Search Results - "Portanova, Joseph P."

CpG DNA induces cyclooxygenase-2 expression and prostaglandin production by Chen, Yongjin, Zhang, Juan, Moore, Steven A., Ballas, Zuhair K., Portanova, Joseph P., Krieg, Arthur M., Berg, Daniel J.

“…Unmethylated CpG motifs found in bacterial DNA are potent activators of the innate and acquired immune systems, and rapidly induce the production of…”
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Acute Lymphoid and Gastrointestinal Toxicity Induced by Selective p38α Map Kinase and Map Kinase–Activated Protein Kinase-2 (MK2) Inhibitors in the Dog by Morris, Dale L., O’Neil, Shawn P., Devraj, Rajesh V., Portanova, Joseph P., Gilles, Richard W., Gross, Cindy J., Curtiss, Sandra W., Komocsar, Wendy J., Garner, Debra S., Happa, Fernando A., Kraus, Lori J., Nikula, Kristen J., Monahan, Joseph B., Selness, Shaun R., Galluppi, Gerald R., Shevlin, Kimberly M., Kramer, Jeffrey A., Walker, John K., Messing, Dean M., Anderson, David R., Mourey, Robert J., Whiteley, Laurence O., Daniels, John S., Yang, Jerry Z., Rowlands, Philip C., Alden, Carl L., Davis, John W., Sagartz, John E.

“…Exposure to moderately selective p38α mitogen-activated protein kinase (MAPK) inhibitors in the Beagle dog results in an acute toxicity consisting of mild…”
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Selective neutralization of prostaglandin E2 blocks inflammation, hyperalgesia, and interleukin 6 production in vivo by Portanova, J P, Zhang, Y, Anderson, G D, Hauser, S D, Masferrer, J L, Seibert, K, Gregory, S A, Isakson, P C

“…The role of prostaglandin E2 (PGE2) in the development of inflammatory symptoms and cytokine production was evaluated in vivo using a neutralizing anti-PGE2…”
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Acute Lymphoid and Gastrointestinal Toxicity Induced by Selective p38a Map Kinase and Map Kinase-Activated Protein Kinase-2 (MK2) Inhibitors in the Dog by Morris, Dale L, O'Neil, Shawn P, Devraj, Rajesh V, Portanova, Joseph P, Gilles, Richard W, Gross, Cindy J, Curtiss, Sandra W, Komocsar, Wendy J, Garner, Debra S, Happa, Fernando A, Kraus, Lori J, Nikula, Kristen J, Monahan, Joseph B, Selness, Shaun R, Galluppi, Gerald R, Shevlin, Kimberly M, Kramer, Jeffrey A, Walker, John K, Messing, Dean M, Anderson, David R, Mourey, Robert J, Whiteley, Laurence O, Daniels, John S, Yang, Jerry Z, Rowlands, Philip C, Alden, Carl L, Davis, John W, Sagartz, John E

“…Exposure to moderately selective p38a mitogen-activated protein kinase (MAPK) inhibitors in the Beagle dog results in an acute toxicity consisting of mild…”
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Characterization of a monoclonal antibody that neutralizes the activity of prostaglandin E2 by Mnich, SJ, Veenhuizen, AW, Monahan, JB, Sheehan, KC, Lynch, KR, Isakson, PC, Portanova, JP

“…We describe the generation of an IgG1 mAb, 2B5, that neutralizes the biologic activity of PGE2 in vitro and in vivo. The Ab was derived from a BALB/c mouse…”
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The contribution of L3T4+ T cells to lymphoproliferation and autoantibody production in MRL-lpr/lpr mice by SANTORO, T. J, PORTANOVA, J. P, KOTZIN, B. L

“…The current study examines the role of the L3T4 T cell subset in the development of lupus-like autoimmunity and lymphoproliferation in lpr-bearing mice…”
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Reactivity of anti-histone antibodies induced by procainamide and hydralazine by Portanova, J P, Rubin, R L, Joslin, F G, Agnello, V D, Tan, E M

