Search Results - "Porter, Danielle P"

The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus by Gordon, Calvin J., Tchesnokov, Egor P., Feng, Joy Y., Porter, Danielle P., Götte, Matthias

“…Antiviral drugs for managing infections with human coronaviruses are not yet approved, posing a serious challenge to current global efforts aimed at containing…”
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Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir by Tchesnokov, Egor P, Feng, Joy Y, Porter, Danielle P, Götte, Matthias

“…Remdesivir (GS-5734) is a 1'-cyano-substituted adenosine nucleotide analogue prodrug that shows broad-spectrum antiviral activity against several RNA viruses…”
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Combination therapy protects macaques against advanced Marburg virus disease by Cross, Robert W., Bornholdt, Zachary A., Prasad, Abhishek N., Borisevich, Viktoriya, Agans, Krystle N., Deer, Daniel J., Abelson, Dafna M., Kim, Do H., Shestowsky, William S., Campbell, Lioudmila A., Bunyan, Elaine, Geisbert, Joan B., Fenton, Karla A., Zeitlin, Larry, Porter, Danielle P., Geisbert, Thomas W.

“…Monoclonal antibodies (mAbs) and remdesivir, a small-molecule antiviral, are promising monotherapies for many viruses, including members of the genera…”
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Effect of remdesivir post-exposure prophylaxis and treatment on pathogenesis of measles in rhesus macaques by Peart Akindele, Nadine A., Katamoni, Laharika Dasharath, Brockhurst, Jacqueline, Ghimire, Shristi, Suwanmanee, San, Pieterse, Lisa, Metcalf Pate, Kelly A., Bunyan, Elaine, Bannister, Roy, Cihlar, Tomas, Porter, Danielle P., Griffin, Diane E.

“…Measles is a systemic disease initiated in the respiratory tract with widespread measles virus (MeV) infection of lymphoid tissue. Mortality can be…”
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Prevention and therapy of SARS-CoV-2 and the B.1.351 variant in mice by Martinez, David R., Schäfer, Alexandra, Leist, Sarah R., Li, Dapeng, Gully, Kendra, Yount, Boyd, Feng, Joy Y., Bunyan, Elaine, Porter, Danielle P., Cihlar, Tomas, Montgomery, Stephanie A., Haynes, Barton F., Baric, Ralph S., Nussenzweig, Michel C., Sheahan, Timothy P.

“…Improving clinical care for individuals infected with SARS-CoV-2 variants is a global health priority. Small-molecule antivirals like remdesivir (RDV) and…”
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Expanded profiling of Remdesivir as a broad-spectrum antiviral and low potential for interaction with other medications in vitro by Radoshitzky, Sheli R., Iversen, Patrick, Lu, Xianghan, Zou, Jing, Kaptein, Suzanne J. F., Stuthman, Kelly S., Van Tongeren, Sean A., Steffens, Jesse, Gong, Ruoyu, Truong, Hoa, Sapre, Annapurna A., Yang, Huiling, Xie, Xiaodong, Chia, Jia Jun, Song, Zhijuan J., Leventhal, Stacey M., Chan, Josolyn, Shornikov, Alex, Zhang, Xin, Cowfer, David, Yu, Helen, Warren, Travis, Cihlar, Tomas, Porter, Danielle P., Neyts, Johan, Shi, Pei-Yong, Wells, Jay, Bilello, John P., Feng, Joy Y.

“…Remdesivir (GS-5734; VEKLURY) is a single diastereomer monophosphoramidate prodrug of an adenosine analog (GS-441524). Remdesivir is taken up by target cells…”
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Remdesivir is efficacious in rhesus monkeys exposed to aerosolized Ebola virus by Warren, Travis K., Kane, Christopher D., Wells, Jay, Stuthman, Kelly S., Van Tongeren, Sean A., Garza, Nicole L., Donnelly, Ginger, Steffens, Jesse, Gomba, Laura, Weidner, Jessica M., Norris, Sarah, Zeng, Xiankun, Bannister, Roy, Cihlar, Tomas, Bavari, Sina, Porter, Danielle P., Iversen, Patrick L.

