Search Results - "Porter, C. W"

Investigating the observed sensitivities of air-quality extremes to meteorological drivers via quantile regression by Porter, W C, Heald, C L, Cooley, D, Russell, B

“…Air pollution variability is strongly dependent on meteorology. However, quantifying the impacts of changes in regional climatology on pollution extremes can…”
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Polyamine biosynthesis impacts cellular folate requirements necessary to maintain S-adenosylmethionine and nucleotide pools by Bistulfi, G, Diegelman, P, Foster, B.A, Kramer, D.L, Porter, C.W, Smiraglia, D.J

“…Folate (vitamin B9) is utilized for synthesis of both S-adenosylmethionine (AdoMet) and deoxythymidine monophosphate (dTMP), which are required for methylation…”
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Apoptotic signaling in polyamine analogue-treated SK-MEL-28 human melanoma cells by YING CHEN, KRAMER, Debora L, DIEGELMAN, Paula, VUJCIC, Slavoljub, PORTER, Carl W

“…N(1),N(11)-Diethylnorspermine (DENSPM) is a polyamine analogue with clinicalrelevance as an experimental anticancer agent and the ability to elicit a profound…”
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Generation of a Mouse Model for Arginase II Deficiency by Targeted Disruption of the Arginase II Gene by Shi, Ou, Morris, Sidney M., Zoghbi, Huda, Porter, Carl W., O'Brien, William E.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The polyamine oxidase inhibitor MDL-72,527 selectively induces apoptosis of transformed hematopoietic cells through lysosomotropic effects by HAIQING DAI, KRAMER, D. L, CHUNYING YANG, MURTI, K. G, PORTER, C. W, CLEVELAND, J. L

“…Polyamine oxidase functions in the polyamine catabolic pathway, converting N1-acetyl-spermidine and -spermine into putrescine (Put) and spermidine (Spd),…”
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CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity by REGENASS, U, METT, H, STANEK, J, MUELLER, M, KRAMER, D, PORTER, C. W

“…Inhibitors of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (SAMDC), derived from methylglyoxal-bis(guanylhydrazone) (MGBG), have been…”
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Polyamine and polyamine analog regulation of spermidine/spermine N1-acetyltransferase in MALME-3M human melanoma cells by Fogel-Petrovic, M., Shappell, N.W., Bergeron, R.J., Porter, C.W.

“…In MALME-3M human melanoma cells the polyamine analog N1,N12-bis(ethyl)spermine (BESPM) suppresses the key polyamine biosynthetic enzymes, ornithine and…”
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Correlations between polyamine analogue-induced increases in spermidine/spermine N1-acetyltransferase activity, polyamine pool depletion, and growth inhibition in human melanoma cell lines by PORTER, C. W, GANIS, B, LIBBY, P. R, BERGERON, R. J

“…The polyamine analogue, N1,N12-bis(ethyl(-spermine (BESPM), is known to suppress ornithine and S-adenosylmethionine decarboxylase levels, deplete intracellular…”
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Dependence of Trichomonas vaginalis upon polyamine backconversion by Yarlett, Nigel, Martinez, Martha P, Goldberg, Burt, Kramer, Debora L, Porter, Carl W

“…Haskins Laboratories 1 and Department of Chemistry and Physical Sciences 2 , Pace University, 41 Park Row, New York, NY 10038, USA Department of Biology, St…”
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Regulation of polyamine transport by polyamines and polyamine analogs by Kramer, D L, Miller, J T, Bergeron, R J, Khomutov, R, Khomutov, A, Porter, C W

“…Regulation of polyamine transport in murine L1210 leukemia cells was characterized in order to better understand its relationship to specific intracellular…”
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Effects of novel spermine analogues on cell cycle progression and apoptosis in MALME-3M human melanoma cells by KRAMER, D. L, FOGEL-PETROVIC, M, DIEGELMAN, P, COOLEY, J. M, BERNACKI, R. J, MCMANIS, J. S, BERGERON, R. J, PORTER, C. W

“…On the basis of encouraging preclinical findings, polyamine analogues have emerged as a novel class of experimental antitumor agents. The spermine derivative…”
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Human prostatic carcinoma cell lines display altered regulation of polyamine transport in response to polyamine analogs and inhibitors by Mi, Z., Kramer, D.L., Miller, J.T., Bergeron, R.J., Bernacki, R., Porter, C.W.

“…BACKGROUND The possibility was investigated that complex homeostatic mechanisms which maintain polyamine pools in prostate‐derived tumors may differ from those…”
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Interference with polyamine biosynthesis and/or function by analogs of polyamines or methionine as a potential anticancer chemotherapeutic strategy by Porter, C W, Sufrin, J R

“…The obvious goal in cancer chemotherapy is selectivity. Highly cytotoxic agents abound but their usefulness as anticancer agents extends only so far as their…”
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Regulation of spermidine/spermine N1-acetyltransferase by intracellular polyamine pools : Evidence for a functional role in polyamine homeostasis by Shappell, N.W., Fogel-Petrovic, M.F., Porter, C.W.

“…Through its role in polyamine acetylation and the back-conversion pathway, spermidine/spermine N 1-acetyltransferase (SSAT) has the potential to control…”
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Differential induction of spermidine/spermine N1-acetyltransferase in human lung cancer cells by the bis(ethyl)polyamine analogues by CASERO, R. A. JR, CELANO, P, ERVIN, S. J, PORTER, C. W, BERGERON, R. J, LIBBY, P. R

“…We have investigated the induction of an important polyamine metabolic enzyme, spermidine/spermine N1-acetyltransferase, in two human lung cancer cell lines…”
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Polyamine metabolism and tumorigenesis in the Apc(Min/+) mouse by Berger, F G, Kramer, D L, Porter, C W

“…While polyamine homoeostasis is clearly important in maintenance of normal cell function, the roles of these cations, as well as the enzymes that regulate…”
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Antitumor efficacy of N1,N11-diethylnorspermine on a human bladder tumor xenograft in nude athymic mice by SHARMA, A, GLAVES, D, PORTER, C. W, RAGHAVAN, D, BERNACKI, R. J

“…The spermine analogue N1,N11-diethylnorspermine (DENSPM) has been shown to induce the polyamine-acetylating enzyme spermidine/spermine N1-acetyltransferase,…”
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Polyamine analogue-mediated cell cycle responses in human melanoma cells involves the p53, p21, Rb regulatory pathway by Kramer, D L, Vujcic, S, Diegelman, P, White, C, Black, J D, Porter, C W

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The mechanisms and meteorological drivers of the summertime ozone–temperature relationship by Porter, William C, Heald, Colette L

“…Surface ozone (O3) pollution levels are strongly correlated with daytime surface temperatures, especially in highly polluted regions. This correlation is…”
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Lysosomal sequestration of polyamine analogues in chinese hamster ovary cells resistant to the S-adenosylmethionine decarboxylase inhibitor, CGP-48664 by KRAMER, D. L, BLACK, J. D, METT, H, BERGERON, R. J, PORTER, C. W

“…CGP-48664, an inhibitor of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (AdoMetDC), is presently undergoing Phase 1 clinical trials as…”
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