholas J.M.

“…Objective: Although a number of pharmacologic agents have been shown to reduce intimal hyperplasia in animal models of restenosis, to date no systemic agent…”
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Endothelin-1 is a mediator of intimal hyperplasia in organ culture of human saphenous vein by Masood, I., Porter, K. E., London, N. J. M.

“…Background Endothelin‐1 (ET‐1) is a powerful vasoconstrictor and a potent mitogen for vascular smooth muscle cells. Excessive smooth muscle cell proliferation…”
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Hypoxic inhibition of human cardiac fibroblast invasion and MMP-2 activation may impair adaptive myocardial remodelling by Morley, M E, Riches, K, Peers, C, Porter, K E

“…Cardiac fibroblasts account for up to two-thirds of the total number of cells in the normal heart and are responsible for extracellular matrix homoeostasis. In…”
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Production and Inhibition of the Gelatinolytic Matrix Metalloproteinases in a Human Model of Vein Graft Stenosis by Porter, K.E, Thompson, M.M, Loftus, I.M, McDermott, E, Jones, L, Crowther, M, Bell, P.R.F, London, N.J.M

“…Objectives: human vein graft stenoses are caused by intimal hyperplasia, a process which is characterised by extensive degradation and accumulation of…”
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Characterisation of Fractalkine/CX3CL1 and Fractalkine Receptor (CX3CR1) Expression in Abdominal Aortic Aneurysm Disease by Patel, A, Jagadesham, V.P, Porter, K.E, Scott, D.J.A, Carding, S.R

“…Abstract Objectives Fractalkine (CX3CL1) promotes adhesion and extravasation of leucocytes through interactions with fractalkine receptor (CX3CR1) expressed on…”
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Human saphenous vein organ culture: A useful model of intimal hyperplasia? by Porter, Karen E., Varty, Kevin, Jones, Louise, Bell, Peter R.F., London, Nicholas J.M.

“…Although cell culture techniques and animal models of intimal hyperplasia have increased our current understanding of the aetiology of vein graft stenosis, the…”
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