“…Efficacious therapeutics for Ebola virus disease are in great demand. Ebola virus infections mediated by mucosal exposure, and aerosolization in particular,…”
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Repurposing an In Vitro Measles Virus Dissemination Assay for Screening of Antiviral Compounds by Schmitz, Katharina S, Lange, Mona V, Gommers, Lennert, Handrejk, Kim, Porter, Danielle P, Alabi, Christopher A, Moscona, Anne, Porotto, Matteo, de Vries, Rory D, de Swart, Rik L

“…Measles virus (MV) is a highly contagious respiratory virus responsible for outbreaks associated with significant morbidity and mortality among children and…”
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No Remdesivir Resistance Observed in the Phase 3 Severe and Moderate COVID-19 SIMPLE Trials by Hedskog, Charlotte, Spinner, Christoph D, Protzer, Ulrike, Hoffmann, Dieter, Ko, Chunkyu, Gottlieb, Robert L, Askar, Medhat, Roestenberg, Meta, de Vries, Jutte J C, Carbo, Ellen C, Martin, Ross, Li, Jiani, Han, Dong, Rodriguez, Lauren, Parvangada, Aiyappa, Perry, Jason K, Ferrer, Ricard, Antón, Andrés, Andrés, Cristina, Casares, Vanessa, Günthard, Huldrych F, Huber, Michael, McComsey, Grace A, Sadri, Navid, Aberg, Judith A, van Bakel, Harm, Porter, Danielle P

“…Remdesivir (RDV) is a broad-spectrum nucleotide analog prodrug approved for the treatment of COVID-19 in hospitalized and non-hospitalized patients with…”
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Characterization of the Cynomolgus Macaque Model of Marburg Virus Disease and Assessment of Timing for Therapeutic Treatment Testing by Zumbrun, Elizabeth E, Garvey, Carly B, Wells, Jay B, Lynn, Ginger C, Van Tongeren, Sean, Steffens, Jesse T, Wetzel, Kelly S, Gomba, Laura M, O'Brien, Kristan A, Rossi, Franco D, Zeng, Xiankun, Lee, Eric D, Raymond, Jo Lynne W, Hoffman, Diana A, Jay, Alexandra N, Brown, Elizabeth S, Kallgren, Paul A, Norris, Sarah L, Cantey-Kiser, Jean, Kudiya, Humza, Arthur, Chris, Blair, Christiana, Babusis, Darius, Chu, Victor C, Singh, Bali, Bannister, Roy, Porter, Danielle P, Cihlar, Tomas, Dye, John M

“…Marburg virus (MARV) causes severe disease and high mortality in humans. The objective of this study was to characterize disease manifestations and…”
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Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency by Gordon, Calvin J., Tchesnokov, Egor P., Woolner, Emma, Perry, Jason K., Feng, Joy Y., Porter, Danielle P., Götte, Matthias

“…Effective treatments for coronavirus disease 2019 (COVID-19) are urgently needed to control this current pandemic, caused by severe acute respiratory syndrome…”
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Combination therapy with remdesivir and monoclonal antibodies protects nonhuman primates against advanced Sudan virus disease by Cross, Robert W, Bornholdt, Zachary A, Prasad, Abhishek N, Woolsey, Courtney, Borisevich, Viktoriya, Agans, Krystle N, Deer, Daniel J, Abelson, Dafna M, Kim, Do H, Shestowsky, William S, Campbell, Lioudmila A, Bunyan, Elaine, Geisbert, Joan B, Dobias, Natalie S, Fenton, Karla A, Porter, Danielle P, Zeitlin, Larry, Geisbert, Thomas W

“…A major challenge in managing acute viral infections is ameliorating disease when treatment is delayed. Previously, we reported the success of a 2-pronged mAb…”
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Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2 by Williamson, Brandi N., Feldmann, Friederike, Schwarz, Benjamin, Meade-White, Kimberly, Porter, Danielle P., Schulz, Jonathan, van Doremalen, Neeltje, Leighton, Ian, Yinda, Claude Kwe, Pérez-Pérez, Lizzette, Okumura, Atsushi, Lovaglio, Jamie, Hanley, Patrick W., Saturday, Greg, Bosio, Catharine M., Anzick, Sarah, Barbian, Kent, Cihlar, Tomas, Martens, Craig, Scott, Dana P., Munster, Vincent J., de Wit, Emmie

