Search Results - "Portal, Lolita"

Cardioprotective Signaling Pathways in Obese Mice Submitted to Regular Exercise: Effect on Oxysterols by Barau, Caroline, Leick, Shirin, Caccia, Claudio, Portal, Lolita, Leoni, Valerio, Le Corvoisier, Philippe, Morin, Didier, Ghaleh, Bijan, Pons, Sandrine

“…Exercise induces cardioprotection against myocardial infarction, despite obesity, by restoring pro-survival pathways and increasing resistance of mitochondrial…”
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The CO-releasing molecule CORM-3 protects adult cardiomyocytes against hypoxia-reoxygenation by modulating pH restoration by Portal, Lolita, Morin, Didier, Motterlini, Roberto, Ghaleh, Bijan, Pons, Sandrine

“…Several studies have reported that CORM-3, a water-soluble carbon monoxide releasing molecule, elicits cardioprotection against myocardial infarction but the…”
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Abstract 4139141: Predicted efficacy of inclisiran on cardiovascular outcomes in lower extremity peripheral artery disease: results of the In Silico Sirius study by Mahe, Guillaume, Angoulvant, Denis, Amarenco, Pierre, Bastien, Alexandre, Bechet, Emmanuelle, Boccara, Franck, Boissel, Jean-Pierre, Cariou, Bertrand, Courcelles, Eulalie, diatchenko, Alizee, Filipovics, Anne, Kahoul, Riad, Granjeon-Noriot, Solene, Peyronnet, Emmanuel, Portal, Lolita, Porte, Solene, Wang, Yishu, Steg, Philippe

“…Abstract only Introduction: Symptomatic lower extremity peripheral artery disease (PAD) patients have the highest risk of cardiovascular (CV) outcomes among…”
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Abstract 4134364: Predicted Low-Density Lipoprotein Cholesterol and Cardiovascular Outcomes Lowering With Inclisiran in Patients With or Without stroke: Insights from SIRIUS in silico trial by Amarenco, Pierre, Angoulvant, Denis, Bastien, Alexandre, Bechet, Emmanuelle, Boccara, Franck, Boissel, Jean-Pierre, Cariou, Bertrand, Courcelles, Eulalie, diatchenko, Alizee, Filipovics, Anne, Kahoul, Riad, Granjeon-Noriot, Solene, Mahe, Guillaume, Peyronnet, Emmanuel, Portal, Lolita, Porte, Solene, Wang, Yishu, Steg, Philippe

“…Abstract only Introduction: Inclisiran, an siRNA, targeting PCSK9 mRNA, reduces LDL-c levels. In SIRIUS in silico trial (NCT05974345), inclisiran was predicted…”
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Abstract 4139801: Predicted efficacy of Inclisiran compared to active comparators on Cardiovascular Outcomes in patients with established atherosclerotic cardiovascular disease: results from the In Silico SIRIUS trial by Cariou, Bertrand, Angoulvant, Denis, Amarenco, Pierre, Bastien, Alexandre, Bechet, Emmanuelle, Boissel, Jean-Pierre, Courcelles, Eulalie, Filipovics, Anne, Granjeon-Noriot, Solene, Kahoul, Riad, Mahe, Guillaume, Peyronnet, Emmanuel, Portal, Lolita, Wang, Yishu, Steg, Philippe, Boccara, Franck

“…Abstract only Background: Inclisiran, an siRNA targeting PCSK9 mRNA, administered twice-yearly, substantially and sustainably reduced LDL-C. Data quantifying…”
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Predicting the efficacy of inclisiran on cardiovascular outcomes in patients with established atherosclerotic cardiovascular disease: Primary results of the in silico SIRIUS trial by Angoulvant, Denis, Amarenco, Pierre, Bastien, Alexandre, Bechet, Emmanuelle, Boccara, Franck, Boissel, Jean-Pierre, Cariou, Bertrand, Courcelles, Eulalie, Diatchenko, Alizee, Filipovics, Anne, Granjeon-Noriot, Solene, Kahoul, Riad, Mahé, Guillaume, Peyronnet, Emmanuel, Portal, Lolita, Porte, Solène, Wang, Yishu, Steg, Philippe Gabriel

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Regular treadmill exercise restores cardioprotective signaling pathways in obese mice independently from improvement in associated co-morbidities by Pons, Sandrine, Martin, Valérie, Portal, Lolita, Zini, Roland, Morin, Didier, Berdeaux, Alain, Ghaleh, Bijan

“…Abstract Obesity is a major health issue that impedes the ability of preconditioning and postconditioning to protect the myocardium against infarction…”
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In-silico trial emulation to predict the cardiovascular protection of new lipid-lowering drugs: an illustration through the design of the SIRIUS programme by Angoulvant, Denis, Granjeon-Noriot, Solène, Amarenco, Pierre, Bastien, Alexandre, Bechet, Emmanuelle, Boccara, Franck, Boissel, Jean-Pierre, Cariou, Bertrand, Courcelles, Eulalie, Diatchenko, Alizée, Filipovics, Anne, Kahoul, Riad, Mahé, Guillaume, Peyronnet, Emmanuel, Portal, Lolita, Porte, Solène, Wang, Yishu, Steg, Philippe Gabriel

“…Abstract Introduction Inclisiran, an siRNA targeting hepatic PCSK9 mRNA, administered twice-yearly (after initial and 3-month doses), substantially and…”
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VALIDATION OF AN IN-SILICO KNOWLEDGE-BASED MECHANISTIC MODEL OF ATHEROSCLEROTIC CARDIOVASCULAR DISEASE FOR THE SIRIUS STUDY by Angoulvant, Denis, Amarenco, Pierre, BASTIEN, Alexandre, BECHET, Emmanuelle, Boccara, Franck, Boissel, Jean Pierre, Cariou, Bertrand, Courcelles, Eulalie, Diatchenko, Alizée, Granjeon-Noriot, Solene, Mahé, Guillaume, Peyronnet, Emmanuel, PORTAL, Lolita, Porte, Solène, Wang, Yishu, Steg, Philippe Gabriel

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A model of hypoxia-reoxygenation on isolated adult mouse cardiomyocytes: characterization, comparison with ischemia-reperfusion, and application to the cardioprotective effect of regular treadmill exercise by Portal, Lolita, Martin, Valérie, Assaly, Rana, d'Anglemont de Tassigny, Alexandra, Michineau, Stéphanie, Berdeaux, Alain, Ghaleh, Bijan, Pons, Sandrine

“…The use of in vitro experimental models of hypoxia-reoxygenation (H/R) that mimic in vivo ischemia-reperfusion represents a powerful tool to investigate…”
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