The Demographic and Clinical Characteristics of Ulcerative Colitis in a Northeast Brazilian Population

Introduction. The purpose of this study was to describe the clinical and demographic characteristics of UC in Bahia, a Brazilian state, and to identify the variables associated with extensive colitis, steroid therapy, immunosuppression, and colectomy. Methods. In this cross-sectional study UC patien...

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Bibliographic Details
Published in:	BioMed research international Vol. 2015; no. 2015; pp. 1 - 8
Main Authors:	Santana, Genoile Oliveira, de Souza, Mariana Tinoco Lordello, Lisboa, Sonyara Rauedys Oliveira, Ribeiro, Camila Paula Oliveira, Mendes, Carlos Maurício Cardeal, Lyra, Andre Castro, da Silva, Bruno César, Portela, Renata Cavalcanti
Format:	Journal Article
Language:	English
Published:	Cairo, Egypt Hindawi Publishing Corporation 01-01-2015 John Wiley & Sons, Inc Hindawi Limited
Subjects:	Adolescent Adult Age Factors Aged Brazil - epidemiology Child Colectomy - methods Colitis, Ulcerative - diagnosis Colitis, Ulcerative - epidemiology Colitis, Ulcerative - therapy Cross-Sectional Studies Diarrhea - complications Distribution Family Health Female Gastroenterology Hospitalization Hospitals Humans Immunosuppressive Agents - therapeutic use Inflammatory bowel disease Male Middle Aged Poisson Distribution Population Prevalence Risk Factors Rural areas Rural Population Steroids Steroids - therapeutic use Studies Tumor necrosis factor-TNF Ulcerative colitis Urban Population Weight Loss Young Adult Brazil
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Summary:	Introduction. The purpose of this study was to describe the clinical and demographic characteristics of UC in Bahia, a Brazilian state, and to identify the variables associated with extensive colitis, steroid therapy, immunosuppression, and colectomy. Methods. In this cross-sectional study UC patients were interviewed, and additional information was collected from the medical records. Descriptive statistics and multivariate Poisson regression analysis were used. Results. This study included 267 individuals, the mean age of whom was 39.4 years at diagnosis. There was a predominance of females and left-side colitis. Extensive colitis was positively associated with male gender, diarrhea, weight loss, and a younger age at diagnosis. In contrast, active smoking and a family history of IBD were negatively associated with extensive colitis. Positive associations were observed between steroid therapy and diarrhea, weight loss, urban patients, extraintestinal manifestations (EIMs), and hospitalization. Younger age and weight loss at diagnosis, a family history of IBD, extensive colitis, EIMs, hospitalization, and steroid therapy were all positively associated with immunosuppression. In contrast, Caucasian individuals, smokers, patients with rectal bleeding, and rural patients areas were all observed to have a decreased likelihood of immunosuppression. Conclusions. Our results corroborate the association between higher prevalence of extensive colitis and younger age at diagnosis. An association between steroid therapy and clinical presentation at diagnosis was observed. The observation that white individuals and rural patients use less immunosuppressive drugs highlights the need to study the influence of environmental and genetic factors on the behavior of UC in this population.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Academic Editor: Kian Keyashian
ISSN:	2314-6133 2314-6141
DOI:	10.1155/2015/359130