“…Effective therapies to treat coronavirus disease 2019 (COVID-19) are urgently needed. While many investigational, approved, and repurposed drugs have been…”
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Emergent HIV-1 Drug Resistance Mutations Were Not Present at Low-Frequency at Baseline in Non-Nucleoside Reverse Transcriptase Inhibitor-Treated Subjects in the STaR Study by Porter, Danielle P, Daeumer, Martin, Thielen, Alexander, Chang, Silvia, Martin, Ross, Cohen, Cal, Miller, Michael D, White, Kirsten L

“…At Week 96 of the Single-Tablet Regimen (STaR) study, more treatment-naïve subjects that received rilpivirine/emtricitabine/tenofovir DF (RPV/FTC/TDF)…”
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Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action by Tchesnokov, Egor P., Gordon, Calvin J., Woolner, Emma, Kocinkova, Dana, Perry, Jason K., Feng, Joy Y., Porter, Danielle P., Götte, Matthias

“…Remdesivir (RDV) is a direct-acting antiviral agent that is used to treat patients with severe coronavirus disease 2019 (COVID-19). RDV targets the viral…”
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Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice by Pruijssers, Andrea J., George, Amelia S., Schäfer, Alexandra, Leist, Sarah R., Gralinksi, Lisa E., Dinnon, Kenneth H., Yount, Boyd L., Agostini, Maria L., Stevens, Laura J., Chappell, James D., Lu, Xiaotao, Hughes, Tia M., Gully, Kendra, Martinez, David R., Brown, Ariane J., Graham, Rachel L., Perry, Jason K., Du Pont, Venice, Pitts, Jared, Ma, Bin, Babusis, Darius, Murakami, Eisuke, Feng, Joy Y., Bilello, John P., Porter, Danielle P., Cihlar, Tomas, Baric, Ralph S., Denison, Mark R., Sheahan, Timothy P.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the novel viral disease COVID-19. With no approved therapies, this…”
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Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms by Stevens, Laura J, Pruijssers, Andrea J, Lee, Hery W, Gordon, Calvin J, Tchesnokov, Egor P, Gribble, Jennifer, George, Amelia S, Hughes, Tia M, Lu, Xiaotao, Li, Jiani, Perry, Jason K, Porter, Danielle P, Cihlar, Tomas, Sheahan, Timothy P, Baric, Ralph S, Götte, Matthias, Denison, Mark R

“…The nucleoside analog remdesivir (RDV) is a Food and Drug Administration-approved antiviral for treatment of severe acute respiratory syndrome coronavirus 2…”
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Remdesivir efficacy against yellow fever in a hamster model by Julander, Justin G., Bunyan, Elaine, Jordan, Robert, Porter, Danielle P.

“…Yellow fever virus (YFV) continues to cause periodic outbreaks of severe disease throughout tropical regions of South America and Africa despite the…”
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Remdesivir and GS-441524 Retain Antiviral Activity against Delta, Omicron, and Other Emergent SARS-CoV-2 Variants by Pitts, Jared, Li, Jiani, Perry, Jason K, Du Pont, Venice, Riola, Nicholas, Rodriguez, Lauren, Lu, Xianghan, Kurhade, Chaitanya, Xie, Xuping, Camus, Gregory, Manhas, Savrina, Martin, Ross, Shi, Pei-Yong, Cihlar, Tomas, Porter, Danielle P, Mo, Hongmei, Maiorova, Evguenia, Bilello, John P

“…Genetic variation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in the emergence and rapid spread of multiple variants…”
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Remdesivir (GS-5734) Is Efficacious in Cynomolgus Macaques Infected With Marburg Virus by Porter, Danielle P, Weidner, Jessica M, Gomba, Laura, Bannister, Roy, Blair, Christiana, Jordan, Robert, Wells, Jay, Wetzel, Kelly, Garza, Nicole, Van Tongeren, Sean, Donnelly, Ginger, Steffens, Jesse, Moreau, Alicia, Bearss, Jeremy, Lee, Eric, Bavari, Sina, Cihlar, Tomas, Warren, Travis K

“…Abstract Marburg virus (MARV) is a filovirus with documented human case-fatality rates of up to 90%. Here, we evaluated the therapeutic efficacy of remdesivir…”
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