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Acute lymphoid and gastrointestinal toxicity induced by selective p38alpha map kinase and map kinase-activated protein kinase-2 (MK2) inhibitors in the dog by Morris, Dale L, O'Neil, Shawn P, Devraj, Rajesh V, Portanova, Joseph P, Gilles, Richard W, Gross, Cindy J, Curtiss, Sandra W, Komocsar, Wendy J, Garner, Debra S, Happa, Fernando A, Kraus, Lori J, Nikula, Kristen J, Monahan, Joseph B, Selness, Shaun R, Galluppi, Gerald R, Shevlin, Kimberly M, Kramer, Jeffrey A, Walker, John K, Messing, Dean M, Anderson, David R, Mourey, Robert J, Whiteley, Laurence O, Daniels, John S, Yang, Jerry Z, Rowlands, Philip C, Alden, Carl L, Davis, 2nd, John W, Sagartz, John E

“…Exposure to moderately selective p38alpha mitogen-activated protein kinase (MAPK) inhibitors in the Beagle dog results in an acute toxicity consisting of mild…”
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An early post-mutational selection event directs expansion of autoreactive B cells in murine lupus by Portanova, Joseph P., Creadon, Geralyn, Zhang, Xianghua, Smith, Diana S., Kotzin, Brian L., Wysocki, Larry J.

“…We report evidence for a strong selection event directing the outgrowth of autoreactive B cells in spontaneous murine lupus. The event occurred shortly…”
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Rapid and selective induction of blood eosinophilia in guinea pigs by recombinant human interleukin 5 by Portanova, Joseph P., Christine, Lori J., Rangwala, Shaukat H., Compton, Robert P., Hirsch, Jeffrey L., Smith, Walter G., Monahan, Joseph B.

“…Interleukin 5 (IL-5) has been implicated as a causal mediator in the development of pulmonary eosinophilia and airway hyperreactivity in human asthma…”
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Interleukin 2 is a proliferative signal for B cells from autoimmune mice by Lehmann, K R, Kotzin, B L, Portanova, J P, Santoro, T J

“…T cells from murine lupus strains manifest complex defects in interleukin 2 (IL 2) production and receptor expression. The capacity of B cells from such mice…”
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Rabbits immunized with mixtures of staphylococcal protein A and autologous IgG produce anti-human IgG antibodies by Portanova, J P, Abeyounis, C J, Milgrom, F

“…The results of this study provide evidence that protein A may render IgG immunogenic in the autologous host. Antibodies to human but not rabbit IgG were…”
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Distribution of anti-histone-antibody-secreting cells in NZB/NZW mice by Portanova, J P, Kotzin, B L, Coleman, E A, Claman, H N

“…Using a histone-specific plaque assay, we examined anti-histone-antibody (AHA) production at the organ level in the autoimmune NZB/NZW strain. The spleen had…”
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The use of staphylococcal protein A in the mixed agglutination test by Portanova, J P, Abeyounis, C J, Milgrom, F

“…A mixed agglutination (MA) test employing staphylococcal protein A (SpA) instead of an antiglobulin reagent has been developed for the detection of IgG…”
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The role of histones as nuclear autoantigens in drug-related lupus erythematosus by Tan, E M, Portanova, J P

“…Patients with drug-related lupus erythematosus produce antibodies to nuclear histones which can be detected by a three-step indirect immunofluorescence…”
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Drug-induced lupus: clinical and serological studies by Harmon, C E, Portanova, J P

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No demonstrable relationship between IgM and IgG antinuclear antibody levels and acetylator phenotype in patients with systemic lupus erythematosus by Portanova, J P, Small, C J, Kohler, P F

“…To ascertain the possible influence of acetylator phenotype on antinuclear antibodies in systemic lupus erythematosus (SLE), we assayed sera from 11 rapid…”
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Self-reactive T cells in murine lupus: analysis of genetic contributions and development of self-tolerance by Kotzin, B L, Herron, L R, Babcock, S K, Portanova, J P, Palmer, E

“…Our understanding of the immune mechanisms that lead to systemic lupus erythematosus has been greatly advanced by the availability of murine models which…”
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